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| Product | Description | |
|---|---|---|
| PF 06551600 malonate | PF 06551600 is a potent and selective JAK3 inhibitor with IC50 value of 33.1 μM, exhibiting >1,000-fold selectivity over JAK1 and JAK2. It inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. It also inhibits Th1 and Th17 T-cell differentiation and function in vitro. Synonyms: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate. Grades: ≥98% by HPLC. CAS No. 2140301-97-7. Molecular formula: C15H19N5O·C3H4O4. Mole weight: 389.41. |  |
| PF-06648671 | PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimers disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1587727-31-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120789. |  |
| PF-06650833 | PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), which is an omnipresently expressed serine/threonine kinase involved in the regulation of innate immunity. PF-06650833 is useful for the treatment of autoimmune and inflammatory diseases associated with lnterleukin-1 Receptor Associated Kinase (IRAK) and more particularly modulates the function of IRAK. It is undergoing testing in a Phase II clinical study. Synonyms: zimlovisertib; PF 06650833; PF06650833. CAS No. 1817626-54-2. Molecular formula: C18H20FN3O4. Mole weight: 361.373. | |
| PF-06651600 | PF-06651600 is a selective JAK3 inhibitor with IC50 value of 0.346 nM. It was shown to inhibit Th1 and Th17 cell differentiation and function in vitro. Synonyms: Ritlecitinib; PF 06651600; PF06651600; 2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-. Grades: >98%. CAS No. 1792180-81-4. Molecular formula: C15H19N5O. Mole weight: 285.351. | |
| PF-06700841 tosylate | PF-06700841 is a potent and selective inhibitor of TYK2 and JAK1. It has the potential to treat plaque psoriasis and lupus erythematosus. Synonyms: Brepocitinib tosylate; [(1S)-2,2-difluorocyclopropyl]-[(1R,5S)-3-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone tosylate. Grades: ≥98%. CAS No. 2140301-96-6. Molecular formula: C18H21F2N7O·C7H8O3S. Mole weight: 561.61. | |
| PF-06726304 | PF-06726304 is a potent and selective EZH2 inhibitor. It also inhibits H3K27me3 with IC50 value of 15 nM. Synonyms: 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one. CAS No. 1616287-82-1. Molecular formula: C22H21Cl2N3O3. Mole weight: 446.33. | |
| PF-06726304 | PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 with K i s of 0.7 and 3.0 nM, respectively. PF-06726304 displays robust antitumor growth activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1616287-82-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103682. | |
| PF 06726304 acetate | | |
| PF-06747775 | PF-06747775, a methylpurin derivative, has been found to be an epidermal growth factor receptor antagonist and could probably be effective against cell lung cancer through restrain EGFR-mediated signaling. It is still under Phase-I trial in Non-small cell lung cancer. Synonyms: YXX2180047; Egfr T790M inhibitor PF-06747775; PF-06747775; N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-methylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide. Grades: 98%. CAS No. 1776112-90-3. Molecular formula: C18H22FN9O2. Mole weight: 415.43. | |
| PF-06767832 | PF-06767832 is a cell permeable, potent and selective M1 muscarinic acetylcholine receptor Positive Allosteric Modulator (PAM). Synonyms: PF-06767832; PF 06767832; PF06767832; PF-6767832; PF 6767832; PF6767832; N-[(3R,4S)-3-hydroxyoxan-4-yl]-5-methyl-4-[[4-(1,3-thiazol-4-yl)phenyl]methyl]pyridine-2-carboxamide; GTPL9228; SCHEMBL17440029; PF-06767832; N-[(3R,4S)-3-hydroxyoxan-4-yl]-5-methyl-4-[[4-(1,3-thiazol-4-yl)phenyl]methyl]pyridine-2-carboxamide. Grades: >98%. CAS No. 1859081-58-5. Molecular formula: C22H23N3O3S. Mole weight: 409.50. | |
| PF-06821497 | PF-06821497. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one. CAS No. 1844849-10-0. Molecular formula: C22H24Cl2N2O5. Mole weight: 467.34. Purity: 0.98. Product ID: ACM1844849100. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PF-06835919 | PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK) , with IC 50 s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketohexokinase inhibitor 1. CAS No. 2102501-84-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00461. | |
