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| Product | Description | |
|---|---|---|
| Pozanicline dihydrochloride | Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor ( nAChR ) agonist with a K i of 16.7 nM for binding to [ 3 H]cytisine sites [1]. Pozanicline is an α4β2 -selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K i of 17 nM while binding to α7 nAChR is insignificant [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-089 dihydrochloride. CAS No. 161416-61-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110160. |  |
| Pozelimab | Pozelimab (REGN3918) is a fully human IgG4 anti-C5 monoclonal antibody. Pozelimab binds to C5 and C5 variants with high affinity and blocks complement-mediated hemolysis. Pozelimab can be used for the research of complement-mediated diseases [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN3918. CAS No. 2096328-94-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99786. | |
| Poziotinib | Poziotinib (HM781-36B) is an orally active, irreversible pan- HER inhibitor, which effectively inhibits EGFR wt , HER-2 and HER-4 with IC 50 s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFR T790M and EGFR L858R/T790M , with IC 50 s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HM781-36B; NOV120101. CAS No. 1092364-38-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15730. | |
| Poziotinib | Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: HM781-36B; NOV120101; NOV-120101; NOV 120101; Poziotinib. CAS No. 1092364-38-9. Molecular formula: C23H21Cl2FN4O3. Mole weight: 491.344. |  |
| Poziotinib Hydrochloride | Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: Poziotinib HCl; NOV120101 hydrochloride; HM 781-36B hydrochloride. CAS No. 1429757-68-5. Molecular formula: C23H22Cl3FN4O3. Mole weight: 527.80. | |
| PP1 | PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 μM), or ZAP-70 (IC50 ≥ 0.6 μM). Synonyms: PP1; PP 1; PP1. Grades: >98%. CAS No. 172889-26-8. Molecular formula: C16H19N5. Mole weight: 281.36. | |
| PP1 | PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC 50 of 5 and 6 nM for Lck and Fyn, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGL 1872; EI 275. CAS No. 172889-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13804. | |
| PP 1 | PP 1. Group: Biochemicals. Grades: Purified. CAS No. 172889-26-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PP102 | PP102 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp), and has antibacterial activity against both gram-negative and gram-positive bacteria, but no activity against fungi. Grades: ≥95%. | |
| PP113 | PP113 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp), and has antibacterial activity against both gram-negative and gram-positive bacteria, but no activity against fungi. Grades: >98%. | |
| PP121 | PP121 is a multitargeted dual receptor tyrosine kinases inhibitor. PP121 blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases. Synonyms: PP121; PP 121; PP-121. CAS No. 1092788-83-4. Molecular formula: C17H17N7. Mole weight: 319.372. | |
| PP 121 | PP 121. Group: Biochemicals. Grades: Purified. CAS No. 1092788-83-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| P, P'-[ (1, 2-Phenylene) bis (methylene) ]bisphosphonic Acid P,P,P',P'-tetraethyl ester | P, P'-[ (1, 2-Phenylene) bis (methylene) ]bisphosphonic Acid P,P,P',P'-tetraethyl ester. Group: Biochemicals. Alternative Names: (o-Phenylenedimethylene) diphosphonic Acid Tetraethyl Ester; [1, 2-Phenylenebis (methylene) ]bisphosphonic Acid Tetraethyl Ester; Tetraethyl o-Xylylenediphosphonate. Grades: Highly Purified. CAS No. 42092-05-7. Pack Sizes: 1g. Molecular Formula: C16H28O6P2, Molecular Weight: 378.34. US Biological Life Sciences. | Worldwide |
