A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Sapphire sphere; diameter(mm), 5.00; grade 25. Group: Windows & spheres.
Sapphire substrate, 10x10x0.432mm, EPI polished one side, C-axis, LED grade
Emery is an odorless, white, crystalline powder. Natural aluminum oxide. Very high melting and hard. Used for polishing, grinding, and abrasive operations. An inhalation hazard when present as a dust.;DryPowder, PelletsLargeCrystals;WHITE POWDER.;Odorless, white, crystalline powder.;Odorless, white, crystalline powder. Group: Single crystals. Product ID: oxo(oxoalumanyloxy)alumane. Molecular formula: 101.961g/mol. Mole weight: Al2O3;Al2O3. O=[Al]O[Al]=O. InChI=1S/2Al.3O. TWNQGVIAIRXVLR-UHFFFAOYSA-N.
Sapphire substrate, 10x10x0.432mm, EPI polished two sides, C-axis, LED grade
Sapphire substrate, 10x10x0.432mm, EPI polished two sides, C-axis, LED grade. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished one side, C-axis, HEMCOR single crystal
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished one side, C-axis, HEMCOR single crystal. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished two sides, C-axis, HEMCOR single crystal
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished two sides, C-axis, HEMCOR single crystal. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.432mm thick, EPI polished one side, C-axis, HEMCOR single crystal
Sapphire substrate, 50.8mm dia x 0.432mm thick, EPI polished one side, C-axis, HEMCOR single crystal. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.432mm thick, EPI polished two sides, C-axis, HEMCOR single crystal
Emery is an odorless, white, crystalline powder. Natural aluminum oxide. Very high melting and hard. Used for polishing, grinding, and abrasive operations. An inhalation hazard when present as a dust.;DryPowder, PelletsLargeCrystals;WHITE POWDER.;Odorless, white, crystalline powder.;Odorless, white, crystalline powder. Group: Single crystals. Product ID: oxo(oxoalumanyloxy)alumane. Molecular formula: 101.961g/mol. Mole weight: Al2O3;Al2O3. O=[Al]O[Al]=O. InChI=1S/2Al.3O. TWNQGVIAIRXVLR-UHFFFAOYSA-N.
Sapropterin-[d3]
A deuterated Sapropterin. Sapropterin is a cofactor for phenylalanine hydroxylase. Synonyms: (R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one-D3. Grade: >95%. Molecular formula: C9H12D3N5O3. Mole weight: 244.27.
Sapropterin dihydrochloride
Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride. CAS No. 69056-38-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0124A.
Sapropterin Dihydrochloride
Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.[1] Chemically, its structure is that of a reduced pteridine derivative. Group: Biochemicals. Alternative Names: (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; 6R-BH4. CAS No. 17528-72-2. Pack Sizes: 50mg, 100mg, 250mg. US Biological Life Sciences.
Worldwide
Sapurimycin
It is produced by the strain of Str. sp. DO-116. It has anti-gram-positive bacteria effect. In vivo, it has the effect of anti-leukemia P388 and sarcoma 180 cells. Determination in vitro, it has the effect of causing single strand breaks in superhelical plasmid DNA. Synonyms: Antibiotic DC 116; 4H-Anthra(1,2-b)pyran-5-acetic acid, 7,12-dihydro-8,11-dihydroxy-2-(2-methyl-3-(1-propenyl)oxiranyl)-4,7,12-trioxo-, (2-alpha,3-alpha(Z))-(+)-. CAS No. 133021-37-1. Molecular formula: C25H18O9. Mole weight: 462.40.
Saquayamycin A
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: saquayamycin; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3-[[(2S,5S,6S)-5-[[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R-trans)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3-[[5-[(5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-,[2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-65-8. Molecular formula: C43H48O16. Mole weight: 820.83.
Saquayamycin A1
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]- -Darabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3,4a,8,12b-tetrahydroxy-3-methyl-, (3R,4aR,12bS)-; (3R)-9-[4-O-[(2R,6S)-5,6-Dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3α,4aα,8,12bα-tetrahydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione. Grade: 95%. CAS No. 99260-66-9. Molecular formula: C31H32O12. Mole weight: 596.58.