| PF-06835919 | PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF-06835919; PF 06835919; PF06835919; MDK1846; MDK-1846; MDK 1846; ketohexokinase inhibitor; ketohexokinase-In-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2102501-84-6. Molecular formula: C16H19F3N4O2. Mole weight: 356.35. Purity: >98%. IUPACName: 2-((1R,5S,6R)-3-(2-((S)-2-methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)acetic acid. Canonical SMILES: O=C(C[C@@H]1[C@]2(CN(C[C@@]12[H])C3=NC(N4[C@H](CC4)C)=NC(C(F)(F)F)=C3)[H])O. Product ID: ACM2102501846. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ketohexokinase inhibitor 1. | |
| PF-06840003 | PF-06840003 is a highly selective inhibitor of IDO1 (IC50 = 0.41mcM), an immunosuppressive enzyme induced by multiple cancers. Study in vitro showed that PF-06840003 led to IDO-1-induced T-cell anergy. Study in vivo revealed that it significantly suppressed tumor growth in combination with avelumab in mouse model. Uses: Antitumor drug. Synonyms: EOS200271, EOS-200271; EOS 200271; PF-06840003; PF 06840003; PF06840003. CAS No. 198474-05-4. Molecular formula: C12H9FN2O2. Mole weight: 232.21. | |
| PF-06869206 | PF-06869206 is an orally bioavailable inhibitor of sodium-phosphate cotransporter 2a (NaPi2a), a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Synonyms: NaPi2a inhibitor; 3-Chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile. Grades: ≥98%. CAS No. 2227425-05-8. Molecular formula: C15H14ClF3N4O2. Mole weight: 374.75. | |
| PF-06873600 | PF-06873600 Inhibitor. Uses: Scientific use. Product Category: T8463. CAS No. 2185857-97-8. |  |
| PF-06873600 | Ebvaciclib, also known as PF-06873600, is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon administration, PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ebvaciclib; PF-06873600; PF 06873600; PF06873600. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2185857-97-8. Molecular formula: C20H27F2N5O4S. Mole weight: 471.52. Purity: >98%. IUPACName: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-. Canonical SMILES: O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@H]4[C@](C)(O)CCC4. Product ID: ACM2185857978. Alfa Chemistry ISO 9001:2015 Certified. | |
| PF-06939999 | PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRMT5-IN-3. CAS No. 2159123-14-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131493. | |
| PF-06952229 | PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1801333-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136244. | |
| PF-07258669 | PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2755890-53-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148349. | |
| PF-07265807 | PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC 50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2412356-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147218. | |
| PF-07284892 | PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC 50 value of 21 nM. PF-07284892 decreases the expression of pERK [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-558. CAS No. 2498597-94-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-153740. | |
| PF-07321332 | PF-07321332 is an orally available SARS-CoV 3C-like protease (3CLPRO) inhibitor. 3C-like protease (3CLPRO) is the main protease found in coronaviruses, which cleaves the coronavirus polyprotein at eleven conserved sites. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase I clinical trial in healthy human participants. Synonyms: PF 07321332; PF07321332. Grades: 98%. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.53. | |
| PF-07321332 | Nirmatrelvir, also known as PF-07321332 (brand name: Paxlovid), is an orally bioavailable 3C-like protease (3CLPRO) inhibitor and SARS-CoV-2 Mpro inhibitor. This drug is being investigated for safety, tolerability, and pharmacokinetics before moving on to studies of efficacy in the treatment or prophylaxis of COVID-19. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. PF-07321332 is an oral COVID-19 antiviral clinical candidate. By inhibiting the main protease, PF-07321332 prevents the virus from cleaving long protein chains into the parts it needs to reproduce itself. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nirmatrelvir; PF-07321332; PF 07321332; PF07321332; brand name Paxlovid. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.54. Purity: >98%. IUPACName: (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide. Canonical SMILES: [H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C#N)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C. Product ID: ACM2628280408. Alfa Chemistry ISO 9001:2015 Certified. | |
| PF 1018 | PF1018 is an insecticidal agent isolated from the culture broth of Humicola sp. PF1018. Synonyms: Antibiotic PF 1018; PF1018. CAS No. 131256-42-3. Molecular formula: C28H35NO3. Mole weight: 433.6. | |