| PP13 | PP13 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp). It has antibacterial activity against E. coli, B. subtilis, S. aureus, S. lutea and B. pumilu (MIC 8-23 μM), but no activity against fungi. Synonyms: Gly-Ala-Ala-Arg-Lys-Ser-Ile-Arg-Leu-His-Arg-Leu-Tyr-Thr-Trp-Lys-Ala-Thr-Ile-Tyr-Thr-Arg. Grades: ≥97%. Molecular formula: C121H197N39O29. Mole weight: 2662.15. | |
| PP1 (4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine) | Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses. Group: Biochemicals. Alternative Names: 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-26-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog) | A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C16H18IN5, Molecular Weight: 407.3. US Biological Life Sciences. | Worldwide |
| PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor) | A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PP2 | PP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities. Group: Inhibitors. Alternative Names: PP2; PP-2; PP 2; AG 1879; AG-1879; AG1879. CAS No. 172889-27-9. Molecular formula: C15H16ClN5. Mole weight: 301.77. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Canonical SMILES: NC1=C2C (N (C (C) (C)C)N=C2C3=CC=C (Cl)C=C3)=NC=N1. Catalog: ACM172889279. |  |
| PP2 | PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC 50 s of 4 and 5 nM for Lck and Fyn , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGL 1879. CAS No. 172889-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13805. | |
| PP2 | PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Synonyms: PP-2; PP 2; AG 1879; AG-1879; AG1879. CAS No. 172889-27-9. Molecular formula: C15H16ClN5. Mole weight: 301.77. | |
| PP 2 | PP 2. Group: Biochemicals. Alternative Names: AGL 1879; PP 2 (enzyme inhibitor); Src kinase inhibitor PP2; 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.77. US Biological Life Sciences. | Worldwide |
| PP242 | PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 μM for p110α, p110β, p110δ, p110γ and DNA-PK, respectively. Synonyms: PP 242; PP-242; Torkinib. CAS No. 1092351-67-1. Molecular formula: C16H16N6O. Mole weight: 308.345. | |
| PP 242 | PP 242. Group: Biochemicals. Alternative Names: 2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol. Grades: Highly Purified. CAS No. 1092351-67-1. Pack Sizes: 10mg. Molecular Formula: C16H16N6O, Molecular Weight: 308.339999999999. US Biological Life Sciences. | Worldwide |
| PP242 (2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol) | A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC?? = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242 is a more effective mTORC1 inhibitor than Rapamycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 1092351-67-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PP2 (4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879) | Highly potent and selective Scr family tyrosine kinase inhibitor. Reduces cancer metastasis. Apoptotic. Antitumor compound. RIP2 inhbitor. Blocks TGF-beta-mediated cellular responses. Autophagy modulator. Group: Biochemicals. Alternative Names: 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.8. US Biological Life Sciences. | Worldwide |
| PP2A Activating Ligand, ITH12246 | A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences. | Worldwide |
| PP 3 | PP 3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2. It inhibits EGFR kinase (IC50 = 2.7 μM). Synonyms: PP 3; PP3; PP-3; 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 5334-30-5. Molecular formula: C11H9N5. Mole weight: 211.22. | |
| PP 3 | PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC 50 of 2.7 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5334-30-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108484. | |
| PP 3 | PP 3. Group: Biochemicals. Grades: Purified. CAS No. 5334-30-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PP30 | PP30 is an antimicrobial peptide found in Pteromalus puparum. It has antibacterial activity, but no activity against fungi. Synonyms: Tyr-Val-Pro-Pro-Val-Gln-Lys-Pro-His-Pro-Asn-Gly-Pro-Lys-Phe-Pro-Thr-Phe-Pro. Grades: ≥97%. Molecular formula: C105H151N25O24. Mole weight: 2147.51. | |