Saquayamycin B
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3-[[(2S,5S,6S)-5-[[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3-[[5-[(5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-67-0. Molecular formula: C43H48O16. Mole weight: 820.83.
Saquayamycin B1
Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1). Group: Biochemicals. Alternative Names: 9- (2, 9-dimethyl-3-oxo-4, 4a, 5a, 6, 7, 9, 9a, 10a-octahydrodipyrano [4, 2-a: 4', 3'-e] [1, 4]dioxin-7-yl) -3, 4a, 8, 12b-tetrahydroxy-3-methyl-2, 4-dihydrobenzo [a]anthracene-1, 7, 12-trione. Grades: Highly Purified. CAS No. 99260-68-1. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.
Worldwide
Saquayamycin B1
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-RL-erythro-hexopyranos-4-ulos-1-yl)-a-Darabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3,4a,8,12b-tetrahydroxy-3-methyl-, (3R,4aR,12bS)-. Grade: ≥95%. CAS No. 99260-68-1. Molecular formula: C31H32O12. Mole weight: 596.58.
Saquayamycin C
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]oxy]-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[tetrahydro-6-methyl-5-[(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]-2H-pyran-2-yl]oxy]-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-70-5. Molecular formula: C43H52O16. Mole weight: 824.86.
Saquayamycin C1
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: (3R)-9-[4-O-[(2R,6S)-Tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3α,4aα,8,12bα-tetrahydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione. CAS No. 99260-69-2. Molecular formula: C31H34O12. Mole weight: 598.59.
Saquayamycin D
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]oxy]-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[tetrahydro-6-methyl-5-[(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]-2H-pyran-2-yl]oxy]-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-71-6. Molecular formula: C43H50O16. Mole weight: 822.85.
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: n1-[(1s,2r)-3-[(3s,4as,8as)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1h)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-butanediamide;SAGUINAVIR;SAQUINAVIR;2-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID;(2S)-N-[(2S,3R)-4-[(3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE;FLUNIXIN;FLUNIXINE;SAQUINAVIRMESYLATE(SUBJECTTOPATENTFREE). Product Category: Inhibitors. Appearance: Solid. CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.84. Purity: 0.9973. Canonical SMILES: O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2[C@H](C(NC(C)(C)C)=O)C[C@@](CCCC3)([H])[C@@]3([H])C2)=O)C4=NC5=CC=CC=C5C=C4. Product ID: ACM127779208. Alfa Chemistry ISO 9001:2015 Certified.
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at Saquinavir as a possible anti-cancer agent. Group: Biochemicals. Alternative Names: Saquinavir; Ro 31-8959; (2S) -N- [ (2S, 3R) -4- [ (3S, 4aS, 8aS) -3- (tert-butylcarbamoyl) -decahydroisoquinolin-2-yl] -3-hydroxy-1-phenylbutan-2-yl] -2- [ (quinolin-2-yl) formamido] butanediamide. Grades: Highly Purified. CAS No. 127779-20-8. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C38H50N6O5, Molecular Weight: 670.84. US Biological Life Sciences.
Worldwide
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.36 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8959. CAS No. 127779-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17007.
Saquinavir-[d6]
A deuterated squinavir. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases. Synonyms: (2S)-N1[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2-(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide-d6; Fortovase-d6; Invirase-d6; Ro 31-8959-d6. Grade: >95%. Molecular formula: C38H44D6N6O5. Mole weight: 676.90.
