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| Product | Description | |
|---|---|---|
| Saquayamycin C | It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]oxy]-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[tetrahydro-6-methyl-5-[(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]-2H-pyran-2-yl]oxy]-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-70-5. Molecular formula: C43H52O16. Mole weight: 824.86. |  |
| Saquayamycin C1 | It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: (3R)-9-[4-O-[(2R,6S)-Tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3α,4aα,8,12bα-tetrahydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione. CAS No. 99260-69-2. Molecular formula: C31H34O12. Mole weight: 598.59. | |
| Saquayamycin D | It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]oxy]-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[tetrahydro-6-methyl-5-[(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]-2H-pyran-2-yl]oxy]-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-71-6. Molecular formula: C43H50O16. Mole weight: 822.85. | |
| Saquinavir | Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at Saquinavir as a possible anti-cancer agent. Group: Biochemicals. Alternative Names: Saquinavir; Ro 31-8959; (2S) -N- [ (2S, 3R) -4- [ (3S, 4aS, 8aS) -3- (tert-butylcarbamoyl) -decahydroisoquinolin-2-yl] -3-hydroxy-1-phenylbutan-2-yl] -2- [ (quinolin-2-yl) formamido] butanediamide. Grades: Highly Purified. CAS No. 127779-20-8. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C38H50N6O5, Molecular Weight: 670.84. US Biological Life Sciences. |  Worldwide |
| Saquinavir | Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.36 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8959. CAS No. 127779-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17007. |  |
| Saquinavir | An HIV protease inhibitor. It is often used in combination with ritonavir or lopinavir/ritonavir for HIV/AIDS infection therapy. Uses: Hiv protease inhibitors. Synonyms: Invirase; Fortovase; saguinavir; Ro 31-8959; Ro 31 8959; Ro318959. Grades: ≥98%. CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.8. | |
| Saquinavir | Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM. Group: Inhibitors. Alternative Names: n1-[ (1s, 2r) -3-[ (3s, 4as, 8as) -3-[[ (1, 1-dimethylethyl) amino]carbonyl]octahydro-2 (1h) -isoquinolinyl]-2-hydroxy-1- (phenylmethyl) propyl]-2-[ (2-quinolinylcarbonyl) amino]-butanediamide; SAGUINAVIR; SAQUINAVIR; 2-[[2-METHYL-3- (TRIFLUOROMETHYL) PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID; (2S)-N-[ (2S, 3R)-4-[ (3S, 4AS, 8AS)-3- (TERT-BUTYLCARBAMOYL)-3, 4, 4A, 5, 6, 7, 8, 8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2- (QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE; FLUNIXIN; FLUNIXINE; SAQUINAVIRMESYLATE (SUBJECTTOPATENTFREE). CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.84. Appearance: Solid. Purity: 0.9973. Canonical SMILES: O=C (N[C@@H] (CC (N)=O)C (N[C@@H] (CC1=CC=CC=C1)[C@H] (O)CN2[C@H] (C (NC (C) (C)C)=O)C[C@@] (CCCC3) ([H])[C@@]3 ([H])C2)=O)C4=NC5=CC=CC=C5C=C4. Catalog: ACM127779208. |  |
| Saquinavir-d9 | Labeled Saquinavir. A selective HIV protease inhibitor. Antiviral. Group: Biochemicals. Alternative Names: (2S) -N1 [ (1S, 2R) -3- [ (3S, 4aS, 8aS) -3- [ [ (1, 1-Dimethylethyl) amino] carbonyl] octahydro-2- (1H) -isoquinolinyl] -2-hydroxy-1- (phenylmethyl) propyl] -2- [ (2-quinolinylcarbonyl) amino] butanediamide-d9; Fortovase-d9; Invirase-d9; Ro 31-8959-d9. Grades: Highly Purified. CAS No. 1356355-11-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Saquinavir Hydroxy-tert-butylamide | Saquinavir Hydroxy-tert-butylamide. Group: Biochemicals. Alternative Names: (2S) -N1-[ (1S, 2R) -2-Hydroxy-3-[ (3S, 4aS, 8aS) -octahydro-3-[[ (2-hydroxy-1, 1-dimethylethyl) amino]carbonyl]-2 (1H) -isoquinolinyl]-1- (phenylmethyl) propyl]-2-[ (2-quinolinylcarbonyl) amino]-butanediamide. Grades: Highly Purified. CAS No. 438200-34-1. Pack Sizes: 1mg. Molecular Formula: C38H50N6O6, Molecular Weight: 686.84. US Biological Life Sciences. | Worldwide |