| PP3 (4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine; NSC 1401) | A negative control for the Src family kinase inhibitor PP2. Inhibits the activity of EGFR kinase at an IC50 = 2.7uM. Group: Biochemicals. Alternative Names: 4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine; NSC 1401. Grades: Purified. CAS No. 5334-30-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PP58 | PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR , FGFR and Src family activities with nanomolar IC 50 values. Uses: Scientific research. Group: Signaling pathways. CAS No. 212391-58-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18622. | |
| pp60 c-src (521-533) (phosphorylated) | pp60 c-src (521-533) (phosphorylated). Group: Biochemicals. Grades: Purified. CAS No. 149299-77-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| pp60 c-src (521-533) (phosphorylated) | pp60 c-src (521-533) (phosphorylated), the pp60 c-src carboxy-terminal phosphoregulatory peptide phosphorylated at Tyr527, participates in the regulation of kinase activity through binding intramolecularly or intermolecularly to the SH2 domain of the pp60 c-src protein. Synonyms: H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(PO3H2)-Gln-Pro-Gly-Glu-Asn-Leu-OH; L-threonyl-L-seryl-L-threonyl-L-alpha-glutamyl-L-prolyl-L-glutaminyl-O4-phosphono-L-tyrosyl-L-glutaminyl-L-prolyl-glycyl-L-alpha-glutamyl-L-asparagyl-L-leucine; L-Leucine, L-threonyl-L-seryl-L-threonyl-L-a-glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-glutaminyl-L-prolylglycyl-L-a-glutamyl-L-asparaginyl-; Thr-Ser-Thr-Glu-Pro-Gln-O-Phosphono-Tyr-Gln-Pro-Gly-Glu-Asn-Leu-OH. Grades: >99%. CAS No. 149299-77-4. Molecular formula: C62H95N16O28P. Mole weight: 1543.48. | |
| pp60v-src Autophosphorylation site | pp60v-src Autophosphorylation site is a synthetic peptide. pp60v-src Autophosphorylation site can be used for various biochemical studies [1]. Uses: Scientific research. Group: Peptides. CAS No. 81493-98-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3744. | |
| PPA | PPA is an ADC linker (US20060073528A1). PPA can be used for making antibody-drug conjugate [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 452072-22-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-141664. | |
| PPA-904 | PPA-904 is a specific phenothiazine photosensitizer that reached a phase II trial in patients with chronic venous Leg ulcer but was subsequently discontinued. Synonyms: PPA-904; PPA 904; PPA904; dibutyl-[7-(dibutylamino)phenothiazin-3-ylidene]azanium;bromide; Phenothiazin-5-ium, 3,7-bis(dibutylamino)-, bromide. CAS No. 30189-85-6. Molecular formula: C28H42BrN3S. Mole weight: 532.62. | |
| PPACK Dihydrochloride (D-Phe-Pro-Arg-CMK, D-Phenylalanyl-L-prolyl-L-arginine Chloromethyl Ketone) | A highly potent, selective and irreversible thrombin inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 142036-63-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PPACKII trifluoroacetate salt | PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins. Human tissue kallikreins (hKs) are a class of secreted serine proteases that is involved in the release of vasodepressor peptides or kinins from a plasma substrate. Synonyms: H-D-Phe-Phe-Arg-Chloromethyl Ketone; (2R)-2-amino-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide trifluoroacetate salt. Grades: ≥95%. CAS No. 649748-23-2. Molecular formula: C25H33ClN6O3·2CF3COOH. Mole weight: 729.1. | |
| PPACK TFA | PPACK TFA is a plasminogen activator (rt-PA) inhibitor. PPACK TFA can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK TFA also inhibits the binding of rt-PA to plasma protease inhibitors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 157379-44-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122542B. | |
