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| Product | Description | |
|---|---|---|
| PF 8380 | PF 8380. Group: Biochemicals. Grades: Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| PF-8380 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF-8380 | PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester. Grades: ≥95%. CAS No. 1144035-53-9. Molecular formula: C22H21Cl2N3O5. Mole weight: 478.33. |  |
| PF-8380 | PF-8380 is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 1144035-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344. |  |
| PF-8380 hydrochloride | PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344A. | |
| PF 915275 | PF-915275 is a selective and potent and inhibitor of human 11β-hydroxysteroid dehydrogenase type 1(11βHSD1) inhibitor with Ki 2.3 nM. It has good preclinical pharmacokinetic properties. It inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. It maintains potency in our cellular assay against human 11βHSD1 and is selective against human 11βHSD2 in vitro. It displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. It has good in vitro pharmacokinetic properties. It has low clearance and high permeability. It has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. Uses: Pf-915275 inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. it has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. Synonyms: PF-915275; PF 915275; PF915275; N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide;[1,1'-Bip;4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide. Grades: >98 %. CAS No. 857290-04-1. Molecular formula: C18H14N4O2S. Mole weight: 350.39. | |
| PF 915275 | PF 915275. Group: Biochemicals. Grades: Purified. CAS No. 857290-04-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF 9184 | This active molecular is selective mPGES-1 (microsomal prostaglandin E synthase-1 inhibitor. mPGES-1 is an enzyme induced during the inflammatory response and it is for developing anti-inflammatory drugs. PF-9184 inhibited recombinant human mPGES-1 with IC50 value of 16.5nM. PF-9184 had no effect against COX-1 and COX-2 with more than 6500-fold selectivity. PF-9184 inhibited PGE(2) synthesis with IC50 value in the range of 0.5-5 mM in serum-free cell and human whole blood cultures. Uses: Anti-inflammatory agent. Synonyms: N-(3',4'-Dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Grades: 98%. CAS No. 1221971-47-6. Molecular formula: C21H14Cl2N2O4S. Mole weight: 461.31. | |
| PF 945863 | PF 945863, an orally active macrolide antibiotic, is active against multidrug resistant respiratory tract bacterial strains. Synonyms: PF 945863; PF945863; PF-945863; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone. Grades: ≥98% by HPLC. CAS No. 893556-85-9. Molecular formula: C44H65N5O10. Mole weight: 824.01. | |
| PF-956980 | PF-956980, a close analogue of Tofacitinib, is a JAK3-selective inhibitor used as an anti-inflammatory agent. Besides, some studies showed that PF-956980 strikingly reversed the cytoprotective action of IL-4 on CLL cells. Synonyms: PF-956980; PF 956980; PF956980; Methanone, [(3R,?4R)?-4-methyl-3-(methyl-7H-pyrrolo[2,?3-d]?pyrimidin-4-ylamino)?-1-piperidinyl]?-1-pyrrolidinyl-. CAS No. 1262832-74-5. Molecular formula: C18H26N6O. Mole weight: 342.44. | |
| PF-956980 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-956980 Hydrate | PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. PF-956980 is used as immunosuppressive agent. Group: Biochemicals. Alternative Names: [(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinylmethanone Hydrate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF9601N | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 998425 | PF 998425 is a novel, nonsteroidal androgen receptor (AR) antagonist (IC50= 26 nM and 90 nM in AR binding assays and cellular assays respectively) for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. PF 998425 exhibits low affinity for progesterone receptor (IC50 > 10 μM). Uses: Androgen receptor antagonists. Synonyms: 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile; PF0998425; PF 0998425; PF-0998425. Grades: ≥98% by HPLC. CAS No. 1076225-27-8. Molecular formula: C14H14F3NO. Mole weight: 269.26. | |
