American Chemical Suppliers
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Product | Description | |
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LY 288513 Quick inquiry Where to buy Suppliers range | LY 288513 is a CCK2 receptor antagonist with IC50 value of 16nM. It shows anxiolytic and antipsychotic properties in vivo. Synonyms: LY 288513; LY288513; LY-288513; (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 147523-65-7. Molecular formula: C22H18BrN3O2. Mole weight: 436.3. | |
LY2886721 Quick inquiry Where to buy Suppliers range | LY2886721, under the IUPAC name N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, is the first oral small molecule inhibitting Beta secretase (BACE) to reach Phase 2 clinical research. It was developed by Eli Lilly & Co. with the potention to treat Alzheimer's Disease. Synonyms: N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide; LY2886721; LY-2886721; LY 2886721. CAS No. 1262036-50-9. Molecular formula: C18H16F2N4O2S. Mole weight: 390.41. | |
LY 2886721 hydrochloride Quick inquiry Where to buy Suppliers range | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. Uses: Potential treatment of alzheimer's disease. Synonyms: LY 2886721 hydrochloride; LY2886721 hydrochloride; LY-2886721 hydrochloride; N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1262036-49-6. Molecular formula: C18H16F2N4O2S.HCl. Mole weight: 426.87. | |
LY 290324 Quick inquiry Where to buy Suppliers range | LY 290324, a quinoline derivative, has been found to be a Leukotriene D4 receptor antagonist that could be probably effective as antiallergic and antiasthmatic agent. It has no development-reported since 1998. Synonyms: LY290324; LY-290324; 5-(2-(1-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)benzyl)indol-7-yl)ethyl)-1H-tetrazole. Grades: 98%. CAS No. 146554-87-2. Molecular formula: C29H24Cl2N6. Mole weight: 527.45. | |
LY2922470 Quick inquiry Where to buy Suppliers range | LY2922470 Inhibitor. Uses: Scientific use. Product Category: T15810. CAS No. 1423018-12-5. | |
LY 292728 Quick inquiry Where to buy Suppliers range | LY 292728, an oxoxanthene derivative, has been found to be a leukotriene B4 receptor antagonist that has once been studied as an antiasthmatic agent. Synonyms: LY 292728; LY292728; LY-292728; CHEMBL292782; 9h-xanthene-4-propanoic acid, 7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-9-oxo-; 9H-Xanthene-4-propanoicacid,7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propox. Grades: 98%. CAS No. 153034-77-6. Molecular formula: C34H29FO9. Mole weight: 600.60. | |
LY 293284 Quick inquiry Where to buy Suppliers range | LY-293284 is a Serotonin 1A receptor agonist developed by Eli Lilly. It is a selective 5-HT1A receptor full agonist. LY-293284 is far more selective for 5-HT1A with over 1000x selectivity over other serotonin receptor subtypes and other targets. No development was reported for the treatment of Anxiety disorders and Major depressive disorder. Uses: Anxiety disorders; major depressive disorder. Synonyms: LY 293284; LY293284; LY-293284. (R)-1-(4-(dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indol-6-yl)-Ethanone. Grades: 98%. CAS No. 141318-62-9. Molecular formula: C19H26N2O. Mole weight: 298.43. | |
LY-293559 Quick inquiry Where to buy Suppliers range | LY 215490, a decahydroisoquinoline derivative, has been found to be an AMPA receptor antagonist that could be a neuroprotective agent in the study of focal ischaemia. Synonyms: LY-293559; LY 215490; LY-215490; CHEMBL70937; SCHEMBL3678843; ZINC5760; (3R,4aS,6S,8aS)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid. Grades: 98%. CAS No. 150010-68-7. Molecular formula: C13H21N5O2. Mole weight: 279.34. | |
LY 293606 Quick inquiry Where to buy Suppliers range | GYKI-53405 is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) antagonist. It can bind to Xenopus brain membranes with KD and Bmax values of 4.5 mM and 35 pmol mg-1 protein respectively. Synonyms: GYKI-53405; GYKI 53405; GYKI53405; LY 293606; LY-293606; LY293606; 1-(4-Aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine. Grades: 98%. CAS No. 143691-37-6. Molecular formula: C19H19N3O3. Mole weight: 337.38. | |
