A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 896203-18-2. Pack Sizes: 5 mg. Product ID: HY-111527.
PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 927691-21-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18078.
PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC 50 value of 49 nM and 135 nM on rhesus and human M1 receptor , respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1144504-35-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118342.
PQQ DISODIUM SALT
PQQ DISODIUM SALT, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. CAS No. 122628-50-6. Product ID: CDF4-0242. Molecular formula: C14H4N2Na2O8. Category: Nutrients. Product Keywords: Nutrients; PQQ DISODIUM SALT; CDF4-0242; Nutrients; C14H4N2Na2O8; 122628-50-6. EC Number: 209-118-9. Storage: 2-8°C. Applications: Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function. Product Description: Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function.
PQR620
PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1927857-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100026.
PqsR/LasR-IN-3
PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC 50 of 109.01 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2581109-51-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146329.
PQT-12
Band gap: 2.27 eV. Uses: Pqt-12 is a solution processable p-type, π-conjugated semiconductor for felxible printed electronics such as high sensitivity chemical sensors based on organic thin film transistors. it can also be used as donor material in organic solar cells.researches show that the microstructure of pqt-12 can be controled by the choice of solvent.study has shown pqt-12 spin-coated on a donor substrate can be t. Additional or Alternative Names: Poly(3,3'''-didodecyl[2,2':5',2'':5'',2'''-quaterthiophene]-5,5'''-diyl),Poly(4,4''-didodecyl[2,2':5',2'':5'',2'''-quaterthiophene]-5,5'''-diyl). Product Category: Flexible Printed Electronics. CAS No. 827343-06-6. Molecular formula: (C40H56S4)n. Product ID: ACM827343066. Alfa Chemistry ISO 9001:2015 Certified. Categories: Pgt 126.
PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851627-62-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-16405.
PR 37454
PR 37454 is a polyether antibiotic produced by Streptomyces gypseus DS 27461. It is active against gram-positive bacteria and coccidium. Synonyms: PR-37454; PR37454. Molecular formula: C48H82O18. Mole weight: 947.15.
PR 39 (porcine)
PR 39 (porcine) is a gene-encoded, proline-arginine-rich porcine antimicrobial peptide with multiple biological functions. It might function in the inflammatory milieu not only to kill bacteria, but also to aid in modulating the viability of inflammatory cells by regulating apoptosis. Uses: Anti-bacterial agents. Synonyms: PR39 (porcine); PR-39 (porcine); H-RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2; H-Arg-Arg-Arg-Pro-Arg-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Pro-Phe-Phe-Pro-Pro-Arg-Leu-Pro-Pro-Arg-Ile-Pro-Pro-Gly-Phe-Pro-Pro-Arg-Phe-Pro-Pro-Arg-Phe-Pro-NH2; L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-tyrosyl-L-leucyl-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-leucyl-L-prolyl-L-prolyl-L-arginyl-L-isoleucyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-phenylalanyl-L-prolinamide. Grade: >98%. CAS No. 139637-11-9. Molecular formula: C229H346N70O40. Mole weight: 4719.74.
PR 619
PR 619. Group: Biochemicals. Alternative Names: Thiocyanic Acid C,C'-(2,6-Diamino-3,5-pyridinediyl) Ester; Thiocyanic Acid C,C'-(2,6-Diamino-3,5-pyridinediyl) Ester; 2,6-Diamino-3,5-dithiocyanopyridine. Grades: Highly Purified. CAS No. 2645-32-1. Pack Sizes: 25mg. Molecular Formula: C7H5N5S2, Molecular Weight: 223.28. US Biological Life Sciences.
PR-619 is a broad-range and reversible DUB inhibitor with EC50s of 3.93, 4.9, 6.86, 7.2, and 8.61 ?M for USP4, USP8, USP7, USP2, and USP5, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2645-32-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13814.
Pracinostat
Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-?-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB939. CAS No. 929016-96-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13322.
Pracinostat
Pracinostat is a potent and orally active histone deacetylase (HDAC) inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. The selectivity of Pracinostat for tumor tissues makes it a promising therapeutic candidate for use in patients with advanced solid malignancies. Group: Biochemicals. Alternative Names: (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide; (E)-3-[2-Butyl-1-(2-diethylaminoethyl)-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide; Kaempferol 3-O- β-D-(6-E-p-Coumaroylglucoside); SB 939; SB939; (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide. Grades: Highly Purified. CAS No. 929016-96-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Practolol
Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6673-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119802.
Pradefovir mesylate
Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a K m of 60 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Remofovir mesylate. CAS No. 625095-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-112690A.
Pradigastat
Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC 50 at 0.157 μM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC 50 of 5 μM, 1.66μM, 3.34μM and 0.973μM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LCQ-908. CAS No. 956136-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16278.
Pradimicin A
Pradimicin A is an antibiotic produced by Actinomadura hibisca. It has strong antifungal and yeast activity. Synonyms: Pradimicin A|117704-65-1|CHEBI:8349|(R)-2-((5S,6S)-1,6,9,14-Tetrahydroxy-5-(((2S,3R,4S,5S,6R)-3-hydroxy-6-methyl-5-(methylamino)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-11-methoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxamido)propanoic acid|Pradimicin-A|BMY 28567|BMY-28567|(2R)-2-[[(5S,6S)-1,6,9,14-tetrahydroxy-5-[(2S,3R. Grade: ≥98% (HPLC). CAS No. 117704-65-1. Molecular formula: C40H44N2O18. Mole weight: 840.78.
Pradimicin B
Pradimicin B is an antibiotic produced by Actinomadura hibisca. It has strong antifungal and yeast activity. CAS No. 117704-66-2. Molecular formula: C35H36N2O14. Mole weight: 708.66.
Pradimicin L
Pradimicin L is an antibiotic produced by Actinomadura verrucosospora subsp. neohibisca. It has antifungal activity. Grade: >98%. CAS No. 142062-87-1. Molecular formula: C41H46N2O19. Mole weight: 870.80.
Pradimicin M
Pradimicin M is an antibiotic produced by Actinomadura hibisca. α-glycosidase and β-galactosidase inhibitor. Synonyms: 11-O-Demethylpradinone; (5S,6S)-1,5,6,9,11,14-hexahydroxy-3-methyl-8,13-dioxo-5,6-dihydrobenzo[a]tetracene-2-carboxylic acid. CAS No. 132971-63-2. Molecular formula: C24H16O10. Mole weight: 464.38.
Pradimicin Q
Pradimicin Q is an antibiotic produced by Actinomadura verrucosospora subsp. neohibisca R 103-3. The cytotoxicity (IC50) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively. Synonyms: Benzo(a)naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,5,7,9,11,14-hexahydroxy-3-methyl-8,13-dioxo-. CAS No. 141869-53-6. Molecular formula: C24H16O10. Mole weight: 464.38.
Pradimicin T1
Pradimicin T1 is an antibiotic produced by Actinomyces AA 3798. It has activity against filamentous fungi and yeast-like fungi. Synonyms: Glycine, N-((5-((6-deoxy-3-O-beta-D-xylopyranosyl-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-3-methyl-8,13-dioxo-11-(beta-L-xylopyranosyloxy)benzo(a)naphthacen-2-yl)carbonyl)-, (5S-trans)-. CAS No. 149598-64-1. Molecular formula: C42H45NO23. Mole weight: 931.80.
Pradimicin T2
Pradimicin T2 is an antibiotic produced by Actinomyces AA 3798. It has activity against filamentous fungi and yeast-like fungi. Synonyms: Glycine, N-((5-((6-deoxy-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-3-methyl-8,13-dioxo-11-(beta-L-xylopyranosyloxy)benzo(a)naphthacen-2-yl)carbonyl)-, (5S-trans)-. CAS No. 149598-63-0. Molecular formula: C37H37NO19. Mole weight: 799.68.
Pradofloxacin
Pradofloxacin is a third-generation fluoroquinolone antibacterial agent. CAS No. 195532-12-8. Product ID: API195532128. Molecular formula: C21H21FN4O3. Mole weight: 396.41. SMILES: C1C[C@H]2CN(C[C@H]2NC1)C3=C(C=C4C(=C3C#N)N(C=C(C4=O)C(=O)O)C5CC5)F. Category: Antibiotic APIs.
Pradofloxacin hydrochloride. Group: Biochemicals. Alternative Names: 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride; (4aS-cis)-Pradofloxacin hydrochloride. Grades: Highly Purified. CAS No. 195532-14-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C21H22ClFN4O3. US Biological Life Sciences.