| PF-998425 | PF-998425 is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. Group: Biochemicals. Alternative Names: rel- (-) -4-[ (1R, 2R) -2-Hydroxycyclohexyl]-2- (trifluoromethyl) benzonitrile. Grades: Highly Purified. CAS No. 1076225-27-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF9 tetrasodium salt | PF9 tetrasodium salt is an activator of GPR17 (EC50 = 36 pM). Synonyms: PF9 tetrasodium salt; PF 9 tetrasodium salt; PF-9 tetrasodium salt; 2-(Phenylethynyl)adenosine-5'-triphosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 851265-78-6. Molecular formula: C18H16N5Na4O13P3. Mole weight: 695.23. | |
| PF9 tetrasodium salt | PF9 tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 851265-78-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PF-AKT400 | PF-AKT400 is an APT competitor inhibitor of AKR kinase. This compound was first described as compound 42 in J. Med. Chem. 2010, 53, 4615-4622 by a group of Pfizer scientists. The paper describes the design and synthesis of novel, ATP-competitive Akt inhibitors from an elaborated 3-aminopyrrolidine scaffold. Key findings include the discovery of an initial lead that was modestly selective and medicinal chemistry optimization of that lead to provide more selective analogues. Analysis of the data suggested that highly lipophilic analogues would likely suffer from poor overall properties. Central to the discussion is the concept of optimization of lipophilic efficiency and the ability to balance overall druglike propeties with the careful control of lipophilicity in the lead series. Discovery of the nonracemic amide series and subsequent modification produced an advanced analogue that performed well in advanced preclinical assays, including xenograft tumor growth inhibition studies, and this analogue was nominated for clinical development. The compound has no official name, has molecule weight 400.43. We temporally call this compound as PF-AKT400. Synonyms: PF-AKT400; PFAKT400; Lig1; Lig-1; Lig 1; PF AKT400; AKT-0286; AKT 0286; AKT0286. CAS No. 1004990-28-6. Molecular formula: C20H22F2N6O. Mole weight: 400.43. | |
| PF-CBP1 | PF-CBP1, also known as PF-06670910, is a selective CBP/p300 bromodomain inhibitor (IC50 values are 125 and 363 nM, respectively) with >100-fold selectivity for CBP over BRD4. Also, PF-CBP1 significantly reduces levels of RGS4 mRNA levels in neurons. Synonyms: 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine; PF-CBP1; PF-CBP-1; PF-CBP 1; PF-06670910; PF 06670910; PF06670910.PF-CBP1; PF CBP1; PFCBP1. CAS No. 1962928-21-7. Molecular formula: C29H36N4O3. Mole weight: 488.63. | |
| PF-CBP1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-CBP1 HCl | PF-CBP1, also known as PF-06670910, is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively) with more than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins. Also, PF-CBP1 significantly reduces levels of RGS4 mRNA levels in neurons. Synonyms: 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride; PF-CBP1 HCl; PF-CBP1; hydrochloride; PF-CBP1; PF-CBP-1; PF-CBP 1; PF-06670910; PF 06670910; PF06670910. CAS No. 2070014-93-4. Molecular formula: C29H37ClN4O3. Mole weight: 525.09. | |
| PFD | PFD. Group: Organic light-emitting diode (oled) materials. Alternative Names: Poly(9,9-di-n-dodecylfluorene). CAS No. 248256-53-3. |  |
| PfDHODH-IN-1 | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183945-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135648. | |
| PF-DMB | PF-DMB. Group: Organic light-emitting diode (oled) materials. Alternative Names: PF-DMB; Poly[(9,9-dihexylfluoren-2,7-diyl)-alt-(2,5-dimethyl-1,4-phenylene)]. CAS No. 579505-48-9. 96%. | |
| PFE-360 | PFE-360 Inhibitor. Uses: Scientific use. Product Category: T16512. CAS No. 1527475-61-1. |  |
| PffBT4T-2OD | Band gap: 1.65 eV. Uses: Requires hot ink processing (i.e. coating with ink at temperature 100-110 °c to ensure good coatability). Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials synthetic tools and reagents. Alternative Names: PCE-11, Poly[(5, 6-difluoro-2, 1, 3-benzothiadiazol-4, 7-diyl)-alt-(3, 3'''-di(2-octyldodecyl)-2, 2', 5', 2'', 5'', 2'''-quaterthiophen-5, 5'''-diyl)]. CAS No. 1644164-62-4. Pack Sizes: 100 mg in glass bottle. Mole weight: (C62H88F2N2S5)n. | |