| PF 1022A | PF1022A, an anthelmintic cyclodepsipeptide isolated from cultured mycelia of Mycelia Sterilia, has very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. It has potent repellant activity against Ascaridiagalli in chicken. In vitro, it has activity against Trichinella spiralis and Nippostrongylus brasiliensis. Synonyms: PF1022A; PF-1022A; cyclo[N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe-N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe]; cyclo[N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl-N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl]; Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]. Grades: >98%. CAS No. 133413-70-4. Molecular formula: C52H76N4O12. Mole weight: 949.18. | |
| PF-1057A | PF-1057A is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057A; PF1057A. CAS No. 89162-70-9. Molecular formula: C31H56O10S2. Mole weight: 652.9. | |
| PF-1057B | PF-1057B is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057B; PF1057B. CAS No. 89020-47-3. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
| PF-1057C | PF-1057C is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057C; PF1057C. CAS No. 89020-48-4. Molecular formula: C35H60O12S2. Mole weight: 737. | |
| PF-1057D | PF-1057D is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057D; PF1057D. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
| PF-1092A | PF-1092A is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 3.0 x 10 nM. Synonyms: PF 1092A; PF1092A. Molecular formula: C17H20O5. Mole weight: 304.34. | |
| PF-1092B | PF-1092B is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(2) nM. Synonyms: PF 1092B; PF1092B. Molecular formula: C17H20O5. Mole weight: 304.34. | |
| PF-1092C | PF-1092C is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(3) nM. Synonyms: PF 1092C; PF1092C. Molecular formula: C15H18O4. Mole weight: 262.3. | |
| PF-1163A | PF-1163A is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: (3S,10R,13S)-3-[[4-(2-Hydroxyethoxy)phenyl]methyl]-13-[(2S)-2-hydroxypentyl]-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione. Grades: ≥95%. CAS No. 258871-59-9. Molecular formula: C27H43NO6. Mole weight: 477.6. | |
| PF-1163B | PF-1163B is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: Antibiotic PF-1163B; (-)-PF 1163B; 3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione. Grades: ≥95%. CAS No. 258871-60-2. Molecular formula: C27H43NO5. Mole weight: 461.63. | |
| PF-1355 | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Synonyms: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Molecular formula: C14H15N3O4S. Mole weight: 321.35. | |
| Pf 184 | Pf 184. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF 184, NCGC00263213-01, FT-0673646, 1187460-81-6, 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide. Product Category: Heterocyclic Organic Compound. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: C32H32ClFN6O4. Purity: >98 %. IUPACName: 8-[[2-[(3S,4R)-3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-5-chloropyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide. Canonical SMILES: CC1(CN(CC1(C)CO)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl)CO. Product ID: ACM1187460816. Alfa Chemistry ISO 9001:2015 Certified. Categories: PF-184563. | |
| PF184 | PF184. CAS No: 1187460-81-6 |  Sarchem Laboratories New Jersey NJ |
| PF 184 | PF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM) with selectivity over 85 other kinases, demonstrating target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. Synonyms: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide; PF-184; PF184; PF 184. Grades: ≥98% by HPLC. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: 619.09. | |
| PF 184 | PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. Group: Biochemicals. Alternative Names: 8- [ [ [5-Chloro-2- [3, 4-dimethyl-3, 4-bis (hydroxymethyl) -1-pyrrolidinyl] -4-pyridinyl] carbonyl] amino] -1- (4-fluorophenyl) -4, 5-dihydro-1H-benz [g] indazole-3-carboxamide. Grades: Highly Purified. CAS No. 1187460-81-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PF-232798 | PF-232798 is a second-generation oral CCR5 antagonist. It has broad-spectrum anti-HIV-1 activity. Synonyms: PF 232798; PF-00232798; CHEMBL1649931; 63P7W7886U; PF232798. Grades: 98%. CAS No. 849753-15-7. Molecular formula: C29H40FN5O2. Mole weight: 509.7. | |
