A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered ashwagandha extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Asian Ginseng Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Bacopa Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Bilberry Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Black Cohosh Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Black Pepper Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Cat?s Claw Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Cellulose
Powdered cellulose occurs as a white or almost white, odorless and tasteless powder of various particle sizes, ranging from a freeflowing fine or granular dense powder, to a coarse, fluffy, nonflowing material. Synonyms: Cellulose, Powdered; Alpha-cellulose; Arbocel; cellulosi pulvis; E460; Elcema; KC Flock; Microcel 3E-150; Sanacel; Sanacel Pharma; Sancel-W; Solka-Floc. CAS No. 9004-34-6. Product ID: PE0367. Molecular formula: (C6H10O5)n, n?500. Mole weight: ?243 000 Since cellulose is extracted from natural polymers, the chain lengths can vary, as can the molecular weight. Category: Adsorbents; Glidants; Suspending Agentss; Diluents; Disintegrating Agentss. Product Keywords: Suspending Agents; Adsorbents; PE0367; Powdered Cellulose; Adsorbents; Glidants; Suspending Agentss; Diluents; Disintegrating Agentss; (C6H10O5)n, n?500; 9004-34-6. UNII: SMD1X3XO9M. Chemical Name: Cellulose. Grade: Pharmceutical Excipients. Administration route: Oral; Dental; Sublingual; Oral; Topical. Dosage Form: Toothpaste, tablets (including sustained and controlled release preparations, etc.), capsules, drops, dry suspensions, etc. Stability and Storage Conditions: Powdered cellulose is a stable, slightly hygroscopic substance; it should be kept in an airtight container in a cool, dry place. Commonly used amount and the maximum amount: Capsule filler: 0~100%; tablet binder: 5%~25%; tablet disintegrant: 5%~15%; tablet glidant: 1%~2%.
Powdered Cellulose
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Centella Asiatica Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Chaste Tree Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Chinese Salvia Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Decaffeinated Green Tea Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Echinacea Angustifolia Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Echinacea Purpurea Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Eleuthero Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Forskohlii Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Garcinia Hydroxycitrate Extract
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Powdered ginger
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Powdered Holy Basil Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered kava extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Malabar-Nut-Tree, Leaf Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered milk thistle extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Phyllanthus Amarus Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Red Clover Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Rosemary Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Rosemary Hydrophilic Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered St. John?s Wort Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Powdered Valerian Extract
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
p-Oxalotoluidide
p-Oxalotoluidide. Group: Biochemicals. Alternative Names: N1, N2-Bis (4-methylphenyl) ethanediamide; N, N'-Bis (4-methylphenyl) ethanediamide; NSC 401961. Grades: Highly Purified. CAS No. 3299-61-4. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C16H16N2O2. US Biological Life Sciences.
Worldwide
p-Oxanisidide
p-Oxanisidide. Group: Biochemicals. Alternative Names: N1, N2-Bis (4-methoxyphenyl) ethanediamide; N,N'-Bis(4-methoxyphenyl)oxamide; N,N'-Di-p-anisylamide. Grades: Highly Purified. CAS No. 3299-63-6. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C16H16N2O4. US Biological Life Sciences.
Worldwide
Pozanicline
Pozanicline, a pyridine derivative, has been found to be a nicotinic receptor modulator that was once studied in Alzheimer's disease as a neuroprotective agent. Synonyms: Pozanicline; ABT-089; ABT 089; ABT089; A-87089; A-87089.0; Pozanicline; UNII-CL2002R563; CHEMBL127071; Pozanicline (USAN); 2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine. Grades: 98%. CAS No. 161417-03-4. Molecular formula: C11H16N2O. Mole weight: 192.26.
Pozanicline dihydrochloride
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor ( nAChR ) agonist with a K i of 16.7 nM for binding to [ 3 H]cytisine sites [1]. Pozanicline is an α4β2 -selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K i of 17 nM while binding to α7 nAChR is insignificant [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-089 dihydrochloride. CAS No. 161416-61-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110160.
Pozelimab
Pozelimab (REGN3918) is a fully human IgG4 anti-C5 monoclonal antibody. Pozelimab binds to C5 and C5 variants with high affinity and blocks complement-mediated hemolysis. Pozelimab can be used for the research of complement-mediated diseases [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN3918. CAS No. 2096328-94-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99786.
Poziotinib
Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: HM781-36B; NOV120101; NOV-120101; NOV 120101; Poziotinib. CAS No. 1092364-38-9. Molecular formula: C23H21Cl2FN4O3. Mole weight: 491.344.
Poziotinib
Poziotinib (HM781-36B) is an orally active, irreversible pan- HER inhibitor, which effectively inhibits EGFR wt , HER-2 and HER-4 with IC 50 s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFR T790M and EGFR L858R/T790M , with IC 50 s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HM781-36B; NOV120101. CAS No. 1092364-38-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15730.
Poziotinib Hydrochloride
Poziotinib, also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival. Synonyms: Poziotinib HCl; NOV120101 hydrochloride; HM 781-36B hydrochloride. CAS No. 1429757-68-5. Molecular formula: C23H22Cl3FN4O3. Mole weight: 527.80.
PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC 50 of 5 and 6 nM for Lck and Fyn, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGL 1872; EI 275. CAS No. 172889-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13804.
