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| Product | Description | |
|---|---|---|
| SB-216 | SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756818-39-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144898. |  |
| SB 216763 | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SB 216763 | SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC 50 s of 34.3 nM for both GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 280744-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12012. | |
| SB216763 (3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole- 2,5-dione) | The maleimide derivative SB216763 is a potent and selective cell permeable inhibitor of glycogen synthase kinase 3 (GSK-3). Research studies using peptide-based protein kinase assays show that SB216763 inhibits GSK-3alpha in an ATP competitive manner with an IC50 of 34nM, and is an equally effective GSK3-B inhibitor. Similar assays demonstrate that SB216763 (at concentrations up to 10uM) does not inhibit as many as 24 other serine/threonine and tyrosine protein kinases (1). As a consequence of inhibiting GSK-3, SB216763 stimulates glycogen synthesis in human liver cells (EC50 3.6uM) via glycogen synthase activation and induces expression of a B-catenin regulated reporter gene in HEK293 cells (1). Furthermore, SB216763 induces accumulation of B-catenin, a key downstream effector in the Wnt signaling pathway, in many cell types (2-5). Additional research indicates that SB216763 can prevent neuronal cell death induced by PI3 kinase pathway inhibition (2). Glycogen synthase kinase 3 inhibi Group: Biochemicals. Grades: Highly Purified. CAS No. 280744-09-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| SB 216763 (SB216763, SB-216763, SCHEMBL30251) | SB 216763 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3), including the alpha and beta isozymes. It displays neuroprotectant properties and stimulates glycogen synthesis in liver cells. SB 216763 is reported to be used to maintain the undifferentiated state of mouse embryonic stem cells. Group: Biochemicals. Alternative Names: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione. Grades: Highly Purified. CAS No. 280744-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB 218078 | SB 218078. Group: Biochemicals. Grades: Purified. CAS No. 135897-06-2. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| SB-219383 | SB-219383 is a tyrosyl tRNA synthetase inhibitor produced by Micromonospora sp. NCIMB 40684. Synonyms: SB 219383; SB219383. Molecular formula: C17H23N3O9. Mole weight: 413.4. |  |
| SB 220025 | A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC?? = 60 nM). Group: Fluorescence/luminescence spectroscopy. | |
| SB 220025 trihydrochloride | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| SB 222200 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| SB-222200 | SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 174635-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15722. | |
| SB 224289A | SB 224289A. Group: Biochemicals. Alternative Names: [2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)-methanone Hydrochloride. Grades: Highly Purified. CAS No. 180084-26-8. Pack Sizes: 10mg. Molecular Formula: C32H33ClN4O3, Molecular Weight: 557.08. US Biological Life Sciences. | Worldwide |
| SB-224289 hydrochloride | SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-224289A. CAS No. 180084-26-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101105A. | |
| SB 22484 | SB 22484 is a member of the aurodox type antibiotic group produced in submerged-fermentation cultures of Streptomyces sp. NRRL 15496. It is composed of two pairs of isomers with MW's of 752 and 766. It strongly inhibited neisseriae and were also active against Streptococci, Ureaplasma urealyticum and Haemophilus influenzae. Synonyms: SB-22484; SB22484; Antibiotic SB 22484. | |
| SB225002 | SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 182498-32-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16711. | |
| SB225002 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 239063 | SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38?, with equipotent inhibitory activity against p38? and p38?. SB 239063 has no effect on p38? or p38?. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193551-21-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-11068. | |
| SB 239063 | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 239063 - CAS 798558-40-4 | A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the ?- and ?-isoforms (IC?? = 44 nM), but not the ?- or ?-isoform (IC?? > 100 μM), of MAP kinase p38. Group: Fluorescence/luminescence spectroscopy. | |
| SB 242084 Hydrochloride (5-HT2C Receptor Antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride) | A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 181632-25-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SB 242235 | SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC 50 of 1.0?μM in primary human chondrocytes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193746-75-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18306. | |
| SB 243213 dihydrochloride | SB 243213 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 200940-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB-253514 | SB-253514 is an inhibitor of lipoprotein associated phospholipase A2 produced by Pseudomonas fluorescens DSM 11579. Synonyms: SB 253514; SB253514. Molecular formula: C28H46N2O9. Mole weight: 554.7. | |
| SB-258585 dihydrochloride | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| SB-258585 hydrochloride | SB-258585 is a high affinity ligand for the 5-HT 6 receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT 6 receptors. SB-258585 can be used to label recombinant and natural 5-HT 6 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216468-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103141. | |
| SB-258719 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB265610 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-265610 | SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). It inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SB-265610; SB 265610; SB265610. Product Category: Antagonists. Appearance: Solid powder. CAS No. 211096-49-0. Molecular formula: C14H9BrN6O. Mole weight: 357.17. Purity: >98%. IUPACName: N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea. Canonical SMILES: O=C(NC1=C2N=NNC2=C(C#N)C=C1)NC3=CC=CC=C3Br. Product ID: ACM211096490. Alfa Chemistry ISO 9001:2015 Certified. |  |
| SB-268262 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB269652 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-269970 | SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK i of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 201038-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15370. | |
| SB-269970 hydrochloride | SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK i of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-269970A. CAS No. 261901-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15370A. | |
| SB-269970 hydrochloride | powder, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-269970 Hydrochloride (5-HT7 Serotonin Receptor Antagonist, SB-269970, SB 26,970, SB 26,970) | A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B). Group: Biochemicals. Grades: Highly Purified. CAS No. 261901-57-9. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S·HCl. US Biological Life Sciences. | Worldwide |
| SB-271046A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 271046 Hydrochloride | SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pK i of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC 50 =0.16 μM) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 271046A. CAS No. 209481-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14336A. | |
| SB-273005 | SB-273005 is an orally active non-peptide ?v?3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for ?v?3 and ?v?5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. [1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 205678-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19307. | |
| SB-277011-A Dihydrochloride (SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A) | A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56mg/kg and strong physiological response at 32mg/kg. Group: Biochemicals. Grades: Highly Purified. CAS No. 1226917-67-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| SB-277011-A hydrochloride hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Sb 277011 hydrochloride | Sb 277011 hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SB 277011 Hydrochloride;N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]- 4-quinolinecarboxaMide Hydrochloride;SB 277011A Hydrochloride;SB 277211 Hydrochloride;SB-277011-A hydrochloride hydrate. CAS No. 215804-67-4. Molecular formula: C28H30N4O. Mole weight: 438.564. Purity: 98%+. IUPACName: N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide. Canonical SMILES: C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45. Product ID: ACM215804674. Alfa Chemistry ISO 9001:2015 Certified. | |
| SB 277011 hydrochloride | SB 277011 hydrochloride. Group: Biochemicals. Alternative Names: N-[trans-4-[2- (6-Cyano-3, 4-dihydro-2 (1H) -isoquinolinyl) ethyl]cyclohexyl]-4-quinolinecarboxamide hydrochloride; SB 277011A hydrochloride; SB 277211 hydrochloride. Grades: Highly Purified. CAS No. 215804-67-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C28H31ClN4O. US Biological Life Sciences. | Worldwide |
| SB-277011 hydrochloride | SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D 3 receptor (D 3 R) antagonist with K i values of 10.7 nM and 11.2 nM at rodent and human D 3 R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK i s of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT 1B , and 5-HT 1D receptors, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-277011A hydrochloride. CAS No. 215804-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10847B. | |
| SB 290157 - CAS 1140525-25-2 | A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC?? = 200 nM). Group: Fluorescence/luminescence spectroscopy. | |
| SB290157 trifluoroacetate | SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1140525-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101502A. | |
| SB290157 trifluoroacetate salt | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 297006 | SB 297006. Group: Biochemicals. Grades: Purified. CAS No. 58816-69-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB 297006 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-311009 | SB-311009 is an inhibitor of lipoprotein associated phospholipase A2 produced by Pseudomonas fluorescens DSM 11579. Synonyms: SB 311009; SB311009. Molecular formula: C22H36N2O5. Mole weight: 408.5. | |
| SB-315021 | SB-315021 is an inhibitor of lipoprotein associated phospholipase A2 produced by Pseudomonas fluorescens DSM 11579. Synonyms: SB 315021; SB315021. Molecular formula: C28H46N2O9. Mole weight: 554.7. | |
| SB 328437 | SB 328437. Group: Biochemicals. Grades: Purified. CAS No. 247580-43-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB 328437 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC 50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006)-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 247580-43-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103363. | |
| SB 334867 | SB 334867. Group: Biochemicals. Alternative Names: N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-urea Hydrochloride. Grades: Highly Purified. CAS No. 249889-64-3. Pack Sizes: 10mg. Molecular Formula: C17H14ClN5O2, Molecular Weight: 355.78. US Biological Life Sciences. | Worldwide |
| SB-334867 | SB-334867 (SB 334867A) is an excellent,selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 334867A. CAS No. 249889-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10895. | |
| SB-334867 free base | SB-334867 free base (SB334867A free base) is an excellent, selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB334867A free base. CAS No. 792173-99-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10895A. | |
| SB-366791 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| SB-366791 | SB-366791 is a potent and selective vanilloid receptor ( VR1/TRPV1 ) antagonist ( IC 50 =5.7 nM). SB-366791 can be used for the research of inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 472981-92-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12245. | |
| SB366791 (N-(3-Methoxyphenyl)-4-chlorocinnamide) | Potent and selective TRPV1 antagonist. Glutamatergic synaptic transmission inhibitor. Group: Biochemicals. Alternative Names: N-(3-Methoxyphenyl)-4-chlorocinnamide. Grades: Highly Purified. CAS No. 472981-92-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H14ClNO2, Molecular Weight: 287.8. US Biological Life Sciences. | Worldwide |
| SB 399885 hydrochloride | SB 399885 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 402713-81-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB-399885 hydrochloride | SB-399885 hydrochloride is a 5-HT 6 receptor antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 402713-81-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103099. | |
| SB-399885 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 399885 Hydrochloride (5-HT6 Receptor Antagonist, SB 399885) | A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimers disease. Group: Biochemicals. Alternative Names: N- (3, 5-Dichloro-2-methoxyphenyl) -4-methoxy-3- (1-piperazinyl) benzenesulfonamide Hydrochloride; SB 399885 Monohydrochloride. Grades: Highly Purified. CAS No. 402713-80-8. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB-3CT | SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 292605-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12354. | |
| SB?3CT | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| SB-408124 | SB-408124 is a non-peptide OX1 receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 288150-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-70068. | |
| SB-408124 Hydrochloride | SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-90-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-76612. | |
| SB 415286 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 415286 | SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α , with an IC 50 of 77.5 nM, and a K i of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 264218-23-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15438. | |
| SB 431542 | SB 431542 is a potent and selective inhibitor of the TGF- β1 receptor ALK5 (IC50 = 94 nM)1. It inhibits ALK4 only at higher concentrations (IC50 = 140nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB 431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB 431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5. Group: Biochemicals. Alternative Names: 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide. Grades: Highly Purified. CAS No. 301836-41-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SB-431542 | SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10431. | |
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