A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Mirogabalin Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246542-68-6. Molecular formula: C16H27NO2. Mole weight: 265.4. Catalog: APB1246542686.
Mirogabalin Impurity 7
Mirogabalin Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1138245-15-4. Molecular formula: C12H19NO2. Mole weight: 209.29. Catalog: APB1138245154.
Mirogabalin Impurity 8
Mirogabalin Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246542-77-7. Molecular formula: C16H27NO2. Mole weight: 265.4. Catalog: APB1246542777.
Mirtazapine
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT 2 , 5-HT 3 , histamine H1 receptor and α2-adrenoceptor antagonist with pK i values of 8.05, 8.1, 9.3 and 6.95, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Org3770; 6-Azamianserin. CAS No. 85650-52-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0352.
Mirtazapine
Mirtazapine. Group: Biochemicals. Grades: Purified. CAS No. 85650-52-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Mirtazapine
100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H19N3. CAS No. 61337-67-5. Prepack ID 30757834-100mg. Molecular Weight 265.35. See USA prepack pricing.
An a 2-Adrenergic blocker. An analogue of Mianserin. Antidepressant. Group: Biochemicals. Alternative Names: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; Org-3770; Remeron; Zispin. Grades: Highly Purified. CAS No. 85650-52-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
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Mirtazapine-[d3]
Mirtazapine-[d3] is the labelled analogue of Mirtazapine, which is a potent tetracyclic antidepressant. It is a potent antagonist of 5-HT2, 5-HT3, and histamine 1 (H1) receptors. Synonyms: Mirtazapine D3; 1,2,3,4,10,14b-Hexahydro-2-(methyl-d3)-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; Remeron-d3; Zispin-d3; Mepirzepine-d3; Remergil-d3; Promyrtil-d3; Norset-d3. Grade: 95% by HPLC; 98% atom D. CAS No. 1216678-68-0. Molecular formula: C17H16D3N3. Mole weight: 268.37.
An a 2-Adrenergic blocker. An analogue of Mianserin. Antidepressant. Group: Biochemicals. Alternative Names: 1,2,3,4,10,14b-Hexahydro-2-(methyl-d3)-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; Org-3770-d3; Remeron-d3; Zispin-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Mirtazapine-[d4]
Mirtazapine-[d4] is the labelled analogue of Mirtazapine, which is a potent tetracyclic antidepressant. It is a potent antagonist of 5-HT2, 5-HT3, and histamine 1 (H1) receptors. Synonyms: Mirtazapine D4; 1,2,3,4,10,14b-Hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine-d4; Remeron-d4; Zispin-d4; Mepirzepine-d4; Remergil-d4; Promyrtil-d4; Norset-d4. Grade: ≥99%; ≥99% atom D. CAS No. 1215898-55-7. Molecular formula: C17H15D4N3. Mole weight: 269.38.
Mirtazapine Impurity 15
Mirtazapine Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1705597-66-5. Molecular formula: C21H25N3O6. Mole weight: 415.45. Catalog: APB1705597665.
Mirtazapine Impurity 17
Mirtazapine Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1330264-96-4. Molecular formula: C17H16D3N3O. Mole weight: 284.38. Catalog: APB1330264964.
Mirtazapine Impurity 5
Mirtazapine Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1080533-15-8. Molecular formula: C23H28N3O6+. Mole weight: 442.49. Catalog: APB1080533158.
Mirtazapine N-Oxide
Mirtazapine N-Oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Mirtazapine Imp. A (EP), Mirtazapine USP Related Compound B, (14bRS)-2-Methyl-1,2,3,4,10-14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine 2-Oxide, 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine 2-oxide, Mirtazapine USP RC B, Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, 2-oxide. CAS No. 155172-12-6. IUPAC Name: (14bRS)-2-Methyl-1,2,3,4,10-14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine 2-oxide. Molecular formula: C17H19N3O. Mole weight: 281.35. Catalog: APS155172126. SMILES: C[N+]1([O-])CCN2C(C1)c3ccccc3Cc4cccnc24. Format: Neat.
Mirtazapine N-Oxide
A metabolite of Mirtazapine. Group: Biochemicals. Alternative Names: 1,2,3,4,10,14b-Hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine 2-Oxide. Grades: Highly Purified. CAS No. 155172-12-6. Pack Sizes: 5mg. US Biological Life Sciences.
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Mirtazapine Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Mirtazapine Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Mirtazapine Related Compound C
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Mirtazapine Related Compound D
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Mirtazapine resolution mixture
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Mirtazapine (Standard)
Mirtazapine (Standard) is the analytical standard of Mirtazapine. This product is intended for research and analytical applications. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT 2 , 5-HT 3 , histamine H1 receptor and α2-adrenoceptor antagonist with pK i values of 8.05, 8.1, 9.3 and 6.95, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Org3770 (Standard); 6-Azamianserin (Standard). CAS No. 85650-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0352R.
Mirvetuximab
Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: M9346A. CAS No. 1453084-36-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99225.
Mirvetuximab soravtansine (solution)
Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α ( FRα ) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMGN853 (solution). CAS No. 1453084-37-1. Pack Sizes: 1 mg (10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5); 5 mg (10.246 mg/mL * 488 μL in 10mM Histidine pH=5.5). Product ID: HY-132258A.
Mirzotamab
Mirzotamab is an IgG1? monoclonal antibody targeting to CD276/B7-H3 with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC)[1][2][3]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2229859-11-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99740.
Description General description We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here. Application Mischmetal-nickel alloy is a hydrogen storage alloy, which consists of rare earth metals and transition metals. It can be used as an anode material for the formation of nickel-metal hydride batteries. These batteries can further be utilized in hybrid vehicles. Packaging 10 g in glass bottle. Group: Hydrogen storage materials electrode materials. CAS No. 54426-34-5. Mole weight: (Ce,La,Nd,Pr)Ni5. 1S/Co.La.Ni. OPDRIGFSUGVDKR-UHFFFAOYSA-N.
Mischmetal nickel alloy,(ce,la,nd,pr). Uses: Designed for use in research and industrial production. Additional or Alternative Names: MISCHMETAL NICKEL ALLOY, (CE, LA,ND, PR);Mischmetal-nickelalloy;Mischmetal-nickel alloy hydrogen-storage grade. Product Category: Renewable & Alternative Energy. CAS No. 54426-34-5. Molecular formula: (Ce,La,Nd,Pr)Ni5. Purity: 0.96. Product ID: ACM54426345. Alfa Chemistry ISO 9001:2015 Certified.
Misgurin
A novel antimicrobial peptide, named misgurin, was isolated and characterized from the loach (mudfish), Misgurnus anguillicaudatus. Misgurin showed a strong antimicrobial activity in vitro against a broad spectrum of microorganisms without significant hemolytic activity and was about 6 times more potent than magainin 2. Molecular formula: C106H189N41O29. Mole weight: 2501.88.
m-Isobutyl Ibuprofen
An Ibuprofen impurity used in the study of potent noncompetitive interleukin-8 inhibitors. Group: Biochemicals. Alternative Names: α -Methyl-3- (2-methylpropyl) benzeneacetic Acid, α - (3-Isobutylphenyl) propionic Acid; α -Methyl-3- (2-methylpropyl) phenylacetic Acid; 2- (3-Isobutylphenyl) propionic Acid. Grades: Highly Purified. CAS No. 66622-47-7. Pack Sizes: 25mg. US Biological Life Sciences.
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Misonidazole
Misonidazole (Ro 7-0582; SR 1354) is a hypoxic tumor cell radiosensitizer [1]. Misonidazole also has antimicrobial effects [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 7-0582; SR 1354. CAS No. 13551-87-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-105061.
Misoprostol
A cytoprotective prostaglandin PGE1 analogue. Group: Biochemicals. Alternative Names: (11α,13E)-(+/-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic Acid Methyl Ester; Cytotec; Misogon; Misoprostil; SC 29333. Grades: Highly Purified. CAS No. 59122-46-2. Pack Sizes: 25mg. US Biological Life Sciences.
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Misoprostol, 1% in Cellulose
Misoprostol, 1% in Cellulose. Group: Biochemicals. Alternative Names: (11a,13E)-(+/-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester; Cytotec; Misogon. Grades: Highly Purified. CAS No. 59122-46-2. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C22H38O5, Molecular Weight: 382.53. US Biological Life Sciences.
Worldwide
Misoprostol acid (10 mg in 1 mL methyl acetate)
Misoprostol acid (10 mg in 1 mL methyl acetate). Group: Biochemicals. Alternative Names: (11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic acid; Misoprostol free acid; (+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E1. Grades: Highly Purified. CAS No. 112137-89-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C21H36O5. US Biological Life Sciences.
Worldwide
Misoprostol-d4
Labelled Misoprostol, a cytoprotective prostaglandin PGE1 analogue. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase) -deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-348. CAS No. 1260075-17-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12689.
Mitazalimab
Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ADC-1013; JNJ-64457107. CAS No. 2055640-86-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99742.
Mithramycin
Mithramycin was the first of the aureolic acid class of antitumor antibiotics isolated from Streptomyces. Mithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin has also been shown to induce differentiation of leukemic cells accompanied by an early decrease in c-myc expression and selectively inhibit collagen-1 gene expression in human fibroblasts. Group: Biochemicals. Grades: Highly Purified. CAS No. 18378-89-7. Pack Sizes: 1mg. US Biological Life Sciences.
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Mithramycin A
Mithramycin A. Group: Biochemicals. Alternative Names: Aureolic acid. Grades: Highly Purified. CAS No. 18378-89-7. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C52H76O24. US Biological Life Sciences.
Worldwide
Mithramycin A
5mg Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C52H76O24. CAS No. 18378-89-7. Prepack ID 50053396-5mg. Molecular Weight 1085.15. See USA prepack pricing.
Mithramycin A
Mithramycin A is an antineoplastic antibiotic produced by Streptomyces plicatus. Mithramycin A is a polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA. Uses: Antibiotics, antineoplastic, fluorescent dyes, nucleic acid synthesis inhibitors, protein synthesis inhibitors. Synonyms: D-threo-2-Pentulose, 5-deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-, (1S)-; [1S(2S,3S)]-5-Deoxy-1-C-[7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-lyxo-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose; A 2371; Antibiotic LA 7017; Aureolic acid; Mithracin; Mithramycin A; Mitramycin; NSC 24559; PA 144; Plicamycin; Plicatomycin. Grade: ≥95% by HPLC. CAS No. 18378-89-7. Molecular formula: C52H76O24. Mole weight: 1085.14.
100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H24NO3 ·0.5Ca. CAS No. 145525-41-3. Prepack ID 23856829-100mg. Molecular Weight 334.44. See USA prepack pricing.
Mitiglinide calcium
Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. Synonyms: KAD-1229; KAD 1229; KAD1229. Grade: >98%. CAS No. 145525-41-3. Molecular formula: (C19H24NO3)2.Ca. Mole weight: 668.88.
Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAD-1229 anhydrous; S21403 anhydrous. CAS No. 145525-41-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-17398.
Mitiglinide calcium hydrate
Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAD-1229; S-21403. CAS No. 207844-01-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0682A.
Mitindomide
Mitindomide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Benzenebismaleimide adduct; tricyclo<4.2.2.02,5>dec-9-ene-3,4,7,8-tetracarboxylic acid diimide; 3a,3b,4,4a,7a,8,8b-octahydro-4,8-ethenopyrrolo[3,4:3,4]cyclobut[1,2-f]isoindole-1,3,5,7[2H,6H]tetrone. Product Category: Heterocyclic Organic Compound. CAS No. 10403-51-7. Molecular formula: C14H12N2O4. Mole weight: 272.26. Purity: 0.96. IUPACName: Mitindomide. Density: 1.518g/cm³. Product ID: ACM10403517. Alfa Chemistry ISO 9001:2015 Certified.
Mitiperstat
Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD4831. CAS No. 1933460-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145581.
Mitiromycin A2
Mitiromycin A2 is a quinone antibiotic produced by Streptorverticilliim verticillatus AA-849, AB-286. It has weak anti-Gram-positive bacteria activity. Synonyms: Mitiromycin; 2-Hydroxy-6-methoxy-7,11-dimethyl-4,4a,10,10a,11,11a-hexahydroazireno[2',3':3,4]pyrrolo[1,2-a][1,3]oxazino[4,5-b]indole-5,8-dione. CAS No. 27164-43-8. Molecular formula: C16H17N3O5. Mole weight: 331.32.
MitMAB
MitMAB. Group: Biochemicals. Grades: Purified. CAS No. 1119-97-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 394694-98-5. Pack Sizes: 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115467.
MitoBloCK-6
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 ?M). MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia[1][2][3][4][5][6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 303215-67-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-122652.
A cell-permeable, stable dichlorosalicylalde hyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700nM, 900nM, and 1.4uM for ALR, Erv1, and Erv2, respectively). Significantly reduces the import of CX9 proteins, Erv1, Tim23, and ADP/ATP carrier (AAC). However, it does not affect mitochondrial membrane integrity as evidenced by the lack of aconitase, AAC, Tim54, Mia40, and cytochrome c release. Has no effect on protein disulfide isomerase, flavin adenine dinucleotide, and succinate dehydrogenase activities and does not disrupt mitochondrial net work or reduce viability of cells even at high concentrations (~100uM in HeLa and HEK293 cells). Reported to specifically cause cytochrome c release, activate caspase-3, and induce apoptosis in human embryonic stem cells (~20uM), but not in differentiated cells. Reversibly impairs cardiac development and reduces heart rate in zebra fish that is attributed to mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??Cl?N?O, Primary Target: Erv1. US Biological Life Sciences.
A cell permeable naphthalene derivative that promotes the translocation of ATF2 from nucleus to mitochondria via PKCe that results in mitochondrial membrane leakage and cell death in melanoma cells (WM793 and UACC903). Diminishes cell motility and anchorage-free growth in melanoma cells (<90% at 10uM) and reduces their migration in an ATF2-dependent manner. Shown to reduce ATF2 phosphorylation on Thr52, 69, and 71. However, it does not affect the activity of Erk1/2, Akt, pan-PKC. Cells expressing ATF2T52E do not exhibit any loss of mitochondrial membrane potential. Does not induce apoptosis in normal melanocytes even at high concentrations (~20 mM) and has no effect on the localization or translocation of p53, STAT3, or b-catenin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6
The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1. Group: Fluorescence/luminescence spectroscopy.
Mitochondrial fusion promoter M1
Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 219315-22-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111475.
A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50=5.3 and 4.42 mM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5uM 24h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5uM 24h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin at 5uM is shown to completely offset the mitochondrial fusion effect by 5uM M1 in Mfn1 knockout MEF. Comparing to mdivi-1, M1 exerts its effect via promoting fusion rather than inhibiting fission or division. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
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mitochondrial intermediate peptidase
A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family). Group: Enzymes. Synonyms: mitochondrial intermediate precursor-processing proteinase; MIP. Enzyme Commission Number: EC 3.4.24.59. CAS No. 136447-30-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4341; mitochondrial intermediate peptidase; EC 3.4.24.59; 136447-30-8; mitochondrial intermediate precursor-processing proteinase; MIP. Cat No: EXWM-4341.
mitochondrial processing peptidase
Known from the mitochondrial matrix of fungi and mammals. Formed from two subunits, both homologous with pitrilysin, and the products of the MAS1 and MAS2 genes in yeast. In peptidase family M16 (pitrilysin family). Group: Enzymes. Synonyms: processing enhancing peptidase (for one of two subunits); mitochondrial protein precursor-processing proteinase; matrix peptidase; matrix processing peptidase; matrix processing proteinase; mitochondrial protein precursor-processing proteinase; MPP. Enzyme Commission Number: EC 3.4.24.64. CAS No. 86280-61-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4347; mitochondrial processing peptidase; EC 3.4.24.64; 86280-61-7; processing enhancing peptidase (for one of two subunits); mitochondrial protein precursor-processing proteinase; matrix peptidase; matrix processing peptidase; matrix processing proteinase; mitochondrial protein precursor-processing proteinase; MPP. Cat No: EXWM-4347.
mitochondrial protein-transporting ATPase
A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. (TIM is the protein transport machinery of the inner mitochondrial membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.). Group: Enzymes. Enzyme Commission Number: EC 7.4.2.3 (Formerly EC 3.6.3.51). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4690; mitochondrial protein-transporting ATPase; EC 3.6.3.51. Cat No: EXWM-4690.
A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Group: Biochemicals. Grades: Highly Purified. CAS No. 56396-35-1. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences.
Worldwide
mitochondrial tRNA pseudouridine27/28 synthase
The mitochondrial enzyme Pus2p is specific for position 27 or 28 in mitochondrial tRNA. Group: Enzymes. Synonyms: Pus2; Pus2p; RNA:pseudouridine synthases 2. Enzyme Commission Number: EC 5.4.99.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5586; mitochondrial tRNA pseudouridine27/28 synthase; EC 5.4.99.44; Pus2; Pus2p; RNA:pseudouridine synthases 2. Cat No: EXWM-5586.
Mitochondria-Targeted Compound Library
A unique collection of 447 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; - Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5300. Categories: Mitochondria-Targeted Compounds Libraries.