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| Product | Description | |
|---|---|---|
| SB-399885 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SB 399885 Hydrochloride (5-HT6 Receptor Antagonist, SB 399885) | A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimers disease. Group: Biochemicals. Alternative Names: N- (3, 5-Dichloro-2-methoxyphenyl) -4-methoxy-3- (1-piperazinyl) benzenesulfonamide Hydrochloride; SB 399885 Monohydrochloride. Grades: Highly Purified. CAS No. 402713-80-8. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SB-3CT | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. Besides, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. Synonyms: MMP-2/MMP-9 Inhibitor IV; 2- ( (4-phenoxyphenylsulfonyl) methyl) thiirane; SB-3CT; SB3CT; SB3-CT; IN1250; IN 1250; IN-1250. Grades: 98%. CAS No. 292605-14-2. Molecular formula: C15H14O3S2. Mole weight: 306.394. |  |
| SB-3CT | SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 292605-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12354. |  |
| SB?3CT | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| SB 4 | SB 4 is a potent and selective BMP4 signaling agonist with EC50 value of 74 nM. It enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation. Synonyms: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole. Grades: ≥99% by HPLC. CAS No. 100874-08-6. Molecular formula: C14H10BrNOS. Mole weight: 320.2. | |
| SB408124 | SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. Synonyms: SB-408124; SB 408124; SB408124. Grades: >98%. CAS No. 288150-92-5. Molecular formula: C19H18F2N4O. Mole weight: 356.37. | |
| SB-408124 | SB-408124 is a non-peptide OX1 receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 288150-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-70068. | |
| SB-408124 Hydrochloride | SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-90-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-76612. | |
| SB-408124 (Hydrochloride) | SB-408124 (Hydrochloride) is the hydrochloride salt form of SB-408124. SB-408124 is a selective antagonist of OX1 (for human OX1 Kb= 21.7nM; for human OX2 Kb=1405nM). In vivo: after oral administration it moderates Orexin-A blocking the vasopressin (VP) l. Synonyms: 1-(6, 8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea; hydrochlorideSB-408124 (Hydrochloride)1431697-90-3C19H18F2N4O.ClH3024AHCS-1073; HY-76612; W-5807; SB-408124 (Hydrochloride); CS 1073; HY 76612; W 5807; SB 408124 (Hydrochloride); CS1073; HY76612; W5807; SB408124 (Hydrochloride);1-(6,8-Difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea hydrochloride. CAS No. 1431697-90-3. Molecular formula: C19H19ClF2N4O. Mole weight: 392.84. | |
| SB415286 | SB415286 is a potent GSK3α inhibitor with IC50 and Ki values of 78 nM and 31 nM,respectively. Synonyms: SB-415286; SB 415286; SB415286. Grades: >98%. CAS No. 264218-23-7. Molecular formula: C16H10ClN3O5. Mole weight: 359.72. | |
| SB 415286 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 415286 | SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α , with an IC 50 of 77.5 nM, and a K i of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 264218-23-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15438. | |
| SB-423562 | SB-423562 is a short-acting calcium sensitive receptor (CaR) antagonist. Synonyms: UNII-615K7YBS59. Grades: 98%. CAS No. 351490-27-2. Molecular formula: C26H32N2O4. Mole weight: 436.5. | |
| SB431542 | SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. Uses: Reprogramming, differentiation. Synonyms: SB431542; SB-431542; SB 431542. Grades: 98%. CAS No. 301836-41-9. Molecular formula: C22H16N4O3. Mole weight: 384.39. | |
| SB 431542 | SB 431542 is a potent and selective inhibitor of the TGF- β1 receptor ALK5 (IC50 = 94 nM)1. It inhibits ALK4 only at higher concentrations (IC50 = 140nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB 431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB 431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5. Group: Biochemicals. Alternative Names: 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide. Grades: Highly Purified. CAS No. 301836-41-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SB-431542 | SB-431542 Inhibitor. Uses: Scientific use. Product Category: T1726. CAS No. 301836-41-9. |  |
| SB-431542 | SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10431. | |
| SB-431542 (GMP) | SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-? receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-10431G. | |
| SB 431542 hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| SB-431542 (Standard) | SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-10431R. | |
