A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Fotagliptin benzoate is a Dipeptidyl Peptidase IV ( DPP-4 ) inhibitor ( IC 50 =2.27 nM). Fotagliptin benzoate displays great security in rat and dog. Fotagliptin benzoate can be used for Type 2 diabetes mellitus research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SAL067. CAS No. 1403496-40-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123377A.
Fotemustine
Fotemustine is a DNA-alkylating agent, with antitumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S10036. CAS No. 92118-27-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0733.
Fotemustine
Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. Synonyms: Muphoran, S 10036. Grade: >98%. CAS No. 92118-27-9. Molecular formula: C9H19ClN3O5P. Mole weight: 315.691.
Foundry Fluxes (blended, fused and granular). We offer a variety of products for diverse applications and maintain an extensive inventory at our warehouses to provide prompt shipment and on-time delivery to our customers.
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FOUNDRY RESIN
FOUNDRY RESIN. Group: Polymers.
Fowlicidin-2
Fowlicidin-2, which is composed of 31 amino acids, is widely expressed in the majority of tissues in chickens and has an important role in innate immunity.
Fowlicidin 3
Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. It is highly potent against a broad range of Gram-negative and Gram-positive bacteria in vitro, including antibiotic-resistant strains, with minimum inhibitory concentrations in the range 1-2 microM.
Fox04
FOXO4 is a peptide antagonist intended to reverse ageing effects in animal subjects through selective induction of apoptosis of senescent cells. Grade: 95.2%. Molecular formula: C228H388N86O64. Mole weight: 5358.05.
FOXO1-IN-3
FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2451093-95-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153617.
A cell-permeable oxodihydroquinoline that preferentially inhibits the transcription activity of Forkhead box O family member Foxo1 (IC503nM) over that of the functionally related Foxo3a and Foxo4 (70%, 20%, and 3% inhibition, respectively, in HepG2-based reporter assays; [AS184256]0nM) via direct binding of the active Foxo1, but not the Ser256-phosphorylated / inactive form of Foxo1. Shown to inhibit gluconeogenesis in rat heptoma Fao cultures (IC50CnM against glucose production) in vitro and in liver of both non-diabetic and diabetic mice during a 26-hour fasting period (100mg/kg/8h p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 347.4. US Biological Life Sciences.
Worldwide
FOXO4-DRI
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells[1]. Uses: Scientific research. Group: Peptides. CAS No. 2460055-10-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4157.
FOXO4-DRI
FOXO4-DRI is a peptide acting as a specific FOXO4 blocker. It has been demonstrated to alleviate age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.FOXO4-DRI is a peptide acting as a specific FOXO4 blocker. It has been demonstrated to alleviate age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. FOXO4-DRI is a standard FOXO4 protein that is synthesized to prevent normal FOXO4 from binding to p53, thereby eliminating senescent cells and improving organ function and the ''biological age'' of young tissues. FOXO4-DRI affects a variety of cellular processes, including insulin signaling, cell cycle regulation, and oxidative stress signaling pathways, it is a cell-penetrative peptide, meaning it can enter cells from the inside and perform its role, and it has been shown in animal studies to selectively induce apoptosis in senescence cells, potentially reversing some of the effects of aging. Synonyms: FOXO 4-DRI; Anti-aging peptide FOXO4-DRI; H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH; Forkhead box O transcription factor 4-D-Retro-Inverso; Proxofim; D-Retro Inv. Grade: 95%. CAS No. 2460055-10-9. Molecular for
Foxy 5
Foxy 5. Group: Biochemicals. Grades: Purified. CAS No. 881188-51-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Foxy-5
A Wnt5a peptide mimetic. It has been undergoing clinical trials for the treatment of prostate cancer, colorectal cancer, metastatic colon cancer, metastatic breast cancer, and metastatic prostate cancer. Synonyms: Foxy 5; Foxy5; (2S)-2-[[(2S)-4-carboxy-2-[[(2R)-2-[[2-[[(2S)-3-carboxy-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]propanoyl]amino]acetyl]amino]-3-sulfanylpropanoyl]amino]butanoyl]amino]-4-methylpentanoic acid. Grade: >95%. CAS No. 881188-51-8. Molecular formula: C26H42N6O12S2. Mole weight: 694.8.
