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| Product | Description | |
|---|---|---|
| PF 184 | PF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM) with selectivity over 85 other kinases, demonstrating target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. Synonyms: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide; PF-184; PF184; PF 184. Grades: ≥98% by HPLC. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: 619.09. |  |
| PF 184 | PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. Group: Biochemicals. Alternative Names: 8- [ [ [5-Chloro-2- [3, 4-dimethyl-3, 4-bis (hydroxymethyl) -1-pyrrolidinyl] -4-pyridinyl] carbonyl] amino] -1- (4-fluorophenyl) -4, 5-dihydro-1H-benz [g] indazole-3-carboxamide. Grades: Highly Purified. CAS No. 1187460-81-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PF-232798 | PF-232798 is a second-generation oral CCR5 antagonist. It has broad-spectrum anti-HIV-1 activity. Synonyms: PF 232798; PF-00232798; CHEMBL1649931; 63P7W7886U; PF232798. Grades: 98%. CAS No. 849753-15-7. Molecular formula: C29H40FN5O2. Mole weight: 509.7. | |
| PF-2545920 | PF-2545920 a highly selective and potent PDE10A inhibitor. It was active with an ED50 of 1 mg/kg. Synonyms: PF-2545920; PF 2545920; PF2545920; MP-10; MP10; MP 10, Mardepodect. Grades: >98%. CAS No. 898562-94-2. Molecular formula: C25H20N4O. Mole weight: 392.45. | |
| PF-2545920 hydrochloride | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF2EH | PF2EH. Group: Organic light-emitting diode (oled) materials. Alternative Names: POLY(9 9-BIS-(2-ETHYLHEXYL)-9H-FLUORENE&; POLY(9,9-DI-(2-ETHYLHEXYL)FLUORENYL-2,&; Poly[9,9-di-(2-ethylhexyl)fluorenyl-2,7-diyl]; Poly[9,9-bis-(2-ethylhexyl)-9H-fluorene-2,7-diyl]; Poly[9,9-bis(2-ehtylhexyl)fluorenyl-2,7-diyl]; Poly[9,9-bis-(2-ethylhexyl)-9H-f. CAS No. 188201-16-3. Product ID: (2-amino-2-oxoethyl) 3-[benzyl-(4-chlorophenyl)sulfamoyl]-4-chlorobenzoate. Molecular formula: 493.4g/mol. Mole weight: C22H18Cl2N2O5S. C1=CC=C (C=C1)CN (C2=CC=C (C=C2)Cl)S (=O) (=O)C3=C (C=CC (=C3)C (=O)OCC (=O)N)Cl. InChI=1S / C22H18Cl2N2O5S / c23-17-7-9-18 (10-8-17) 26 (13-15-4-2-1-3-5-15) 32 (29, 30) 20-12-16 (6-11-19 (20) 24) 22 (28) 31-14-21 (25) 27 / h1-12H, 13-14H2, (H2, 25, 27). UZIUTJBYUHKEGE-UHFFFAOYSA-N. |  |
| PF-3084014 | PF-3084014 is a selective γ-secretase inhibitor (IC50 = 6.2 nM in a cell-free assay). It has been shown to inhibit self-renewal and proliferation of cancer stem cells. Synonyms: Nirogacestat; PF 3084014; PF3084014. Grades: >98%. CAS No. 1290543-63-3. Molecular formula: C27H41F2N5O. Mole weight: 489.66. | |
| PF 3084014 hydrobromide | PF 3084014 is a potent and selective γ-secretase inhibitor (IC50 = 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). It potently reduces Aβ relative to Notch-related endpoints in vitro and in vivo. Synonyms: Nirogacestat hydrobromide; (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide. Grades: ≥98% by HPLC. CAS No. 1962925-29-6. Molecular formula: C27H41F2N5O·HBr. Mole weight: 651.47. | |
| PF-3274167 | PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Synonyms: PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167. Grades: 98%. CAS No. 900510-03-4. Molecular formula: C19H19ClFN5O3. Mole weight: 419.84. | |
| PF 3644022 | PF 3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (IC50 = 5.2 nM; Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF 3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-onel; PF-3644022; PF 3644022; PF3644022. Grades: ≥98% by HPLC. CAS No. 1276121-88-0. Molecular formula: C21H18N4OS. Mole weight: 374.46. | |
| PF-3644022 | PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNF? production and has anti-inflammatory effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1276121-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107427. |  |
| PF-3644022 | PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Group: Biochemicals. Alternative Names: (10R)-9, 10, 11, 12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1, 4]diazepino[5', 6':4, 5]thieno[3, 2-f]quinolin-8-one. Grades: Highly Purified. CAS No. 1276121-88-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3644022 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-3716556 | PF 3716556 is a potent and selective P-CAB with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease. Synonyms: PF-03716556; PF 03716556; PF03716556; PF-3716556; PF 3716556; PF3716556. Grades: >98%. CAS No. 928774-43-0. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| PF-3758309 | PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 ( K d = 2.7 nM; K i =18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-03758309. CAS No. 898044-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13007. | |
| PF 3758309 dihydrochloride | PF 3758309 dihydrochloride is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 (IC50 = 1.3 nM; Kd = 2.7 nM). PF 3758309 inhibits phosphorylation of a natural PAK4 substrate in cells with an IC50 ~1 nM and inhibits anchorage-independent growth (expected biology for PAK4 inhibition) at 240 pM. Synonyms: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride; PF 3758309 dihydrochloride; PF3758309 dihydrochloride; PF-3758309 dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H30N8OS.2HCl. Mole weight: 563.55. | |
| PF-376304 | PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Synonyms: PF 376304; PF376304. Grades: 98%. CAS No. 851757-93-2. Molecular formula: C17H24N8O3. Mole weight: 388.42. | |
| PF-3774076 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 3845 | PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3845 | PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Synonyms: PF3845; PF-3845; PF 3845. Grades: 0.98. CAS No. 1196109-52-0. Molecular formula: C24H23F3N4O2. Mole weight: 456.469. | |
| PF-3845 | PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH) , with a K i of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196109-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14380. | |
| PF 3845 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4136309 | PF-4136309 is a potent, selective, and orally bioavailable antagonist of CCR2, a chemokine receptor of the super family of seven-transmembrane G-protein-coupled receptors (GPCRs). Synonyms: (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide; PF4136309; PF 4136309; PF04136309; PF-04136309; INCB8761; INCB 8761; INCB-8761. CAS No. 1341224-83-6. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. | |
| PF-4136309 | PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB8761. CAS No. 1341224-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13245. | |
| PF-4191834 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4217329 | PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well tolerated in preclinical species. Uses: Pf-04217329 is useful for intraocular pressure of glaucoma. Synonyms: PF-4217329, PF 4217329, PF4217329, PF-04217329, PF04217329, PF 04217329, Taprenepag isopropyl; Propan-2-yl 2- [3- [ [ (4-pyrazol-1-ylphenyl) methyl-pyridin-3-ylsulfonylamino] methyl] phenoxy] acetate; PF4217329; PF-04217329; PF04217329; Isopropyl 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetate. Grades: >98 %. CAS No. 1005549-94-9. Molecular formula: C27H28N4O5S. Mole weight: 520.60. | |
| PF 429242 | PF 429242 is a reversible, competitive, cell permeable inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM) without disrupting a panel of serine proteases. Some studies reported that the inhibition of SKI-1/S1P, a master lipo- 387 genic regulator, could impair HCV genome replication, lipid droplet 388 homeostasis and the production of infectious HCV virions. Synonyms: PF-429242; PF 429242; PF429242. Benzamide, 4-[(diethylamino)?methyl]?-N-[2-(2-methoxyphenyl)?ethyl]?-N-(3R)?-3-pyrrolidinyl-; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide. CAS No. 947303-87-9. Molecular formula: C25H35N3O2. Mole weight: 409.56. | |
| PF 429242 dihydrochloride | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Synonyms: PF-429242 dihydrochloride; PF429242 dihydrochloride. Grades: ≥97% by HPLC. CAS No. 2248666-66-0. Molecular formula: C25H35N3O2·2HCl. Mole weight: 482.49. | |
| PF-429242 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF429242 dihydrochloride | PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2248666-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13447A. | |
| PF 431396 | PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences. | Worldwide |
| PF-431396 | PF-431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Synonyms: PF-431396; PF 431396; PF431396. Grades: >98%. CAS No. 717906-29-1. Molecular formula: C22H21F3N6O3S. Mole weight: 506.5. | |