| SB 452533 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 452533 | SB 452533 is a potent and selective TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Synonyms: SB452533; SB 452533; SB-452533. N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea; 1-(2-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea. Grades: ≥98% by HPLC. CAS No. 459429-39-1. Molecular formula: C18H22BrN3O. Mole weight: 376.29. | |
| SB505124 | SB505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5, ALK4 and ALK7) with potential anticancer activity. SB505124 selectively inhibits signaling from TGF-β and activin but does not inhibit other ALK family members. Synonyms: SB-505124; 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine. Grades: >98%. CAS No. 694433-59-5. Molecular formula: C20H21N3O2. Mole weight: 335.407. | |
| SB 505124 | SB 505124. Group: Biochemicals. Grades: Purified. CAS No. 694433-59-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB-505124 | SB-505124 Inhibitor. Uses: Scientific use. Product Category: T2462. CAS No. 694433-59-5. | |
| SB-505124 | SB-505124 is a selective inhibitor of TGF-? Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6. Uses: Scientific research. Group: Signaling pathways. CAS No. 694433-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13521. | |
| SB-505124 hydrochloride | SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β-induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells. Synonyms: SB 505124 hydrochloride; SB505124 hydrochloride; SB505124 HCl; SB 505124 HCl; SB-505124 HCl. Grades: >98%. CAS No. 356559-13-2. Molecular formula: C20H22ClN3O2. Mole weight: 371.86. | |
| SB-505124 hydrochloride hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB525334 | SB525334 Inhibitor. Uses: Scientific use. Product Category: T1763. CAS No. 356559-20-1. | |
| SB525334 | SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. Synonyms: SB525334; SB-525334; SB 525334. Grades: >98%. CAS No. 356559-20-1. Molecular formula: C21H21N5. Mole weight: 343.42494. | |
| SB 525334 | SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC 50 of 14.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 356559-20-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12043. | |
| SB-525334 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-525334 | SB-525334. CAS No: 356559-20-1 |  Sarchem Laboratories New Jersey NJ |
| SB 525334 (SB-525334, 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline) | SB 525334 (SB-525334, 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline). Group: Biochemicals. Grades: Highly Purified. CAS No. 356559-20-1. Pack Sizes: 10mg, 50mg. Molecular Formula: C21H21N5, Molecular Weight: 343.4. US Biological Life Sciences. | Worldwide |
| SB-590885 | SB-590885 is a potent B-Raf inhibitor with a K i of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 405554-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10966. | |
| SB-590885 | SB-590885 is a novel triarylimidazole that selectively inhibits Raf kinases. SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration. Malignant cells expressing oncogenic B-Raf show selective inhibition of mitogen-activated protein kinase activation, proliferation, transformation, and tumorigenicity when exposed to SB-590885, whereas other cancer cell lines and normal cells display variable sensitivities or resistance to similar treatment. Synonyms: SB590885; SB 590885. Grades: 0.98. CAS No. 405554-55-4. Molecular formula: C27H27N5O2. Mole weight: 453.54. | |
| SB-590885 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 611812 | SB 611812 is a urotensin-II (UT) antagonist that inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. SB 611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation, and decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling. Synonyms: SB-611812; SB 611812; SB611812. 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 345892-71-9. Molecular formula: C17H16Cl3F3N2O3S. Mole weight: 491.74. | |
| SB 612111 | SB 612111 hydrochloride is a selective nociceptin/orphanin FQ (NOP) receptor antagonist (Ki value 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). It modulates the pronociceptive action of nociceptin in an acute pain model and enhances morphine action in morphine-tolerant animals and inhibits hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; (5S,7S)-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol hydrochloride. Grades: 99%. CAS No. 371980-98-2. Molecular formula: C24H29Cl2NO. Mole weight: 418.4. | |
| SB 612111 hydrochloride | SB 612111 hydrochloride. CAS No: 371980-98-2 | Sarchem Laboratories New Jersey NJ |
| SB 612111 hydrochloride | SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki = 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors, respectively). SB 612111 exhibits antagonist activity at the pronociceptive action of nociceptin in an acute pain model. SB 612111 potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride. Grades: ≥97% by HPLC. CAS No. 371980-94-8. Molecular formula: C24H29Cl2NO.HCl. Mole weight: 454.86. | |
| SB-612111 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-612111 hydrochloride | SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 hydrochloride exhibits selectivity for ?-,??- and??-receptors with Ki values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18618A. | |
| SB-633825 | SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956613-01-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108333. | |
| SB-649868 | SB-649868 is a potent and selective orally active orexin ( OX ) 1 and OX 2 receptor antagonist ( pK i =9.4 and 9.5 at the OX 1 and OX 2 receptor, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK649868. CAS No. 380899-24-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10806. | |
| SB-649868 | SB-649868 is a novel, orally active dual orexin receptor antagonist of orexin(OX)1 and OX2 receptor (pKi=9.4 and 9.5 at the OX1 and OX2 receptor, respectively), potentially for the treatment of insomnia and sleep disorder. Synonyms: N-[[(2S)-1-[5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl]piperidin-2-yl]methyl]-1-benzofuran-4-carboxamide; (14C)SB 649868; (14C)SB-649868; (14C)SB649868; N-((1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide; SB 649868; SB-649868; SB649868; GSK-649868; GSK-649868; GSK649868. CAS No. 380899-24-1. Molecular formula: C26H24FN3O3S. Mole weight: 477.55. | |
| SB 657510 | SB 657510 is a selective urotensin-II (UT) receptor/GRP14 antagonist (Ki = 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors, respectively). SB 657510 was also shown to inhibit U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonize the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). Synonyms: SB 657510; SB657510; SB-657510; 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 474960-44-6. Molecular formula: C19H22BrClN2O5S. Mole weight: 505.81. | |
| SB 657510 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB-674042 | SB-674042 is potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM), by binding with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells. Uses: Potent and selective non-peptide orexin ox1 receptor antagonist. Synonyms: SB 674042; SB-674042; SB674042; [5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone. Grades: ≥98%. CAS No. 483313-22-0. Molecular formula: C24H21FN4O2S. Mole weight: 448.51. | |
| SB-674042 | SB-674042 is a potent and selective non-peptide orexin OX 1 receptor antagonist (K d =5.03 nM), exhibits 100-fold selectivity for OX 1 over OX 2 receptors with IC 50 values of 3.76 nM and 531 nM, respectively [1] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 483313-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10898. | |
| SB-699551 | SB-699551 is a potent and selective 5-HT5A antagonist with a K i value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1 , and decreases the phosphorylation levels of AKT , PRAS40 , P70S6K , FOXO1 , and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 864741-95-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-103100. | |
| SB 699551 dihydrochloride | SB 699551 is a selective 5-HT5A receptor antagonist (pKi = 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors, respectively). Synonyms: SB 699551 dihydrochloride; SB699551 dihydrochloride; SB-699551 dihydrochloride; N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 864741-95-7. Molecular formula: C34H45N3O.2HCl. Mole weight: 584.66. | |
| SB 699551 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 699551 Dihydrochloride (5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551) | A selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTP-gamma-S binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7). Group: Biochemicals. Grades: Highly Purified. CAS No. 791789-61-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O·2HCl. US Biological Life Sciences. | Worldwide |
| SB705498 | SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Synonyms: SB-705498; SB 705498; SB705498. Grades: >98%. CAS No. 501951-42-4. Molecular formula: C17H16BrF3N4O. Mole weight: 429.23. | |
| SB-705498 | SB-705498. Group: Biochemicals. Grades: Highly Purified. CAS No. 501951-42-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. US Biological Life Sciences. | Worldwide |
| SB 706375 | SB 706375 is a high affinity and non-peptide antagonist of the mammalian urotensin-II (UT) receptor displaying ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones. SB 706375 also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Synonyms: SB-706375; SB 706375; SB706375. 2-Bromo-4, 5-dimethoxy-N-[3-[[ (3R) -1-methyl-3-pyrrolidinyl]oxy]-4- (trifluoromethyl) phenyl]benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 733734-61-7. Molecular formula: C20H22BrF3N2O5S. Mole weight: 539.36. | |
| SB 706504 | SB 706504 is a p38 MAPK inhibitor. SB 706504 inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs), and it also suppresses LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Synonyms: SB 706504; SB706504; SB-706504; N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine; 1-cyano-2-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine. Grades: ≥98% by HPLC. CAS No. 911110-38-8. Molecular formula: C24H19F3N8O. Mole weight: 492.46. | |
| SB742457 | SB742457 is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease. Synonyms: SB742457; SB 742457; SB-742457; RVT-101; RVT 101; RVT101. intepirdine. GSK 742457; GSK742457; GSK-742457. Grades: >98%. CAS No. 607742-69-8. Molecular formula: C19H19N3O2S. Mole weight: 353.44. | |
| SB 742457 hydrochloride | SB 742457 hydrochloride is a selective 5-HT6 antagonist with >100-fold selectivity over other receptors. It is a potential agent added to stabilize donepezil treatment in subjects with mild-to-moderate Alzheimer's disease. Uses: Potential treatment of alzheimer's disease in combination with donepezil. Synonyms: GSK-742457 hydrochloride; RVT-101 hydrochloride; SB-742457 hydrochloride; GSK 742457 hydrochloride; RVT 101 hydrochloride; SB 742457 hydrochloride; GSK742457 hydrochloride; RVT101 hydrochloride; SB742457 hydrochloride; Intepirdine hydrochloride; 3-Phenylsulfonyl-8-piperazin-1-yl-quinoline hydrochloride. Grades: 99%. CAS No. 607742-55-2. Molecular formula: C19H19N3O2S.HCl. Mole weight: 389.9. | |
| SB-743921 HCl | SB-743921 is a synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. Synonyms: SB-743921; SB 743921; SB743921. Grades: >98%. CAS No. 940929-33-9. Molecular formula: C31H34Cl2N2O3. Mole weight: 553.524. | |
| SB-743921 hydrochloride | SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5) , with a K i of 0.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 940929-33-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12069. | |
| SB743921 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SB 747651A dihydrochloride | SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay). SB 747651A has been shown to inhibit MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells, and suppress IL-10 production in macrophages. Synonyms: SB747651A dihydrochloride; SB 747651A dihydrochloride; SB-747651A dihydrochloride; 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1781882-72-1. Molecular formula: C16H22N8O.2HCl. Mole weight: 415.32. | |
| SB-747651A dihydrochloride | SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1781882-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110313. | |
| SB 747651A tetrahydrochloride | SB 747651A tetrahydrochloride is a potent and ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1) with an IC50 value of 11 nM. Synonyms: SB 747651A tetrahydrochloride; SB747651A tetrahydrochloride; SB-747651A tetrahydrochloride; 4-[1-ethyl-7-[(piperidin-4-ylamino)methyl]imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine tetrahydrochloride. Grades: 98%. CAS No. 2108968-31-4. Molecular formula: C16H22N8O.4HCl. Mole weight: 488.24. | |
| SB756050 | SB756050 is a selective TGR5 agonist currently undergone testing in a phase 1 clinical trials study in the treatment of type 2 diabetes. Synonyms: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]-1,4-diazepane; SB756050; F1018-1711; 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane; SB-756050; SB 756050; SB756050. CAS No. 447410-57-3. Molecular formula: C21H28N2O8S2. Mole weight: 500.59. | |
| SB 772077B dihydrochloride | SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC50 ~ 5.6 nM at recombinant human ROCK1 and 2) exhibiting potent vasodilator activity. SB 772077B decreases pulmonary and systemic arterial blood pressure levels and increases cardiac output. Synonyms: SB-7720770 2HCl; SB 7720770 2HCl; SB7720770 2HCl; SB-7720770 dihydrochloride; SB 7720770 dihydrochloride; SB7720770 dihydrochloride; (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 607373-46-6. Molecular formula: C15H18N8O2.2HCl. Mole weight: 415.28. | |
| SB-772077B dihydrochloride | SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 607373-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108518. | |
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