| Saquinavir mesylate | Saquinavir mesylate. Group: Biochemicals. Grades: Purified. CAS No. 149845-06-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Saquinavir mesylate | Saquinavir Mesylate (Ro 31-8959/003) is an HIV protease inhibitor used in retrovirus research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8959/003. CAS No. 149845-06-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17003. | |
| Saquinavir Mesylate | Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. It inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at saquinavir as a possible anti-cancer agent. Uses: Hiv protease inhibitors. Synonyms: Invirase; Ro 31-8959/003. Grades: >98%. CAS No. 149845-06-7. Molecular formula: C39H54N6O8S. Mole weight: 766.95. | |
| Saquinavir, Mesylate (Fortovase, Invirase, Ro 31-8959) | A selective HIV protease inhibitor. Group: Biochemicals. Alternative Names: Fortovase, Invirase, Ro 31-8959. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SAR-020106 | SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo. SAR-020106 can enhance antitumor activity with selected anticancer drugs in vivo and may therefore have clinical utility. Synonyms: SAR020106; SAR 020106; SAR-20106; SAR20106; SAR 20106. Grades: 98%. CAS No. 1184843-57-9. Molecular formula: C19H19ClN6O. Mole weight: 382.852. | |
| SAR125844 | SAR125844 is inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis. Synonyms: SAR 125844; SAR-125844; 1-(6-((6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea; Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-. Grades: >98%. CAS No. 1116743-46-4. Molecular formula: C25H23FN8O2S2. Mole weight: 550.63. | |
| SAR125844 | SAR125844 is a potent, selective, and ATP-competitive MET kinase inhibitor with the value of IC 50 is 4.2 nM and K i is 2.8 nM. SAR125844 has antitumor activity and can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116743-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16446. | |
| SAR131675 | SAR131675 is a potent and selective VEGFR3 inhibitor with an IC 50 of 23 nM. SAR131675 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433953-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15458. | |
| SAR131675 | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. Group: Biochemicals. Alternative Names: 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide. Grades: Highly Purified. CAS No. 1092538-80-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 358.39. US Biological Life Sciences. | Worldwide |
| SAR131675 | SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20 nM. Synonyms: (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-. Grades: >98%. CAS No. 1433953-83-3. Molecular formula: C18H22N4O4. Mole weight: 358.39. | |
| SAR131675 (Racemate) | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nmol/L, respectively. Synonyms: (Rac)-SAR131675; 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-, (±)-. Grades: ≥95%. CAS No. 1092539-44-0. Molecular formula: C18H22N4O4. Mole weight: 358.40. | |
| SAR156497 | SAR156497 is a selective Aurora A, B and C inhibitor with in vitro and in vivo efficacy IC50 value is 0.5 nM for Aurora A; 1.0 nM for Aurora B (incenp) and 3.0 nM for Aurora C (incenp). In vitro, SAR156497 shows very good antiproliferative activity on a large panel of tumor cell lines. Uses: Anti-tumor. Synonyms: SAR156497; SAR156497; SAR 156497. Grades: 98%. CAS No. 1256137-14-0. Molecular formula: C27H24N4O4. Mole weight: 468.5. | |
| SAR191801 | SAR191801 is a hPGDS inhibitor and the IC50 value of which is 12 nM that was determined through fluorescence polarization. Uses: Sar191801 is a hpgds inhibitor. Synonyms: SAR 191801; SAR-191801; SAR191801;HPGDS-IN-1; SCHEMBL2493135; 1234708-04-3; C22H20N6O3; 2-Pyridin-2-yl-pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methyl-ethyl)-1,2,4-oxadiazol-3-yl]-benzylamide; N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyrimidine-5-c. Grades: 98%. CAS No. 1234708-04-3. Molecular formula: C22H20N6O3. Mole weight: 416.43. | |
| SAR-20347 | Cas No. 1450881-55-6. | |
| SAR 216471 hydrochloride | SAR 216471 hydrochloride is a potent and reversible P2Y12 antagonist (IC50 = 17 nM), displaying antiplatelet and antithrombotic activity in vivo. Synonyms: SAR 216471 hydrochloride; SAR-216471 hydrochloride; SAR216471 hydrochloride; 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1279829-64-9. Molecular formula: C28H31ClN8O3.HCl. Mole weight: 599.51. | |
| SAR247799 | SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC 50 s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S1P1 agonist 3. CAS No. 1315311-14-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115831. | |
| SAR260301 | SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform. SAR260301 is being investigated for the treatment of PTEN-deficient tumors. SAR260301 displayed improved physicochemical and in vitro pharmacokinetic properties. SAR260301 demonstrated significant in vivo activity in a UACC-62 xenograft model in mice, warranting further preclinical investigation. Synonyms: SAR-260301; SAR 260301. Grades: >98%. CAS No. 1260612-13-2. Molecular formula: C19H22N4O3. Mole weight: 354.41. | |
| SAR-405 | SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd=1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines. Synonyms: SAR 405; SAR405; 4H-Pyrimido[1,?2-a]?pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)?methyl]?-6,?7,?8,?9-tetrahydro-2-[(3R)?-3-methyl-4-morpholinyl]?-8-(trifluoromethyl)?-, (8S)?-; (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.85. | |
| SAR-405 | SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells. Group: Inhibitors. Alternative Names: SAR-405; SAR 405; SAR405. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.86. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one. Canonical SMILES: O=C1C=C (N2[C@H] (C)COCC2)N=C3N (CC4=CC (Cl)=CN=C4)[C@H] (C (F) (F)F)CCN31. Catalog: ACM1523406394. | |
| SAR405838 | MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. Synonyms: SAR-405838; SAR 405838; SAR405838; MI-773; MI773; MI 773. Grades: >98%. CAS No. 1303607-60-4. Molecular formula: C29H34Cl2FN3O3. Mole weight: 562.50. | |
| SAR407899 | SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC 50 of 135 nM for ROCK-2 , and K i s of 36 nM and 41 nM for human and rat ROCK-2 , respectively. SAR407899 shows stable inhibition of migrasome formation. Uses: Scientific research. Group: Signaling pathways. CAS No. 923359-38-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687A. | |
| SAR-407899 | SAR-407899 is a potent, ATP-competitive ROCK inhibitor. It is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. It is highly selective in panel of 117 receptor and enzyme targets in vitro. It demonstrated concentration-dependent inhibition of Rho-kinase-mediated phosphorylation of myosin phosphatase, platelet-derived growth factor-induced proliferation, thrombin-induced stress fiber formation, and monocyte chemotactic protein-1-stimulated chemotaxis in vitro. It potently inhibits endothelin-1-induced constriction of renal resistance arteries. It has good antihypertensive activity and lowered blood pressure in a variety of rodent models. Uses: Sar-407899 has good antihypertensive activity. Synonyms: SAR407899; SAR 407899; SAR-407899; 6-Piperidin-4-yloxy-2H-isoquinolin-1-one;6-(Piperidin-4-yloxy)isoquinolin-1(2H)-one. Grades: >98 %. CAS No. 923359-38-0. Molecular formula: C14H16N2O2. Mole weight: 244.29. | |