| PPACK trifluoroacetate salt | PPACK is a non-competitive inhibitor of human alpha-thrombin. It was shown to inhibit thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM). Synonyms: Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone. Grades: ≥95%. Molecular formula: C21H31ClN6O3·xCF3COOH. Mole weight: 450.96. | |
| PPADS tetrasodium | PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC 50 s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like ( IC 50 ~0.9 mM) and recombinant P2Y4 ( IC 50 ~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca 2+ exchanger in guinea pig airway smooth muscle [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192575-19-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-101044. | |
| PPADS Tetrasodium | PPADS Tetrasodium. Group: Biochemicals. Alternative Names: 4-[2-[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic Acid Tetrasodium Salt. Grades: Highly Purified. CAS No. 192575-19-2. Pack Sizes: 25mg. Molecular Formula: C14H10N3Na4O12PS2, Molecular Weight: 599.299999999999. US Biological Life Sciences. | Worldwide |
| PPADS tetrasodium salt | PPADS tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 192575-19-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PPADS tetrasodium salt | PPADS tetrasodium salt, a non-selective P2 purinergic antagonist, blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. It delays onset of calcium responses to mild hypoosmotic stress in cortical slices. Synonyms: 1,3-Benzenedisulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-, sodium salt (1:4); 1,3-Benzenedisulfonic acid, 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-, tetrasodium salt; PPADS tetrasodium; 4-[2-[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic Acid; Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt. Grades: ≥95%. CAS No. 192575-19-2. Molecular formula: C14H10N3Na4O12PS2. Mole weight: 599.30. | |
| PPAHV | PPAHV. Group: Biochemicals. Grades: Purified. CAS No. 175796-50-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PPAHV | PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM), and is agonist at rat VR1(TRPV1) (EC50 between 3 and 10 μM) but virtually inactive at human VR1(TRPV1) (EC50>10 μM). It displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Synonyms: [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9-[phenylacetyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester benzeneacetic acid; Phorbol 12-phenylacetate 13-acetate 20-homovanillate. Grades: ≥98% by HPLC. CAS No. 175796-50-6. Molecular formula: C39H44O11. Mole weight: 688.77. | |
| Pp-AMP1 | Pp-AMP1 is a chitin-binding peptide and an antimicrobial peptide found in Phyllostachys edulis (Japanese Bamboo Shoots, ?Phyllostachys pubescens), and has activity against gram-negative bacteria, gram-positive bacteria and fungi. Synonyms: ?Phyllostachys pubescens antimicrobial peptide-1. Grades: >98%. | |
| Pp-AMP2 | Pp-AMP2 is a chitin-binding peptide and an antimicrobial peptide found in Phyllostachys edulis (Japanese Bamboo Shoots, ?Phyllostachys pubescens), and has activity against gram-negative bacteria, gram-positive bacteria and fungi. Synonyms: ?Phyllostachys pubescens antimicrobial peptide-2. Grades: >98%. | |
| PPAR agonist 1 | An agonist of PPAR α and PPAR &gamma. Synonyms: Benzenepropanoic acid, α -methoxy-4-[[3-[4-[ (methylsulfonyl) oxy]phenyl]propyl]amino]-, (αS)-. CAS No. 539813-69-9. Molecular formula: C20H25NO6S. Mole weight: 407.48. | |