| PF-2545920 | PF-2545920 a highly selective and potent PDE10A inhibitor. It was active with an ED50 of 1 mg/kg. Synonyms: PF-2545920; PF 2545920; PF2545920; MP-10; MP10; MP 10, Mardepodect. Grades: >98%. CAS No. 898562-94-2. Molecular formula: C25H20N4O. Mole weight: 392.45. | |
| PF2EH | PF2EH. Group: Organic light-emitting diode (oled) materials. Alternative Names: POLY(9 9-BIS-(2-ETHYLHEXYL)-9H-FLUORENE&; POLY(9,9-DI-(2-ETHYLHEXYL)FLUORENYL-2,&; Poly[9,9-di-(2-ethylhexyl)fluorenyl-2,7-diyl]; Poly[9,9-bis-(2-ethylhexyl)-9H-fluorene-2,7-diyl]; Poly[9,9-bis(2-ehtylhexyl)fluorenyl-2,7-diyl]; Poly[9,9-bis-(2-ethylhexyl)-9H-f. CAS No. 188201-16-3. Product ID: (2-amino-2-oxoethyl) 3-[benzyl-(4-chlorophenyl)sulfamoyl]-4-chlorobenzoate. Molecular formula: 493.4g/mol. Mole weight: C22H18Cl2N2O5S. C1=CC=C (C=C1)CN (C2=CC=C (C=C2)Cl)S (=O) (=O)C3=C (C=CC (=C3)C (=O)OCC (=O)N)Cl. InChI=1S / C22H18Cl2N2O5S / c23-17-7-9-18 (10-8-17) 26 (13-15-4-2-1-3-5-15) 32 (29, 30) 20-12-16 (6-11-19 (20) 24) 22 (28) 31-14-21 (25) 27 / h1-12H, 13-14H2, (H2, 25, 27). UZIUTJBYUHKEGE-UHFFFAOYSA-N. |  |
| PF-3084014 | PF-3084014 is a selective γ-secretase inhibitor (IC50 = 6.2 nM in a cell-free assay). It has been shown to inhibit self-renewal and proliferation of cancer stem cells. Synonyms: Nirogacestat; PF 3084014; PF3084014. Grades: >98%. CAS No. 1290543-63-3. Molecular formula: C27H41F2N5O. Mole weight: 489.66. | |
| PF 3084014 hydrobromide | PF 3084014 is a potent and selective γ-secretase inhibitor (IC50 = 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). It potently reduces Aβ relative to Notch-related endpoints in vitro and in vivo. Synonyms: Nirogacestat hydrobromide; (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide. Grades: ≥98% by HPLC. CAS No. 1962925-29-6. Molecular formula: C27H41F2N5O·HBr. Mole weight: 651.47. | |
| PF-3274167 | PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Synonyms: PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167. Grades: 98%. CAS No. 900510-03-4. Molecular formula: C19H19ClFN5O3. Mole weight: 419.84. | |
| PF 3644022 | PF 3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (IC50 = 5.2 nM; Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF 3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-onel; PF-3644022; PF 3644022; PF3644022. Grades: ≥98% by HPLC. CAS No. 1276121-88-0. Molecular formula: C21H18N4OS. Mole weight: 374.46. | |
| PF-3644022 | PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Group: Biochemicals. Alternative Names: (10R)-9, 10, 11, 12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1, 4]diazepino[5', 6':4, 5]thieno[3, 2-f]quinolin-8-one. Grades: Highly Purified. CAS No. 1276121-88-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3716556 | PF 3716556 is a potent and selective P-CAB with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease. Synonyms: PF-03716556; PF 03716556; PF03716556; PF-3716556; PF 3716556; PF3716556. Grades: >98%. CAS No. 928774-43-0. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| PF-3758309 | PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 ( K d = 2.7 nM; K i =18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-03758309. CAS No. 898044-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13007. | |
| PF 3758309 dihydrochloride | PF 3758309 dihydrochloride is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 (IC50 = 1.3 nM; Kd = 2.7 nM). PF 3758309 inhibits phosphorylation of a natural PAK4 substrate in cells with an IC50 ~1 nM and inhibits anchorage-independent growth (expected biology for PAK4 inhibition) at 240 pM. Synonyms: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride; PF 3758309 dihydrochloride; PF3758309 dihydrochloride; PF-3758309 dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H30N8OS.2HCl. Mole weight: 563.55. | |
| PF-376304 | PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Synonyms: PF 376304; PF376304. Grades: 98%. CAS No. 851757-93-2. Molecular formula: C17H24N8O3. Mole weight: 388.42. | |
| PF 3845 | PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3845 | PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH) , with a K i of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196109-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14380. | |
| PF-3845 | PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Synonyms: PF3845; PF-3845; PF 3845. Grades: 0.98. CAS No. 1196109-52-0. Molecular formula: C24H23F3N4O2. Mole weight: 456.469. | |