| SAR-407899 hydrochloride | SAR-407899 hydrochloride is the hydrochloride form of SAR-407899, which is a potent, ATP-competitive ROCK inhibitor. It has good antihypertensive activity. Uses: Sar-407899 hydrochloride has good antihypertensive activity. Synonyms: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride; SAR407899; SAR 407899; SAR-407899; SAR407899 HCl. Grades: >98%. CAS No. 923262-96-8. Molecular formula: C14H17ClN2O2. Mole weight: 280.75. | |
| SAR407899 hydrochloride | SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC 50 of 135 nM for ROCK-2 , and K i s of 36 nM and 41 nM for human and rat ROCK-2 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 923262-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687. | |
| SAR441255 | SAR441255 is a synthetic peptide agonist of the GLP-1, GCG, and GIP receptors. SAR441255 showed substantial body weight loss and improved glucose control in diabetic obese monkeys. Synonyms: H-Aib-HGTFTSDLSKL-K(γGlu-γGlu-Palm acid)-EEQRQ-AibEFIEWLKA-dAla-GPPS-Aib-KPPPK-NH2. Molecular formula: C206H323N51O66. Mole weight: 4570.06. | |
| SAR-489883 | SAR-489883 is a potent and selective inhibitor of protein kinase R (PKR), which is potentially used to treat Alzheimer's disease. SAR-489883 reduced cognitive impairment in a mouse study, induced rescue of deficits in synaptic proteins (PSD-95, SNAP-25 and synaptophysin) as well as reduction of levels of interleukin-1 beta in ex vivo analyses. Uses: The potential treatment of alzheimer's disease. Synonyms: SAR489883; SAR 489883. | |
| SAR629 | SAR-629 is a Monoglyceride lipase (MGL) inhibitor and can also be known as 2-arachidonoylglycerol (2-AG) degradation inhibitor. MGL is a serine hydrolase which can hydrolyse 2-AG into arachidonic acid and glycerol. 2-AG is an endogenous ligand of cannabinoid receptors and it plays an important role in various physiological processes in the brain. Synonyms: (4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1221418-42-3. Molecular formula: C20H19F2N5O. Mole weight: 383.40. | |
| SAR7334 | SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC. Uses: Sar7334 is a trpc6 inhibitor that could be valuable in studying sorts of diseases related to trpc. Synonyms: SAR7334; CPA1588; SAR 7334; CPA 1588; SAR-7334; CPA-1588; 4-(((1R,2R)-2-((R)-3-aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile; 1333207-63-8; 1333210-07-3; C21H22ClN3O. Grades: 98%. CAS No. 1333210-07-3. Molecular formula: C21H22ClN3O. Mole weight: 367.87. | |
| SAR7334 hydrochloride | The hydrochloride salt form of SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC. Uses: The hydrochloride salt form of sar7334 is a trpc6 inhibitor that could be valuable in studying sorts of diseases related to trpc. Synonyms: SAR7334 hydrochloride; CPA1588 hydrochloride; SAR 7334 hydrochloride; CPA 1588 hydrochloride; SAR-7334 hydrochloride; CPA-1588 hydrochloride; 4-(((1R,2R)-2-((R)-3-aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile; 1333207-63-8; 1333210-07-3; C21H22ClN3O. Grades: 97%. CAS No. 1333207-63-8. Molecular formula: C21H24Cl3N3O. Mole weight: 440.79. | |
| Saracatinib | Saracatinib (AZD0530) is a potent Src family inhibitor with IC 50 s of 2.7 to 11 nM for c-Src , Lck , c-YES , Lyn , Fyn , Fgr , and Blk. Saracatinib shows high selectivity over other tyrosine kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD0530. CAS No. 379231-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10234. | |
| Saracatinib | An oral, selective dual inhibitor of Src and ABL kinase. Group: Biochemicals. Alternative Names: N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine; 7- [2- [4-Methylpiperazin-1-yl] ethoxy] -5- [ [tetrahydropyran-4-yl] oxy] -4- [ [6-chloro-2, 3-methylenedioxyphenyl] amino] quinazoline. Grades: Highly Purified. CAS No. 379231-04-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Saracatinib | Saracatinib, also known as AZD0530, is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. Src and Abl are protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. Saracatinib binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption. Uses: Antineoplastic agents. Synonyms: AZD 0530; AZD-0530; AZD0530. Grades: >98%. CAS No. 379231-04-6. Molecular formula: C27H32ClN5O5. Mole weight: 542.03. | |
| Saracatinib Difumarate | Saracatinib Difumarate is a tyrosine kinase inhibitor selectively targeting Src and Abl, which are commonly overexpressed in chronic myeloid leukema cells. Synonyms: AZD 0530 difumarate; AZD0530 difumarate; AZD-0530 difumarate; (E)-but-2-enedioic acid;N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine. Grades: 99%. CAS No. 893428-72-3. Molecular formula: C27H32ClN5O5.2C4H4O4. Mole weight: 774.17. | |
| Sarafloxacin | Sarafloxacin. Group: Biochemicals. Grades: Highly Purified. CAS No. 98105-99-8. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C20H17F2N3O3. US Biological Life Sciences. | Worldwide |
| Sarafloxacin (6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid) | A Fluorinated quinolone antibacterial. Group: Biochemicals. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Sarafloxacin hydrochloride | Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. It inhibits bacterial Topo II α (DNA gyrase, topoisomerase) and is effective against Mycobacterium tuberculosis. Synonyms: Sarafloxacin HCl; A-56620; A 56620; A56620. Grades: >98%. CAS No. 91296-87-6. Molecular formula: C20H17F2N3O3.HCl. Mole weight: 421.83. | |
| Sarafloxacin hydrochloride | Sarafloxacin hydrochloride. Group: Biochemicals. Alternative Names: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride; A 56620; PD 121960. Grades: Highly Purified. CAS No. 91296-87-6. Pack Sizes: 500mg, 1g, 2g, 5g. Molecular Formula: C20H18ClF2N3O3. US Biological Life Sciences. | Worldwide |
| Sarafloxacin hydrochloride | Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A-56620 hydrochloride. CAS No. 91296-87-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0343A. | |
| Sarafotoxin S6a | Sarafotoxin S6a. Group: Biochemicals. Grades: Purified. CAS No. 126738-34-9. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Sarafotoxin S6a | Sarafotoxin S6a is an endothelin receptor agonist (EC50 = 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta, respectively). CAS No. 126738-34-9. Molecular formula: C105H156N28O34S5. Mole weight: 2514.85. | |
| Sarafotoxin s 6a(reduced)(9ci) | Heterocyclic Organic Compound. CAS No. 119965-38-7. Molecular formula: C105H160N28O34S5. Mole weight: 2514.85. Purity: 0.96. Catalog: ACM119965387. | |
| Sarafotoxin s6b | Heterocyclic Organic Compound. CAS No. 116303-65-2. Molecular formula: C110H159N27O34S5. Mole weight: 2563.92. Purity: 0.96. Catalog: ACM116303652. | |
| Sarafotoxin S6b | Sarafotoxins (SRTXs) are group of toxins present in a venom of Atractaspis engaddensis, and in clinical trials cause similar symptoms to patients diagnosed with acute giardiasis.[1] Together with endothelins (ETs), they form a homogenous family of strong vasoconstrictor isopeptides. Among them, few slightly different substances can be named, as SRTX-a, SRTX-b, SRTX-c, which were initially derived from Atractaspis engaddensis. Each contains twenty-one amino acid residues that spontaneously fold into a defined tertiary structure with two interchain-cysteine linkages (disulfide bonds) and a long hydrophobic tail.[2] There are also other compounds, however, they are mostly derivations of previously mentioned ones. The main differences in the family of endothelin and sarafotoxins appear at N-terminal of peptides, as C-terminal in all of them is almost the same.[3]. Group: Biochemicals. Grades: Purified. CAS No. 116303-65-2. Pack Sizes: 100ug. Molecular Formula: C110H159N27O34S5, Molecular Weight: 2564. US Biological Life Sciences. | Worldwide |