Foxy-5
Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting ?-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 881188-51-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1416.
Foy 251
FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonat;FOY 251;4-(4-guanidinobenzoyloxy)phenylacetic acid;4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonate. Product Category: Inhibitors. Appearance: White Solid. CAS No. 71079-09-9. Molecular formula: C17H19N3O7S. Mole weight: 409.413660 [g/mol]. Purity: 0.96. IUPACName: 2-[4-[4-(diaminomethylideneamino)benzoyl]oxyphenyl]acetic acid; methanesulfonic acid. Canonical SMILES: O=C(O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O. Density: 1.36g/cm³. Product ID: ACM71079099. Alfa Chemistry ISO 9001:2015 Certified.
A metabolite of Camostat. It is a pollen protease inhibitor for prevention and control of allergy. Group: Biochemicals. Alternative Names: 4-[[4-[ (Aminoiminomethyl) amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonate. Grades: Highly Purified. CAS No. 71079-09-9. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 409.41. US Biological Life Sciences.
Fozivudine tidoxil, an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity, is a reverse transcriptase inhibitor potentially for the treatment of HIV infection. Fozivudine tidoxil, a member of the NRTI family, is incorporated into the newly synthesized DNA strand during intracellular viral replication and irreversibly binds to the viral RT, thereby disrupting the reverse transcription of the virus. Synonyms: BM-211290; Fozivudine; 3'-Azido-3'-deoxy-5'-thymidylic Acid Mono(2-(decyloxy)-3-(dodecylthio)propyl) Ester; 3'-Azido-5'-O-{[2-(decyloxy)-3-(dodecylsulfanyl)propoxy](hydroxy)phosphoryl}-3'-deoxythymidine; 5'-Thymidylic acid, 3'-azido-3'-deoxy-, mono(2-(decyloxy)-3-(dodecylthio)propyl) ester. Grade: ≥95%. CAS No. 141790-23-0. Molecular formula: C35H64N5O8PS. Mole weight: 745.95.
FPA 124
FPA 124 is an Akt/PKB inhibitor (IC50 = 100 nM) that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Synonyms: FPA 124; FPA124; FPA-124; Akt Inhibitor XI; Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex. CAS No. 902779-59-3. Molecular formula: C11H9Cl2CuN3O2S. Mole weight: 381.73.
FPFT-2216, a molecular glue compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1? (CK1?). FPFT-2216 can be used for the research of cancer and inflammatory disease[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2367619-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145319.
FPFT-2216
FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), Ikaros (IKZF1) and Aiolos (IKZF3) zinc finger transcription factors, and casein kinase 1α (CK1α). Synonyms: 2,6-Piperidinedione, 3-[4-(4-methoxy-3-thienyl)-1H-1,2,3-triazol-1-yl]-. CAS No. 2367619-87-0. Molecular formula: C12H12N4O3S. Mole weight: 292.31.
Fpg Protein from Escherichia coli
?90% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution, >20,000 units/mg protein. Group: Fluorescence/luminescence spectroscopy.
Fpg Protein from Escherichia coli, Recombinant
Fpg protein, a key enzyme in the DNA base excision repair pathway (BER), catalyses the excision of a broad spectrum of modified purines such as formamidopyrimidine (Fapy) and 8-oxoguanine (8-oxo-G). Fpg possess both DNA glycosylase activity that removes the mutated base and AP-lyase activity that releases ribose, leaving both 5'-and 3'-phosphorylated ends in the DNA. Several analytical methods based on Fpg protein activity in vitro were developed for detection and quantitation of oxidative damage to DNA mainly for FapyA, FapyG and 8-oxo-G. The fpg gene was cloned by Boiteux, et al. Fpg protein possess a zinc finger motif at its C-terminus (one zinc atom per molecule). ... Protein. Mole weight: mol wt 30.2 kDa (269 amino acids, predicted from the nucleotide sequence). Activity: >20 ,000 units/mg protein. Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 50 mM potassium HEPES, pH 7.5, 1 mM DTT, 1 mM EDTA, and 200 mM NaCl. Source: E. coli. Species: Escherichia coli. Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5 (N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein; DNA-formamidopyrimidine glycosylase; EC 3.2.2.23; 78783-53-6;
FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes. Synonyms: FPH 1; FPH-1; 2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide. Grade: >98%. CAS No. 708219-39-0. Molecular formula: C16H15ClF2N2O3S. Mole weight: 388.82.
