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A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. Group: Biochemicals. Alternative Names: 4- (N-Maleimidomethyl) cyclohexane-1-carboxylic Acid N-Hydroxysuccinimide Ester; NSC 344483; SMCC. Grades: Highly Purified. CAS No. 64987-85-5. Pack Sizes: 25mg, 100mg, 250mg, 500mg. US Biological Life Sciences.
A compound used potentially for the radioiodination of monoclonal antibodies. Used in Antibody labelling. Group: Biochemicals. Alternative Names: p-MeATE. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Group: Biochemicals. Alternative Names: SMPB. Grades: Highly Purified. CAS No. 79886-55-8. Pack Sizes: 10mg. US Biological Life Sciences.
N-Succinimidyl-5-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carboxylateis a protected intermediate in the synthesis of purine metabolites. Synonyms: 1-[[[5-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]oxy]-2,5-pyrrolidinedione. CAS No. 53459-70-4. Molecular formula: C19H22N4O11. Mole weight: 482.4.
A heterobifunctional sulfhydryl cross-linking reagent. Group: Biochemicals. Alternative Names: MTS-3-NHS. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
N-hydroxysuccinimide ester of palmitic acid. Esters of N-hydroxysuccinimide have been used for the preparation of N-acylamino acids, aminoacyl-tRNA, coenzyme A, thioglycolic acid, ceramides, etc. Group: Biochemicals. Alternative Names: Palmitic Acid N-hydroxysuccinimide Ester. Grades: Highly Purified. CAS No. 14464-31-4. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
N-Succinimidyl-p-formylbenzoate
N-Succinimidyl-p-formylbenzoate. Group: Biochemicals. Alternative Names: 4-Carboxybenzaldehyde N-hydroxysuccinimide ester; 4- [ [ (2, 5-Dioxo-1-pyrrolidinyl) oxy] carbonyl] benzaldehyde; SFBc. Grades: Highly Purified. CAS No. 60444-78-2. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C12H9NO5. US Biological Life Sciences.
Worldwide
N-Succinimidyl-S-acetylthioacetate
N-Succinimidyl-S-acetylthioacetate. Group: Biochemicals. Alternative Names: Ethanethioic acid S-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] ester; SATA. Grades: Highly Purified. CAS No. 76931-93-6. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C8H9NO5S. US Biological Life Sciences.
Worldwide
N-Succinimidyl-S-acetylthioacetate
N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: SATA. CAS No. 76931-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135233.
N-Succinimidyl-S-acetylthioacetate
A thiolating reagent for primary amines. Synonyms: SATA; 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate. CAS No. 76931-93-6. Molecular formula: C8H9NO5S. Mole weight: 231.23.
N-Succinimidyl-S-acetylthioacetate ≥97% (NMR)
N-Succinimidyl-S-acetylthioacetate ≥97% (NMR). Group: Biochemicals. Grades: Reagent Grade. CAS No. 76931-93-6. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Worldwide
N-Succinimidyl-S-acetylthioacetate (SATA)
Reacts with primary amines to add protected sulfhydryls. Group: Biochemicals. Alternative Names: SATA. Grades: Highly Purified. CAS No. 76931-93-6. Pack Sizes: 500mg. US Biological Life Sciences.
Worldwide
N-Succinimidyl-S-acetylthiopropionate
N-Succinimidyl-S-acetylthiopropionate. Group: Biochemicals. Alternative Names: Ethanethioic acid S-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl] ester; 3-(Acetylthio)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester; SATP. Grades: Highly Purified. CAS No. 84271-78-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C9H11NO5S. US Biological Life Sciences.
N-(Succinyl)-2-acetamido-2-deoxy-b-D-glucopyranosylhydroxylamine is a biomedical wonder, emerging as a paramount tool in studying an array of illnesses such as bacterial infections. By selectively modulating disease-related enzymes and receptors, this extraordinary product has a promising biomedical prospect. Molecular formula: C12H18N2O8. Mole weight: 318.28.
N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate dibarium salt
N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate dibarium salt, an indispensable compound for biomedical research, showcases its cardinal significance in exploring metabolic pathways and diseases like cancer and diabetes. Its utilization as a reagent for synthesizing associated compounds and examining intracellular signaling pathways underpins its significance. Uses: A metabolite of purine. purine metabolism by adenylosuccinasedeficient. since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible. Synonyms: SAICAR Dibarium salt; N-[(5-Amino-1-b-D-ribofuranosylimidazol-4-yl)carbonyl]-L-aspartic acid. CAS No. 6057-44-9. Molecular formula: C13H15Ba2N4O12P. Mole weight: 724.91.