LY 294002 Quick inquiry Where to buy Suppliers range | Cas No. 154447-36-6. | |
LY 294002 Quick inquiry Where to buy Suppliers range | LY 294002. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Catalog: APS002222. Format: Neat. | |
LY294002 Quick inquiry Where to buy Suppliers range | LY294002 is a potent inhibitor of phosphoinositide PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. Synonyms: LY294002; LY-294002; LY 294002; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholino-8-phenyl-4H-chromen-4-one. Grades: >98%. CAS No. 154447-36-6. Molecular formula: C19H17NO3. Mole weight: 307.349. | |
LY294002 Quick inquiry Where to buy Suppliers range | LY294002 Inhibitor. Uses: Scientific use. Product Category: T2008. CAS No. 154447-36-6. | |
LY294002 Quick inquiry Where to buy Suppliers range | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. | Worldwide |
LY 294002 hydrochloride Quick inquiry Where to buy Suppliers range | LY 294002 hydrochloride is a PI 3-kinase inhibitor with IC50 values of 0.31μM for PI 3-Kβ, 0.73μM for PI 3-Kα, 1.06μM for PI 3-Kδ and 6.60μM for PI 3-K&gamma. It can inhibit proliferation and induce apoptosis in human colon cancer cells. Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride. Grades: ≥99% by HPLC. CAS No. 934389-88-5. Molecular formula: C19H17NO3.HCl. Mole weight: 343.81. | |
LY 294002 hydrochloride Quick inquiry Where to buy Suppliers range | LY 294002 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 934389-88-5. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
LY2955303 Quick inquiry Where to buy Suppliers range | LY 2955303, is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. Uses: Osteoarthritis pain. Synonyms: 4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic Acid; LY-2955303; LY2955303; 4-(5-[3,5-Bis(2-methyl-2-propanyl)phenyl]-1-{4-[(4-methyl-1-piperazinyl)carbonyl]phenyl}-1H-pyrazol-3-yl)benzoic acid; Benzoic acid, 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-. Grades: 98%. CAS No. 1433497-19-8. Molecular formula: C36H42N4O3. Mole weight: 578.74. | |
LY 2955303 hydrochloride Quick inquiry Where to buy Suppliers range | LY 2955303 hydrochloride is a potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and RARγ, respectively) commonly used for the treatment of osteoarthritis joint pain. Uses: The treatment of osteoarthritis joint pain. Synonyms: LY 2955303 hydrochloride; LY2955303 hydrochloride; LY-2955303 hydrochloride; 4-(5-(3,5-di-tert-butylphenyl)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrazol-3-yl)benzoic acid hydrochloride. Grades: 98%. Molecular formula: C36H42N4O3.HCl. Mole weight: 615.2. | |
LY2979165 Quick inquiry Where to buy Suppliers range | LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants. Synonyms: LY-2979165; LY 2979165. Grades: 0.98. CAS No. 1311385-32-6. Molecular formula: C13H22N6O6S. Mole weight: 390.415. | |
LY3009120 Quick inquiry Where to buy Suppliers range | LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1. Synonyms: LY3009120; LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978. Grades: 98%. CAS No. 1454682-72-4. Molecular formula: C23H29FN6O. Mole weight: 424.51. | |
LY 302148 Quick inquiry Where to buy Suppliers range | LY 302148 is a 5-HT1F receptor agonist with potential for migraine therapeutics. Synonyms: 5-fluoro-3-[1-[2-(1-methylpyrazol-4-yl)ethyl]piperidin-4-yl]-1H-indole; 5-fluoro-3-(1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-4-piperidinyl)-1H-indole; LY 302148; LY 302148, monohydrochloride; LY-302148. Grades: >98%. CAS No. 182564-47-2. Molecular formula: C19H23FN4. Mole weight: 326.42. | |
LY-3023414 Quick inquiry Where to buy Suppliers range | LY3023414, a quinoline derivative, has been found to be a PI3Kα and mTOR inhibitor that could influence cell proliferation and cycle of tumor cells. It was just planed a Phase II trial for Pancreatic cancer by Eli Lilly. Uses: Ly3023414 has been found to be a pi3kα and mtor inhibitor that could influence cell proliferation and cycle of tumor cells. Synonyms: LY3023414; UNII-C88817F47Y; LY-3023414; C88817F47Y; GTPL8918; 8-[5-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one. Grades: 98%. CAS No. 1386874-06-1. Molecular formula: C23H25N4O3. Mole weight: 406.48. | |
LY 303511 Quick inquiry Where to buy Suppliers range | LY 303511. Group: Biochemicals. Grades: Purified. CAS No. 154447-38-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
LY 303511 Quick inquiry Where to buy Suppliers range | LY 303511 is an inactive analogue of the phosphoinositide 3-kinase inhibitor LY294002, but it does not inhibit PI3K. It enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells, and reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM in MIN6 insulinoma cells. Synonyms: EM 101; 8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one; 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-; 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one; NSC736787. Grades: >98%. CAS No. 154447-38-8. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
LY303511 hydrochloride Quick inquiry Where to buy Suppliers range | Cas No. 854127-90-5. | |
LY3039478 Quick inquiry Where to buy Suppliers range | LY3039478 is an orally active inhibitor of Notch and γ-secretase, with an IC50 of 1 nM in most of the tumor cell lines tested. Synonyms: Crenigacestat; N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide; 4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide; Butanamide, N-((1S)-2-(((7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido(3,2-a)(3)benzazepin-7-yl)amino)-1-methyl-2-oxoethyl)-4,4,4-trifluoro-. Grades: >98%. CAS No. 1421438-81-4. Molecular formula: C22H23F3N4O4. Mole weight: 464.44. | |
LY-306669 Quick inquiry Where to buy Suppliers range | LY-306669, a tetrazol derivative, has been found to be a leukotriene B4 receptor antagonist that was once studied its effect in acute lung injury. Synonyms: LY306669; LY 306669; 5-Ethyl-3'-fluoro-4-((6-methyl-6-(1H-tetrazol-5-yl)heptyl)oxy)-(1,1'-bipenyl)-2-ol monosodium salt; LY-306669; DTXSID70165296; HE116606. Grades: 98%. CAS No. 153227-04-4. Molecular formula: C23H28FN4NaO2. Mole weight: 434.49. | |
LY310762 Quick inquiry Where to buy Suppliers range | LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. Synonyms: LY310762; LY 310762; LY-310762; LY310762 HCl. Grades: >98%. CAS No. 192927-92-7. Molecular formula: C24H27FN2O2.HCl. Mole weight: 430.94. | |
LY 311727 Quick inquiry Where to buy Suppliers range | LY 311727. Group: Biochemicals. Grades: Purified. CAS No. 164083-84-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
LY311727 Quick inquiry Where to buy Suppliers range | LY311727 is an inhibitor of Group IIA sPLA2 (IC50 = 0.47 μM). LY311727 inhibited sPLA2-induced platelet aggregation. Synonyms: LY-311727; LY 311727; 3-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxypropylphosphonic acid. Grades: ≥95%. CAS No. 164083-84-5. Molecular formula: C22H27N2O5P. Mole weight: 430.4. | |
LY3130481 Quick inquiry Where to buy Suppliers range | LY3130481, a benzothiazol derivative, has been found to be the first AMPA receptor antagonist that could be probably effective in studies of epilepsy. It has just been planed a Phase I trial by Cerecor. Synonyms: LY3130481; LY-3130481; LY 3130481; CERC-611; CERC611; CERC 611. (S)-6-(1-(1-(5-(2-hydroxyethoxy)pyridin-2-yl)-1H-pyrazol-3-yl)ethyl)benzo[d]thiazol-2(3H)-one. Grades: 98%. CAS No. 1610802-47-5. Molecular formula: C19H18N4O3S. Mole weight: 382.44. | |
LY 315920 Quick inquiry Where to buy Suppliers range | LY 315920. Group: Biochemicals. Grades: Purified. CAS No. 172732-68-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
LY-3177833 Quick inquiry Where to buy Suppliers range | LY-3177833 is a selective CDC7 (IC50 = 3.3 nM) and pMCM2 (IC50 = 290nM) inhibitor. It exhibits an antitumor activity in a wide range of cancers. Uses: Antitumor drug. Synonyms: (3R)-3-(5-Fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-1H-isoindol-1-one; LY-3177833; LY 3177833; LY3177833. CAS No. 1627696-51-8. Molecular formula: C16H12FN5O. Mole weight: 309.3. | |
LY 320135 Quick inquiry Where to buy Suppliers range | LY 320135. Group: Biochemicals. Grades: Purified. CAS No. 176977-56-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
