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| Product | Description | |
|---|---|---|
| GMBS | GMBS is a non-cleavable linker widely used in antibody-drug conjugation development. Its unparalleled efficacy stems from its chemical cross-linking ability, promoting the covalent binding of proteins, peptides, antibodies and countless other molecules. Notably, GMBS occupies a key position in the fields of drug delivery systems, diagnostics, and evolving bioconjugation technologies. Synonyms: 4-Maleimidobutyric acid N-succinimidyl ester; N-(gamma-Maleimidobutyryloxy)succinimide; 4-Maleimidobutyric acid N-hydroxysuccinimide ester; 4-Maleimidobutyric acid n-succinimidyl ester; (GMBS); 4-Maleimidobutyric acid NHS. Grade: ≥ 98%. CAS No. 80307-12-6. Molecular formula: C12H12N2O6. Mole weight: 280.23. |  |
| GMC 1-116 | GMC 1-116 is a metabolite of clozapine with weak 5-HT2 affinity and high M1 affinity (IC50 = 27 nM). Synonyms: 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol; 8-Hydroxyclozapine; AC1L9SL1; 6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-3-ol. Grade: 99%. CAS No. 63687-94-5. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| GMC 1-165 | GMC 1-165 is an analogue of clozapine with 5-HT2A/2C and hM1 receptor affinities. Synonyms: 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-2-ol; 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-ol. Grade: 99%. CAS No. 156632-07-4. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| GMC 1-169 | GMC 1-169 is an atypical antipsychotic devoid of muscarinic activity. Uses: Atypical antipsychotic. Synonyms: [6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate. Grade: 99%. CAS No. 183140-97-8. Molecular formula: C19H19F3N4O3S. Mole weight: 440.44. | |
| GMC 15-27 | GMC 15-27 is a selective 5-HT1B/1D antagonist. Synonyms: 4'-(Aminoiminomethyl)-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-[1,1'-biphenyl]-4-carboxamide. Grade: 98%. CAS No. 256227-71-1. Molecular formula: C27H31N5O2. Mole weight: 457.57. | |
| GMC 2-113 | GMC 2-113 is a selective 5-HT1B antagonist. Synonyms: BDBM50084961; ZINC13805066; N-[4-hydroxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide. Grade: 98%. CAS No. 256227-77-7. Molecular formula: C28H29N5O3. Mole weight: 483.56. | |
| GMC 2-118 | GMC 2-118 is a potent and selective 5-HT1B antagonist. Synonyms: [4-[[4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoyl]amino]-2-(4-methylpiperazin-1-yl)phenyl] methanesulfonate. Grade: 98%. CAS No. 256227-78-8. Molecular formula: C29H31N5O5S. Mole weight: 561.65. | |
| GMC 2-29 | GMC 2-29 is a potent and selective 5-HT1B/1D antagonist. Synonyms: N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide. Grade: 99%. CAS No. 148672-15-5. Molecular formula: C29H31N5O3. Mole weight: 497.59. | |
| GMC 2-83 | GMC 2-83 is an atypical antipsychotic without muscarinic activity. Uses: Atypical antipsychotic. Synonyms: [6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-8-yl] trifluoromethanesulfonate. Grade: 99%. CAS No. 183140-98-9. Molecular formula: C19H18F3N3O4S. Mole weight: 441.42. | |
| GMC 3-15 | GMC 3-15 is a potent and selective 5-HT1B/1D antagonist. Synonyms: 4-[4-[[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]carbamoyl]phenyl]-3-methylbenzamide. Grade: 99%. CAS No. 691846-63-6. Molecular formula: C27H30N4O3. Mole weight: 458.55. | |
| GMC 61-39 | GMC 61-39 is a clozapine-like atypical antipsychotic. Uses: Atypical antipsychotic. Synonyms: [3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate. Grade: 98%. CAS No. 234113-94-1. Molecular formula: C19H18ClF3N4O3S. Mole weight: 474.88. | |
| GM-CSF from mouse | Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. |  |
| g-Melanotropin | It has been located in the cryptic region of the ACTH/β-lipotropin precursor protein from the intermediate lobe of bovine pituitary. Synonyms: gamma-Melanocyte-stimulating hormone; Δ-MSH; γ2-MSH; gamma-melanotrophin. CAS No. 72711-43-4. Molecular formula: C74H99N21O16S. Mole weight: 1570.77. | |
| G. mellonella moricin-like peptide A | The moricin-like peptides were particularly active against filamentous fungi, preventing the growth of Fusarium graminearum at 3 microg/ml, and were also active against yeasts, gram-positive bacteria and gram-negative bacteria. | |
| GMF-? human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| GmoDef | GmoDef is isolated from Glossina morsitans [tsetse fly] and has antimicrobial activity. | |