N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Dibenzyl Ester 2',3',5'-Triacetate is a protected intermediate of purine metabolites. Synonyms: N-[5-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonyl]-L-aspartic Acid Dibenzyl Ester. Molecular formula: C33H36N4O12. Mole weight: 680.66.
N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt
Cas No. 17388-80-6.
N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin
N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin is a fluorescently labeled tripeptide activated with succ-ester. Synonyms: N-(3-carboxypropanoyl)alanylalanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)phenylalaninamide. Grades: >98%. CAS No. 71973-79-0. Molecular formula: C29H32 N4 O8. Mole weight: 564.59.
N-Succinyl-Ala-Ala-Pro-Leu p-nitroanilide
N-Succinyl-Ala-Ala-Pro-Leu p-nitroanilide is a sensitive substrate for human and especially porcine pancreatic elastases. Synonyms: succinyl-L-Ala-L-Ala-L-Pro-L-Leu-p-nitroanilide; 4-((S)-1-((S)-1-((S)-2-((S)-4-methyl-1-(4-nitrophenylamino)-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-4-oxobutanoic acid. CAS No. 70968-04-6. Molecular formula: C27H38N6O9. Mole weight: 590.63.
Arginine, N2-acetylarginine and N2-glutamylarginine do not act as substrates. This is the second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase). Group: Enzymes. Synonyms: N2-succinylarginine dihydrolase; arginine succinylhydrolase; SADH; AruB; AstB; 2-N-succinyl-L-arginine iminohydrolase (decarboxylating). Enzyme Commission Number: EC 3.5.3.23. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4525; N-succinylarginine dihydrolase; EC 3.5.3.23; N2-succinylarginine dihydrolase; arginine succinylhydrolase; SADH; AruB; AstB; 2-N-succinyl-L-arginine iminohydrolase (decarboxylating). Cat No: EXWM-4525.
N-Succinyl-Gly-Gly-Phe-p-nitroanilide
N-Succinyl-Gly-Gly-Phe-p-nitroanilide is a substrate for the assay of chymotrypsin activity. Synonyms: Suc-Gly-Gly-Phe-Pna; N-(3-Carboxypropionyl)glycylglycyl-N-(p-nitrophenyl)-3-phenyl-L-alaninamide; N-Suc-Gly-Phe-4-nitroanilide; N-Succinylglycyl-phenylalanine-4-nitroanilide. CAS No. 68982-90-1. Molecular formula: C23H25N5O8. Mole weight: 499.47.
N-Succinyl-L-tyrosine. Group: Biochemicals. Alternative Names: N-(3-Carboxy-1-oxopropyl)-L-tyrosine; Clavulanic acid impurity G. Grades: Highly Purified. CAS No. 374816-32-7. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C13H15NO6. US Biological Life Sciences.
Worldwide
N-(Succinyl)-O-b-D-galactopyranosylhydroxylamine
N-(Succinyl)-O-b-D-galactopyranosylhydroxylamine is an exceptional biomedical substance, finding its application in the research of targeting explicit enzymes or pathways implicated in the advancement of diverse maladies, comprising cancer and inflammatory disorders. Molecular formula: C10H15NO8. Mole weight: 277.23.
N-(Succinyl)-O-b-D-glucopyranosylhydroxylamine
N-(Succinyl)-O-b-D-lactosylhydroxylamine
N-(Succinyl)-O-b-D-maltosylhydroxylamine
N-succinylornithine carbamoyltransferase
This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 ? Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine. Group: Enzymes. Synonyms: succinylornithine transcarbamylase; N-succinyl-L-ornithine transcarbamylase; SOTCase. Enzyme Commission Number: EC 2.1.3.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2013; N-succinylornithine carbamoyltransferase; EC 2.1.3.11; succinylornithine transcarbamylase; N-succinyl-L-ornithine transcarbamylase; SOTCase. Cat No: EXWM-2013.
N-Sulfinyl-p-toluenesulfonamide. Group: Biochemicals. Alternative Names: N-Thionyl-p-toluenesulfonamide. Grades: Highly Purified. CAS No. 4104-47-6. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
N-sulfoglucosamine-3-sulfatase
The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue. Group: Enzymes. Synonyms: chondroitinsulfatase. Enzyme Commission Number: EC 3.1.6.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3748; N-sulfoglucosamine-3-sulfatase; EC 3.1.6.15; chondroitinsulfatase. Cat No: EXWM-3748.