| PF-431396 | PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 717906-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10460. | |
| PF-431396 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4618433 | PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1166393-85-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18312. | |
| PF 4693627 | PF 4693627 is a potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) that has the potential to treat inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). Uses: Potential treatment of inflammation. Synonyms: PF-4693627; PF 4693627; PF4693627. 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide. Grades: 99%. CAS No. 1312815-93-2. Molecular formula: C26H29Cl2N3O3. Mole weight: 502.43. | |
| PF-4708671 | PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR. Synonyms: PF-4708671; PF4708671; PF 4708671. Grades: 0.98. CAS No. 1255517-76-0. Molecular formula: C19H21F3N6. Mole weight: 390.40545. | |
| PF-4708671 | PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Group: Biochemicals. Alternative Names: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671. Grades: Highly Purified. CAS No. 1255517-76-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-4708671 | PF-4708671 is a potent cell-permeable S6K1 inhibitor with a K i of 20 nM and IC 50 of 160 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255517-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15773. | |
| PF-4708671 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 477736 | Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| PF 477736 | PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF 00477736. CAS No. 952021-60-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10032. | |
| PF-477736 | PF-477736 is a proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. Synonyms: PF-477736; PF-477736; PF-477736; PF-00477736; PF00477736; PF 00477736. CAS No. 952021-60-2. Molecular formula: C22H25N7O2. Mole weight: 419.489. | |
| PF-477736 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 4778574 | PF 4778574 is a potent brain penetrant AMPA receptor positive allosteric modulator (PAM) (Ki = 85 nM) that has been shown to enhance cognition in animal models. Synonyms: PF-4778574; PF 4778574; PF4778574. N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide. Grades: ≥98% by HPLC. CAS No. 1219633-99-4. Molecular formula: C19H22N2O3S2. Mole weight: 390.52. | |
| PF-4778574 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 4800567 | PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM). Synonyms: PF 4800567; PF4800567; PF-4800567; 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine. Grades: 98%. CAS No. 1188296-52-7. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
| PF-4800567 | PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1? (IC50, 711 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1188296-52-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12470. | |
| PF 4800567 hydrochloride | PF 4800567 is a casein kinase 1e (CK1e) selective inhibitor that is 22 fold selective for the CK1e isoform over CK1d (IC50= 32 and 711 nM for CK1ε and CK1δ respectively). Synonyms: PF 4800567 hydrochloride; PF-4800567 hydrochloride; PF4800567 hydrochloride; 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 1391052-28-0. Molecular formula: C17H18ClN5O2.HCl. Mole weight: 396.27. | |
| PF-4800567 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4800567 Hydrochloride | PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. Group: Biochemicals. Alternative Names: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-4840154 | PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively. Uses: Pf-4840154 has been foundd to be superior than mustard oil as a trpa1 agonists. Synonyms: PF-4840154; PF 4840154; PF4840154. CHEMBL1818218; GTPL-6309; CS-5066; GTPL 6309; CS 5066; GTPL6309; CS5066; SCHEMBL17185544; BDBM50350947. Grades: 98%. CAS No. 1332708-14-1. Molecular formula: C26H38N6O2. Mole weight: 466.62. | |
| PF-4942847 | PF-4942847. Group: Biochemicals. Alternative Names: 2-Amino-4-[4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide; PF04942847. Grades: Highly Purified. CAS No. 1207961-33-8. Pack Sizes: 5mg. Molecular Formula: C22H23ClF3N7O2, Molecular Weight: 509.91. US Biological Life Sciences. | Worldwide |
| PF-4981517 | PF-4981517 (CYP3cide) is a potent, efficient, and specific time-dependent inactivator of human CYP3A4. Synonyms: CYP3cide, PF-04981517; PF 4981517; PF4981517. Grades: >98%. CAS No. 1390637-82-7. Molecular formula: C26H32N8. Mole weight: 456.59. | |
| PF-4989216 | PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. Although PF-4989216 inhibits the phosphorylation of PI3K downstream molecules in the NSCLCs with PTEN loss (NCI-H1650), PF-4989216 does not sufficiently induce anti-tumor efficacy in NCI-H1650. PF-4989216 is a potential cancer drug candidate for erlotinib resistant non-small-cell lung cancer patients with PIK3CA mutation. Synonyms: PF-4989216; PF 4989216; PF4989216. CAS No. 1276553-09-3. Molecular formula: C18H13FN6OS. Mole weight: 380.401. | |
| PF-4 (CXCL4) human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| PF-4 from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| PF 5006739 | PF 5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) (IC50 values are 3.9 and 17 nM, respectively). It mediates circadian rhythm phase-delaying effects in vivo. Synonyms: PF 5006739; PF5006739; PF-5006739; 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-Pyrimidinamine; 4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine. Grades: ≥98% by HPLC. CAS No. 1293395-67-1. Molecular formula: C22H22FN7O. Mole weight: 419.46. | |
| PF-5006739 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-5006739 | PF-5006739 is a potent and selective inhibitor of CK1?/? with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1293395-67-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12443. | |
| PF 5081090 | PF 5081090, a pyridone methylsulfone hydroxamate, is a potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa). Synonyms: PF 5081090; PF5081090; PF-5081090; (α R)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide; (2R)-4-[4-(2-Fluoro-4-methoxyphenyl)-2-oxo-2H-pyridin-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide. Grades: ≥98% by HPLC. CAS No. 1312473-63-4. Molecular formula: C18H21FN2O6S. Mole weight: 412.43. | |
| PF-5081090 | PF-5081090 is a pyridone methylsulfone hydroxamate LpxC inhibitor. PF-5081090 is used as an antibiotic in the treatment of serious gram-negative infections. Group: Biochemicals. Alternative Names: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide. Grades: Highly Purified. CAS No. 1312473-63-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PF-5081090 | PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LpxC-4. CAS No. 1312473-63-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103251. | |
| PF 514273 | PF 514273 is a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. Synonyms: PF 514273; PF514273; PF-514273; 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one. Grades: ≥98% by HPLC. CAS No. 851728-60-4. Molecular formula: C21H17Cl2F2N3O2. Mole weight: 452.28. | |
| PF 514273 | PF 514273. Group: Biochemicals. Grades: Purified. CAS No. 851728-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-514273 | A novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. Group: Biochemicals. Alternative Names: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one. Grades: Highly Purified. CAS No. 851728-60-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-514273 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-5190457 | PF-5190457 is a selective Growth hormone secretagogue receptor inverse agonist and it can increase insulin secretion in glucose-stimulated human islets. No recent reports of development were reported for phase-I development in Type-2-diabetes-mellitus. Uses: Type 2 diabetes mellitus. Synonyms: PF-5190457; PF 5190457; PF5190457; PF-05190457; PF05190457; PF 05190457; (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one. Grades: 95%. CAS No. 1334782-79-4. Molecular formula: C29H32N6OS. Mole weight: 512.67. | |
| PF-5190457 | PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-05190457. CAS No. 1334782-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12584. | |
| PF-5274857 | PF-5274857 is a potent and selective Smoothened (Smo) antagonist that inhibits Hedgehog (Hh) signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood-brain barrier. Synonyms: 1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one. Grades: >98%. CAS No. 1373615-35-0. Molecular formula: C20H25ClN4O3S. Mole weight: 436.96. | |
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