A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Saponite is a naturally occurring 2:1 phyllosilicate clay of the smectite (montmorillonite) group. It is a magnesium-rich hydrated aluminum silicate and is present as a component of some commercial magnesium aluminum silicate clays. It occurs in soft, amorphous masses in the cavities of certain rocks. Saponite occurs as a white to off-white, dull powder composed of fine-grained crystals of colloidal size. The material is greasy or soapy to the touch and swells on the addition of water. Synonyms: Afrodit; aluminum-saponite; auxite; cathkinite; ferroan saponite; griffithite; licianite; lucianite; piotine; zebedassite. CAS No. 1319-41-1. Product ID: PE0381. Molecular formula: (Ca0.5Na)0.3(Mg, Fe2+)3(Si, Al)4O10(OH)2·4H2O. Mole weight: ?480. Category: Adsorbents; Emulsifiers. Product Keywords: Pharmaceutical Excipients; Excipients for Solid Dosage Form; Filler Excipients; Absorbent; Saponite; PE0381; 1319-41-1; 1319-41-1. Chemical Name: Saponite. Grade: Pharmceutical Excipients. Stability and Storage Conditions: Saponite is a stable material and should be stored in a cool, dry place. Applications: Saponite is a colloidal material present in various naturally occurring clays such as magnesium aluminum silicates and is therefore suitable for use in pharmaceutical formulation applications as an adsorbent, viscosity-increasing agent, suspending agent,or as an oil-in-water emulsifying agent. Saponite, as a component of magnesium alu
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 94344-54-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-59001.
Sappanchalcone
Anti-inflammatory agent. Group: Biochemicals. Alternative Names: (2E)-3-(3,4-Dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)-2-propen-1-one. Grades: Highly Purified. CAS No. 94344-54-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Sappanone A
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma [1]. Uses: Scientific research. Group: Natural products. CAS No. 102067-84-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-113556.
Sapphire Optical Window, 12.7mm (0.5in) dia x 1mm (0.04in) thick
Sapphire Optical Window, 12.7mm (0.5in) dia x 1mm (0.04in) thick. Group: Windows & spheres.
Sapphire Optical Window, 25.4mm (1.0in) dia x 1mm (0.04in) thick
Sapphire Optical Window, 25.4mm (1.0in) dia x 1mm (0.04in) thick. Group: Windows & spheres.
Sapphire Optical Window, 25.4mm (1.0in) dia x 2mm (0.08in) thick
Sapphire Optical Window, 25.4mm (1.0in) dia x 2mm (0.08in) thick. Group: Windows & spheres.
Sapphire Optical Window, 50.8mm (2.0in) dia x 1mm (0.04in) thick
Sapphire Optical Window, 50.8mm (2.0in) dia x 1mm (0.04in) thick. Group: Windows & spheres.
Sapphire Optical Window, 50.8mm (2.0in) dia x 3mm (0.12in) thick
Sapphire Optical Window, 50.8mm (2.0in) dia x 3mm (0.12in) thick. Group: Windows & spheres.
Sapphire sphere; diameter(mm), 5.00; grade 25. Group: Windows & spheres.
Sapphire substrate, 10x10x0.432mm, EPI polished one side, C-axis, LED grade
Emery is an odorless, white, crystalline powder. Natural aluminum oxide. Very high melting and hard. Used for polishing, grinding, and abrasive operations. An inhalation hazard when present as a dust.;DryPowder, PelletsLargeCrystals;WHITE POWDER.;Odorless, white, crystalline powder.;Odorless, white, crystalline powder. Group: Single crystals. Product ID: oxo(oxoalumanyloxy)alumane. Molecular formula: 101.961g/mol. Mole weight: Al2O3;Al2O3. O=[Al]O[Al]=O. InChI=1S/2Al.3O. TWNQGVIAIRXVLR-UHFFFAOYSA-N.
Sapphire substrate, 10x10x0.432mm, EPI polished two sides, C-axis, LED grade
Sapphire substrate, 10x10x0.432mm, EPI polished two sides, C-axis, LED grade. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished one side, C-axis, HEMCOR single crystal
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished one side, C-axis, HEMCOR single crystal. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished two sides, C-axis, HEMCOR single crystal
Sapphire substrate, 50.8mm dia x 0.332mm thick, EPI polished two sides, C-axis, HEMCOR single crystal. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.432mm thick, EPI polished one side, C-axis, HEMCOR single crystal
Sapphire substrate, 50.8mm dia x 0.432mm thick, EPI polished one side, C-axis, HEMCOR single crystal. Group: Single crystals.
Sapphire substrate, 50.8mm dia x 0.432mm thick, EPI polished two sides, C-axis, HEMCOR single crystal
Emery is an odorless, white, crystalline powder. Natural aluminum oxide. Very high melting and hard. Used for polishing, grinding, and abrasive operations. An inhalation hazard when present as a dust.;DryPowder, PelletsLargeCrystals;WHITE POWDER.;Odorless, white, crystalline powder.;Odorless, white, crystalline powder. Group: Single crystals. Product ID: oxo(oxoalumanyloxy)alumane. Molecular formula: 101.961g/mol. Mole weight: Al2O3;Al2O3. O=[Al]O[Al]=O. InChI=1S/2Al.3O. TWNQGVIAIRXVLR-UHFFFAOYSA-N.
Saprisartan
Saprisartan, a losartan structural derivative, has been found to be a AT1 receptor antagonist that was once studied its activity against hypertension. It has already been discontinued by GlaxoSmithKline. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: GR-138950; GR 138950; GR138950; 1-({3-bromo-2-[2-(trifluoromethane)sulfonamidophenyl]-1-benzofuran-5-yl}methyl)-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide. Grades: 98%. CAS No. 146623-69-0. Molecular formula: C25H22BrF3N4O4S. Mole weight: 611.43.
Sapropterin dihydrochloride
Sapropterin is a naturally occurring cofactor for phenylalanine hydroxylase. Under the trade name Kuvan, sapropterin dihydrochloride is approved for the treatment of hyperphenylalaninaemia and tetrahydrobiopterin deficiency. Synonyms: BioMarin T 1401; Biopten; Kuvan; SUN 0588; Shiratori SN 0588; (6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride; Phenoptin; (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride; (6R)-Tetrahydrobiopterin hydrochloride; (6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride. Grades: >98%. CAS No. 69056-38-8. Molecular formula: C9H17Cl2N5O3. Mole weight: 314.17.
Sapropterin dihydrochloride
Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride. CAS No. 69056-38-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0124A.
Sapropterin Dihydrochloride
Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.[1] Chemically, its structure is that of a reduced pteridine derivative. Group: Biochemicals. Alternative Names: (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; 6R-BH4. CAS No. 17528-72-2. Pack Sizes: 50mg, 100mg, 250mg. US Biological Life Sciences.
Worldwide
Sapropterin Related Compound ((6S)-5,6,7,8-Tetrahydro-L-Biopterin Sulfate)
An impurity of Sapropterin.Sapropterin is an cofactor for phenylalanine hydroxylase. Synonyms: 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, [6S-[6R*(1S*,2R*)]]-, sulfate (1:x) (salt); (S)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one sulfate (1:x); (6S)-5,6,7,8-Tetrahydro-L-erythro-biopterin sulfate; [6S-[6R*(1S*,2R*)]]-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone sulfate (1:x) (salt); (6S)-Tetrahydro-L-biopterin sulfate salt. Grades: ≥95%. CAS No. 109784-74-9. Molecular formula: C9H15N5O3.xH2SO4. Mole weight: 241.25 (free base).
Sapurimycin
It is produced by the strain of Str. sp. DO-116. It has anti-gram-positive bacteria effect. In vivo, it has the effect of anti-leukemia P388 and sarcoma 180 cells. Determination in vitro, it has the effect of causing single strand breaks in superhelical plasmid DNA. Synonyms: Antibiotic DC 116; 4H-Anthra(1,2-b)pyran-5-acetic acid, 7,12-dihydro-8,11-dihydroxy-2-(2-methyl-3-(1-propenyl)oxiranyl)-4,7,12-trioxo-, (2-alpha,3-alpha(Z))-(+)-. CAS No. 133021-37-1. Molecular formula: C25H18O9. Mole weight: 462.40.
Saquayamycin A
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: saquayamycin; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3-[[(2S,5S,6S)-5-[[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R-trans)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3-[[5-[(5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-,[2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-65-8. Molecular formula: C43H48O16. Mole weight: 820.83.
Saquayamycin A1
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]- -Darabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3,4a,8,12b-tetrahydroxy-3-methyl-, (3R,4aR,12bS)-; (3R)-9-[4-O-[(2R,6S)-5,6-Dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3α,4aα,8,12bα-tetrahydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione. Grades: 95%. CAS No. 99260-66-9. Molecular formula: C31H32O12. Mole weight: 596.58.
Saquayamycin B
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3-[[(2S,5S,6S)-5-[[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3-[[5-[(5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-67-0. Molecular formula: C43H48O16. Mole weight: 820.83.
Saquayamycin B1
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-RL-erythro-hexopyranos-4-ulos-1-yl)-a-Darabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3,4a,8,12b-tetrahydroxy-3-methyl-, (3R,4aR,12bS)-. Grades: ≥95%. CAS No. 99260-68-1. Molecular formula: C31H32O12. Mole weight: 596.58.
Saquayamycin B1
Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1). Group: Biochemicals. Alternative Names: 9- (2, 9-dimethyl-3-oxo-4, 4a, 5a, 6, 7, 9, 9a, 10a-octahydrodipyrano [4, 2-a: 4', 3'-e] [1, 4]dioxin-7-yl) -3, 4a, 8, 12b-tetrahydroxy-3-methyl-2, 4-dihydrobenzo [a]anthracene-1, 7, 12-trione. Grades: Highly Purified. CAS No. 99260-68-1. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.
Worldwide
Saquayamycin C
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]oxy]-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[tetrahydro-6-methyl-5-[(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]-2H-pyran-2-yl]oxy]-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-70-5. Molecular formula: C43H52O16. Mole weight: 824.86.
Saquayamycin C1
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: (3R)-9-[4-O-[(2R,6S)-Tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3α,4aα,8,12bα-tetrahydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione. CAS No. 99260-69-2. Molecular formula: C31H34O12. Mole weight: 598.59.
Saquayamycin D
It is produced by the strain of Str. nodosus MH190-16F3. It has antimicrobial effect, but it has weaker effect against gram-negative bacteria. It has inhibitory effect on leukemia P388 cells and adriamycin-resistant P388 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]oxy]-, (3R,4aR,12bS)-; Benz[a]anthracene-1,7,12(2H)-trione, 9-[[2',3-anhydro]-2,6-dideoxy-4-O-(3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl)-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-3-[[tetrahydro-6-methyl-5-[(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy]-2H-pyran-2-yl]oxy]-, [2S-[2a(3S*,4aS*,12bR*),5b(2S*,6R*),6b]]-. CAS No. 99260-71-6. Molecular formula: C43H50O16. Mole weight: 822.85.
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.36 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8959. CAS No. 127779-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17007.
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: n1-[(1s,2r)-3-[(3s,4as,8as)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1h)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-butanediamide;SAGUINAVIR;SAQUINAVIR;2-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID;(2S)-N-[(2S,3R)-4-[(3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE;FLUNIXIN;FLUNIXINE;SAQUINAVIRMESYLATE(SUBJECTTOPATENTFREE). Product Category: Inhibitors. Appearance: Solid. CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.84. Purity: 0.9973. Canonical SMILES: O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2[C@H](C(NC(C)(C)C)=O)C[C@@](CCCC3)([H])[C@@]3([H])C2)=O)C4=NC5=CC=CC=C5C=C4. Product ID: ACM127779208. Alfa Chemistry ISO 9001:2015 Certified.
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at Saquinavir as a possible anti-cancer agent. Group: Biochemicals. Alternative Names: Saquinavir; Ro 31-8959; (2S) -N- [ (2S, 3R) -4- [ (3S, 4aS, 8aS) -3- (tert-butylcarbamoyl) -decahydroisoquinolin-2-yl] -3-hydroxy-1-phenylbutan-2-yl] -2- [ (quinolin-2-yl) formamido] butanediamide. Grades: Highly Purified. CAS No. 127779-20-8. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C38H50N6O5, Molecular Weight: 670.84. US Biological Life Sciences.
Worldwide
Saquinavir
An HIV protease inhibitor. It is often used in combination with ritonavir or lopinavir/ritonavir for HIV/AIDS infection therapy. Uses: Hiv protease inhibitors. Synonyms: Invirase; Fortovase; saguinavir; Ro 31-8959; Ro 31 8959; Ro318959. Grades: ≥98%. CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.8.