N-Sulfo-glucosamine Potassium salt
N-Sulfo-glucosamine Potassium salt is a valuable biomedical product with potent anti-inflammatory properties used in the research of various diseases such as inflammatory disorders and joint diseases, including osteoarthritand rheumatoid arthritis. Synonyms: Potassium N-sulfoglucosamine; Potassium ((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)sulfamate; Potassium 2-deoxy-2-sulfoamino-D-glucose; Glucosamine N-sulfate potassium salt; BWD7N48R1I; D-Glucose, 2-deoxy-2-(sulfoamino)-, potassium salt (1:1); potassium; N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]sulfamate; D-Glucose, 2-deoxy-2-(sulfoamino)-, monopotassium salt; UNII-BWD7N48R1I; C6H12KNO8S; glucosamine sulfate potassium; DTXSID80185203; AKOS016009807; AS-69554; CS-0158491; 38899-05-7; GLUCOSAMINE N-SULFATE POTASSIUM [WHO-DD]; A875974; Q27274928; Potassium((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)sulfamate; POTASSIUM (2R,3R,4S,5R)-3,4,5,6-TETRAHYDROXY-2-(SULFONATOAMINO)HEXANAL; 2-Deoxy-2-sulfoamino-D-glucose potassium salt; 2-Deoxy-2-(sulfoamino)-D-glucose monopotassium salt; D-Glucose, 2-deoxy-2-(sulfoamino)-, monopotassium salt (8CI,9CI); Potassium 2-deoxy-2-sulfoamino-D-glucose. CAS No. 31284-96-5. Molecular formula: C6H12KNO8S. Mole weight: 297.33.
N-sulfoglucosamine sulfohydrolase
This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is N-sulfo-D-glucosamine sulfohydrolase. Other names in common use include sulfoglucosamine sulfamidase, heparin sulfamidase, 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate, and sulphohydrolase). This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation. Group: Enzymes. Synonyms: sulfoglucosamine sulfamidase; heparin sulfamidase; 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase). Enzyme Commission Number: EC 3.10.1.1. CAS No. 37289-41-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3772; N-sulfoglucosamine sulfohydrolase; EC 3.10.1.1; 37289-41-1; sulfoglucosamine sulfamidase; heparin sulfamidase; 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase). Cat No: EXWM-3772.
NT-0796 is an orally active, selective and CNS-penetrant NLRP3 inflammasome inhibitor. NT-0796 inhibits IL-1β release in human PBMC cells with an IC 50 value of 0.32 nM. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 reverses high fat diet-induced obesity, systemic inflammation and astrogliosis in the diet-induced obesity mouse model. NT-0796 is promising for research of neurodegenerative disorders, including Alzheimers disease, Parkinsons disease, multiple sclerosis, and amyotrophic lateral sclerosis [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2272917-13-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156438.
NT113
NT113 is a pan-ERBB inhibitor with high brain penetrance. It can inhibit the growth of glioblastoma xenografts with EGFR amplification. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 can inhibit ERBB family member phosphorylation in vivo and vitro. It can also inhibit the phosphorylation of downstream signaling mediator Akt. No recent reports of development were identified for preclinical development in Glioblastoma in USA. Uses: Glioblastoma. Synonyms: NT-004; NT 004; NT004; NT-113; NT 113; NT113; NT-125; NT 125; NT125; (E)-N-(7-(((1R,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)ethynyl)-4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grades: 98%. CAS No. 1398833-56-1. Molecular formula: C27H25ClFN5O2. Mole weight: 505.98.
NT-157
NT-157, a selective IRS-1/2 inhibitor, has been found to influence cell migratory at some extent and could induce the inhibition of cancer cell survival. The preclinical trails has reported by TyrNovo. IC50: 0.3 to 0.8 μM. Uses: Nt-157 is a selective irs-1/2 inhibitor that has been found to influence cell migratory at some extent and could induce the inhibition of cancer cell survival. Synonyms: NT-157; NT 157; NT157; AK174915; AK 174915; AK-174915; AKOS025404921; CS-5531; CS 5531; CS5531;(4E)-2-bromo-6-hydroxy-4-[(Z)-3-sulfanyl-3-[(3,4,5-trihydroxyphenyl)methylamino]prop-2-enylidene]cyclohexa-2,5-dien-1-one. Grades: 98%. CAS No. 1384426-12-3. Molecular formula: C16H14BrNO5S. Mole weight: 410.98.