| GMP | Guanosine 5'-monophosphate has been found to be useful in studies of modulation of glutamatergic neurotransmission. Synonyms: Guanosine-5'-monophosphate; 5'-Guanylic Acid. Grade: ≥ 95 % by HPLC. Molecular formula: C10H14N5O8P. Mole weight: 363.22. | |
| GMPαS | GMPαS, a synthesized protein of biotechnological application, is utilized in the biomedical sector for the purpose of investigation into the sprawling domain of inflammatory bowel disease (IBD). This recombinant compound fosters an effective anti-inflammatory response via the suppression of cytokine production associated with the onset of IBD. Additionally, GMPαS's therapeutic possibilities are gaining increasing scientific traction as a potential target for treating a gamut of autoimmune and underlying inflammatory maladies. Synonyms: Guanosine-5'-(α-thio)-monophosphate, Sodium salt. Grade: ≥ 95 % by HPLC. Molecular formula: C10H14N5O7PS (free acid). Mole weight: 379.28 (free acid). | |
| GMP reductase | It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides. In melanocytic cells, GMP reductase gene expression may be regulated by MITF. Group: Enzymes. Synonyms: guanosine 5'-monophosphate reductase; NADPH:GMP oxidoreductase (deaminating); guanosine monophosphate reductase; guanylate reductase; NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating); guanosine 5'-phosphate reductase. Enzyme Commission Number: EC 1.7.1.7. CAS No. 9029-32-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1614; GMP reductase; EC 1.7.1.7; 9029-32-7; guanosine 5'-monophosphate reductase; NADPH:GMP oxidoreductase (deaminating); guanosine monophosphate reductase; guanylate reductase; NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating); guanosine 5'-phosphate reductase. Cat No: EXWM-1614. |  |
| GMP synthase (glutamine-hydrolysing) | Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia. Group: Enzymes. Synonyms: GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5'-phosphate amidotransferase; guanosine 5'-monophosphate synthetase. Enzyme Commission Number: EC 6.3.5.2. CAS No. 37318-71-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5805; GMP synthase (glutamine-hydrolysing); EC 6.3.5.2; 37318-71-1; GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5'-phosphate amidotransferase; guanosine 5'-monophosphate synthetase. Cat No: EXWM-5805. | |
| GMQ | GMQ is a ASIC (acid-sensing ion) channel activator with an EC 50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5361-15-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107757. |  |
| GMQ hydrochloride | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GMQ hydrochloride | GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. It alters the pH dependence of ASIC1a and ASIC1b with no effect on the activation curve of ASIC2a. Synonyms: GMQ monohydrochloride; GMQ HCl; NSC-403387 hydrochloride; NSC 403387 hydrochloride; NSC403387 hydrochloride; NSC-403387 HCl; NSC 403387 HCl; NSC403387 HCl; N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride; 1-(4-Methylquinazolin-2-yl)guanidine hydrochloride. Grade: ≥98% by HPLC. CAS No. 5361-15-9. Molecular formula: C10H11N5.HCl. Mole weight: 237.69. | |
| GMQ hydrochloride | GMQ hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 5361-15-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| GMX1778 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| GN25 | GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227401-27-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117280. | |
| GN44028 | GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1? inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1? transcriptional activity without suppressing HIF-1? mRNA expression, HIF-1? protein accumulation, or HIF-1?/HIF-1? heterodimerization. GN44028 can be used in the research of cancers[1][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1421448-26-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110266. | |
| GN 44028 | GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). It suppresses hypoxia-induced HIF-1α transcriptional activity with no effect on HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Synonyms: GN44028; GN 44028; GN-44028; N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine. Grade: ≥98% by HPLC. CAS No. 1421448-26-1. Molecular formula: C18N15N3O2. Mole weight: 305.33. | |
| GNA002 | GNA002 is a specific, highly potent and covalent EZH2 (enhancer of zeste homolog 2) inhibitor (IC50 = 1.1 μM) that can specifically and covalently bind to Cys668 in the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. It efficiently reduces EZH2-mediated H3K27 trimethylation and reactivates the tumor suppressor genes silenced by polycomb repressor complex 2 (PRC2). Synonyms: (2Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methyl-2-buten-1-yl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen-15-yl]-N-(2-ethoxyethyl)-2-methyl-2-butenamide; 2-Butenamide, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-N-(2-ethoxyethyl)-2-methyl-, (2Z)-. Grade: ≥98%. CAS No. 1385035-79-9. Molecular formula: C42H55NO8. Mole weight: 701.89. | |
| GNA2 N-Glycan | GNA2 N-Glycan is a resplendent biomedicine used for stduying cancer, inflammatory disorders, and neurodegenerative conditions. Synonyms: Monogalacto, fucosylated, biantennary N-linked glycan. | |
| Gnaphaline | A derivative of Flavoxate. Flavoxate is an anticholinergic with antimuscarinic effects. Synonyms: 4H-1-Benzopyran-4-one,5,7-dihydroxy-3,8-dimethoxy-2-phenyl-; 5,7-Dihydroxy-3,8-Dimethoxyflavon. Grade: > 95%. CAS No. 33803-42-8. Molecular formula: C17H14O6. Mole weight: 314.30. | |
| GNCP-2 | GNCP-2 is an antimicrobial cationic peptide found in Guinea pig neutrophils. It has antimicrobial activity. | |
| GNE-0439 | GNE-0439 is an ion channel selective blocker with effect of relieving pain. Synonyms: (4-(4-Propylcyclohexyl)benzoyl)-L-valine; GNE 0439. CAS No. 1241902-40-8. Molecular formula: C21H31NO3. Mole weight: 345.48. | |
| GNE-049 | GNE-049 is a selective and highly potent inhibitor of CBP with an IC50 of 1.1 nM in TR-FRET assay. It also inhibits BRET and BRD4 with IC50s of 12 and 4200 nM, respectively. Synonyms: 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one; 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-1-(oxan-4-yl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one; Ethanone, 1-[3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-1-(tetrahydro-2H-pyran-4-yl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-. Grade: ≥98%. CAS No. 1936421-41-8. Molecular formula: C27H32F2N6O2. Mole weight: 510.58. | |
| GNE-049 | GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1936421-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-108435. | |
| GNE-064 | GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 ?M and inhibits SMARCA2 with an EC50 of 0.10 ?M. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 ?M for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1997321-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149026. | |
| GNE0877 | GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374828-69-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15796. | |
| GNE-0877 | GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. Synonyms: GNE0877; GNE 0877; GNE-0877. CAS No. 1374828-69-9. Molecular formula: C14H16F3N7. Mole weight: 339.326. | |
| GNE-131 | GNE-131 is a potent and selective hNaV1.7 inhibitor with IC50 of 3 nM. Synonyms: GNE 131; GNE131. Grade: 98% by HPLC. CAS No. 1629063-81-5. Molecular formula: C23H30N4O3S. Mole weight: 442.6. | |
| GNE-140 racemate | GNE-140 racemate is the racemate of GNE-140, a potent lactate dehydrogenase A (LDHA) inhibitor. Synonyms: GNE-140 (racemate). Grade: 98% by HPLC. CAS No. 1802977-61-2. Molecular formula: C25H23ClN2O3S2. Mole weight: 499.0. | |
| GNE-140 racemate | GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1802977-61-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100742. | |
| GNE-1858 | GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor. Grade: 99%. CAS No. 2680616-96-8. Molecular formula: C21H26F2N8. Mole weight: 428.48. | |
| GNE 220 | GNE 220 is a potent and selective MAP4K4 inhibitor with an IC50 of 7 nM. Synonyms: GNE-220; GNE220. CAS No. 1199590-75-4. Molecular formula: C25H26N8. Mole weight: 438.54. | |
| GNE 220 hydrochloride | GNE 220 is a potent and selective MAP4K4 inhibitor with an IC50 of 7 nM. Grade: 98%. CAS No. 2448286-21-1. Molecular formula: C25H27ClN8. Mole weight: 474.99. | |
| GNE-272 | GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50s of 0.02, 0.03, 0.41 and 13 μM for CBP, EP300, BRET and BRD4, respectively. It shows significant antiproliferative effects in hematologic cancer cell lines and modulates MYC expression in vivo, corresponding to antitumor activity in AML tumor models. It is also a selective in vivo probe for the Bromodomains of CBP/EP300. Synonyms: (S)-1-(3-((2-fluoro-4-(1-methyl-1h-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one; N-[2-Fluoro-4-(1-methyl-1H-pyrazole-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3beta-yl]-5-acetyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-amine; 1-(3-{[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-1-[(3S)-oxolan-3-yl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one. Grade: ≥95%. CAS No. 1936428-93-1. Molecular formula: C22H25FN6O2. Mole weight: 424.47. | |
| GNE-272 | GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03 and 13 ?M for CBP, EP300 and BRD4, respectively. GNE-272 is also a selective in vivo probe for CBP/EP300[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1936428-93-1. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100726. | |
| GNE-274 | GNE-274, a non-degrader structurally related to GDC-0927 (ER degrader), does not induce ER turnover and acts as a partial ER agonist in breast cancer cell lines. It increases chromatin accessibility of ER-DNA binding sites, while GDAC-0927 does not. It is a potent ER ligand-binding domain (LBD) inhibitor and can be used for the study of cancer. Synonyms: 2H-1-Benzopyran-6-ol, 3-(3-hydroxyphenyl)-4-methyl-2-[4-[(1-propyl-3-azetidinyl)methoxy]phenyl]-, (2S)-. CAS No. 2369048-69-9. Molecular formula: C29H31NO4. Mole weight: 457.56. | |
| GNE 2861 | GNE-2861 is a potent and selective inhibitor of the group 2 p21-activated kinases (PAKs; IC50s = 7.5, 126, and 36 nM for PAK4, -5, and -6, respectively). Synonyms: 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol; 1-[2-[3-(2-aminopyrimidin-4-yl)-2-(2-methoxyethylamino)benzimidazol-5-yl]ethynyl]cyclohexan-1-ol. Grade: ≥98% by HPLC. CAS No. 1394121-05-1. Molecular formula: C22H26N6O2. Mole weight: 406.48. | |
| GNE 2861 | GNE 2861 is a PAK inhibitor that displays group II selectivity. GNE 2861 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394121-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12632. | |
| GNE-317 | GNE-317 is a potent and selective PI3K inhibitor with potential anticncer activity. GNE-317 targets the PI3K pathway and can cross the Blood-Brain Barrier. GNE-317 was identified as having physicochemical properties predictive of low efflux by P-gp and BCRP. Studies in transfected MDCK cells showed that GNE-317 was not a substrate of either transporter. GNE-317 markedly inhibited the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals up to 6-hour postdose. GNE-317 was efficacious in the U87, GS2, and GBM10 orthotopic models, achieving tumor growth inhibition of 90% and 50%, and survival benefit, respectively. GNE-317 could be effective in the treatment of GBM. Synonyms: GNE-317; GNE 317; GNE317. Grade: >98%. CAS No. 1394076-92-6. Molecular formula: C19H22N6O3S. Mole weight: 414.48. | |
| GNE-3500 | GNE-3500 has been found to be a Retinoic acid receptor-related Orphan receptor C agonist that could be probably significant in studies of some inflammatory diseases. Synonyms: GNE-3500; GNE 3500; GNE3500; 1-(4-(3-fluoro-4-(((3S,6R)-3-methyl-1,1-dioxido-6-phenyl-1,2-thiazinan-2-yl)methyl)phenyl)piperazin-1-yl)ethan-1-one. Grade: 98%. CAS No. 1537859-24-7. Molecular formula: C24H30FN3O3S. Mole weight: 459.58. | |
| GNE-3511 | GNE-3511 has been found to be a DLK, MAP3K12 kinase inhibitor that could probably exhibit protection action of primary neurons. IC50: 0.107 uM (DLK). Synonyms: GNE-3511; GNE 3511; GNE3511. CHEMBL3393333; SCHEMBL15602439; BDBM50059190; 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile. Grade: 98%. CAS No. 1496581-76-0. Molecular formula: C23H26F2N6O. Mole weight: 440.50. | |
| GNE-3511 | GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1496581-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12947. | |
| GNE-477 | GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kα) and mTOR (apparent Ki=21 nM). Uses: Designed for use in research and industrial production. Additional or Alternative Names: GNE-477; GNE477; GNE 477. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1032754-81-6. Molecular formula: C21H28N8O3S2. Mole weight: 504.63. Purity: >98%. IUPACName: 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine. Canonical SMILES: NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(CN5CCN(S(=O)(C)=O)CC5)S4)=N2)C=N1. Product ID: ACM1032754816. Alfa Chemistry ISO 9001:2015 Certified. Categories: GE 477L Nuclear Detection and Reporting System. |  |
| GNE-477 | GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR. Synonyms: GNE-477, GNE477, GNE 477. Grade: >98%. CAS No. 1032754-81-6. Molecular formula: C21H28N8O3S2. Mole weight: 504.63. | |
| GNE-493 | GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. Synonyms: GNE493; GNE-493; GNE 493. Grade: >98%. CAS No. 1033735-94-2. Molecular formula: C17H20N6O2S. Mole weight: 372.44. | |
| GNE-495 | GNE-495 is a Selective MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) Inhibitor. IC50 value is 3.7 nM. GNE-495 shows excellent potency and good PK In vivo. GNE-495 was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that are observed in the inducible Map4k4 knockout mice. Synonyms: GNE-495; GNE 495; GNE495. 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide. Grade: 98%. CAS No. 1449277-10-4. Molecular formula: C22H20FN5O2. Mole weight: 405.43. | |
| GNE-495 | GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1449277-10-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100343. | |
| GNE-4997 | GNE-4997, a pyrazol derivative, has been found to be an ITK inhibitor that could have significant biological activities. Ki: 0.09 nM. Synonyms: GNE-4997; GNE-4997; GNE-4997; (4aS,5aR)-N-(1-((R)-((R)-1,1-dioxidotetrahydro-2H-thiopyran-2-yl)(phenyl)methyl)-1H-pyrazol-4-yl)-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide. Grade: 98%. CAS No. 1705602-02-3. Molecular formula: C25H27F2N5O3S. Mole weight: 515.58. | |
| GNE 5729 | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 ?M for GluN2C and GluN2D, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2026635-66-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107409. | |
| GNE-616 | GNE-616 is a potent selective inhibitor of Nav1.7, with potential for the treatment of chronic pain. Synonyms: GNE616. Grade: 98%. CAS No. 2349371-81-7. Molecular formula: C24H23F4N5O3S. Mole weight: 537.53. | |
| GNE-617 | GNE-617 is a novel and specific Nampt inhibitor with an IC50 of 18.9 nM in A549 cell. Synonyms: GNE-617; GNE 617; GNE617. Grade: >98%. CAS No. 1362154-70-8. Molecular formula: C21H15F2N3O3S. Mole weight: 427.42. | |
| GNE-617 | GNE-617 Inhibitor. Uses: Scientific use. Product Category: T4335. CAS No. 1362154-70-8. |  |
| GNE-617 | GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC 50 of 5 nM and exhibits efficacy in xenograft models of cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 1362154-70-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15766. | |
| GNE-617 hydrochloride | GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC 50 of 5 nM and exhibits efficacy in xenograft models of cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-99-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15766A. | |
| GNE-6468 | GNE-6468, an imidazopyrimidine derivative, has been found to be a RORc inverse agonist that could be more effective than other members and be significant in studying the biological activities of RORC. Synonyms: GNE-6468; GNE 6468; GNE6468; 4-(6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl)-2-hydroxybenzoic acid. Grade: 98%. CAS No. 1677668-27-7. Molecular formula: C23H16ClN3O4. Mole weight: 433.85. | |
| GNE-6776 | GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Synonyms: GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide. Grade: 98%. CAS No. 2009273-71-4. Molecular formula: C20H20N4O2. Mole weight: 348.406. | |
| GNE-6776 | GNE-6776 is a selective and orally bioavailable USP7 inhibitor[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2009273-71-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107986. | |
| GNE684 | GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1). Synonyms: (s)-N-((s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl)-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide. Molecular formula: C23H24N6O3. Mole weight: 432.48. | |
| GNE-781 | GNE-781 is a potent, selective and orally active bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). GNE-781 exhibits antitumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner. Synonyms: GNE 781; GNE781. CAS No. 1936422-33-1. Molecular formula: C27H33F2N7O2. Mole weight: 525.59. | |
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