Saquinavir-d9
Labeled Saquinavir. A selective HIV protease inhibitor. Antiviral. Group: Biochemicals. Alternative Names: (2S) -N1 [ (1S, 2R) -3- [ (3S, 4aS, 8aS) -3- [ [ (1, 1-Dimethylethyl) amino] carbonyl] octahydro-2- (1H) -isoquinolinyl] -2-hydroxy-1- (phenylmethyl) propyl] -2- [ (2-quinolinylcarbonyl) amino] butanediamide-d9; Fortovase-d9; Invirase-d9; Ro 31-8959-d9. Grades: Highly Purified. CAS No. 1356355-11-7. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Saquinavir-[d9]
A deuterated squinavir. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases. Synonyms: (2S)-N1[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2-(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide-d9; Fortovase-d9; Invirase-d9; Ro 31-8959-d9. Grade: >98%. CAS No. 1356355-11-7. Molecular formula: C38H41D9N6O5. Mole weight: 679.91.
A selective HIV protease inhibitor. Group: Biochemicals. Alternative Names: Fortovase, Invirase, Ro 31-8959. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Saquinavir Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
SAR125844
SAR125844 is a potent, selective, and ATP-competitive MET kinase inhibitor with the value of IC 50 is 4.2 nM and K i is 2.8 nM. SAR125844 has antitumor activity and can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116743-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16446.
SAR131675
SAR131675 is a potent and selective VEGFR3 inhibitor with an IC 50 of 23 nM. SAR131675 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433953-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15458.
SAR131675
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. Group: Biochemicals. Alternative Names: 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide. Grades: Highly Purified. CAS No. 1092538-80-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 358.39. US Biological Life Sciences.
Worldwide
SAR-20347
SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450881-55-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100895.
SAR247799
SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC 50 s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S1P1 agonist 3. CAS No. 1315311-14-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115831.
SAR405
SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1523406-39-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12481.
SAR-405
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SAR-405; SAR 405; SAR405. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.86. Purity: >98%. IUPACName: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one. Canonical SMILES: O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31. Product ID: ACM1523406394. Alfa Chemistry ISO 9001:2015 Certified. Categories: SR 405 (VA).
SAR407899
SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC 50 of 135 nM for ROCK-2 , and K i s of 36 nM and 41 nM for human and rat ROCK-2 , respectively. SAR407899 shows stable inhibition of migrasome formation. Uses: Scientific research. Group: Signaling pathways. CAS No. 923359-38-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687A.
SAR407899 hydrochloride
SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC 50 of 135 nM for ROCK-2 , and K i s of 36 nM and 41 nM for human and rat ROCK-2 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 923262-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687.
SAR441255
SAR441255 is a synthetic peptide agonist of the GLP-1, GCG, and GIP receptors. SAR441255 showed substantial body weight loss and improved glucose control in diabetic obese monkeys. Synonyms: H-Aib-HGTFTSDLSKL-K(γGlu-γGlu-Palm acid)-EEQRQ-AibEFIEWLKA-dAla-GPPS-Aib-KPPPK-NH2. Molecular formula: C206H323N51O66. Mole weight: 4570.06.
SAR7334
SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1333210-07-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15699.
Saracatinib
Saracatinib (AZD0530) is a potent Src family inhibitor with IC 50 s of 2.7 to 11 nM for c-Src , Lck , c-YES , Lyn , Fyn , Fgr , and Blk. Saracatinib shows high selectivity over other tyrosine kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD0530. CAS No. 379231-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10234.
Saracatinib
An oral, selective dual inhibitor of Src and ABL kinase. Group: Biochemicals. Alternative Names: N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine; 7- [2- [4-Methylpiperazin-1-yl] ethoxy] -5- [ [tetrahydropyran-4-yl] oxy] -4- [ [6-chloro-2, 3-methylenedioxyphenyl] amino] quinazoline. Grades: Highly Purified. CAS No. 379231-04-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg. US Biological Life Sciences.
Worldwide
Sarafloxacin
Sarafloxacin. Group: Biochemicals. Grades: Highly Purified. CAS No. 98105-99-8. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C20H17F2N3O3. US Biological Life Sciences.