| PffBT4T-C9C13 | PffBT4T-C9C13. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. | |
| PFH-A | PFH-A. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dihexylfluorenyl-2,7-diyl)-co-(9,10-anthracene)]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 474975-22-9. Molecular formula: (C39H40)n. Product ID: ACM474975229-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFC Akademik Sofia. |  |
| PFHB | PFHB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dihexylfluorenyl-2,7-diyl)-alt-(N,N'-bis-{p-butylphenyl}-1,4-diaminophenylene)]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 870517-32-1. Molecular formula: (C51H62N2)n. Product ID: ACM870517321. Alfa Chemistry ISO 9001:2015 Certified. Categories: PHBV. | |
| PFI-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFI-1 | PFI-1. Group: Biochemicals. Alternative Names: 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide; 2-Methoxy-N- (1, 2, 3, 4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl) benzenesulfonamide. Grades: Highly Purified. CAS No. 1403764-72-6. Pack Sizes: 5mg. Molecular Formula: C16H17N3O4S, Molecular Weight: 347.39. US Biological Life Sciences. | Worldwide |
| PFI-1 | PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated histone tails. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. Intriguingly, cells exposed to PFI-1 showed significant down-regulation of Aurora B kinase, thus attenuating phosphorylation of the Aurora substrate H3S10 providing an alternative strategy for the specific inhibition of this well established oncology target. Synonyms: PFI1; PFI 1; PFI-1. CAS No. 1403764-72-6. Molecular formula: C16H17N3O4S. Mole weight: 347.39. | |
| PFI-1 | PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated histone tails. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFI1; PFI 1; PFI-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1403764-72-6. Molecular formula: C16H17N3O4S. Mole weight: 347.39. Purity: >98%. IUPACName: 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(N(C)C3)=O)C=C2)=O. Product ID: ACM1403764726. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFM-1 mine. | |
| PFI-2 | PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. Synonyms: PFI-2; PFI 2; PFI2. Grades: >98%. CAS No. 1627676-59-8. Molecular formula: C23H25F4N3O3S. Mole weight: 499.52. | |
| PFI-2 hydrochloride | PFI-2 hydrochloride is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) and is approximately 1,000-fold selective over a panel of 18 other methyltransferases. Besides, following activation of the Hippo signaling pathway in MCF7 cells it inhibits. Synonyms: PFI-2 hydrochloride; PFI 2 hydrochloride; PFI2 hydrochloride; 8-fluoro-N-[(2R)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide;hydrochloride. CAS No. 1627607-87-7. Molecular formula: C23H26ClF4N3O3S. Mole weight: 535.98. | |
| PFI-2 hydrochloride | PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC 50 value of 2.0??nM and (S)-PFI-2 shows inhibiting activity with IC 50 ?value of?1.0??μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-PFI-2 hydrochloride. CAS No. 1627607-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18627A. | |
| PFI-2 Hydrochloride | PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0??nM and (S)-PFI-2 shows inhibiting activity with IC50 ?value of?1.0??μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFI-2; PFI2; PFI 2; (R)-PFI-2; (R)-PFI-2 hydrochloride. PFI-2 hydrochloride. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1627607-87-7. Molecular formula: C23H26ClF4N3O3S. Mole weight: 535.9826 g/mol. Purity: ≥98%. IUPACName: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride. Canonical SMILES: O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl. Product ID: ACM1627607877. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFI-3 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFI-3 | PFI-3, a potent and selective SMARCA2/4 bromodomain inhibitor, is a cell-permeable probe that binds avidly to the structurally-similar SMARCA4 bromodomain (Kd= 89 nM) and PB1(bromodomain 5) (Kd= 48 nM). Synonyms: PFI-3; PFI 3; PFI3. (E)-1-(2-hyd roxyphenyl)-3-[(1R,4R)-2-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-5-yl]prop-2-en-1-one; PF-06687252; PFI-3 compound; PF 06687252; PF06687252. Grades: >98%. CAS No. 1819363-80-8. Molecular formula: C19H19N3O2. Mole weight: 321.38. | |