PP1
PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 μM), or ZAP-70 (IC50 ≥ 0.6 μM). Synonyms: PP1; PP 1; PP1. Grades: >98%. CAS No. 172889-26-8. Molecular formula: C16H19N5. Mole weight: 281.36.
PP 1
PP 1. Group: Biochemicals. Grades: Purified. CAS No. 172889-26-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PP102
PP102 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp), and has antibacterial activity against both gram-negative and gram-positive bacteria, but no activity against fungi. Grades: ≥95%.
PP113
PP113 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp), and has antibacterial activity against both gram-negative and gram-positive bacteria, but no activity against fungi. Grades: >98%.
PP121
PP121 is a multitargeted dual receptor tyrosine kinases inhibitor. PP121 blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases. Synonyms: PP121; PP 121; PP-121. CAS No. 1092788-83-4. Molecular formula: C17H17N7. Mole weight: 319.372.
PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092788-83-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10372.
PP 121
PP 121. Group: Biochemicals. Grades: Purified. CAS No. 1092788-83-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
P, P'-[ (1, 2-Phenylene) bis (methylene) ]bisphosphonic Acid P,P,P',P'-tetraethyl ester
P, P'-[ (1, 2-Phenylene) bis (methylene) ]bisphosphonic Acid P,P,P',P'-tetraethyl ester. Group: Biochemicals. Alternative Names: (o-Phenylenedimethylene) diphosphonic Acid Tetraethyl Ester; [1, 2-Phenylenebis (methylene) ]bisphosphonic Acid Tetraethyl Ester; Tetraethyl o-Xylylenediphosphonate. Grades: Highly Purified. CAS No. 42092-05-7. Pack Sizes: 1g. Molecular Formula: C16H28O6P2, Molecular Weight: 378.34. US Biological Life Sciences.
Worldwide
PP13
PP13 is an antimicrobial peptide found in Pteromalus puparum (endoparasitic wasp). It has antibacterial activity against E. coli, B. subtilis, S. aureus, S. lutea and B. pumilu (MIC 8-23 μM), but no activity against fungi. Synonyms: Gly-Ala-Ala-Arg-Lys-Ser-Ile-Arg-Leu-His-Arg-Leu-Tyr-Thr-Trp-Lys-Ala-Thr-Ile-Tyr-Thr-Arg. Grades: ≥97%. Molecular formula: C121H197N39O29. Mole weight: 2662.15.
Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses. Group: Biochemicals. Alternative Names: 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-26-8. Pack Sizes: 1mg. US Biological Life Sciences.
PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases. Group: Fluorescence/luminescence spectroscopy.
PP1 Analog III, 3-MB-PP1 - CAS 956025-83-5
PP1 Analog III, 3-MB-PP1 primarily used in Inhibition. Group: Fluorescence/luminescence spectroscopy.
PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog)
A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C16H18IN5, Molecular Weight: 407.3. US Biological Life Sciences.
Worldwide
PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor)
A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. US Biological Life Sciences.
PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Synonyms: PP-2; PP 2; AG 1879; AG-1879; AG1879. CAS No. 172889-27-9. Molecular formula: C15H16ClN5. Mole weight: 301.77.
PP2
PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC 50 s of 4 and 5 nM for Lck and Fyn , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGL 1879. CAS No. 172889-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13805.
PP2
PP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PP2; PP-2; PP 2; AG 1879; AG-1879; AG1879. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 172889-27-9. Molecular formula: C15H16ClN5. Mole weight: 301.77. Purity: >98%. IUPACName: 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Canonical SMILES: NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(Cl)C=C3)=NC=N1. Product ID: ACM172889279. Alfa Chemistry ISO 9001:2015 Certified.
PP 2
PP 2. Group: Biochemicals. Alternative Names: AGL 1879; PP 2 (enzyme inhibitor); Src kinase inhibitor PP2; 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.77. US Biological Life Sciences.
Worldwide
PP242
PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 μM for p110α, p110β, p110δ, p110γ and DNA-PK, respectively. Synonyms: PP 242; PP-242; Torkinib. CAS No. 1092351-67-1. Molecular formula: C16H16N6O. Mole weight: 308.345.
PP 242
PP 242. Group: Biochemicals. Alternative Names: 2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol. Grades: Highly Purified. CAS No. 1092351-67-1. Pack Sizes: 10mg. Molecular Formula: C16H16N6O, Molecular Weight: 308.339999999999. US Biological Life Sciences.
A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC?? = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242 is a more effective mTORC1 inhibitor than Rapamycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 1092351-67-1. Pack Sizes: 1mg. US Biological Life Sciences.
PP2 (4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine, AG 1879)
Highly potent and selective Scr family tyrosine kinase inhibitor. Reduces cancer metastasis. Apoptotic. Antitumor compound. RIP2 inhbitor. Blocks TGF-beta-mediated cellular responses. Autophagy modulator. Group: Biochemicals. Alternative Names: 4-Amino-5-(4-chlorophenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine. Grades: Highly Purified. CAS No. 172889-27-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H16ClN5, Molecular Weight: 301.8. US Biological Life Sciences.
Worldwide
PP2A Activating Ligand, ITH12246
A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences.