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| Product | Description | |
|---|---|---|
| Nebivolol Impurity 36 | Nebivolol Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 6-fluorochroman-2-carboxylate. CAS No. 1219915-01-1. Molecular formula: C11H11FO3. Mole weight: 210.20. Catalog: APB1219915011. |  |
| Nebivolol Impurity 37 | Nebivolol Impurity 37. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-ethyl 6-fluorochroman-2-carboxylate. CAS No. 1335103-88-2. Molecular formula: C12H13FO3. Mole weight: 224.23. Catalog: APB1335103882. | |
| Nebivolol Impurity 38 | Nebivolol Impurity 38. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-ethyl 6-fluorochroman-2-carboxylate. CAS No. 1335103-90-6. Molecular formula: C12H13FO3. Mole weight: 224.23. Catalog: APB1335103906. | |
| Nebivolol Impurity 39 | Nebivolol Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-chloro-1-(6-fluorochroman-2-yl)ethanone. CAS No. 1219914-99-4. Molecular formula: C11H10ClFO2. Mole weight: 228.65. Catalog: APB1219914994. | |
| Nebivolol Impurity 4 | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.25 nM. Synonyms: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,?4-dihydro-α-[[(phenylmethyl)?amino]?methyl]?-, (αS,?2S)?-. Grades: > 95%. CAS No. 129050-29-9. Molecular formula: C17H18FNO2. Mole weight: 287.34. |  |
| Nebivolol Impurity 40 | Nebivolol Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2-chloro-1-(6-fluorochroman-2-yl)ethanone. CAS No. 1219915-00-0. Molecular formula: C11H10ClFO2. Mole weight: 228.65. Catalog: APB1219915000. | |
| Nebivolol Impurity 47 | Nebivolol Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2-(benzylamino)-1-((S)-6-fluorochroman-2-yl)ethanol. CAS No. 1030385-16-0. Molecular formula: C18H20FNO2. Mole weight: 301.36. Catalog: APB1030385160. | |
| Nebivolol Impurity 5 | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.26 nM. Synonyms: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,?4-dihydro-α-[[(phenylmethyl)?amino]?methyl]?-. Grades: > 95%. CAS No. 99199-91-4. Molecular formula: C17H18FNO2. Mole weight: 287.34. | |
| Nebivolol Impurity 6 (SS) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.27 nM. Synonyms: (S)-(benzylamino)((S)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.26. | |
| Nebivolol Impurity 7 (RR) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.28 nM. Synonyms: (R)-(benzylamino)((R)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. | |
| Nebivolol Impurity 8 (SR) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.29 nM. Synonyms: (S)-(benzylamino)((R)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. | |
| Nebivolol Impurity 9 (RS) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.30 nM. Synonyms: (R)-(benzylamino)((S)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. | |
| Nebivolol Impurity A | This active molecular is a β-adrenergic receptor antagonist. Levonebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and left ventricular failure in Europe. It is highly cardioselective under certain circumstances. In Apr 2015, US FDA approved an ANDA for nebivolol submitted by Amerigen. In Jan 2016, Forest Laboratories and the University of Chicago withdrew a phase II/III trial for Hypertension in patients with chronic obstructive pulmonary disease in USA. Uses: Treatment of hypertension and left ventricular failure. Synonyms: R67145; R-67145; R 67145; Levonebivolol. (αS,α'S,2R,2'S)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; [2S-[2R*[R*[R*(S*)]]]]-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-methanol; Levonebivolol; R 67145; l-Nebivolol. Grades: 98%. CAS No. 118457-16-2. Molecular formula: C22H25F2NO4. Mole weight: 405.44. | |
| Nebivolol Impurity B (SR,SS) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.17 nM. Synonyms: [2S-[2R*[R*[S*(R*)]]]]-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol. Grades: > 95%. CAS No. 119365-25-2. Molecular formula: C22H25F2NO4. Mole weight: 405.45. | |
| Nebivolol Impurity I HCl (RR,SR) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.21 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'S,?2R,?2'R)?-. Grades: > 95%. CAS No. 920275-20-3. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. | |
| Nebivolol Impurity II HCl (SS,RS) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.22 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'S,?2S,?2'S)?-. Grades: > 95%. CAS No. 920299-27-0. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. | |
| Nebivolol O-Beta-D-Glucuronide | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.10 nM. Synonyms: Nebivolol O-β-D-Glucuronide; 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-[2-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino]ethyl β-D-Glucopyranosiduronic Acid. Grades: > 95%. Molecular formula: C28H33F2NO10. Mole weight: 581.57. | |
| Nebivolol Related Compound 1 HCl (Mixture of (RR,SR) and (SS,RS) Isomer) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.36 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'R,?2S,?2'R)?-; + 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'S,?2R,?2'S)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. | |
| Nebivolol Related Compound 2(Mixture of Diastereomers) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.37 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, (αR,?α'R,?2R,?2'S)?-; + 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, (αS,?α'S,?2R,?2'S)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. Mole weight: 405.45. | |