Saquinavir-d9
Labeled Saquinavir. A selective HIV protease inhibitor. Antiviral. Group: Biochemicals. Alternative Names: (2S) -N1 [ (1S, 2R) -3- [ (3S, 4aS, 8aS) -3- [ [ (1, 1-Dimethylethyl) amino] carbonyl] octahydro-2- (1H) -isoquinolinyl] -2-hydroxy-1- (phenylmethyl) propyl] -2- [ (2-quinolinylcarbonyl) amino] butanediamide-d9; Fortovase-d9; Invirase-d9; Ro 31-8959-d9. Grades: Highly Purified. CAS No. 1356355-11-7. Pack Sizes: 1mg. US Biological Life Sciences.
Saquinavir Mesylate (Ro 31-8959/003) is an HIV protease inhibitor used in retrovirus research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8959/003. CAS No. 149845-06-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17003.
Saquinavir mesylate
Saquinavir mesylate. Group: Biochemicals. Grades: Purified. CAS No. 149845-06-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Saquinavir Mesylate
Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. It inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at saquinavir as a possible anti-cancer agent. Uses: Hiv protease inhibitors. Synonyms: Invirase; Ro 31-8959/003. Grades: >98%. CAS No. 149845-06-7. Molecular formula: C39H54N6O8S. Mole weight: 766.95.
Saquinavir Mesylate
Atorvastatin Intermediate. CAS No. 149845-06-7. Product ID: 8-04459.
A selective HIV protease inhibitor. Group: Biochemicals. Alternative Names: Fortovase, Invirase, Ro 31-8959. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Saquinavir Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
SAR-020106
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo. SAR-020106 can enhance antitumor activity with selected anticancer drugs in vivo and may therefore have clinical utility. Synonyms: SAR020106; SAR 020106; SAR-20106; SAR20106; SAR 20106. Grades: 98%. CAS No. 1184843-57-9. Molecular formula: C19H19ClN6O. Mole weight: 382.852.
SAR125844
SAR125844 is a potent, selective, and ATP-competitive MET kinase inhibitor with the value of IC 50 is 4.2 nM and K i is 2.8 nM. SAR125844 has antitumor activity and can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116743-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16446.
SAR125844
SAR125844 is inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis. Synonyms: SAR 125844; SAR-125844; 1-(6-((6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea; Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-. Grades: >98%. CAS No. 1116743-46-4. Molecular formula: C25H23FN8O2S2. Mole weight: 550.63.
SAR131675
SAR131675 is a potent and selective VEGFR3 inhibitor with an IC 50 of 23 nM. SAR131675 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433953-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15458.
SAR131675
SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20 nM. Synonyms: (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-. Grades: >98%. CAS No. 1433953-83-3. Molecular formula: C18H22N4O4. Mole weight: 358.39.
SAR131675
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. Group: Biochemicals. Alternative Names: 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide. Grades: Highly Purified. CAS No. 1092538-80-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 358.39. US Biological Life Sciences.
Worldwide
SAR131675 (Racemate)
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nmol/L, respectively. Synonyms: (Rac)-SAR131675; 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-, (±)-. Grades: ≥95%. CAS No. 1092539-44-0. Molecular formula: C18H22N4O4. Mole weight: 358.40.
SAR156497
SAR156497 is a selective Aurora A, B and C inhibitor with in vitro and in vivo efficacy IC50 value is 0.5 nM for Aurora A; 1.0 nM for Aurora B (incenp) and 3.0 nM for Aurora C (incenp). In vitro, SAR156497 shows very good antiproliferative activity on a large panel of tumor cell lines. Uses: Anti-tumor. Synonyms: SAR156497; SAR156497; SAR 156497. Grades: 98%. CAS No. 1256137-14-0. Molecular formula: C27H24N4O4. Mole weight: 468.5.
SAR191801
SAR191801 is a hPGDS inhibitor and the IC50 value of which is 12 nM that was determined through fluorescence polarization. Uses: Sar191801 is a hpgds inhibitor. Synonyms: SAR 191801; SAR-191801; SAR191801;HPGDS-IN-1; SCHEMBL2493135; 1234708-04-3; C22H20N6O3; 2-Pyridin-2-yl-pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methyl-ethyl)-1,2,4-oxadiazol-3-yl]-benzylamide; N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyrimidine-5-c. Grades: 98%. CAS No. 1234708-04-3. Molecular formula: C22H20N6O3. Mole weight: 416.43.
SAR-20347
SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450881-55-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100895.