A Fluorinated quinolone antibacterial. Group: Biochemicals. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Sarafloxacin-[d8] Hydrochloride
Sarafloxacin-[d8] Hydrochloride is the labelled hydrochloride form of Sarafloxacin. Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. Synonyms: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl-d8)-3-quinolinecarboxylic Acid Hydrochloride; A 56620-d8; PD 121960-d8; Sarafin-d8. Grade: >98%. CAS No. 1352879-52-7. Molecular formula: C20H10D8ClF2N3O3. Mole weight: 429.87.
Sarafloxacin-[d8] hydrochloride hydrate
Sarafloxacin-[d8] hydrochloride hydrate is a labelled analogue of Sarafloxacin. Sarafloxacin is a topoisomerase II ligase inhibitor used as a quinolone antibiotic drug. Synonyms: Sarafloxacin-D8 hydrochloride hydrate; Difloxacino-d8 hydrochloride hydrate; Difloxacinum-d8 hydrochloride hydrate; Sarafloxacino-d8 hydrochloride hydrate; Sarafloxacinum-d8 hydrochloride hydrate; 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazine-D8-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate. Grade: 95% by HPLC; 98% atom D. Molecular formula: C20H9D8F2N3O3.HCl.H2O. Mole weight: 447.87.
Sarafloxacin-d8 hydrochloride trihydrate
analytical standard. Group: Application areas.
Sarafloxacin hydrochloride
Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A-56620 hydrochloride. CAS No. 91296-87-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0343A.
Sarafloxacin hydrochloride
Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. It inhibits bacterial Topo II α (DNA gyrase, topoisomerase) and is effective against Mycobacterium tuberculosis. Synonyms: Sarafloxacin HCl; A-56620; A 56620; A56620. Grade: >98%. CAS No. 91296-87-6. Molecular formula: C20H17F2N3O3.HCl. Mole weight: 421.83.
Sarafloxacin hydrochloride
Sarafloxacin hydrochloride. Group: Biochemicals. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride; A 56620; PD 121960. Grades: Highly Purified. CAS No. 91296-87-6. Pack Sizes: 500mg, 1g, 2g, 5g. Molecular Formula: C20H18ClF2N3O3. US Biological Life Sciences.
Worldwide
Sarafloxacin hydrochloride hydrate
analytical standard. Group: Application areas.
Sarafotoxin S6a
Sarafotoxin S6a. Group: Biochemicals. Grades: Purified. CAS No. 126738-34-9. Pack Sizes: 100ug. US Biological Life Sciences.
Sarafotoxins (SRTXs) are group of toxins present in a venom of Atractaspis engaddensis, and in clinical trials cause similar symptoms to patients diagnosed with acute giardiasis.[1] Together with endothelins (ETs), they form a homogenous family of strong vasoconstrictor isopeptides. Among them, few slightly different substances can be named, as SRTX-a, SRTX-b, SRTX-c, which were initially derived from Atractaspis engaddensis. Each contains twenty-one amino acid residues that spontaneously fold into a defined tertiary structure with two interchain-cysteine linkages (disulfide bonds) and a long hydrophobic tail.[2] There are also other compounds, however, they are mostly derivations of previously mentioned ones. The main differences in the family of endothelin and sarafotoxins appear at N-terminal of peptides, as C-terminal in all of them is almost the same.[3]. Group: Biochemicals. Grades: Purified. CAS No. 116303-65-2. Pack Sizes: 100ug. Molecular Formula: C110H159N27O34S5, Molecular Weight: 2564. US Biological Life Sciences.
Worldwide
Sarafotoxin S6c
Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki = 0.29 and 28000 nM at ETB and ETA receptors, respectively). Uses: Vasoconstrictor agents. Synonyms: Sarafotoxin C; S6C; H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH (Disulfide bridge: Cys1-Cys15, Cys3-Cys11); L-cysteinyl-L-threonyl-L-cysteinyl-L-asparagyl-L-alpha-aspartyl-L-methionyl-L-threonyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-cysteinyl-L-leucyl-L-asparagyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide). Grade: ≥95% by HPLC. CAS No. 121695-87-2. Molecular formula: C103H147N27O37S5. Mole weight: 2515.75.