LY 320135 Quick inquiry Where to buy Suppliers range | LY 320135 is a selective CB1 receptor antagonist. Uses: Cannabinoid receptor antagonists. Synonyms: LY320135; LY 320135; LY-320135. 4-[[6-Methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]benzonitrile. Grades: ≥98% by HPLC. CAS No. 176977-56-3. Molecular formula: C24H17NO4. Mole weight: 383.4. | |
LY3214996 Quick inquiry Where to buy Suppliers range | LY3214996 is a highly selective and orally available inhibitor of ERK1 an dERK2 (IC50= 5 nM for both enzymes in biochemical assays)and thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. Synonyms: temuterkib; LY-3214996; LY 3214996. CAS No. 1951483-29-6. Molecular formula: C22H27N7O2S. Mole weight: 453.56. | |
LY-326325 Quick inquiry Where to buy Suppliers range | LY-326325, a decahydroisoquinaline derivative, has been found to be an AMPA receptor antagonist and was once studied for neuroprotection. Synonyms: LY 326325; LY326325; LY326325; (-)-(3S,4aR,6R,8R)-6-(2-(1(2)H-Tetrazol-5-yl)ethyl)dec ahydroisoquinaline-3-carboxylic acid; (4aalpha,8aalpha)-6beta-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3beta-carboxylic acid. Grades: 98%. CAS No. 177314-99-7. Molecular formula: C13H21N5O2. Mole weight: 279.34. | |
LY 333531 hydrochloride Quick inquiry Where to buy Suppliers range | LY 333531 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 169939-93-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
LY-333,531 hydrochloride Quick inquiry Where to buy Suppliers range | Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H28N4O3 HCl. US Biological Life Sciences. | Worldwide |
LY-333,531 hydrochloride (Ruboxistaurin) Quick inquiry Where to buy Suppliers range | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
LY 333531 mesylate Quick inquiry Where to buy Suppliers range | LY 333531 mesylate is an orally-available protein kinase C β (PKC-β) specific inhibitor used for the treatment of diabetic nephropathy and diabetic macular edema. Uses: The treatment of diabetic nephropathy and diabetic macular edema. Synonyms: LY 333531 mesylate; LY333531 mesylate; LY-333531 mesylate; Ruboxistaurin mesylate; (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione mesylate. Grades: 99%. CAS No. 192050-59-2. Molecular formula: C28H28N4O3.CH4O3S. Mole weight: 564.65. | |
LY 334370 hydrochloride Quick inquiry Where to buy Suppliers range | LY 334370 hydrochloride is a 5-HT1F receptor agonist. It shows antimigraine effects. Synonyms: Benzamide, 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-, hydrochloride (1:1); Benzamide, 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-, monohydrochloride; LY-334370 hydrochloride; LY334370 hydrochloride. Grades: ≥99% by HPLC. CAS No. 199673-74-0. Molecular formula: C21H22FN3O.HCl. Mole weight: 387.88. | |
LY-334370 hydrochloride hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC), powder. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 387.88 (anhydrous basis). Catalog: IAR4241555. Assay: ≥98% (HPLC). | |
LY 338979 Quick inquiry Where to buy Suppliers range | LY 338979. Group: Organic Light-Emitting Diode (OLED) Materials. CAS No. 193281-00-4. IUPAC Name: (2S)-2-[[4-[2-(2-amino-4,6-dioxo-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid. Molecular Weight: 443.4g/mol. Molecular Formula: C20H21N5O7. SMILES: C1=CC (=CC=C1CCC2C3=C (NC2=O)N=C (NC3=O)N)C (=O)NC (CCC (=O)O)C (=O)O. InChI: InChI=1S/C20H21N5O7/c21-20-24-15-14(18(30)25-20)11(17(29)23-15)6-3-9-1-4-10(5-2-9)16(28)22-12(19(31)32)7-8-13(26)27/h1-2, 4-5, 11-12H, 3, 6-8H2, (H, 22, 28)(H, 26, 27)(H, 31, 32)(H4, 21, 23, 24, 25, 29, 30)/t11?, 12-/m0/s1. InChIKey: YVRHJHKPTURIID-KIYNQFGBSA-N. | |
LY 338979 Quick inquiry Where to buy Suppliers range | LY 338979 is a metabolite of the antifolate Pemetrexed. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid. Grades: Highly Purified. CAS No. 193281-00-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
LY 338979 Dimethyl Ester Quick inquiry Where to buy Suppliers range | Protected LY 338979 (L486650), a metabolite of the antifolate Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester. Grades: Highly Purified. CAS No. 1320346-45-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