| Nebivolol Related Compound 3 HCl (Mixture of (RS,SR), (SR,SR) and (SR,RS) Isomers) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.38 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αR,?α'S,?2S,?2'R)?-; + 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'R,?2S,?2'R)?-; 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1)?, (αS,?α'R,?2S,?2'R)?-. Grades: > 95%. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. | |
| Nebivolol Related Compound 4 (Mixture of (R,R) and (S,S) Isomers) | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.39 nM. Synonyms: (S)-(benzylamino)((S)-chroman-2-yl)methanol;& (R)-(benzylamino)((R)-chroman-2-yl)methanol. Grades: > 95%. Molecular formula: C12H16FNO2. Mole weight: 225.27. | |
| Nebivolol Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Nebivolol Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Ne-Boc-D-lysine | Ne-Boc-D-lysine. Group: Biochemicals. Alternative Names: D-Lys(Boc)-OH. Grades: Highly Purified. CAS No. 31202-69-4. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. |  Worldwide |
| Ne-Boc-D-lysine-2-chlorotrityl resin | Ne-Boc-D-lysine-2-chlorotrityl resin. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine 98+% (HPLC) | Ne-Boc-D-lysine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 31202-69-4. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine allyl ester hydrochloride | Ne-Boc-D-lysine allyl ester hydrochloride. Group: Biochemicals. Alternative Names: D-Lys(Boc)-OAll·HCl. Grades: Highly Purified. CAS No. 218962-73-3. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine allyl ester hydrochloride 98+% (HPLC) | Ne-Boc-D-lysine allyl ester hydrochloride 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine methyl ester hydrochloride | Ne-Boc-D-lysine methyl ester hydrochloride. Group: Biochemicals. Alternative Names: D-Lys(Boc)-OMe·HCl. Grades: Highly Purified. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine methyl ester hydrochloride 98+% (HPLC) | Ne-Boc-D-lysine methyl ester hydrochloride 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine tert-butyl ester hydrochloride | Ne-Boc-D-lysine tert-butyl ester hydrochloride. Group: Biochemicals. Alternative Names: D-Lys(Boc)-OtBu·HCl. Grades: Highly Purified. CAS No. 201007-86-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-D-lysine tert-butyl ester hydrochloride 99+% (TLC) | Ne-Boc-D-lysine tert-butyl ester hydrochloride 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 201007-86-5. Pack Sizes: 1g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine-2-chlorotrityl resin | Ne-Boc-L-lysine-2-chlorotrityl resin. Group: Biochemicals. Alternative Names: L-Lys(Boc)-2-chlorotrityl resin. Grades: Highly Purified. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine-2-chlorotrityl resin, 0.3-0.8 meq/g | Ne-Boc-L-lysine-2-chlorotrityl resin, 0.3-0.8 meq/g. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine 4-nitroanilide | Ne-Boc-L-lysine 4-nitroanilide. Group: Biochemicals. Alternative Names: L-Lys(Boc)-pNA. Grades: Highly Purified. CAS No. 172422-76-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine 4-nitroanilide 99+% (HPLC) | Ne-Boc-L-lysine 4-nitroanilide 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-Lysine 99+% | Ne-Boc-L-Lysine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine allyl ester hydrochloride 99+% (HPLC) | Ne-Boc-L-lysine allyl ester hydrochloride 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine amide hydrochloride | Ne-Boc-L-lysine amide hydrochloride. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine methyl ester hydrochloride | Ne-Boc-L-lysine methyl ester hydrochloride. Group: Biochemicals. Alternative Names: L-Lys(Boc)-OMe·HCl. Grades: Highly Purified. CAS No. 2389-48-2. Pack Sizes: 2g, 5g, 10g, 25g, 50g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine methyl ester hydrochloride 98+% (HPLC) | Ne-Boc-L-lysine methyl ester hydrochloride 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine tert-butyl ester hydrochloride 98+% | Ne-Boc-L-lysine tert-butyl ester hydrochloride 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Neboglamine hydrochloride | Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CR-2249 hydrochloride; XY-2401 hydrochloride. CAS No. 2759182-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114753A. |  |
| Nebramine Disulfate | Nebramine Sulfate is a degradation product on the antibiotic Tobramycin. Synonyms: 2-Deoxy-4-O-(2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl)-D-streptamine Sulfate; 3'-Deoxyneamin Sulfate; 3'-Deoxyneamine Sulfate; 3'-Deoxyneomycin A Sulfate; Nebramycin VIII Sulfate; Tobramine Sulfate. Grades: > 95%. CAS No. 71122-29-7. Molecular formula: C12H26N4O5. 2 H2O4S. Mole weight: 306.36 2 98.08. | |
| nebramycin 5' synthase | Requires Fe(III). The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin. Group: Enzymes. Synonyms: tobramycin carbamoyltransferase; TobZ. Enzyme Commission Number: EC 6.1.2.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5666; nebramycin 5' synthase; EC 6.1.2.2; tobramycin carbamoyltransferase; TobZ. Cat No: EXWM-5666. |  |