| Sarafotoxin S6b | Sarafotoxin S6b is a non-selective endothelin receptor agonist with vasoconstrictor activity. CAS No. 116303-65-2. Molecular formula: C110H159N27O34S5. Mole weight: 2564. | |
| Sarafotoxin s 6b(9ci) | Heterocyclic Organic Compound. Alternative Names: CSCKDMTDKECLYFCHQDVIW;CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP;H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH;H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-TYR-PHE-C. CAS No. 120972-53-4. Molecular formula: C110H159N27O34S5. Mole weight: 2563.93. Purity: 0.96. IUPACName: SARAFOTOXIN S6B. Density: 1.298 g/cm³. Catalog: ACM120972534. | |
| Sarafotoxin S6c | Sarafotoxin S6c. Group: Biochemicals. Grades: Purified. CAS No. 121695-87-2. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Sarafotoxin S6c | Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki = 0.29 and 28000 nM at ETB and ETA receptors, respectively). Uses: Vasoconstrictor agents. Synonyms: Sarafotoxin C; S6C; H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH (Disulfide bridge: Cys1-Cys15, Cys3-Cys11); L-cysteinyl-L-threonyl-L-cysteinyl-L-asparagyl-L-alpha-aspartyl-L-methionyl-L-threonyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-cysteinyl-L-leucyl-L-asparagyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide). Grades: ≥95% by HPLC. CAS No. 121695-87-2. Molecular formula: C103H147N27O37S5. Mole weight: 2515.75. | |
| Sarafotoxin s 6c(reduced)(9ci) | Heterocyclic Organic Compound. Alternative Names: [LYS4] SARAFOTOXIN S6C;SARAFOTOXIN 6C, [LYS4]-;L-Cys-L-Thr-L-Cys-L-Asn-L-Asp-L-Met-L-Thr-L-Asp-L-Glu-L-Glu-L-Cys-L-Leu-L-Asn-L-Phe-L-Cys-L-His-L-Gln-L-Asp-L-Val-L-Ile-L-Trp-OH;Sarafotoxin c?reduced?;Sarafotoxin S 6c?reduced?. CAS No. 116495-45-5. Molecular formula: C103H151N27O37S5. Mole weight: 2529.82. Purity: 0.96. IUPACName: Sarafotoxin c (reduced). Canonical SMILES: CCC (C)C (C (=O)NC (CC1=CNC2=CC=CC=C21)C (=O)O)NC (=O)C (C (C)C)NC (=O)C (CC (=O)O)NC (=O)C (CCC (=O)N)NC (=O)C (CC3=CNC=N3)NC (=O)C4CSSCC (C (=O)NC (C (=O)NC5CSSCC (C (=O)NC (C (=O)NC (C (=O)NC (C (=O)N4)CC6=CC=CC=C6)CC (=O)N)CC (C)C)NC (=O)C (NC (=O)C (NC (=O)C (NC (=O)C (NC (=O)C (NC (=O)C (NC (=O)C (NC5=O)CCCCN)CC (=O)O)CCSC)C (C)O)CC (=O)O)CCC (=O)O)CCC (=O)O)C (C)O)N. Catalog: ACM116495455. | |
| Saralasin | Saralasin. Group: Biochemicals. Grades: Purified. CAS No. 34273-10-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Saralasin | Saralasin is a competitive and nonselective angiotensin II receptor antagonist. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: (Sar1,Val5,Ala8)-Angiotensin II; Aralasin; Saralasinum. Grades: ≥97% by HPLC. CAS No. 34273-10-4. Molecular formula: C42H65N13O10. Mole weight: 912.04. | |
| Sar-arg-val-tyr-ile-his-pro-gly acetate salt | Heterocyclic Organic Compound. Alternative Names: SAR-ARG-VAL-TYR-ILE-HIS-PRO-GLY ACETATE SALT;[SAR1,GLY8]-ANGIOTENSIN II ACETATE SALT;(sar1,gly8)-angiotensin ii acetate;[Sar1, Gly8]-Angiotensin II hydrate acetate salt. CAS No. 100900-29-6. Molecular formula: C44H69N13O12. Mole weight: 972.1. Appearance: White powder. Purity: 0.96. IUPACName: SAR-ARG-VAL-TYR-ILE-HIS-PRO-GLY ACETATE SALT. Catalog: ACM100900296. | |
| Sar-arg-val-tyr-ile-his-pro-phe | Heterocyclic Organic Compound. Alternative Names: [SAR1]ANGIOTENSIN II, HUMAN;(SAR1)-ANGIOTENSIN II;(SAR1,PHE8) ANGIOTENSIN II;SAR-ARG-VAL-TYR-ILE-HIS-PRO-PHE;(SAR1)-ANGIOTENSIN II ACETATE;angiotensin II, Sar(1)-Ile(5)-;H-Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH;[Sar1]angiotensin II?guinea pig?. CAS No. 102029-89-0. Molecular formula: C49H71N13O10. Mole weight: 1002.17. Purity: 0.96. IUPACName: acetic acid; 2-[[1-[2-[[2-[[2-[[2-[[5- (diaminomethylideneamino) -2-[[2- (methylamino) acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3- (4-hydroxyphenyl) propanoyl]amino]-3-methylpentanoyl]amino]-3- (1H-imidazol-5-yl) propanoyl]pyrrolidine-2-carbonyl]amin. Catalog: ACM102029890. | |
