A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Mitragynine is an indole alkaloid from the plant M. speciosa. It has stimulatory, antinociceptive, and opiate-like effects, acting through noradrenergic, serotonergic, and opioid receptors.1,2 Mitragynine has a higher affinity for the μ-opioid receptor than the δ- or κ-opioid receptors (pKi = 8.14, 7.22, and 5.96, respectively).2 Mitragynine and its derivatives have been identified in products sold as incense.3 The identification and quantification of mitragynine and related alkaloids, as well as their phase I and II metabolites, have been described.4-6 This product is intended for forensic applications.This product is qualified as a Reference Material that has been manufactured and tested to ISO/IEC 17025 and ISO 17034 international standards. Group: Biochemicals. Alternative Names: (αE,2S,3S,12bS)-3-Ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic Acid Methyl Ester; (-)-Mitragynine; 9-Methoxy-corynantheidine; 16,17-Didehydro-9,17-dimethoxy-corynan-16-carboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 4098-40-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 398.5. US Biological Life Sciences.
Worldwide
Mitragynine-D3 solution
100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Hallucinogens standards.
Mitraphylline
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils [1]. Uses: Scientific research. Group: Natural products. CAS No. 509-80-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6946.
Mitraphylline
Mitraphylline is an alkaloid isolated from Uncaria rhynchophylla anti-inflammatory activity and inhibiting lipopolysaccharide-mediated activation of primary human neutrophils. Synonyms: Mitraphilline. Grade: 98%. CAS No. 509-80-8. Molecular formula: C21H24N2O4. Mole weight: 368.43.
Mivacurium
Mivacurium. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133814-19-4. Molecular formula: C58H80N2O142+. Mole weight: 1029.28. Catalog: APB133814194.
Mivacurium Chloride
Mivacurium Chloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 106861-44-3. Molecular formula: C58H80Cl2N2O14. Mole weight: 1100.18. Catalog: APB106861443.
Mivacurium Chloride
An isoquinoline derivative that is used as a short-acting non-depolarizing agent. Alternative Names: Mivacron. BW B109OU dichloride. Mivacurii chloridum. CAS No. 106861-44-3. Product ID: API106861443. Molecular formula: C58H80Cl2N2O14. Mole weight: 1100.2. EINECS: 643-006-4. SMILES: C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CCC=CCCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]. Appearance: Solid Powder. Category: Non-depolarizing Agent.
Mivacurium Chloride Impurity 11
Mivacurium Chloride Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 104758-51-2. Molecular formula: C58H80Cl2N2O14. Mole weight: 1100.18. Catalog: APB104758512.
Mivacurium Chloride Impurity 12
Mivacurium Chloride Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 107740-63-6. Molecular formula: C58H80Cl2N2O14. Mole weight: 1100.18. Catalog: APB107740636.
Mivacurium Chloride Impurity 13
Mivacurium Chloride Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1R,1'R,2R,2'R)-2,2'-((((E)-oct-4-enedioyl)bis(oxy))bis(propane-3,1-diyl))bis(6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-ium) chloride. CAS No. 107740-65-8. Molecular formula: C58H80N2O14·2Cl. Mole weight: 1098.5. Catalog: APB107740658.
Mivacurium Chloride Impurity 21
Mivacurium Chloride Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026602-92-5. Molecular formula: C6H13ClO2. Mole weight: 152.62. Catalog: APB1026602925.
Mivacurium Chloride Impurity 23
Mivacurium Chloride Impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 104758-47-6. Molecular formula: C22H29NO5. Mole weight: 387.48. Catalog: APB104758476.
Mivacurium Chloride Impurity A
Mivacurium Chloride Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1R,2S)-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-ium chloride. CAS No. 107740-66-9. Molecular formula: C25H36NO6·Cl. Mole weight: 482.01. Catalog: APB107740669.
Mivacurium Chloride Impurity B
Mivacurium Chloride Impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1R,2R)-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-ium chloride. CAS No. 107740-64-7. Molecular formula: C25H36NO6·Cl. Mole weight: 482.01. Catalog: APB107740647.
Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 106861-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1700A.
Mivebresib
Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a K i of 1.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABBV-075. CAS No. 1445993-26-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100015.
Mix Coal Tar/Petroleum Extract in Methylene Chloride
Mix Coal Tar/Petroleum Extract in Methylene Chloride. Uses: For analytical and research use. Group: Process materials, geological, cement & soils. Catalog: APS009969. Shipping: Room Temperature.
Mixoxantrone HCI. Group: Biochemicals. Grades: Highly Purified. CAS No. 70476-82-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C22H28N4O6HCI. US Biological Life Sciences.
Worldwide
Mixture of 1,2,3-Propanetriol 2-(Dihydrogen phosphate) Sodium Salt Hydrate and 1,2,3-Propanetriol 1-(Dihydrogen phosphate) Sodium Salt Hydrate
1,2,3-Propanetriol 2-(Dihydrogen phosphate) is a serine-threonine phosphatase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g, 10g. Molecular Formula: C3H7Na2O6P xH2O. US Biological Life Sciences.
Worldwide
Mixture of (R)-Apomorphine-11-sulfate Potassium Salt-d5 + (R)-Apomorphine-10-sulfate. (d4-Major) (90%)
(R)-Apomorphine-11-sulfate Potassium Salt-d5 is the isotope labelled analog of (R)-Apomorphine-11-sulfate Potassium Salt (A727520); a derivative of (R)-Apomorphine (A727500) which is a dopamine (D1 and D2) receptor agonist, emetic, and antiparkinsonian. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C17H11D5KNO5S. US Biological Life Sciences.
Worldwide
Miyakamide A1
Miyakamide A1 is an antibiotic produced by Aspergillus flavus var. columnaris FKI-0739. It has insecticidal effect. Miyakamide A1 inhibits the growth of Artemia salina at a minimum concentration of 5 μg/mL. Miyakamide A1 has weak antixanthomonas activity. It inhibits P388 cells with an IC50 of 10.5 μg/mL. CAS No. 497252-38-7. Molecular formula: C31H32N4O3. Mole weight: 508.61.
Miyakamide A2
Miyakamide A2 is an antibiotic produced by Aspergillus flavus var. columnaris FKI-0739. It has insecticidal effect. Miyakamide A2 inhibits the growth of Artemia salina at a minimum concentration of 5 μg/mL. Miyakamide A1 has weak antixanthomonas activity. It inhibits P388 cells with an IC50 of 12.2 μg/mL. CAS No. 497252-39-8. Molecular formula: C31H32N4O3. Mole weight: 508.61.
Miyakamide B1
Miyakamide B1 is an antibiotic produced by Aspergillus flavus var. columnaris FKI-0739. It has insecticidal effect. Miyakamide B1 inhibits the growth of Artemia salina at a minimum concentration of 20 μg/mL. It inhibits P388 cells with an IC50 of 8.8 μg/mL. CAS No. 497182-82-8. Molecular formula: C31H32N4O4. Mole weight: 524.61.
Miyakamide B2
Miyakamide B2 is an antibiotic produced by Aspergillus flavus var. columnaris FKI-0739. It has insecticidal effect. Miyakamide B2 inhibits the growth of Artemia salina at a minimum concentration of 20 μg/mL. It inhibits P388 cells with an IC50 of 7.6 μg/mL. CAS No. 497182-83-9. Molecular formula: C31H32N4O4. Mole weight: 524.61.
Mizacorat
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD9567. CAS No. 1893415-00-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-120012.
Mizagliflozin
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a K i of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base. CAS No. 666843-10-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17638.
Mizolastine
Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165 , VEGF120 , TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 108612-45-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0164.
Mizolastine
A highly selective histamine H1-receptor antagonist (with no anticholinergic, antiadrenergic, or antiserotonin activity) for use in the treatment of allergic disorders, especially rhinitis and urticaria. Group: Biochemicals. Alternative Names: 2- [ [1- [1- [ (4-Fluorophenyl) methyl] -1H-benzimidazol-2-yl] -4-piperidinyl] methylamino] - 4(1H)-pyrimidinone; MKC 431; Mistamine; Mizollen; SL 850324; Zolistan. Grades: Highly Purified. CAS No. 108612-45-9. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Mizolastine
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Uses: Histamine h1 antagonists, non-sedating. Synonyms: Mizollen; SL 850324; SL850324; SL-850324; Mistalin; Mistamine; Mizolastina; Mizolastine. Grade: >98%. CAS No. 108612-45-9. Molecular formula: C24H25FN6O. Mole weight: 432.49.
Mizoribine
Mizoribine. Group: Biochemicals. Alternative Names: 1-(b-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide. Grades: Highly Purified. CAS No. 50924-49-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C9H13N3O6. US Biological Life Sciences.
Worldwide
Mizoribine
Bredinin is a nucleoside antibiotic produced by Eupenicillum brefeldianum M-2166. It has anti-L-5178Y cell and anti-pox virus activity, not against bacteria and fungi. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: N'-(b-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide; Bredinin; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxy-1H-imidazole-4-carboxamide; 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide. Grade: ≥95%. CAS No. 50924-49-7. Molecular formula: C9H13N3O6. Mole weight: 259.22.
Bredinin is a nucleoside antibiotic produced by Eupenicillum brefeldianum M-2166. It has anti-L-5178Y cell and anti-pox virus activity, not against bacteria and fungi. Alternative Names: Bredinin. HE-69. MLS000028813. CAS No. 50924-49-7. Product ID: API50924497. Molecular formula: C9H13N3O6. Mole weight: 259.22. EINECS: 637-144-4. SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N. Appearance: White Crystal. Category: Antibiotic APIs.
Mizoribine
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC 50 of approximately 100 μM for anti-HCV activity. Immunosuppressant [1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC 50 s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 289637; HE 69. CAS No. 50924-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17470.
MIZORIBINE
MIZORIBINE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N'-[BETA-D-RIBOFURANOSYL]-5-HYDROXYIMIDAZOLE-4-CARBOXAMIDE. Product Category: Heterocyclic Organic Compound. CAS No. 50524-49-7. Molecular formula: C9H13N3O6. Mole weight: 259.22. Purity: 0.96. IUPACName: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide. Canonical SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N. Density: 2.06g/cm³. Product ID: ACM50524497. Alfa Chemistry ISO 9001:2015 Certified.
MJ347-81F4-B is originally isolated from Amycolatopsis sp. MJ347-81F4. It has good anti-gram-positive bacteria activity, including clinically isolated methicillin-resistant Staphylococcus aureus (MIC 0.05-0.2 μg/mL). Molecular formula: C60H58N14O18S5. Mole weight: 1423.51.
MJN110
MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively[1]. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1438416-21-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117474.
MJN228 is a lipid-binding protein nucleobindin-1 ( NUCB1 ) inhibitor with an IC 50 of 3.3 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 459168-97-9. Pack Sizes: 1 mg. Product ID: HY-118319.
MK-0159
MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2641484-61-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150508.
MK 0343
MK 0343. Group: Biochemicals. Grades: Purified. CAS No. 233275-76-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC50 values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for ?v?1, ?v?3, ?v?5, ?v?6, ?v?8 and ?5?1, respectively[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-000845704. CAS No. 227963-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15102.
MK-0493
MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R) , demonstrating significant reductions in energy intake [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 455956-93-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118930.
MK-0493 hydrochloride
MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R) , demonstrating significant reductions in energy intake [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 455957-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-118930A.
MK 0677
MK 0677. Group: Biochemicals. Grades: Purified. CAS No. 159752-10-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
MK-0731
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 845256-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-50672.
Mk-0752
Mk-0752. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MK-0752, 471905-41-6, MK 0752, 471905-41-6, MK0752, MK 0752, 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid, cc-14, SureCN756247, SureCN756248, SureCN756249, MK0752, RW3012, BCP9000935, BCP9000936, CS-0253, QC-1905, RL03744, NCGC00263184-01, HY-10974, X7591, L-000891675. Product Category: Heterocyclic Organic Compound. CAS No. 952578-68-6. Molecular formula: C21H21ClF2O4S. Mole weight: 442.903846 [g/mol]. Purity: 0.96. IUPACName: 3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid. Canonical SMILES: C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl. Density: 1.361±0.06 g/cm³ (20 °C, 760 mmHg). Product ID: ACM952578686. Alfa Chemistry ISO 9001:2015 Certified.
MK-0752
MK-0752 is a gamma secretase inhibitor in clinical development. Group: Biochemicals. Alternative Names: cis-4-[ (4-Chlorophenyl) sulfonyl]-4- (2, 5-difluorophenyl) cyclohexanepropanoic Acid. Grades: Highly Purified. CAS No. 471905-41-6. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
MK-0752
MK-0752 is a potent, orally active and specific ?-secretase inhibitor, showing dose-dependent reduction of A?40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS A? in vivo[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 471905-41-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10974.
MK 0812
MK 0812. Group: Biochemicals. Grades: Highly Purified. CAS No. 624733-88-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
MK-0822
MK-0822 is a newly developed bone-targeting dual action pro-drug for osteoporosis and bone metastasis. It is also an inhibitor of cathepsin K, an enzyme involved in bone resorption. Group: Biochemicals. Alternative Names: N- (1-cyanocyclopropyl) -4-fluoro-N2-{ (1S) -2, 2, 2-trifluoro-1-[4'- (methylsulfonyl) biphenyl-4-yl]ethyl}-L-leucinamide, Odanacatib. Grades: Highly Purified. CAS No. 603139-19-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
MK 0893
MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 870823-12-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50663.
MK-1084
MK-1084 is a selective KRAS G12C inhibitor that is currently in Phase I clinical trial (NCT05067283). MK-1084 exhibits anticancer activity and can be used either alone or in combination with pembrolizumab (HY-P9902) for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2641216-67-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-162431.
MK 1903
MK 1903. Group: Biochemicals. Grades: Purified. CAS No. 1268882-43-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir. MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir. Group: Biochemicals. Alternative Names: (6S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N, 6-dimethyl-1, 9-dioxo-1, 2, 6, 7, 8, 9-hexahydropyrazino[1', 2':1, 5]pyrrolo[2, 3-d]pyridazine-4-carboxamide. Grades: Highly Purified. CAS No. 869901-69-9. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
MK 212 hydrochloride
MK 212 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 61655-58-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
MK-2206 is an orally active, highly potent and selective allosteric Akt inhibitor, with IC 50 s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. MK-2206 has anticancer activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1032349-77-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108232.
A highly selective non-ATP competitive allosteric Akt inhibitor with IC??s of 8nM, 2nM and 65nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr308 and Ser473 in 3T3-L1 adipocytes with IC?? values of 0.11 and 0.18uM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC?? = 0.47uM) and glucose transport (IC?? = 0.14uM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G. Group: Biochemicals. Grades: Highly Purified. CAS No. 1032350-13-2. Pack Sizes: 500ug, 1mg. US Biological Life Sciences.
Worldwide
MK-2206 dihydrochloride
MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC 50 s of 5 nM, 12 nM, and 65 nM for AKT1 , AKT2 , and AKT3 , respectively. MK-2206 dihydrochloride induces autophagy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-2206 (2HCl). CAS No. 1032350-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10358.
MK-2206 dihydrochloride
MK-2206 dihydrochloride. Group: Biochemicals. Alternative Names: 8-[4- (1-Aminocyclobutyl) phenyl]-9-phenyl-1, 2, 4-triazolo[3, 4-f][1, 6]naphthyridin-3 (2H) -one hydrochloride. Grades: Highly Purified. CAS No. 1032350-13-2. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C25H23Cl2N5O. US Biological Life Sciences.