| Nebramycin IV | Nebramycin IV is an aminoglycoside antibiotic produced by Streptomyces tenebrarius. Nebramycin IV has a broad antibacterial spectrum and has a strong effect on Gram-positive and negative bacteria and mycobacteria. Synonyms: Nebramycin factor 4; 6''-O-Carbamoylkanamycin B; 6-O-(3-Amino-6-carbamoyl-3-deoxy-α-D-glucopyranosyl)-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine. CAS No. 51736-76-6. Molecular formula: C19H38N6O11. Mole weight: 526.54. | |
| Nebularine | Alternate Names: Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C??H??N?O? , Molecular Weight: 252.2. US Biological Life Sciences. | Worldwide |
| Nebularine | Nebularine is originally isolated from Agaricus nebularis. Shown to have inhibitory effects against mouse Sarcoma 180 and mycobacteria. Synonyms: Purine-9-ß-D-ribofuranoside; 9-β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; N-D-Ribosylpurine; Purinosine; NSC 65423. Grades: ≥ 95% by HPLC. CAS No. 550-33-4. Molecular formula: C10H12N4O4. Mole weight: 252.23. | |
| Nebularine (High Purity) | Nucleoside analog. Cytotoxic. DNA, RNA and protein synthesis inhibitor. Shows anticancer activity. Anti-mycobacterial. Has tuberculostatic activity. Antifungal activity. Antiviral (anti-Herpes). Adenosine deaminase inhibitor. Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA. Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Nebularine (Purine-9-ß-D-Ribofuranoside) | Shown to have inhibitory effects against mouse Sarcoma 180 and mycobacteria. Group: Biochemicals. Alternative Names: Purine-9-ß-D-Ribofuranoside. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Nebumetone Impurity A | An impurity of Nabumetone, which is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. Synonyms: 3-(6-Methoxy-2-naphthalenyl)-5-methylcyclohexanone. Grades: > 95%. CAS No. 343272-52-6. Molecular formula: C18H20O2. Mole weight: 268.36. | |
| Nebumetone Impurity B | An impurity of Nabumetone, which is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. Synonyms: 5-(6-Methoxy-2-naphthalenyl)-3-methyl-2-vyclohexen-1-one. Grades: > 95%. CAS No. 343272-51-5. Molecular formula: C19H22N2. Mole weight: 278.4. | |
| Nebumetone Impurity D | Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Uses: Adrenergic uptake inhibitors. Synonyms: 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine Hydrochloride; Chrytemin; Imiprin; G-22355; Tofranil. Grades: > 95%. CAS No. 113-52-0. Molecular formula: C19H25ClN2. Mole weight: 316.87. | |
| NECA | NECA. Group: Biochemicals. Grades: Purified. CAS No. 35920-39-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| N-e-Carbobenzyloxy-L-lysine | N-e-Carbobenzyloxy-L-lysine. CAS No. 7778-80-5. Product ID: 1-01498. Molecular formula: K2O4S. Mole weight: 174.25. Properties: bp 1689°C mp 1067°C d 2.66. |  |
| Ne-Carboxymethyl-L-lysine (2-Amino-6-(carboxymethyl-amino)-hexanoic Acid) | Atmosphere: Inert gas. Group: Biochemicals. Alternative Names: 2-Amino-6-(carboxymethyl-amino)-hexanoic Acid. Grades: Highly Purified. CAS No. 5746-4-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ne-Carboxymethyl-L-lysine 98+% | Ne-Carboxymethyl-L-lysine 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences. | Worldwide |
| Necitumumab | Necitumumab is a human IgG monoclonal antibody directed against EGFR. Necitumumab can be used for research of NSCLC, colorectal cancer, etc [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 906805-06-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9964. | |
| Necitumumab | Necitumumab is a human IgG1 monoclonal antibody that binds to EGFR. Necitumumab has been approved for the treatment of squamous NSCLC. Synonyms: Portrazza. CAS No. 906805-06-9. | |
| Necrocide 1 | Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1247028-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14307. | |
| Necroptosis-IN-1 | Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosis inhibitor. Necroptosis-IN-1 is a RIPK inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1391980-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-135826. | |
| Necroptosis-IN-3 | Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis [1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1 [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 547698-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148454. | |
| Necrosis Inhibitor, Necrox-2 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrosis Inhibitor, Necrox-5 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, Dihydrochloride) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. Synonyms: Necrostatin-1; Necrostatin1; Necrostatin 1; Nec-1; Nec 1; Nec1. Grades: >98%. CAS No. 4311-88-0. Molecular formula: C13H13N3OS. Mole weight: 259.33. | |
| Necrostatin-1 | Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC 50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase ( EC 50 =182 nM). Necrostatin-1 is also an IDO inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15760. | |
| Necrostatin-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopypharmaceutical toxicology. | |
| Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1) | Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC50 = 180nM). Group: Biochemicals. Alternative Names: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 (inactive control) | Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-1 (inactive control). CAS No. 64419-92-7. Pack Sizes: 1 mg. Product ID: HY-121954. | |
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