| PF-4136309 | PF-4136309 is a potent, selective, and orally bioavailable antagonist of CCR2, a chemokine receptor of the super family of seven-transmembrane G-protein-coupled receptors (GPCRs). Synonyms: (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide; PF4136309; PF 4136309; PF04136309; PF-04136309; INCB8761; INCB 8761; INCB-8761. CAS No. 1341224-83-6. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. | |
| PF-4217329 | PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well tolerated in preclinical species. Uses: Pf-04217329 is useful for intraocular pressure of glaucoma. Synonyms: PF-4217329, PF 4217329, PF4217329, PF-04217329, PF04217329, PF 04217329, Taprenepag isopropyl; Propan-2-yl 2- [3- [ [ (4-pyrazol-1-ylphenyl) methyl-pyridin-3-ylsulfonylamino] methyl] phenoxy] acetate; PF4217329; PF-04217329; PF04217329; Isopropyl 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetate. Grades: >98 %. CAS No. 1005549-94-9. Molecular formula: C27H28N4O5S. Mole weight: 520.60. | |
| PF 429242 | PF 429242 is a reversible, competitive, cell permeable inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM) without disrupting a panel of serine proteases. Some studies reported that the inhibition of SKI-1/S1P, a master lipo- 387 genic regulator, could impair HCV genome replication, lipid droplet 388 homeostasis and the production of infectious HCV virions. Synonyms: PF-429242; PF 429242; PF429242. Benzamide, 4-[(diethylamino)?methyl]?-N-[2-(2-methoxyphenyl)?ethyl]?-N-(3R)?-3-pyrrolidinyl-; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide. CAS No. 947303-87-9. Molecular formula: C25H35N3O2. Mole weight: 409.56. | |
| PF 429242 dihydrochloride | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Synonyms: PF-429242 dihydrochloride; PF429242 dihydrochloride. Grades: ≥97% by HPLC. CAS No. 2248666-66-0. Molecular formula: C25H35N3O2·2HCl. Mole weight: 482.49. | |
| PF 431396 | PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences. | Worldwide |
| PF-431396 | PF-431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Synonyms: PF-431396; PF 431396; PF431396. Grades: >98%. CAS No. 717906-29-1. Molecular formula: C22H21F3N6O3S. Mole weight: 506.5. | |
| PF 4693627 | PF 4693627 is a potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) that has the potential to treat inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). Uses: Potential treatment of inflammation. Synonyms: PF-4693627; PF 4693627; PF4693627. 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide. Grades: 99%. CAS No. 1312815-93-2. Molecular formula: C26H29Cl2N3O3. Mole weight: 502.43. | |
| PF-4708671 | PF-4708671 is a potent cell-permeable S6K1 inhibitor with a K i of 20 nM and IC 50 of 160 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255517-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15773. | |
| PF-4708671 | PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR. Synonyms: PF-4708671; PF4708671; PF 4708671. Grades: 0.98. CAS No. 1255517-76-0. Molecular formula: C19H21F3N6. Mole weight: 390.40545. | |
| PF-4708671 | PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Group: Biochemicals. Alternative Names: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671. Grades: Highly Purified. CAS No. 1255517-76-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF 477736 | Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| PF-477736 | PF-477736 is a proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. Synonyms: PF-477736; PF-477736; PF-477736; PF-00477736; PF00477736; PF 00477736. CAS No. 952021-60-2. Molecular formula: C22H25N7O2. Mole weight: 419.489. | |
| PF 4778574 | PF 4778574 is a potent brain penetrant AMPA receptor positive allosteric modulator (PAM) (Ki = 85 nM) that has been shown to enhance cognition in animal models. Synonyms: PF-4778574; PF 4778574; PF4778574. N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide. Grades: ≥98% by HPLC. CAS No. 1219633-99-4. Molecular formula: C19H22N2O3S2. Mole weight: 390.52. | |
| PF 4800567 | PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM). Synonyms: PF 4800567; PF4800567; PF-4800567; 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine. Grades: 98%. CAS No. 1188296-52-7. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
| PF 4800567 hydrochloride | PF 4800567 is a casein kinase 1e (CK1e) selective inhibitor that is 22 fold selective for the CK1e isoform over CK1d (IC50= 32 and 711 nM for CK1ε and CK1δ respectively). Synonyms: PF 4800567 hydrochloride; PF-4800567 hydrochloride; PF4800567 hydrochloride; 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 1391052-28-0. Molecular formula: C17H18ClN5O2.HCl. Mole weight: 396.27. | |
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