LY-338979 Dimethyl Ester Quick inquiry Where to buy Suppliers range | LY-338979 dimethyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Dimethyl N-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate; N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester; L-Glutamic acid, N-[4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, dimethyl ester. Grades: ≥95%. CAS No. 1320346-45-9. Molecular formula: C22H25N5O7. Mole weight: 471.46. | |
LY341495 Quick inquiry Where to buy Suppliers range | Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo. Synonyms: LY 341495; LY-341495. Grades: >98%. CAS No. 201943-63-7. Molecular formula: C20H19NO5. Mole weight: 353.37. | |
LY 341495 disodium salt Quick inquiry Where to buy Suppliers range | Disodium salt of LY 341495. LY 341495 is a group II metabotropic glutamate receptor antagonist. Synonyms: LY 341495 disodium salt; LY341495 disodium salt; LY-341495 disodium salt; (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt. Grades: ≥97% by HPLC. Molecular formula: C20H17NNa2O5. Mole weight: 397.33. | |
LY 341495 disodium salt Quick inquiry Where to buy Suppliers range | LY 341495 disodium salt. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
LY 344864 Quick inquiry Where to buy Suppliers range | LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for SR-1F, SR-1A, SR-1B. Synonyms: N-[(6R)-6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]-4-fluorobenzamide;hydrochlorideLY-344864; LY344864; LY 344864; LY-344864 HCl; LY-344864 hydrochloride. Grades: >99 %. CAS No. 186544-26-3. Molecular formula: C21H22FN3O. Mole weight: 351.42. | |
LY 344864 hydrochloride Quick inquiry Where to buy Suppliers range | LY 344864 hydrochloride is a 5-HT1F receptor agonist with EC50 value of 3 nM. Synonyms: LY 344864 hydrochloride; LY344864 hydrochloride; LY-344864 hydrochloride; N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217756-94-9. Molecular formula: C21H22N3OF.HCl. Mole weight: 387.88. | |
LY-344864 Hydrochloride Quick inquiry Where to buy Suppliers range | LY-344864 Hydrochloride. Group: Biochemicals. Alternative Names: (R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-benzamide Hydrochloride. Grades: Highly Purified. CAS No. 186544-26-3. Pack Sizes: 10mg. Molecular Formula: C21H23ClFN3O, Molecular Weight: 387.88. US Biological Life Sciences. | Worldwide |
LY 344864 Hydrochloride (5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864) Quick inquiry Where to buy Suppliers range | A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935. Group: Biochemicals. Grades: Highly Purified. CAS No. 186544-26-3. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O·HCl. US Biological Life Sciences. | Worldwide |
LY 344864 racemate Quick inquiry Where to buy Suppliers range | LY 344864 racemate is a 5-HT1F receptor agonist. Synonyms: LY 344864 racemate; LY344864 racemate; LY-344864 racemate. CAS No. 186543-64-6. Molecular formula: C21H22FN3O. Mole weight: 351.42. | |
LY 345899 Quick inquiry Where to buy Suppliers range | LY 345899 Inhibitor. Uses: Scientific use. Product Category: T15827. CAS No. 10538-99-5. | |
LY 354740 Quick inquiry Where to buy Suppliers range | LY 354740. Group: Biochemicals. Alternative Names: (+)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxylic acid; (1S, 2S, 5R, 6S)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxylic acidLY354740; Eglumegad; Eglumetad; LY354740. Grades: Highly Purified. CAS No. 176199-48-7. Pack Sizes: 2.5mg. Molecular Formula: C8H11NO4, Molecular Weight: 185.18. US Biological Life Sciences. | Worldwide |
LY 354740 Quick inquiry Where to buy Suppliers range | LY 354740 is a selective group II mGlu receptors agonist with EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors. It shows antianxiety and antiaddictive activity. Synonyms: Eglumetad; LY-354740; LY354740; LY 354740; (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 176199-48-7. Molecular formula: C8H11NO4. Mole weight: 185.18. | |
LY 354740 ((1S, 2S, 5R, 6S)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxy lic Acid, Eglumegad, Eglumetad) Quick inquiry Where to buy Suppliers range | A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100uM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep. Group: Biochemicals. Grades: Highly Purified. CAS No. 176199-48-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
LY-354740 hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 185.18 (anhydrous basis). Catalog: IAR4241546. Assay: ≥98% (HPLC). | |
LY 364947 Quick inquiry Where to buy Suppliers range | LY 364947. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 396129-53-6. IUPAC Name: 4-(3-pyridin-2-yl-1H-pyrazol-4-yl)quinoline. Molecular formula: C17H12N4. Mole weight: 272.30. Catalog: APS396129536. SMILES: c1ccc(nc1)c2n[nH]cc2c3ccnc4ccccc34. Format: Neat. | |
LY 364947 Quick inquiry Where to buy Suppliers range | Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T βR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Group: Biochemicals. Alternative Names: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]quinoline; E 616451; HTS 466284. Grades: Highly Purified. CAS No. 396129-53-6. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??N?, Molecular Weight: 272.3. US Biological Life Sciences. | Worldwide |
LY-364947 Quick inquiry Where to buy Suppliers range | LY364947 is a selective inhibitor of TGF-β type-I receptor with potential anticancer activity. LY364947 inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3). Uses: Reprogramming. Synonyms: LY364947; LY-364947; LY 364947; HTS 466284; HTS466284; HTS-466284. Grades: 98%. CAS No. 396129-53-6. Molecular formula: C17H12N4. Mole weight: 272.31. | |
LY 367385 Quick inquiry Where to buy Suppliers range | LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is used to treat inflammatory diseases and neurodegenerative diseases. Synonyms: LY367385; LY 367385; LY-367385; (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid; 4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid. Grades: ≥99% by HPLC. CAS No. 198419-91-9. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
LY-367385 hydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 198419-91-9 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 245.66. Catalog: ALP198419919. Assay: ≥98% (HPLC). | |
LY 367385 Hydrochloride ((S)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic Acid) Quick inquiry Where to buy Suppliers range | A potent antagonist selective for mGlu1a receptors (IC50 = 8.8uM and >100uM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved. Group: Biochemicals. Grades: Highly Purified. CAS No. 98419-91-9(FR. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
LY 368962 Quick inquiry Where to buy Suppliers range | Synonyms: LY 368962; N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid. Grades: > 95%. CAS No. 193281-05-9. Molecular formula: C19H21N5O7. Mole weight: 431.41. | |
LY 368962 Dimethyl Ester Quick inquiry Where to buy Suppliers range | LY 368962 dimethyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Dimethyl N-{4-[3-(2,6-diamino-4-oxo-1,4-dihydro-5-pyrimidinyl)-3-oxopropyl]benzoyl}-L-glutamate; L-Glutamic acid, N-[4-[3-(2,6-diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-, dimethyl ester; N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid Dimethyl Ester; Dimethyl (4-(3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)-3-oxopropyl)benzoyl)-L-glutamate. Grades: 98%. CAS No. 1798887-66-7. Molecular formula: C21H25N5O7. Mole weight: 459.45. | |
LY 368962 Dimethyl Ester Quick inquiry Where to buy Suppliers range | Protected LY 368962 (L486705), a metabolite of the antifolate Pemetrexed (P219500). Group: Biochemicals. Alternative Names: N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid Dimethyl Ester. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
LY 379268 Quick inquiry Where to buy Suppliers range | LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY379268 can attenuate cocaine-induced increases in DA in nonhuman primates. Synonyms: LY379268; LY 379268; LY-379268; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid. Grades: ≥99% by HPLC. CAS No. 191471-52-0. Molecular formula: C7H9NO5. Mole weight: 187.15. |