| PFI-4 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFI-4 | PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM. Synonyms: PFI-4; PFI 4; PFI4. Grades: 98%. CAS No. 900305-37-5. Molecular formula: C21H24N4O3. Mole weight: 380.44. | |
| PFI-653 | PFI-653, also known as Vanin-1-IN-1, is an inhibitor of vanin-1 (VNN1) enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFI-653; PFI 653; PFI653; Vanin-1-IN-1; Vanin-1IN-1; Vanin-1 IN-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2173134-00-2. Molecular formula: C18H22N6O2. Mole weight: 354.41. Purity: >98%. IUPACName: (2-((pyrazin-2-ylmethyl)amino)pyrimidin-5-yl)(8-oxa-2-azaspiro[4.5]decan-2-yl)methanone. Canonical SMILES: O=C(N1CC2(CCOCC2)CC1)C3=CN=C(NCC4=NC=CN=C4)N=C3. Product ID: ACM2173134002. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFK15 | PFK15 is a potent and selective inhibitor of 6-phosphofructo-2-kinase (PFKFB3) with IC50 of 207 nM. Overexpression of the PFKFB3 enzyme leads to high glycolytic metabolism, which is required for cancer cells to survive in the harsh tumor microenvironment. Synonyms: PFK 015; PFK015; 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one. Grades: >98%. CAS No. 4382-63-2. Molecular formula: C17H12N2O. Mole weight: 260.29. | |
| PFK15 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFK-158 | PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFK158; PFK 158; PFK158; ACTPFK158. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29. Purity: >98%. IUPACName: (E)-1-(pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one. Canonical SMILES: O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2. Product ID: ACM1462249757. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFK-158 | PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells. Synonyms: PFK158; PFK 158; PFK158; ACTPFK158. Grades: >98%. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29. | |
| PFKFB3 Inhibitor, 3PO (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one) | A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| p-Fluoro-a-acetamidocinnamic Acid | p-Fluoro-a-acetamidocinnamic Acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| p-Fluorobenzyl Chloride | p-Fluorobenzyl Chloride. Group: Biochemicals. Alternative Names: α-Chloro-4-fluorotoluene; α-Chloro-p-fluorotoluene; 1-(Chloromethyl)-4-fluorobenzene; 4-Fluorobenzyl Chloride; 4-Fluorophenylmethyl Chloride; NSC 25084; 1-(Chloromethyl)-4-fluorobenzene. Grades: Highly Purified. CAS No. 352-11-4. Pack Sizes: 10g. Molecular Formula: C7H6ClF, Molecular Weight: 144.57. US Biological Life Sciences. | Worldwide |
| p-Fluoro-DL-phenylalanine | p-Fluoro-DL-phenylalanine. Uses: Peptide synthesis. Additional or Alternative Names: 4-fluoro-phenylalanine. Product Category: Amino Acids. CAS No. 51-65-0. Molecular formula: FC6H4CH2CH(NH2)COOH. Mole weight: 183.18. Canonical SMILES: NC(Cc1ccc(F)cc1)C(O)=O. ECNumber: 200-113-7. Product ID: ACM51650. Alfa Chemistry ISO 9001:2015 Certified. | |
| p-Fluorohexahydro-sila-difenidol hydrochloride | powder, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| p-Fluorophenyl-2-thienylketone | p-Fluorophenyl-2-thienylketone. Group: Biochemicals. Alternative Names: (4-Fluorophenyl)-2-thienylmethanone. Grades: Highly Purified. CAS No. 579-49-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| p-Fluoro Prasugrel Thiolactone. (Mixture of Diastereomers) | Intermediate in the synthesis of p-Fluoro Prasugrel (F595875). Group: Biochemicals. Alternative Names: 5-[2-Cyclopropyl-1-(4-fluorophenyl)-2-oxoethyl]-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| p-Fluoropropiophenone | p-Fluoropropiophenone. Group: Biochemicals. Grades: Highly Purified. CAS No. 456-03-1. Pack Sizes: 50g, 100g. US Biological Life Sciences. | Worldwide |
| p-Fluorostyrene | p-Fluorostyrene. Group: Monomers. Alternative Names: 4-Fluorostyrene, 97%, stabilized; AS03795; ST2403438; RTR-033260; 4-Fluorostyrene, 99%; AN-44804; 405-99-2; ACN-S004611; CTK3J0456; I01-7785. CAS No. 405-99-2. Product ID: 1-ethenyl-4-fluorobenzene. Molecular formula: 122.142g/mol. Mole weight: C8H7F. C=CC1=CC=C(C=C1)F. InChI=1S/C8H7F/c1-2-7-3-5-8 (9)6-4-7/h2-6H, 1H2. JWVTWJNGILGLAT-UHFFFAOYSA-N. | |
| PFM01 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFM 01 | PFM 01, a cell-permeable N-alkylated Mirin derivative, is a nuclease-specific MRE11 inhibitor, which enhances non-homologous end-joining (NHEJ) and reduces homologous recombination. Synonyms: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone; PFM01; PFM-01; PFM 01. Grades: ≥98% by HPLC. CAS No. 1558598-41-6. Molecular formula: C14H15NO2S2. Mole weight: 293.4. | |
| PFM39 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFN-B | PFN-B. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-1,4-phenylene]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 673474-79-8. Molecular formula: (C29H34N2)n. Product ID: ACM673474798-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFN (Belgium). | |
| PFNBr | PFNBr. Uses: Designed for use in research and industrial production. Product Category: Perovskite Solar Cells. CAS No. 673474-77-6. Product ID: ACM673474776. Alfa Chemistry ISO 9001:2015 Certified. Categories: 889672-99-5, Penbrook, Pennsylvania. | |
| PFN-Br | PFN-Br. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-bis(3'-((N,N-dimethyl)-N-ethylammonium)-propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)]dibromide. Product Category: Organic Light Emitting Diode (OLED). CAS No. 889672-99-5. Molecular formula: (C56H80N2Br2)n. Product ID: ACM889672995. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFC Brestnik 1948. | |
| PFN-diiodine salt | PFN-diiodine salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly{[(9,9-bis[3-(trimethylammonium)propyl-2,7-fluorene)]-alt-2,7-(9,9-dioctylfluorene)}diiodide. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1687752-60-8. Molecular formula: (C56H80N2I2)n. Product ID: ACM1687752608-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFN-DOF | Phosphorescent host material. Polymer for use in electron transport layer in OPV and OLED applications. Uses: Phosphorescent host material. polymer for use in electron transport layer in opv and oled applications. Group: Organic light-emitting diode (oled) materials. Alternative Names: Poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)]. CAS No. 673474-75-4. Mole weight: (C52H70N2)n. | |
| PFN-FP-I | PFN-FP-I. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-bis(3'-(N,N-trimethylamino)propyl)-2,7-fluorene)-alt-1,4-phenylene]diiodide. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1026670-72-3. Molecular formula: (C31H40I2N2)n. Product ID: ACM1026670723-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFN-OX | PFN-OX. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly{2,7-[9,9-bis(6'-(N,N-diethylamino)hexyl)fluorene]-alt-2,7-[9,9-bis(6-((3-ethyloxetan-3-yl)methoxy)hexyl)fluorene]}. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1345045-27-3. Molecular formula: (C70H102N2O4)nC12H10. Product ID: ACM1345045273. Alfa Chemistry ISO 9001:2015 Certified. Categories: Pano Xhixho. | |
| PFO | PFO. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly(9,9-dioctylfluorenyl-2,7-diyl). Product Category: Organic Light Emitting Diode (OLED). CAS No. 123864-00-6. Molecular formula: (C29H40)n. Product ID: ACM123864006. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFO-BPy | PFO-BPy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt-(6,6'-{2,2'-bipyridine})]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1423043-97-3. Molecular formula: (C39H46N2)n. Product ID: ACM1423043973-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFODBT | PFODBT. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[2,1,3-benzothiadiazole-4,7-diyl-2,5-thiophenediyl(9,9-dioctyl-9H-fluorene-2,7-diyl)-2,5-thiophenediyl];APO3,PFO-DBT;PFTBT. Product Category: Flexible Printed Electronics. CAS No. 782469-77-6. Purity: 95%+. Product ID: ACM782469776-2. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFO-DBT | PFO-DBT. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. | |
| PFO-DMP | PFO-DMP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly(9,9-dioctylfluorenyl-2,7-diyl) end capped with dimethylphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 874816-14-5. Molecular formula: C16H18(C29H40)n. Product ID: ACM874816145. Alfa Chemistry ISO 9001:2015 Certified. | |
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