| PPAR Agonist IX, GQ-16 ((Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione) | A cell-permeable thiazolidinedione that acts as a PPARg-selective agonist (Ki=160nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARg b-sheet structure, exhibiting no detectable activity towards PPARa, PPARd, or RXRa. Although a weaker PPAPg agonist than Thiazolidinediones (TZDs) family rosiglitazone (Max. fold of transactivation induction =8.57 and 24.8 with 10uM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PPARα-MO-1 | A potent PPARα modulator. Synonyms: Benzenepropanoic acid, α-ethoxy-4-[2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy]-. CAS No. 810677-36-2. Molecular formula: C27H37NO5. Mole weight: 455.59. | |
| PPAR-beta/delta Antagonist II, GSK3787 (4-Chloro-N-(2-((5-trifluoromethyl)-2-pyridyl) sulfonyl) ethyl) benzamide, PPARb Antagonist I, PPARd Antagonist I) | A cell-permeable pyridylsulfone that acts as a selective, high affinity PPARb (PPARd) ligand (IC50 in PPAR ligand displacement assays=200nM against human PPARb and >10uM against PPARa or PPARg) and effectively antagonizes agonist-induced, but not basal, PPARb transcription activity both in cultures in vitro (IC50=126nM in CV-1 cells) and in mice in vivo (82% and 71% inhibition of 10mg/kg GW0742-induced Adr and Angptl4 mRNA upregulation, respectively, in colon epithelium; 10mg/kg GSK3787; p.o.) by covalently modifying PPARb at Cys249. GSK3787 is also shown to exhibit weak agonistic activity toward PPARg (1.2-fold increase above basal level by 1uM GSK3787), and effectively block the more potent agonist GW1929 from further stimulation (1.5 and 3.5-fold above basal by 0.3uM GW1929 in the presence or absence of 1uM GSK3787, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 188591-46-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPARbeta/delta Antagonist, PT-S58 (PPARb Antagonist II, Methyl 3- (N- (4- (tert-butylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, PPARd Antagonist II) | A cell-permeable, diaryl sulfonamide PPARb/d subtype-specific pure competitive antagonist with an IC50 of 98nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARb/d specific agonist-induced transcriptional activity in cell cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPAR-beta/delta Inverse Agonist (Methyl 3- (N- (4- (hexylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, ST247) | A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR beta/delta receptor (IC50=93nM). Enhances the interaction of the PPARb/d ligand-binding domain with the co-repressor, SMRT-ID2 (EC50=10nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARb/d- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPARγ-IN-2 | PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes ( EC 50 : 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2682078-97-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156010. | |
| PPAR gamma Modulator, SR1664 ( (S) -4'- ( (2, 3-dimethyl-5- (1- (4-nitrophenyl) ethylcarbamoyl) -1H-indol-1-yl) methyl) biphenyl-2-carboxylic Acid) | A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated gamma (PPAR-g) receptor (Ki=29nM; IC50=80nM), but does not exhibit any transcriptional agonism. Unlike TZD compounds, it does not induce weight gain or diminish hematocrit. Shown to effectively block CDK-5-mediated phosphorylation of Ser273 of PPAR-gamma in adipose tissue. Supresses hepatic glucose production, reduces plasma free fatty acid levels, and improves insulin sensitivity of adipose tissue. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?, Molecular Weight: 547.6. US Biological Life Sciences. | Worldwide |
| PP cream bottle | This cream bottle not only has a large capacity and beautiful appearance, but also can be customized according to customer needs. Product ID: PM-077. Category: Cream bottle. Product Keywords: Cosmetic Plastic Packaging; PP cream bottle; PM-077; Cream bottle;. Administration route: Total height: 63mm. Straight diameter: 86mm. Cover material: pp. Bottle material: pp. |  |