FPH2
FPH2 is a small molecule, which promotes differentiation of iPS-derived hepatocytes. Synonyms: BRD-9424; BRD9424; BRD 9424; FPH2; FPH 2; FPH-2. Grade: >98%. CAS No. 957485-64-2. Molecular formula: C14H16ClN5O2S. Mole weight: 353.83.
FPH2
FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRD-9424. CAS No. 957485-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12281.
FPI-1523 is a potent β-lactamase inhibitor with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. CAS No. 1452459-50-5. Molecular formula: C9H14N4O7S. Mole weight: 322.30.
FPI-1523 sodium
FPI-1523 is a potent β-lactamase inhibitor with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. CAS No. 1452459-52-7. Molecular formula: C9H13N4NaO7S. Mole weight: 344.28.
FPI-1602
FPI-1602 is a β-lactamase inhibitor and shows marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp. CAS No. 1452460-31-9. Molecular formula: C11H17N5O7S. Mole weight: 363.35.
FPL 55712
FPL 55712 is a leukotriene receptor antagonist that inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4. Synonyms: FPL 55712; FPL55712; FPL-55712; 7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid. Grade: ≥97% by HPLC. CAS No. 40785-97-5. Molecular formula: C27H30O9. Mole weight: 498.52.
FPL 55712
FPL 55712. Group: Biochemicals. Grades: Purified. CAS No. 40785-97-5. Pack Sizes: 10mg. US Biological Life Sciences.
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX). FPL 62064 exhibits anti-inflammatory activity. Synonyms: 1H-Pyrazol-3-amine, N-(4-methoxyphenyl)-1-phenyl-; N-(4-methoxyphenyl)-1-phenyl-1H-Pyrazol-3-amine. Grade: 95%. CAS No. 103141-09-9. Molecular formula: C16H15N3O. Mole weight: 265.31.
FPL64176
FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca 2+ channels with an EC 50 value of 16 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120934-96-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103307.
FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist that exhibits antipsychotic and procognitive properties. CAS No. 1648745-46-3. Molecular formula: C21H19FN4O2S. Mole weight: 410.46.
FPPS-IN-11
FPPS-IN-11 is a novel allosteric non-bisphosphonate inhibitor of farnesyl pyrophosphate synthase (FPPS). Synonyms: 1-(Carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid. Grade: >98%. CAS No. 1250273-31-4. Molecular formula: C15H11NO4. Mole weight: 269.25.
FPQIrpic
FPQIrpic. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Iridium(III) bis(2-(2,4-difluorophenyl)quinoline)picolinate. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1621179-34-7. Molecular formula: C36H20F4IrN3O2. Mole weight: 795.11 g/mol. Product ID: ACM1621179347. Alfa Chemistry ISO 9001:2015 Certified.
FPR A14
FPR A14. Group: Biochemicals. Grades: Purified. CAS No. 329691-12-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
FPR A14
FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 = 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization, respectively). Synonyms: AG 14; AG14; AG-14; 1,3-Benzodioxolane-5-carboxylic acid 4'-benzyloxy-3'-methoxybenzylidene hydrazide. Grade: ≥99% by HPLC. CAS No. 329691-12-5. Molecular formula: C23H20N2O5. Mole weight: 404.42.
FPR Agonist 43
FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 903895-98-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19574.
FPS-ZM1
FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. It binds exclusively to RAGE and inhibits β-secretase activity and Aβ production. It also suppresses microglia activation and the neuroinflammatory response in brain. It penetrates the blood-brain barrier and binds to RAGE, thus reducing the protein levels of various cytokines. It inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. It is not toxic to mice and can easily cross the blood-brain barrier in vivo. It might be a novel therapeutic agent to treat AD patients. Uses: Fps-zm1 might be a novel therapeutic agent to treat ad patients. Synonyms: FPS-ZM1; FPS ZM1; FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1; N-benzyl-4-chloro-N-cyclohexylbenzaMide; 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide. Grade: >98 %. CAS No. 945714-67-0. Molecular formula: C20H22ClNO. Mole weight: 327.85.
FPS-ZM1
FPS-ZM1 is a high-affinity RAGE inhibitor with a K i of 25 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 945714-67-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19370.
FPT
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT 1A R , a full agonist at 5-HT 1B R and 5-HT 1D R with EC 50 s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT 7 R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2048491-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160887.
FPTase, GST-Fusion, His Tag, Rat, Recombinant, E. coli
FPTase, GST-Fusion, His Tag, Rat, Recombinant, E. coli, is composed of an74 kDa ?- and 47 kDa ?-subunit. The ?-subunit is expressed as a GST-fusion construct with an N-terminal His Tag sequence. Group: Fluorescence/luminescence spectroscopy.
FPTase, Rat, Recombinant, E. coli
A heterodimeric enzyme that catalyzes the transfer of a 15-carbon isoprenoid group to a variety of cellular proteins including Ras. Group: Fluorescence/luminescence spectroscopy.
FPTQ
FPTQ is a potent mGluR1 antagonist and has anti-oxidant and anti-inflammatory effects in vitro and in vivo. Synonyms: 6-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)quinoline. Grade: 99%. CAS No. 864863-72-9. Molecular formula: C17H12FN5. Mole weight: 305.31.
FP-TZTP
FP-TZTP. Group: Biochemicals. Alternative Names: 3-[4-[(3-Fluoropropyl)thio]-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine. Grades: Highly Purified. CAS No. 424829-90-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C11H16FN3S2. US Biological Life Sciences.
FQI1 is a Late SV40 Factor ( LSF ) inhibitor. FQI1 inhibits cell proliferation, with IC 50 s of 3, 0.79, 6.3 μM for NIH/3T3, HeLa, A549 cells. FQI1 can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 599151-35-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124429.
FQI 1
FQI 1 is a cell-permeable and reversible inhibitor of α-globin transcription factor CP2 (LSF; IC50 = 2.1 μM) and an antiproliferative. FQI 1 induces apoptosis in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 acts via inhibiting LSF-DNA binding. Uses: Antiproliferative. Synonyms: FQI 1; FQI1; FQI-1; 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one; 8-(2-Ethoxy-phenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one. Grade: 99%. CAS No. 599151-35-6. Molecular formula: C18H17NO4. Mole weight: 311.33.
FR054
FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35954-65-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124909A.
FR054
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. In particular, in a model of Triple Negative Breast Cancer (TNBC) cells, MDA-MB-231, these effects are correlated to FR054-dependent reduction of both N- and O-glycosylation level that cause also a strong reduction of cancer cell adhesion and migration. Note: The correct structure for FR054 is CAS#35954-65-5 which is the 6S-isomer. Some vendors are selling wrong structure for FAR054 (the incorrect structure has CAS#10378-06-0, which is the 6R-isomer). Note this product is being supplied as ethanol solution at 100mg/mL. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FR054; FR-054; FR 054. Product Category: Inhibitors. Appearance: Viscouse waxy semi-solid. CAS No. 35954-65-5. Molecular formula: C14H19NO8. Mole weight: 329.31. Purity: >98%. IUPACName: 5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, diacetate (ester), (3aR,5R,6S,7R,7aR)-. Canonical SMILES: CC1=N[C@@]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)([H])[C@@]2([H])O1. Product ID: ACM35954655-1. Alfa Chemistry ISO 9001:2015 Certified.
FR 110302
This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma in Japan. Synonyms: FR 110302; FR110302; FR-110302. 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-1-Naphthalenol. Grade: 98%. CAS No. 119256-94-9. Molecular formula: C28H35NO2. Mole weight: 417.58.