| Sarasinoside | Heterocyclic Organic Compound. Alternative Names: Sarasinoside C1, Sarasinoside-C1, CID73567, 114066-51-2, Cholesta-8,24-dien-23-one, 3-((O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-(O-beta-D-xylopyranosyl-(1-6)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-2))-beta-D-xylopyranosyl)oxy)-4,4-dimethyl-, (3beta,5alpha)-. CAS No. 114066-51-2. Molecular formula: C55H88N2O20. Mole weight: 1097.288620 [g/mol]. Purity: 0.96. IUPACName: N-[2-[5-[3-acetamido-4,5-dihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxy-4-hydroxy-6-[[4,4,10,13-tetramethyl-17-(6-methyl-4-oxohept-5-en-2-yl)-1,2,3,5,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-4,5-dih. Catalog: ACM114066512. | |
| Sarcandrolide D | Terpenoids. Alternative Names: [(1Ar, 1Bs, 2R, 2As, 5Cr, 9Ar, 10S, 10As, 11Ar, 11Bs, 11Cs, 12As, 12Bs)-8-(Acetoxymethyl)-2, 2A, 10, 12A-Tetrahydroxy-1B, 5, 11B-Trimethyl-4, 7-Dioxo-1, 1A, 1B, 2, 2A, 4, 7, 9, 9A, 10, 10A, 11, 11A, 11B, 11C, 12, 12A, 12B-Octadecahydrocyclopropa[4, 5]Cyclopropa[4', 5']Cyclopenta[1', 2':7, 8]Furo[3', 2':10, 10A]Acephenanthryleno[2, 1-B]Furan-10-Yl]Methyl (2E)-2-Methyl-2-Butenoate. CAS No. 1207185-03-2. Molecular formula: C37H42O12. Mole weight: 678.7. Appearance: Powder. Purity: 0.98. IUPACName: [(2R, 8R, 9S, 10S, 12R, 13S, 14S, 16S, 17S, 19R, 20S, 21R, 22S)-5-(acetyloxymethyl)-9, 16, 21, 22-tetrahydroxy-13, 20, 25-trimethyl-4, 24-dioxo-3, 23-dioxanonacyclo[14.10.1.02, 6.02, 14.08, 13.010, 12.017, 19.020, 27.022, 26]heptacosa-1(27), 5, 25-trien-9-yl]methyl (E)-2-methylbut-2-enoate. Canonical SMILES: CC=C (C)C (=O)OCC1 (C2CC2C3 (C1CC4=C (C (=O)OC45C3CC6 (C7CC7C8 (C6=C5C9=C (C (=O)OC9 (C8O)O)C)C)O)COC (=O)C)C)O. Density: 1.5±0.1 g/cm3. Catalog: ACM1207185032. | |
| Sarcandrone A | Flavonoids. CAS No. 1190225-47-8. Molecular formula: C33H30O8. Mole weight: 554.6. Appearance: Yellow powder. Purity: 0.98. IUPACName: (E)-1-[2,4-dihydroxy-3-[(2R,4R)-7-hydroxy-5,8-dimethoxy-2-phenyl-3,4-dihydro-2H-chromen-4-yl]-6-methoxyphenyl]-3-phenylprop-2-en-1-one. Canonical SMILES: COC1=CC (=C (C2=C1C (CC (O2)C3=CC=CC=C3)C4=C (C=C (C (=C4O)C (=O)C=CC5=CC=CC=C5)OC)O)OC)O. Catalog: ACM1190225478. | |
| Sarcandrone B | Flavonoids. CAS No. 1190225-48-9. Molecular formula: C33H30O8. Mole weight: 554.6. Appearance: Yellow powder. Purity: 0.98. IUPACName: (E)-1-[2,6-dihydroxy-3-[(2R,4R)-7-hydroxy-5,8-dimethoxy-2-phenyl-3,4-dihydro-2H-chromen-4-yl]-4-methoxyphenyl]-3-phenylprop-2-en-1-one. Canonical SMILES: COC1=CC (=C (C2=C1C (CC (O2)C3=CC=CC=C3)C4=C (C=C (C (=C4O)C (=O)C=CC5=CC=CC=C5)O)OC)OC)O. Catalog: ACM1190225489. | |
| Sarcoma antigen 1 (715-723) | Synonyms: Cancer/testis antigen 14 (715-723); SAGE1 (715-723). | |
| Sarcophine (NSC250434) | Acetylcholine esterase and ATPase inhibitor. Ichthyotoxin. Tumorigenesis and JB6 cell trans- formation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 55038-27-2. Pack Sizes: 2mg, 10mg. US Biological Life Sciences. | Worldwide |
| Sarcosine | Peptide synthesis. Group: Amino acids. Alternative Names: N-Methylglycine. CAS No. 107-97-1. Molecular formula: CH3NHCH2COOH. Mole weight: 89.09. Canonical SMILES: CNCC(O)=O. ECNumber: 203-538-6. Catalog: ACM107971-1. | |
| Sarcosine | 500g Pack Size. Group: Amino Acids, Biochemicals, Organics, Peptide Reagents. Formula: C3H7NO2. CAS No. 107-97-1. Prepack ID 38645048-500g. Molecular Weight 89.09. See USA prepack pricing. |  |
| Sarcosine | Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: N-Methylglycine; Sarcosin. CAS No. 107-97-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-101037. | |
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