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| Product | Description | |
|---|---|---|
| MKC8866 | MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 ?M in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 ?M and unstresses RPMI 8226 cells with an IC50 of 0.14 ?M[1]. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Orin1001. CAS No. 1338934-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104040. |  |
| MKC8866 | MKC8866 Inhibitor. Uses: Scientific use. Product Category: T15594. CAS No. 1338934-59-0. |  |
| MKC-8866 | MKC-8866, also known as IRE1-IN-8866, is an inhibitor of IRE1 RNase activity. MKC8866 strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic analysis reveal that IRE1α-XBP1s pathway activity is required for c-MYC signaling, one of the most highly activated oncogenic pathways in PCa. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC-8866; MKC 8866; MKC8866; IRE1-IN-8866; IRE1IN8866; IRE1 IN 8866; IRE1-IN8866; IRE1-IN 8866; IRE1IN-8866; IRE1IN 8866. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1338934-59-0. Molecular formula: C18H19NO7. Mole weight: 361.35. Purity: >98%. IUPACName: 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde. Canonical SMILES: O=CC1=C(O)C(OC)=CC2=C1OC(C(CC(N3CCOCC3)=O)=C2C)=O. Product ID: ACM1338934590. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MKI-1 | MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 ?M, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MASTL Kinase Inhibitor-1. CAS No. 1190277-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137552. | |
| MKK6 active human | recombinant, expressed in baculovirus infected Sf9 cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| MKK6/SKK3, active human | ?80% (SDS-PAGE), recombinant, expressed in E. coli, Maltose binding protein tagged, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| MKP3, GST tagged human | recombinant, expressed in E. coli, ?85% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| MKT 077 | MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells.Biological Activity:Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Group: Biochemicals. Alternative Names: 1-Ethyl-2- [ [3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene] methyl] -pyridinium Chloride; FJ 776. Grades: Highly Purified. CAS No. 147366-41-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?OS??; Ci, Molecular Weight: 441.01. US Biological Life Sciences. |  Worldwide |
| MKT-077 | MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity[1]. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm[2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: FJ-776. CAS No. 147366-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15096. | |
| MKT-077 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| ML00253764 | ML00253764 is a selective melanocortin receptor 4 ( MC4R ) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681847-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124740. | |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML095 | ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-25067483. CAS No. 1135318-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128000. | |
| ML095 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML099 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML-10 | ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18 F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216897-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76573. | |
| ML 10302 | ?98%, solid. Group: Fluorescence/luminescence spectroscopy. | |
| ML 10302 | ML 10302 is a potent agonist 5-HT4 receptor with K i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148868-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14441. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 186826-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML115 | ML115 is a molecular probe of the signal transducer and activator of transcription ( STAT3 ). ML115 is a STAT3 agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111152. | |
| ML116 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML120B | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 130 | ML 130. Group: Biochemicals. Grades: Purified. CAS No. 799264-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 133 hydrochloride | ML 133 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1222781-70-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML133 hydrochloride | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML133 hydrochloride | ML133 hydrochloride is a selective K ir 2 family channels inhibitor, with an IC 50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100230A. | |
| ML138 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML141 | ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 ?M, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-2950007. CAS No. 71203-35-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12755. | |
| ML 141 | ML 141. Group: Biochemicals. Grades: Purified. CAS No. 71203-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 141 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 154 | ML 154. Group: Biochemicals. Grades: Purified. CAS No. 1345964-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 161 | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML-161 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1035072-16-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-100002. | |
| ML162 | ML162 Inhibitor. Uses: Scientific use. Product Category: T8970. CAS No. 1035072-16-2. | |
| ML167 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML167 | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (Clk 's) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk 's) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. Purity: >98%. IUPACName: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol. Canonical SMILES: OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1. Product ID: ACM1285702206. Alfa Chemistry ISO 9001:2015 Certified. Categories: M167 VADS. | |
| ML169 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML171 | ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 ?M in HEK293-Nox1 confirmatory assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Acetylphenothiazine; 2-APT. CAS No. 6631-94-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12805. | |
| ML 171 | ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| ML 179 | ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2 ) inverse agonist with an IC 50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1 ; IC 50 >10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML188 | ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 1417700-13-0. Molecular formula: C26H31N3O3. Mole weight: 433.55. Purity: 0.98. IUPACName: N-[(1R)-2-(tert-butylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide. Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)N([C@H](C2=CN=CC=C2)C(=O)NC(C)(C)C)C(=O)C3=CC=CO3. Product ID: ACM1417700130. Alfa Chemistry ISO 9001:2015 Certified. Categories: M1885 Remington-Lee. | |
| ML 190 | ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-193 | ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinsons disease (PD) rats[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID 1261822. CAS No. 713121-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110125. | |
| ML193 trifluoroacetate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML194 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 202 | ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML204 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML 204 | ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML204 hydrochloride | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A. | |
| ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline ) | Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Group: Biochemicals. Grades: Highly Purified. CAS No. 5465-86-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 210 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML-210 | ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1360705-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100003. | |
| ML213 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML213 | ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 489402-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101843. | |
| ML 213 | ML 213. Group: Biochemicals. Grades: Purified. CAS No. 489402-47-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML216 | ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 ?M and 0.97 ?M for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 ?M. Antitumor avtivity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-49852229. CAS No. 1430213-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12342. | |
| ML216 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML218 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 218 hydrochloride | ML 218 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1346233-68-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML221 | ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 ?M in the cAMP assay, and 1.75 ?M in the ?-arrestin assay, and EC80 of 10 nM in both assays. Uses: Scientific research. Group: Signaling pathways. CAS No. 877636-42-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103254. | |
| ML221 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 221 | ML 221. Group: Biochemicals. Grades: Purified. CAS No. 877636-42-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML228 | ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 ?M. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-46742353. CAS No. 1357171-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12754. | |
| ML 228 | ML 228. Group: Biochemicals. Grades: Purified. CAS No. 1357171-62-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML230 | ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID44640177; SID 88095709. CAS No. 1776055-05-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111678. | |
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