Worldwide
Praeruptorin A
Praeruptorin A. Group: Biochemicals. Grades: Plant Grade. CAS No. 73069-27-9. Pack Sizes: 20mg. Molecular Formula: C21H22O7, Molecular Weight: 386.39. US Biological Life Sciences.
Worldwide
Praeruptorin A
Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation [1]. Uses: Scientific research. Group: Natural products. CAS No. 73069-27-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6065.
Praeruptorin B
Praeruptorin B. Group: Biochemicals. CAS No. 81740-07-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Praeruptorin B (Anomalin)
Praeruptorin B (Anomalin). Group: Biochemicals. Alternative Names: (+)-Anomalin; (+)-Praeruptorin B. Grades: Plant Grade. CAS No. 73069-28-0. Pack Sizes: 20mg. Molecular Formula: C24H26O7, Molecular Weight: 426.459. US Biological Life Sciences.
Worldwide
Praeruptorin C
Praeruptorin C. Group: Biochemicals. CAS No. 72463-77-5. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Praeruptorin C (Wulongensin A)
Praeruptorin C (Wulongensin A). Group: Biochemicals. Alternative Names: Wulongensin A. Grades: Plant Grade. CAS No. 72463-77-5. Pack Sizes: 20mg. Molecular Formula: C24H28O7, Molecular Weight: 428.475. US Biological Life Sciences.
Worldwide
Praeruptorin E
Praeruptorin E. Group: Biochemicals. Grades: Plant Grade. CAS No. 78478-28-1. Pack Sizes: 10mg. Molecular Formula: C24H28O7, Molecular Weight: 428.48. US Biological Life Sciences.
Worldwide
Praesorediosic acid
Praesorediosic acid is an aliphatic acid from the lichen parmotrema praesorediosum. Synonyms: ACMC-20mtl9; 2-Furanpentadecanoic acid, 3-carboxy-2,5-dihydro-4-methyl-5-oxo-, (2R)-. CAS No. 130342-70-0. Molecular formula: C21H34O6. Mole weight: 382.49.
Pralatrexate
Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment [1] [2] [3] [4]. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 146464-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10446.
Praliciguat
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC 50 of 197 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IW-1973. CAS No. 1628730-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109039.
Pralidoxime chloride
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-PAM chloride. CAS No. 51-15-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1200.
This compound binds to inactivated acetylcholinesterases and is used to combat poisoning from organophosphates and nerve agents. Group: Biochemicals. Alternative Names: 2-[(Hydroxyimino)methyl]-1-methyl-pyridinium Chloride; 2-Formyl-1-methyl-pyridinium Chloride Oxime; 1-Methylpyridinium-2-aldoxime Chloride; 2-PAM Cl; 2-PAM; Protopam Chloride; 2-Pyridinealdoxime Methochloride; Pyridine-2-aldoxime Methochloride. Grades: Highly Purified. CAS No. 51-15-0. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Pralidoxime iodide
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 94-63-3. Pack Sizes: 10 mM * 1 mL; 25 mg; 100 mg; 250 mg. Product ID: HY-B1738A.
Prallethrin
Prallethrin. Group: Biochemicals. Alternative Names: 2, 2-Dimethyl-3- (2-methyl-1-propen-1-yl) cyclopropanecarboxylic acid 2-methyl-4-oxo-3-(2-propyn-1-yl)-2-cyclopenten-1-yl ester; trans-(±)-4-Hydroxy-3-methyl-2-(2-propynyl)-2-cyclopenten-1-one 2, 2-di methyl -3- (2- methyl propenyl) cyclopropane carboxylate, (8CI); Acetylene C permethrin. Grades: Highly Purified. CAS No. 23031-36-9. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C19H24O3. US Biological Life Sciences.
Worldwide
Pralmorelin
Pralmorelin is a synthetic agonist of ghrelin that can increase food intake. Synonyms: GHRP-2; KP-102; D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide; H-D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2. CAS No. 158861-67-7. Molecular formula: C45H55N9O6. Mole weight: 817.94.
Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC 50 s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BLU-667. CAS No. 2097132-94-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112301.
Pralsetinib
Pralsetinib is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion). CAS No. 2097132-94-8. Product ID: API2097132948. Molecular formula: C27H32FN9O2. Mole weight: 533.6. SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)N[C@@H](C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC. Category: Active Pharmaceutical Ingredients.
Pramipexole
Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K i s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D 2 , D 3 and D 4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 104632-26-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0410.
Pramipexole
Pramipexole. Group: Biochemicals. Grades: Highly Purified. CAS No. 104632-26-0. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C10H17N3S. US Biological Life Sciences.
Worldwide
Pramipexole-[d3]
Pramipexole-[d3] is the labelled analogue of Pramipexole. Pramipexole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Synonyms: Pramipexole D3; (S)-4,5,6,7-Tetrahydro-N6-(propyl-d3)-2,6-benzothiazolediamine Dihydrochloride. Grade: 98% by HPLC; 98% atom D. CAS No. 1217695-77-6. Molecular formula: C10H14D3N3S. Mole weight: 214.34.
A labeled dopamine-D2-receptor agonist. Group: Biochemicals. Alternative Names: (S)-4,5,6,7-Tetrahydro-N6-propyl-d3-2,6-benzothiazolediamine, Dihydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Pramipexole-[d5] Dihydrochloride
Pramipexole-[d5] Dihydrochloride is the labelled analogue of Pramipexole, which is an agonist of dopamine receptor D2, D3 and D4, especially used as D2-receptor agonist. Synonyms: Pramipexole D5 dihydrochloride; (S)-4,5,6,7-Tetrahydro-N6-propyl-d5-2,6-benzothiazolediamine Dihydrochloride. Grade: 95% by HPLC; 95% atom D. CAS No. 1217601-58-5. Molecular formula: C11H14D5ClN3S. Mole weight: 289.28.
Pramipexole dihydrochloride
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K i s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D 2 , D 3 and D 4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 104632-25-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17355.
Pramipexole dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 104632-25-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Pramipexole dihydrochloride
The HCl salt form of pramipexole, a thiazole derivative, is an agonist of dopamine receptor D2, D3 and D4, especially used as D2-receptor agonist which is one of the most classical targets in the treatment of Parkinson's disease. Ki: 3.9, 2.2, 0.5, and 5. Uses: The hcl salt form of pramipexole is an agonist of dopamine receptor d2, d3 and d4, especially used as d2-receptor agonist. Synonyms: (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride; Pramipexole Dihydrochloride; Mirapex ER; Pramipexole hydrochloride; SND919; Mirapex; SUD 919CL2Y; SUD919CL2Y; U-98528E; Sifrol; SND 919; KNS-760704; SND-919; KNS 760704; KNS760704. Grade: 98%. CAS No. 104632-25-9. Molecular formula: C10H17N3S·2(HCl). Mole weight: 284.25.
Pramipexole Dihydrochloride
A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME. Alternative Names: Mirapex. (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride. Mirapex ER. CAS No. 104632-25-9. Product ID: API104632259. Molecular formula: C10H19Cl2N3S. Mole weight: 284.2. EINECS: 629-842-2. SMILES: CCCNC1CCC2=C(C1)SC(=N2)N.Cl.Cl. Appearance: Solid powder. Category: APIs for Parkinson's Disease.
Pramipexole dihydrochloride hydrate
Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K i s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D 2 , D 3 and D 4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191217-81-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0410A.
Pramipexole dihydrochloride monohydrate
Pramipexole dihydrochloride monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 191217-81-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME. Alternative Names: Mirapex. Pramipexole 2HCl Monohydrate. (S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate. CAS No. 191217-81-9. Product ID: API191217819. Molecular formula: C10H21Cl2N3OS. Mole weight: 302.3. EINECS: 687-708-9. SMILES: CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl. Standard: EP. Category: Antipsychotic APIs.
Non-ergot Dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9nM for D3, D2S, D2L and D4 receptors respectively). Exhibits very low affinity for serotoninergic 5-HT2A and 5-HT2B receptors, as well as D1-type receptors. Shows good solubility in aqueous media (100mM water and 100mM DMSO). Immediate-release (IR) pramipexole dihydrochloride is indicated for the treatment of signs and symptoms of idiopathic Parkinsons disease (PD). It is administered alone (without levodopa) or in combination with levodopa, during the entire progress of the disease, up to an advanced stage. Currently, it is also indicated for the treatment of moderate-to-severe primary restless legs syndrome (RLS). Group: Biochemicals. Grades: Highly Purified. CAS No. 104632-25-9. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences.