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| Product | Description | |
|---|---|---|
| YM 022 | YM 022. Group: Biochemicals. Grades: Highly Purified. CAS No. 145084-28-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| YM 022 | YM 022 is a highly potent and selective non-peptide CCK2 silent antagonist (Ki = 68 pM and 63 nM at CCK2 and CCK1 receptors, respectively). YM 022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo with a long duration of action. Synonyms: YM022; YM-022; (R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea; N-[(3R)-2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea; 3-(3-methylphenyl)-1-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea. Grades: ≥99% by HPLC. CAS No. 145084-28-2. Molecular formula: C32H28N4O3. Mole weight: 516.59. |  |
| YM 022 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| YM-08 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YM155 | YM155. Group: Biochemicals. Alternative Names: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium Bromide; Sepantronium bromide; YM 155. Grades: Highly Purified. CAS No. 781661-94-7. Pack Sizes: 10mg. Molecular Formula: C20H19BrN4O3, Molecular Weight: 443.29. US Biological Life Sciences. | Worldwide |
| YM-155 hydrochloride | YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM. Synonyms: YM155 hydrochloride; YM 155 hydrochloride. Grades: >98%. CAS No. 355406-09-6. Molecular formula: C20H19ClN4O3. Mole weight: 398.84. | |
| YM-170320 | YM-170320 is a lipopeptide antibiotic produced by an unidentified fungal strain YL-03706F. It was shown to induce morphological change of colonies in a mutant of Candida tropicalis pK233. It is a novel ergosterol biosynthesis inhibitor. Synonyms: 5-Amino-4-hydroxy-5-oxo-2-[[3-[[2-[(2,6,10,14-tetramethyl-3-hydroxy-1,7-dioxo-8,10-icosadiene-1-yl)amino]propenoyl]amino]-2-methylpropanoyl]amino]pentanoic acid methyl ester. Molecular formula: C37H62N4O9. Mole weight: 706.91. | |
| YM-181741 | YM-181741 is a novel benz[a]anthraquinone antibiotic isolated from the culture broth of actinomycete strain Q57219. It showed selective anti-Helicobacterpylori activity with a MIC value of 0.2 microg/ml. Molecular formula: C19H14O5. Mole weight: 322.3. | |
| YM-201636 | YM201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, can halt glucose entry by insulin in adipocytes. YM201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase. Synonyms: YM 201636; YM201636. Grades: >98%. CAS No. 371942-69-7. Molecular formula: C25H21N7O3. Mole weight: 467.48. | |
| YM-201636 | YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110? with an IC50 of 3.3 ?M. YM-201636 inhibits retroviral replication. Uses: Scientific research. Group: Signaling pathways. CAS No. 371942-69-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13228. |  |
| YM201636, Phosphoinositide Kinase Inhibitor (6-Amino-N- (3- (4- (4-morpholinyl) pyrido[3?2?: 4, 5]furo[3, 2-d]pyrimidin-2-yl) phenyl) -3-pyridine carboxamide) | Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC503nM). It inhibits p110a at higher concentration (IC50=3uM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 also blocks retroviral exit by budding from cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 371942-69-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| YM 202074 | YM 202074 is a high affinity and selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM 202074 binds to an allosteric site of the rat mGlu1 receptor (Ki = 4.8 nM) and inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Synonyms: YM 202074; YM202074; YM-202074; N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate. Grades: ≥99% by HPLC. CAS No. 299900-84-8. Molecular formula: C22H30N4O2S.3/2C4H4O4. Mole weight: 588.67. | |
| YM 202074 | High affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 299900-84-8. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| YM-202074 sesquifumarate salt hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YM-202204 | YM-202204 is an antifungal antibiotic isolated from the culture broth of marine fungus Phoma sp. Q60596. It exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells. Synonyms: 6'-(2,8-Dihydroxy-1,5,7,9,13,15,17-heptamethyl-nonadeca-3,5,11,13-tetraenyl)-3,4,4'-trihydroxy-6-hydroxymethyl-3,4,5,6-tetrahydro-2H-[2,3']bipyranyl-2'-one. Molecular formula: C37H58O9. Mole weight: 646.8. | |
| YM 230888 | YM 230888 is a selective mGlu1 antagonist (Ki = 13 nM) that inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM). YM 230888 displays antinociceptive and analgesic effects in vitro, and exhibits no significant sedative effect on locomotor activity. Synonyms: YM 230888; YM230888; YM-230888; 4-(Cycloheptylamino)-N-[[(2R)-tetrahydro-2-furanyl]methyl]-thieno[2,3-d]pyrimidine-6-methanamine; N-cycloheptyl-6-[[[(2R)-oxolan-2-yl]methylamino]methyl]thieno[2,3-d]pyrimidin-4-amine. Grades: ≥99% by HPLC. CAS No. 446257-23-4. Molecular formula: C19H28N4OS. Mole weight: 360.52. | |
| YM-24074 | YM-24074 is a type I collagenase inhibitor isolated from Streptomyces sp. YL-01869P. Synonyms: YM 24074. Molecular formula: C21H38N4O5. Mole weight: 426.6. | |
| YM 244769 | YM 244769. Group: Biochemicals. Grades: Highly Purified. CAS No. 837424-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| YM 2447690 | YM 2447690. Group: Biochemicals. Alternative Names: N-[ (3-Aminophenyl) methyl]-6-[4-[ (3-fluorophenyl) methoxy]phenoxy]-3-pyridinecarboxamide Hydrochloride. Grades: Highly Purified. CAS No. 837424-39-2. Pack Sizes: 10mg. Molecular Formula: C26H23ClFN3O3, Molecular Weight: 478.94. US Biological Life Sciences. | Worldwide |
| YM-244769 dihydrochloride | YM-244769 dihydrochloride is a potent Na+/Ca2+ exchange inhibitor. It preferentially inhibits NCX3 (IC50 = 18 nM). CAS No. 1780390-65-9. Molecular formula: C26H24Cl2FN3O3. Mole weight: 516.39. | |
| YM-254890 | YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. QS3666. YM-254890 (1, 3, and 10 μg/kg) reduces platelet thrombus formation in a cynomolgus monkey model of femoral artery thrombosis. CAS No. 568580-02-9. Molecular formula: C46H69N7O15. Mole weight: 960.1. | |
| YM-266183 | YM-266183 is a thiopeptide antibiotic produced by Bacillus cereus QN 03323. It exhibits antibacterial against staphylococci and enterococci, including MRSA and VRE. Synonyms: 13',19'-Didehydro-17',19'-dideoxy-28,44-dihydro-41,44-dihydroxy-17'-oxomicrococcin P. Molecular formula: C48H47N13O10S6. Mole weight: 1158.35. | |
| YM-266184 | YM-266184 is a thiopeptide antibiotic produced by Bacillus cereus QN 03323. It exhibits antibacterial against staphylococci and enterococci, including MRSA and VRE. Synonyms: 13',19'-Didehydro-17',19'-dideoxy-28,44-dihydro-41-hydroxy-44-methoxy-17'-oxomicrococcin P. Molecular formula: C49H49N13O10S6. Mole weight: 1172.37. | |
| YM 26734 | YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) with a broad inhibitory profile to several sPLA2s (IC50 = 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE, respectively). YM 26734 displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. YM 26734 is used to ameliorates local inflammatory responses in TPA-induced mouse ear edema. Synonyms: YM 26734; YM26734; YM-26734; 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone; 1-[3-dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]phenyl]dodecan-1-one. Grades: ≥95% by HPLC. CAS No. 144337-18-8. Molecular formula: C45H62O8. Mole weight: 730.97. | |
| YM 26734 | YM 26734. Group: Biochemicals. Grades: Purified. CAS No. 144337-18-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| YM-26734 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YM 298198 dihydrochloride | YM 298198 dihydrochloride is a selective mGluR-1 antagonist. In vivo, YM 298198 exhibits an antinociceptive effect in hyperalgesic mice. Synonyms: YM 298198 dihydrochloride; YM298198 dihydrochloride; YM-298198 dihydrochloride; 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzoimidazole-2-carboxamide dihydrochloride. Grades: 99%. CAS No. 299901-50-1. Molecular formula: C18H22N4OS.2HCl. Mole weight: 415.38. | |
| YM 298198 hydrochloride | Cas No. 1216398-09-2. | |
| YM-298198 hydrochloride | YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216398-09-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103568. | |
| YM-298198 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YM298198 Hydrochloride (6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide Hydrochloride) | A highly potent antagonist selective for mGlu1 receptors (IC50 = 16nM). Biologically active admitted orally or systematically. Often used in assessing the functional roles of mGlu1 receptors in a variety of research areas, such as anxiety and stress related disorders, analgesia, nociceptive pain, and schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 748758-45-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| YM-30059 | YM-30059 is a quinolone antibiotic produced by Arthrobacter sp. YL-02729S. It shows anti-gram-positive bacterial activity and cytotoxicity. It also inhibits li poxygenase. Synonyms: YM 30059. Molecular formula: C19H25NO2. Mole weight: 299.4. | |
| YM-32890 A | YM-32890 A is a macrolide antibiotic isolated from the fermentation broth of cytophaga sp. YL-02905S. It inhibits the growth of staphylococci including a macrolide-resistant strain, but shows no antimicrobial activity against other Gram-positive, Gram-negative bacteria and yeast. Synonyms: YM-32890A; YM-32890-A. Molecular formula: C33H48O6. Mole weight: 540.7. | |
| YM-32890 B | YM-32890 B is a macrolide antibiotic isolated from the fermentation broth of cytophaga sp. YL-02905S. Synonyms: YM-32890B; YM-32890-B. Molecular formula: C33H48O6. Mole weight: 540.7. | |
| YM-341619 | YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation[1]. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AS1617612. CAS No. 643082-52-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134771. | |
| YM-46303 | YM-46303 is an mAChR antagonist which had a binding affinity of 0.39 nM to M3-receptors. YM-46303 exhibits the highest affinities for M1 and M3 receptors. YM-46303 had been in phase II clinical trials by Astellas Pharma for the treatment of urinary incontinence. Synonyms: YM-46303; YM-46303; YM-46303; 1-azabicyclo[2.2.2]octan-4-yl N-(2-phenylphenyl)carbamate;hydrochloride. CAS No. 171722-81-9. Molecular formula: C20H23ClN2O2. Mole weight: 358.86. | |
| YM-47141 | YM-47141 is a cyclic-depsipeptide produced by Flexibacter sp. Q17897. It acts as an elastase inhibitor with IC50 of 1.5 X 10(-7) mol/L. Synonyms: YM 47141; N-(phenylacetyl)-L-phenylalanyl-N-[(3R,6S,9S,14S,17S,18R)-6-(2-amino-2-oxoethyl)-3,18-dimethyl-9,14-bis(2-methylpropyl)-2,5,8,11,12,13,16-heptaoxo-1-oxa-4,7,10,15-tetraazacyclooctadecan-17-yl]-L-threoninamide. Molecular formula: C46H62N8O13. Mole weight: 935. | |
| YM-47142 | YM-47142 is a cyclic-depsipeptide produced by Flexibacter sp. Q17897. It acts as an elastase inhibitor with IC50 of 3.0 X 10(-7) mol/L. Synonyms: YM 47142; N-(3-methylbutanoyl)-L-phenylalanyl-N-[(3R,6S,9S,14S,17S,18R)-6-(2-amino-2-oxoethyl)-3,18-dimethyl-9,14-bis(2-methylpropyl)-2,5,8,11,12,13,16-heptaoxo-1-oxa-4,7,10,15-tetraazacyclooctadecan-17-yl]-L-threoninamide. Molecular formula: C43H64N8O13. Mole weight: 901. | |
| YM-47515 | YM-47515 is an isonitrile antibiotic isolated from Micromonospora echinospora subsp. Echinospora. It is effective against gram-positive bacteria including MRSA. Synonyms: YM 47515. Molecular formula: C17H29NO4. Mole weight: 311.4. | |
| YM-47522 | YM-47522 is an antifungal antibiotic isolated from the culture broth of Bacillus sp. YL-03709B. It exhibited potent in vitro antifungal activity especially against Rhodotorula acuta and Pichia angusta (MIC = 0.05 and 0.75 mM/ml, respectively). It also showed moderate or weak antifungal activity against Candida albicans and Cryptococcus neoformans (MIC = 25 and 6.25 mM/ml, respectively). Synonyms: YM 47522. Molecular formula: C24H33NO4. Mole weight: 399.5. | |
| YM 511 | YM 511 is a potent aromatase (CYP19) inhibitor (IC50 = 0.4 and 0.12 nM at rat ovary and human placenta cells, respectively) that weakly inhibits the synthesis of other steroid hormones. YM 511 decreases plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM). Synonyms: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile; YM511; YM-511; YM 511. Grades: ≥99% by HPLC. CAS No. 148869-05-0. Molecular formula: C16H12BrN5. Mole weight: 354.2. | |
| Ym-53601 | YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 182959-33-7. Molecular formula: C21H21FN2O. Mole weight: 372.86. Purity: 0.9926. Canonical SMILES: F/C(COC1=CC(NC2=C3C=CC=C2)=C3C=C1)=C4CN5CCC/4CC5.[H]Cl. Product ID: ACM182959337. Alfa Chemistry ISO 9001:2015 Certified. |  |
| YM-53601 | YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo[1]. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent[2]. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 182959-33-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100313A. | |
| YM-53601 | YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86. | |
| YM 58483 | YM 58483. Group: Biochemicals. Grades: Highly Purified. CAS No. 223499-30-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| YM 58483 | YM 58483 is a calcium release-activated calcium (CRAC) channel inhibitor. YM 58483 suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM), cytokine production and proliferation of T cells in vitro. YM 58483 exhibits immuno-modulatory and anti-inflammatory activity. Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; Btp2; YM-58483; YM 58483; CRAC Channel Inhibitor, BTP2. Grades: ≥99% by HPLC. CAS No. 223499-30-7. Molecular formula: C15H9F6N5OS. Mole weight: 421.32. | |
| YM-58483 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YM-58483 | YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTP2. CAS No. 223499-30-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100831. | |
| YM 60828 | YM 60828. Group: Biochemicals. Alternative Names: 2- [ [ [ [7- (Aminoiminomethyl) -2-naphthalenyl] methyl] [4- [ [1- (1-iminoethyl) -4-piperidinyl] oxy] phenyl] amino] sulfonyl] acetic acid dihydrochloride; [ [ [ [7- (Aminoiminomethyl) -2-naphthalenyl] methyl] [4- [ [1- (1-iminoethyl) -4-piperidinyl] oxy] phenyl] amino] sulfonyl] acetic acid dihydrochloride. Grades: Highly Purified. CAS No. 179755-65-8. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C27H33Cl2N5O5S. US Biological Life Sciences. | Worldwide |
| YM 750 | YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM), displaying hypocholesterolaemic and antiatherosclerotic activity in vivo. Synonyms: YM 750; YM750; YM-750; N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea; ACAT inhibitors, Yamanouchi. Grades: ≥98% by HPLC. CAS No. 138046-43-2. Molecular formula: C31H36N2O. Mole weight: 452.63. | |
| YM758 | YM758 is a novel 'funny' If current channel (If channel) inhibitor which has a specific bradycardiac effect, and it is under development for the treatment of stable angina and atrial fibrillation. Synonyms: N-[2-[(3R)-3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]ethyl]-4-fluorobenzamide; YM 758; YM-758; YM758 cpd. CAS No. 312752-85-5. Molecular formula: C26H32FN3O4. Mole weight: 469.55. | |
| YM 90709 | YM 90709 is an IL5 receptor antagonist. Synonyms: YM-90709; YM 90709; YM90709. 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline. CAS No. 163769-88-8. Molecular formula: C22H21N3O2. Mole weight: 359.43. | |
| YM-90709 | YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 163769-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19969. | |
| YM 90K hydrochloride | YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki = 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors, respectively). YM 90K hydrochloride displays neuroprotective activity that delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Synonyms: YM90K hydrochloride; YM 90 K hydrochloride; YM-90-K hydrochloride; YM90K HCl; YM-90-K HCl; YM 90 K HCl; 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride. Grades: ≥99% by HPLC. CAS No. 154164-30-4. Molecular formula: C11H7N5O4.HCl. Mole weight: 309.67. | |
| YM976 | YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191219-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108617. | |
| YM 976 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YM 976 | YM 976 is an orally bioactive PDE4 inhibitor (IC50 = 2.2 nM). YM 976 inhibits PDE4 to maintain cAMP and prolong signal transduction. Synonyms: YM976; YM 976; YM-976. 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one. Grades: ≥98% by HPLC. CAS No. 191219-80-4. Molecular formula: C17H16ClN3O. Mole weight: 313.79. | |
| YM 976 | Orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration. Group: Biochemicals. Grades: Highly Purified. CAS No. 191219-80-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Y-(mPEG10K)2-(PEG20k-NH2) | average Mn 40000. Group: Poly(ethylene glycol) and poly(ethylene oxide). | |
| Y-(mPEG10K)2-(PEG20k-NH2) | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 40000. |  |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP and sensitizes cancer cells for low-dose doxorubicin chemotherapy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: YMU1; YMU 1; YMU-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. Purity: >98%. IUPACName: ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate. Canonical SMILES: O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC. Product ID: ACM902589962. Alfa Chemistry ISO 9001:2015 Certified. Categories: YMusic. | |
| YMU1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK; IC50 value 1.65 μM) inhibitor yet not has inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Synonyms: ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate. Grades: 99%. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. | |
| YN-0165J-A | YN-0165J-A is an enteromycin group antibiotic produced by Streptomyces strain YN-0165J. It is effective against Gram-positive and -negative bacteria, but is inactive to Enterobacter cloacae and Pseudomonas aeruginosa. CAS No. 102692-05-7. Molecular formula: C7H13N3O4. Mole weight: 203.2. | |
| YN1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| YNYNGGVKSDLN | Synonyms: Tyr-Asn-Tyr-Asn-Gly-Gly-Val-Lys-Ser-Asp-Leu-Asn. Molecular formula: C58H86N16O21. Mole weight: 1343.42. | |
| YO-01027 | YO-01027 (Dibenzazepine;DBZ) is a potent ?-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dibenzazepine; DBZ. CAS No. 209984-56-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13526. | |
| Yoda1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Yoda 1 | Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 448947-81-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18723. | |
| Yoda 1 | Yoda 1 is a glycine transporters GLYT2 inhibitor as a novel agonist of the mechanotransduction channel Piezo1. Uses: Piezo1 channel activator. Synonyms: GlyT2-IN-1; Yoda1; Yoda-1; Yoda 1;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;2-[(2,6-dichlorophenyl)methylsulfanyl]-5-pyrazin-2-yl-1,3,4-thiadiazole. Grades: ≥98 %. CAS No. 448947-81-7. Molecular formula: C13H8Cl2N4S2. Mole weight: 355.27. | |
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