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| Product | Description | |
|---|---|---|
| LY-3023414 | LY3023414, a quinoline derivative, has been found to be a PI3Kα and mTOR inhibitor that could influence cell proliferation and cycle of tumor cells. It was just planed a Phase II trial for Pancreatic cancer by Eli Lilly. Uses: Ly3023414 has been found to be a pi3kα and mtor inhibitor that could influence cell proliferation and cycle of tumor cells. Synonyms: LY3023414; UNII-C88817F47Y; LY-3023414; C88817F47Y; GTPL8918; 8-[5-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one. Grades: 98%. CAS No. 1386874-06-1. Molecular formula: C23H25N4O3. Mole weight: 406.48. |  |
| LY 303511 | LY 303511. Group: Biochemicals. Grades: Purified. CAS No. 154447-38-8. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| LY 303511 | LY 303511 is an inactive analogue of the phosphoinositide 3-kinase inhibitor LY294002, but it does not inhibit PI3K. It enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells, and reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM in MIN6 insulinoma cells. Synonyms: EM 101; 8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one; 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-; 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one; NSC736787. Grades: >98%. CAS No. 154447-38-8. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
| LY 303511 - CAS 154447-38-8 | A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002. Group: Fluorescence/luminescence spectroscopy. |  |
| LY 303511 hydrochloride | LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K + currents (IC 50 =64.6±9.1 μM) in MIN6 insulinoma cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15643A. |  |
| LY303511 hydrochloride | Cas No. 854127-90-5. | |
| LY3039478 | LY3039478 is an orally active inhibitor of Notch and γ-secretase, with an IC50 of 1 nM in most of the tumor cell lines tested. Synonyms: Crenigacestat; N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide; 4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide; Butanamide, N-((1S)-2-(((7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido(3,2-a)(3)benzazepin-7-yl)amino)-1-methyl-2-oxoethyl)-4,4,4-trifluoro-. Grades: >98%. CAS No. 1421438-81-4. Molecular formula: C22H23F3N4O4. Mole weight: 464.44. | |
| LY-306669 | LY-306669, a tetrazol derivative, has been found to be a leukotriene B4 receptor antagonist that was once studied its effect in acute lung injury. Synonyms: LY306669; LY 306669; 5-Ethyl-3'-fluoro-4-((6-methyl-6-(1H-tetrazol-5-yl)heptyl)oxy)-(1,1'-bipenyl)-2-ol monosodium salt; LY-306669; DTXSID70165296; HE116606. Grades: 98%. CAS No. 153227-04-4. Molecular formula: C23H28FN4NaO2. Mole weight: 434.49. | |
| LY310762 | LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. Synonyms: LY310762; LY 310762; LY-310762; LY310762 HCl. Grades: >98%. CAS No. 192927-92-7. Molecular formula: C24H27FN2O2.HCl. Mole weight: 430.94. | |
| LY311727 | LY311727 is an inhibitor of Group IIA sPLA2 (IC50 = 0.47 μM). LY311727 inhibited sPLA2-induced platelet aggregation. Synonyms: LY-311727; LY 311727; 3-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxypropylphosphonic acid. Grades: ≥95%. CAS No. 164083-84-5. Molecular formula: C22H27N2O5P. Mole weight: 430.4. | |
| LY311727 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| LY 311727 | LY 311727. Group: Biochemicals. Grades: Purified. CAS No. 164083-84-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LY3130481 | LY3130481, a benzothiazol derivative, has been found to be the first AMPA receptor antagonist that could be probably effective in studies of epilepsy. It has just been planed a Phase I trial by Cerecor. Synonyms: LY3130481; LY-3130481; LY 3130481; CERC-611; CERC611; CERC 611. (S)-6-(1-(1-(5-(2-hydroxyethoxy)pyridin-2-yl)-1H-pyrazol-3-yl)ethyl)benzo[d]thiazol-2(3H)-one. Grades: 98%. CAS No. 1610802-47-5. Molecular formula: C19H18N4O3S. Mole weight: 382.44. | |
| LY3154207 | LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity ( EC 50 =3 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1638667-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128770. | |
| LY 315920 | LY 315920. Group: Biochemicals. Grades: Purified. CAS No. 172732-68-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY-3177833 | LY-3177833 is a selective CDC7 (IC50 = 3.3 nM) and pMCM2 (IC50 = 290nM) inhibitor. It exhibits an antitumor activity in a wide range of cancers. Uses: Antitumor drug. Synonyms: (3R)-3-(5-Fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-1H-isoindol-1-one; LY-3177833; LY 3177833; LY3177833. CAS No. 1627696-51-8. Molecular formula: C16H12FN5O. Mole weight: 309.3. | |