| PPDA | PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (Ki= 0.096, 0.125, 0.31 and 0.55 μM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively). PPDA with its high affinity and distinct subunit selectivity may represent an important lead compound for the development of NMDA receptor antagonists of yet greater selectivity. Synonyms: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 684283-16-7. Molecular formula: C21H18N2O5. Mole weight: 378.38. | |
| p,p'-DDD | p,p'-DDD (4,4-DDD) is a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ER&beta. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD can affect sleep times of barbiturates and steroids [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane. CAS No. 72-54-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-B1984. | |
| p,p'-DDE | p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC 50 of 5 μM and a K i of 3.5 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,4'-DDE; p, p'-Dichlorodiphenyldichloroethylene. CAS No. 72-55-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-B1986. | |
| p,p'-DiaMinoquaterphenyl | p,p'-DiaMinoquaterphenyl. Group: other electronic materials. CAS No. 53693-67-7. Product ID: 4-[4-[4-(4-aminophenyl)phenyl]phenyl]aniline. Molecular formula: 336.4g/mol. Mole weight: C24H20N2. C1=CC (=CC=C1C2=CC=C (C=C2)C3=CC=C (C=C3)N)C4=CC=C (C=C4)N. InChI=1S/C24H20N2/c25-23-13-9-21 (10-14-23)19-5-1-17 (2-6-19)18-3-7-20 (8-4-18)22-11-15-24 (26)16-12-22/h1-16H, 25-26H2. JZIAOTUERDUSJC-UHFFFAOYSA-N. |  |
| P,P-Dichlorophenylphosphine | Organic synthesis, for derivation of plasticizers, polymers, antioxidants; oil additives. Group: Other phosphine ligands. Alternative Names: 4-16-00-00972 (Beilstein Handbook Reference); I01-3764; DSSTox_CID_7282; SC-06043; BRN 0508189; EINECS 211-425-8; KS-00000X4J; NSC-66478; K036; Phenylphosphorus dichloride. CAS No. 644-97-3. Molecular formula: C6H5Cl2P. Mole weight: 178.98g/mol. IUPACName: dichloro(phenyl)phosphane. Canonical SMILES: C1=CC=C(C=C1)P(Cl)Cl. Density: 1.14 at 77 ° F (USCG, 1999);1.356 @ 20 DEG C/4 DEG C. ECNumber: 211-425-8. Catalog: ACM644973. | |
| p,p'-Ditolylamine | p,p'-Ditolylamine. Group: Small molecule semiconductor building blockselectroluminescence materials polymers. Alternative Names: 4,4'-Dimethyldiphenylamine. CAS No. 620-93-9. Product ID: 4-methyl-N-(4-methylphenyl)aniline. Molecular formula: 197.28. Mole weight: C14H15N. CC1=CC=C(C=C1)NC2=CC=C(C=C2)C. InChI=1S/C14H15N/c1-11-3-7-13 (8-4-11)15-14-9-5-12 (2)6-10-14/h3-10, 15H, 1-2H3. RHPVVNRNAHRJOQ-UHFFFAOYSA-N. >98.0%(GC). | |
| P,P'-Divinyl-1,2-Diphenylethane | Off-white to white crystalline powder, electronic grade. Group: Monomers. Alternative Names: 1,2-Bis(4-Vinylphenyl)Ethane; 1-Ethenyl-4-[2-(4-Ethenylphenyl)Ethyl]Benzene; Benzene, 1,1'-(1,2-Ethanediyl)Bis[4-Ethenyl-; 1,2-Bis(P-Vinylphenyl)Ethane; Dtxsid80453919; F87990. CAS No. 48174-52-3. Molecular formula: C18H18. Mole weight: 234.34. Purity: 99.5%+. IUPACName: 1-Ethenyl-4-[2-(4-ethenylphenyl)ethyl]benzene. Canonical SMILES: C=CC1=CC=C(C=C1)CCC2=CC=C(C=C2)C=C. Catalog: PR48174523. | |
| p-Pentylbenzoic Acid | Liquid crystal. CAS No. 26311-45-5. Pack Sizes: 10g, 25g. Product ID: FR-0379. M.P. 86-88 (N), 122-124 (I). Mole weight: 192.26. |  Frinton Laboratories |
| p-Pentyloxyaniline | Liquid, d20 0.97, 99%. CAS No. 39905-50-5. Pack Sizes: 10g, 50g. Product ID: FR-1219. B.P. 182-183/20 mm. Mole weight: 179.26. | Frinton Laboratories |
| p-Pentyloxybenzaldehyde | Liquid, 98%. CAS No. 5736-91-4. Pack Sizes: 10g, 50g. Product ID: FR-0786. B.P. 144-147/1 mm. Mole weight: 192.26. | Frinton Laboratories |
| p-Pentyloxybenzoic Acid | Nematic liquid crystal. CAS No. 15872-41-0. Pack Sizes: 5g. Product ID: FR-0334. M.P. 123 (N), 149 (I). Mole weight: 208.26. | Frinton Laboratories |
| p-Pentyloxybenzylidene p-Heptylaniline | 5O.7, low temperature smectic phases. CAS No. 39777-20-3. Pack Sizes: 1g, 5g. Product ID: FR-0193. M.P. 29 (S), 64 (N), 78 (I). Mole weight: 365.56. | Frinton Laboratories |
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