A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences.
ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (Clk 's) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk 's) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. Purity: >98%. IUPACName: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol. Canonical SMILES: OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1. Product ID: ACM1285702206. Alfa Chemistry ISO 9001:2015 Certified. Categories: M167 VADS.
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 ?M in HEK293-Nox1 confirmatory assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Acetylphenothiazine; 2-APT. CAS No. 6631-94-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12805.
ML 171
ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences.
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ML 179
ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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ML-180
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2 ) inverse agonist with an IC 50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1 ; IC 50 >10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115613.
ML188
ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 1417700-13-0. Molecular formula: C26H31N3O3. Mole weight: 433.55. Purity: 0.98. IUPACName: N-[(1R)-2-(tert-butylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide. Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)N([C@H](C2=CN=CC=C2)C(=O)NC(C)(C)C)C(=O)C3=CC=CO3. Product ID: ACM1417700130. Alfa Chemistry ISO 9001:2015 Certified. Categories: M1885 Remington-Lee.
ML 190
ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML-193
ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinsons disease (PD) rats[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID 1261822. CAS No. 713121-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110125.
ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
ML204
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949.
ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML204 hydrochloride
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A.
ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline )
Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Group: Biochemicals. Grades: Highly Purified. CAS No. 5465-86-1. Pack Sizes: 10mg. US Biological Life Sciences.
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 ?M and 0.97 ?M for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 ?M. Antitumor avtivity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-49852229. CAS No. 1430213-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12342.
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 ?M in the cAMP assay, and 1.75 ?M in the ?-arrestin assay, and EC80 of 10 nM in both assays. Uses: Scientific research. Group: Signaling pathways. CAS No. 877636-42-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103254.
ML 221
ML 221. Group: Biochemicals. Grades: Purified. CAS No. 877636-42-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML228
ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 ?M. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-46742353. CAS No. 1357171-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12754.
ML 228
ML 228. Group: Biochemicals. Grades: Purified. CAS No. 1357171-62-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML230
ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID44640177; SID 88095709. CAS No. 1776055-05-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111678.
It has the activity of inhibiting HMG-CoA reductase, and it is produced by the strain of Penicillum citrinum SANK. Synonyms: Compactin diol lactone; ML-236A; 6-(2-(1,2,6,7,8,8a-Hexahydro-8-hydroxy-2-methyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one; desmethylmonacolin J; Antibiotic ML 236A. CAS No. 58889-19-3. Molecular formula: C18H26O4. Mole weight: 306.40.
ML 240. Group: Biochemicals. Grades: Purified. CAS No. 1346527-98-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML241
ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC50 of 0.11 ?M. ML241 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19797.
A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2uM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64uM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5uM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10uM), but does not affect 68 other targets studied. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
ML254 is a potent mGlu 5 potentiator, with EC 50 and pEC 50 of 9.3 nM and 8.03 nM for rat mGlu 5 , respectively. ML254 can be used for researching schizophrenia [1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1428630-86-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16654.
ML 289. Group: Biochemicals. Grades: Purified. CAS No. 1382481-79-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML-290
ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1482500-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112606.
ML 297 (VU 0456810) is a potent and selective GIRK 1/2 activator, with an EC 50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VU 0456810; CID 56642816. CAS No. 1443246-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110192.
ML 297
ML 297. Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
ML 315 is a selective dual inhibitor of CDK and DYRK with IC 50 s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172559-91-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117608A.
ML318 is a novel inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1610516-67-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H8F4N2, Molecular Weight: 280.22. US Biological Life Sciences.