| LY3200882 | LY3200882 is a potent, highly selective, ATP-competitive and orally active TGF-β receptor type 1 (ALK5) inhibitor with an IC 50 of 38.2 nM. LY3200882 inhibits various pro-tumorigenic activities and is also used as an immune modulatory agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1898283-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103021. | |
| LY 320135 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY 320135 | LY 320135 is a selective CB1 receptor antagonist. Uses: Cannabinoid receptor antagonists. Synonyms: LY320135; LY 320135; LY-320135. 4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile. Grades: ≥98% by HPLC. CAS No. 176977-56-3. Molecular formula: C24H17NO4. Mole weight: 383.4. | |
| LY 320135 | LY 320135. Group: Biochemicals. Grades: Purified. CAS No. 176977-56-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY3214996 | LY3214996 is a highly selective and orally available inhibitor of ERK1 an dERK2 (IC50= 5 nM for both enzymes in biochemical assays)and thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. Synonyms: temuterkib; LY-3214996; LY 3214996. CAS No. 1951483-29-6. Molecular formula: C22H27N7O2S. Mole weight: 453.56. | |
| LY-326325 | LY-326325, a decahydroisoquinaline derivative, has been found to be an AMPA receptor antagonist and was once studied for neuroprotection. Synonyms: LY 326325; LY326325; LY326325; (-)-(3S,4aR,6R,8R)-6-(2-(1(2)H-Tetrazol-5-yl)ethyl)dec ahydroisoquinaline-3-carboxylic acid; (4aalpha,8aalpha)-6beta-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3beta-carboxylic acid. Grades: 98%. CAS No. 177314-99-7. Molecular formula: C13H21N5O2. Mole weight: 279.34. | |
| LY3295668 | LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with K i values of 0.8 nM and 1038 nM for AurA and AurB, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AK-01. CAS No. 1919888-06-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114258. | |
| LY 333531 hydrochloride | LY 333531 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 169939-93-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| LY-333,531 hydrochloride | Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O3 HCl. US Biological Life Sciences. | Worldwide |
| LY-333531 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY-333,531 hydrochloride (Ruboxistaurin) | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| LY 333531 mesylate | LY 333531 mesylate is an orally-available protein kinase C β (PKC-β) specific inhibitor used for the treatment of diabetic nephropathy and diabetic macular edema. Uses: The treatment of diabetic nephropathy and diabetic macular edema. Synonyms: LY 333531 mesylate; LY333531 mesylate; LY-333531 mesylate; Ruboxistaurin mesylate; (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione mesylate. Grades: 99%. CAS No. 192050-59-2. Molecular formula: C28H28N4O3.CH4O3S. Mole weight: 564.65. | |
| LY 334370 hydrochloride | LY 334370 hydrochloride is a 5-HT1F receptor agonist. It shows antimigraine effects. Synonyms: Benzamide, 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-, hydrochloride (1:1); Benzamide, 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-, monohydrochloride; LY-334370 hydrochloride; LY334370 hydrochloride. Grades: ≥99% by HPLC. CAS No. 199673-74-0. Molecular formula: C21H22FN3O.HCl. Mole weight: 387.88. | |
| LY-334370 hydrochloride hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| LY 338979 | LY 338979 is a metabolite of the antifolate Pemetrexed. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid. Grades: Highly Purified. CAS No. 193281-00-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| LY 338979 | LY 338979. Group: Organic light-emitting diode (oled) materials. CAS No. 193281-00-4. Product ID: (2S)-2-[[4-[2-(2-amino-4,6-dioxo-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid. Molecular formula: 443.4g/mol. Mole weight: C20H21N5O7. C1=CC (=CC=C1CCC2C3=C (NC2=O)N=C (NC3=O)N)C (=O)NC (CCC (=O)O)C (=O)O. InChI=1S/C20H21N5O7/c21-20-24-15-14 (18 (30)25-20)11 (17 (29)23-15)6-3-9-1-4-10 (5-2-9)16 (28)22-12 (19 (31)32)7-8-13 (26)27/h1-2, 4-5, 11-12H, 3, 6-8H2, (H, 22, 28) (H, 26, 27) (H, 31, 32) (H4, 21, 23, 24, 25, 29, 30)/t11?, 12-/m0/s1. YVRHJHKPTURIID-KIYNQFGBSA-N. |  |
| LY 338979 Dimethyl Ester | Protected LY 338979 (L486650), a metabolite of the antifolate Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester. Grades: Highly Purified. CAS No. 1320346-45-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| LY-338979 Dimethyl Ester | LY-338979 dimethyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Dimethyl N-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate; N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester; L-Glutamic acid, N-[4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, dimethyl ester. Grades: ≥95%. CAS No. 1320346-45-9. Molecular formula: C22H25N5O7. Mole weight: 471.46. | |
| LY341495 | Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo. Synonyms: LY 341495; LY-341495. Grades: >98%. CAS No. 201943-63-7. Molecular formula: C20H19NO5. Mole weight: 353.37. | |
| LY 341495 disodium salt | LY 341495 disodium salt. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY 341495 disodium salt | Disodium salt of LY 341495. LY 341495 is a group II metabotropic glutamate receptor antagonist. Synonyms: LY 341495 disodium salt; LY341495 disodium salt; LY-341495 disodium salt; (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt. Grades: ≥97% by HPLC. Molecular formula: C20H17NNa2O5. Mole weight: 397.33. | |
| LY 344864 | LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for SR-1F, SR-1A, SR-1B. Synonyms: N-[(6R)-6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]-4-fluorobenzamide;hydrochlorideLY-344864; LY344864; LY 344864; LY-344864 HCl; LY-344864 hydrochloride. Grades: >99 %. CAS No. 186544-26-3. Molecular formula: C21H22FN3O. Mole weight: 351.42. | |
| LY 344864 | LY 344864 is a selective, orally active 5-HT 1F receptor agonist with a K i of 6 nM. LY 344864 is a full agonist producing an effect similar in magnitude to serotonin itself. LY 344864 can cross the blood brain barrier to some extent [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 186544-26-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13788. | |
| LY 344864 hydrochloride | LY 344864 hydrochloride is a 5-HT1F receptor agonist with EC50 value of 3 nM. Synonyms: LY 344864 hydrochloride; LY344864 hydrochloride; LY-344864 hydrochloride; N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217756-94-9. Molecular formula: C21H22N3OF.HCl. Mole weight: 387.88. | |
| LY344864 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY-344864 Hydrochloride | LY-344864 Hydrochloride. Group: Biochemicals. Alternative Names: (R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-benzamide Hydrochloride. Grades: Highly Purified. CAS No. 186544-26-3. Pack Sizes: 10mg. Molecular Formula: C21H23ClFN3O, Molecular Weight: 387.88. US Biological Life Sciences. | Worldwide |
| LY 344864 Hydrochloride (5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864) | A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935. Group: Biochemicals. Grades: Highly Purified. CAS No. 186544-26-3. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O·HCl. US Biological Life Sciences. | Worldwide |
| LY 344864 racemate | LY 344864 racemate is a 5-HT1F receptor agonist. Synonyms: LY 344864 racemate; LY344864 racemate; LY-344864 racemate. CAS No. 186543-64-6. Molecular formula: C21H22FN3O. Mole weight: 351.42. | |
| LY 344864 racemate | LY 344864 racemate is a 5-HT 1F receptor agonist extracted from patent US 5708187 A. Uses: Scientific research. Group: Signaling pathways. CAS No. 186543-64-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13788C. | |
| LY 345899 | LY 345899 Inhibitor. Uses: Scientific use. Product Category: T15827. CAS No. 10538-99-5. |  |
| LY3522348 | KHK-IN-3 (Example 1) is a ketohexokinase ( KHK ) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KHK-IN-3. CAS No. 2568608-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149987. | |
| LY 354740 | LY 354740. Group: Biochemicals. Alternative Names: (+)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxylic acid; (1S, 2S, 5R, 6S)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxylic acidLY354740; Eglumegad; Eglumetad; LY354740. Grades: Highly Purified. CAS No. 176199-48-7. Pack Sizes: 2.5mg. Molecular Formula: C8H11NO4, Molecular Weight: 185.18. US Biological Life Sciences. | Worldwide |
| LY 354740 | LY 354740 is a selective group II mGlu receptors agonist with EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors. It shows antianxiety and antiaddictive activity. Synonyms: Eglumetad; LY-354740; LY354740; LY 354740; (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 176199-48-7. Molecular formula: C8H11NO4. Mole weight: 185.18. | |
| LY 354740 ((1S, 2S, 5R, 6S)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxy lic Acid, Eglumegad, Eglumetad) | A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100uM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep. Group: Biochemicals. Grades: Highly Purified. CAS No. 176199-48-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LY-354740 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY 364947 | Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T βR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Group: Biochemicals. Alternative Names: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]quinoline; E 616451; HTS 466284. Grades: Highly Purified. CAS No. 396129-53-6. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??N?, Molecular Weight: 272.3. US Biological Life Sciences. | Worldwide |
| LY-364947 | LY364947 is a selective inhibitor of TGF-β type-I receptor with potential anticancer activity. LY364947 inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3). Uses: Reprogramming. Synonyms: LY364947; LY-364947; LY 364947; HTS 466284; HTS466284; HTS-466284. Grades: 98%. CAS No. 396129-53-6. Molecular formula: C17H12N4. Mole weight: 272.31. | |
| LY-364947 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY367385 | LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC 50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 198419-91-9. Pack Sizes: 1 mg. Product ID: HY-107515. | |
| LY 367385 | LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is used to treat inflammatory diseases and neurodegenerative diseases. Synonyms: LY367385; LY 367385; LY-367385; (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid; 4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid. Grades: ≥99% by HPLC. CAS No. 198419-91-9. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
| LY-367385 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY367385 hydrochloride | LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC 50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2829282-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107515A. | |
| LY 367385 Hydrochloride ((S)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic Acid) | A potent antagonist selective for mGlu1a receptors (IC50 = 8.8uM and >100uM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved. Group: Biochemicals. Grades: Highly Purified. CAS No. 98419-91-9(FR. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| LY 368962 | Synonyms: LY 368962; N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid. Grades: > 95%. CAS No. 193281-05-9. Molecular formula: C19H21N5O7. Mole weight: 431.41. | |
| LY 368962 Dimethyl Ester | Protected LY 368962 (L486705), a metabolite of the antifolate Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid Dimethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LY 368962 Dimethyl Ester | LY 368962 dimethyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Dimethyl N-{4-[3-(2,6-diamino-4-oxo-1,4-dihydro-5-pyrimidinyl)-3-oxopropyl]benzoyl}-L-glutamate; L-Glutamic acid, N-[4-[3-(2,6-diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-, dimethyl ester; N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid Dimethyl Ester; Dimethyl (4-(3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)-3-oxopropyl)benzoyl)-L-glutamate. Grades: 98%. CAS No. 1798887-66-7. Molecular formula: C21H25N5O7. Mole weight: 459.45. | |
| LY 379268 | LY 379268. Group: Biochemicals. Alternative Names: (1R, 4R, 5S, 6R)-4-Amino-2-oxabicyclo[3. 1. 0]hexane-4, 6-dicarboxylic Acid. Grades: Highly Purified. CAS No. 191471-52-0. Pack Sizes: 5mg. Molecular Formula: C7H9NO5, Molecular Weight: 187.15. US Biological Life Sciences. | Worldwide |
| LY 379268 | LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY379268 can attenuate cocaine-induced increases in DA in nonhuman primates. Synonyms: LY379268; LY 379268; LY-379268; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid. Grades: ≥99% by HPLC. CAS No. 191471-52-0. Molecular formula: C7H9NO5. Mole weight: 187.15. | |
| LY 379268 disodium salt | Sodium salt of LY 379268. LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY379268 can attenuate cocaine-induced increases in DA in nonhuman primates. Synonyms: LY 379268 disodium salt; LY379268 disodium salt; LY-379268 disodium salt; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt. Grades: ≥98% by HPLC. Molecular formula: C7H7NNa2O5. Mole weight: 231.11. | |
| LY 379268 disodium salt | LY 379268 disodium salt. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY393558 | LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 271780-64-4. Pack Sizes: 1 mg. Product ID: HY-103089. | |
| LY 393558 | LY 393558. Group: Biochemicals. Grades: Purified. CAS No. 271780-64-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY 393558 | LY 393558 is a 5-HT reuptake inhibitor with pIC50 value of 8.48. It is also a dual 5-HT1B/1D receptor antagonist with pKB values of 9.05 and 8.98 respectively. Synonyms: LY 393558; LY-393558; LY393558; 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide. Grades: ≥97% by HPLC. CAS No. 271780-64-4. Molecular formula: C26H31FN4O4S2. Mole weight: 546.68. | |
| LY404039 | LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Synonyms: GW786034 HCl; LY-404039; LY 404039; LY404039; LY-404,039; LY404,039; LY 404,039; Pomaglumetad. Grades: >98%. CAS No. 635318-11-5. Molecular formula: C7H9NO6S. Mole weight: 235.22. | |
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