A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1572414-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17543.
ML324
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 ?M. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222800-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12725.
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 19992-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101464.
ML334
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 ?M. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LH601A. CAS No. 1432500-66-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110258.
ML336
ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613465-33-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12928.
ML 337
ML 337. Group: Biochemicals. Grades: Purified. CAS No. 1443118-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes ?-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 ?M and 1.4 ?M, respectively. ML339 shows weaker activity against the recruitment of ?-arrestin in mouse CXCR6 receptors, with an IC50 of 18 ?M. ML339 has no inhibitory effect on CXCR5?CXCR4?CXCR6 and apelin receptor (APJ), with IC50 >79 ?M. ML339 has the potential to promote the development of prostate cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2579689-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122197.
ML-339
ML-339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-339; ML 339; ML339. Product Category: Antagonists. Appearance: Solid powder. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.01. Purity: >98%. IUPACName: N-((1R,3s,5S)-9-(2-((2-chlorophenyl)amino)-2-oxoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide. Canonical SMILES: O=C(N[C@@H]1C[C@H](N2CC(NC3=CC=CC=C3Cl)=O)CCC[C@H]2C1)C4=CC(OC)=C(OC)C(OC)=C4. Product ID: ACM2579689839. Alfa Chemistry ISO 9001:2015 Certified. Categories: MD 339.
ML 3403
ML 3403. Group: Biochemicals. Grades: Purified. CAS No. 549505-65-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML346
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 ?M for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100872-83-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18669.
ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-?1[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDN 193719. CAS No. 1062368-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12274.
ML 347
ML 347. Group: Biochemicals. Grades: Purified. CAS No. 1062368-49-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML348
ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GNF-Pf-1127. CAS No. 899713-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100736.
ML 348. Group: Biochemicals. Grades: Purified. CAS No. 899713-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML349
ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890819-86-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100737.
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC 50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 [1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310.
ML 354. Group: Biochemicals. Grades: Purified. CAS No. 89159-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML355
ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 ?M, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. Uses: Scientific research. Group: Signaling pathways. CAS No. 1532593-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12341.
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 ?M) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 ?M), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1991986-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100900.
ML385
ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 846557-71-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100523.
ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 ?M for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 577784-91-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122122.
ML 786 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1237536-18-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
ML-792
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 ?M and >100 ?M, respectively)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1644342-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108702.
ML 7 hydrochloride
ML 7 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 110448-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML-7 hydrochloride
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK ( IC 50 =300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. Uses: Scientific research. Group: Signaling pathways. CAS No. 110448-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15417.
ML-7, Hydrochloride - CAS 110448-33-4
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Group: Fluorescence/luminescence spectroscopy.
ML-9
ML-9 is a selective and potent inhibitor of Akt kinase , inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity [3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with K i values of 4, 32 and 54 μM, respectively [1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105637-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100932.
ML 9 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 105637-50-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML-9, Hydrochloride - CAS 105637-50-1
A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 μM), protein kinase A (Ki = 32 μM), and protein kinase C (Ki = 54 μM). Group: Fluorescence/luminescence spectroscopy.
MLCK inhibitor peptide. Group: Biochemicals. Grades: Purified. CAS No. 198694-74-5. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Mlck inhibitor peptide 18
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-RKKYKYRRK-NH2;MYOSIN LIGHT CHAIN KINASE INHIBITOR PEPTIDE 18;MLCK INHIBITOR PEPTIDE 18. Product Category: Inhibitors. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.62. Purity: 0.9966. Product ID: ACM224579742. Alfa Chemistry ISO 9001:2015 Certified.
MLCK inhibitor peptide 18
MLCK inhibitor peptide 18 is a myosin light chain kinase ( MLCK ) inhibitor with an IC 50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Scientific research. Group: Peptides. CAS No. 224579-74-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1029.
MLCK inhibitor peptide 18
A myosin light chain kinase (MLCK) inhibitor (IC50= 50 nM), and inhibits CaM kinase IIonly at 4000-fold higher concentrations. Synonyms: Myosin Light Chain Kinase Inhibitor Peptide 18. Grade: ≥95%. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.64.
MLCK inhibitor peptide 18
MLCK inhibitor peptide 18. Group: Biochemicals. Grades: Purified. CAS No. 224579-74-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
MLCK inhibitor peptide 18 acetate
MLCK inhibitor peptide 18 acetate is a selective competitive myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM) that inhibits CaM kinase II only at 4000-fold higher concentrations. Synonyms: H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2.CH3CO2H; L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide acetate. Grade: ≥95%. Molecular formula: C62H109N23O13. Mole weight: 1384.67.
MLH3 protein, partial (135-151)
MLH3 protein, partial (135-151) is a 7-aa peptide. MLH3 is a DNA mismatch repair gene associated with mammalian microsatellite instability.
MLi-2
MLi-2 is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinsons disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1627091-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100411.
MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide)
A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Group: Biochemicals. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S?, Primary Target: human MLKL. US Biological Life Sciences.
Worldwide
MLL1/WDR5/Ash2L/RbBP5/DPY30 human
recombinant, expressed in E. coli, ?83% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
MLL1/WDR5/Ash2L/RbBP5 human
recombinant, expressed in E. coli, ?83% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
MLN0905 is a potent, orally active Polo-like kinase 1 (PLK1) inhibitor. MLN0905 has inhibitory potency against PLK1 with an IC50 value of 2 nM. MLN0905 can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228960-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15155.
MLN120B
MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor of IKK? with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML120B. CAS No. 783348-36-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15473.
MLN-4760
MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 ?M) and bovine carboxypeptidase A (CPDA; IC50, 27 ?M). Uses: Scientific research. Group: Signaling pathways. CAS No. 305335-31-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19414.
MLN 4924
A potent and selective inhibitor of NAE. Group: Biochemicals. Alternative Names: Sulfamic Acid [ (1S, 2S, 4R) -4- [4- [ [ (1S) -2, 3-dihydro-1H-inden-1-yl] amino] -7H-pyrrolo [2, 3-d] pyrimidin-7-yl] -2-hydroxycyclopentyl] methyl Ester. Grades: Highly Purified. CAS No. 905579-51-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences.
Worldwide
MLN8054
MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC 50 of 4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 869363-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10180.
MLN 8054
An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic Acid. Grades: Highly Purified. CAS No. 869363-13-3. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
MLN 8237
Antagonist of Aurora A serine/threonine protein kinase; antineoplastic. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib. Grades: Highly Purified. CAS No. 1028486-01-2. Pack Sizes: 10mg. Molecular Formula: C27H20ClFN4O4, Molecular Weight: 518.92. US Biological Life Sciences.