American Chemical Suppliers
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Product | Description | |
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PF184 Quick inquiry Where to buy Suppliers range | PF184. CAS No: 1187460-81-6 | Sarchem Laboratories New Jersey NJ |
PF-232798 Quick inquiry Where to buy Suppliers range | PF-232798 is a second-generation oral CCR5 antagonist. It has broad-spectrum anti-HIV-1 activity. Synonyms: PF 232798; PF-00232798; CHEMBL1649931; 63P7W7886U; PF232798. Grades: 98%. CAS No. 849753-15-7. Molecular formula: C29H40FN5O2. Mole weight: 509.7. | |
PF-2545920 Quick inquiry Where to buy Suppliers range | PF-2545920 a highly selective and potent PDE10A inhibitor. It was active with an ED50 of 1 mg/kg. Synonyms: PF-2545920; PF 2545920; PF2545920; MP-10; MP10; MP 10, Mardepodect. Grades: >98%. CAS No. 898562-94-2. Molecular formula: C25H20N4O. Mole weight: 392.45. | |
PF-2545920 hydrochloride Quick inquiry Where to buy Suppliers range | ≥97% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 898562-94-2 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 428.91. Catalog: ALP898562942. Assay: ≥97% (HPLC). | |
PF2EH Quick inquiry Where to buy Suppliers range | PF2EH. Group: Flexible Printed Electronics. Alternative Names: POLY(9 9-BIS-(2-ETHYLHEXYL)-9H-FLUORENE&;POLY(9,9-DI-(2-ETHYLHEXYL)FLUORENYL-2,&;Poly[9,9-di-(2-ethylhexyl)fluorenyl-2,7-diyl];Poly[9,9-bis-(2-ethylhexyl)-9H-fluorene-2,7-diyl];Poly[9,9-bis(2-ehtylhexyl)fluorenyl-2,7-diyl];Poly[9,9-bis-(2-ethylhexyl)-9H-f. CAS No. 188201-16-3. Molecular formula: (C29H40)n. | |
PF-3084014 Quick inquiry Where to buy Suppliers range | PF-3084014 is a selective γ-secretase inhibitor (IC50 = 6.2 nM in a cell-free assay). It has been shown to inhibit self-renewal and proliferation of cancer stem cells. Synonyms: Nirogacestat; PF 3084014; PF3084014. Grades: >98%. CAS No. 1290543-63-3. Molecular formula: C27H41F2N5O. Mole weight: 489.66. | |
PF 3084014 hydrobromide Quick inquiry Where to buy Suppliers range | PF 3084014 is a potent and selective γ-secretase inhibitor (IC50 = 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). It potently reduces Aβ relative to Notch-related endpoints in vitro and in vivo. Synonyms: Nirogacestat hydrobromide; (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide. Grades: ≥98% by HPLC. CAS No. 1962925-29-6. Molecular formula: C27H41F2N5O·HBr. Mole weight: 651.47. | |
PF-3274167 Quick inquiry Where to buy Suppliers range | PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Synonyms: PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167. Grades: 98%. CAS No. 900510-03-4. Molecular formula: C19H19ClFN5O3. Mole weight: 419.84. | |
PF 3644022 Quick inquiry Where to buy Suppliers range | PF 3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (IC50 = 5.2 nM; Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF 3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-onel; PF-3644022; PF 3644022; PF3644022. Grades: ≥98% by HPLC. CAS No. 1276121-88-0. Molecular formula: C21H18N4OS. Mole weight: 374.46. | |
PF-3644022 Quick inquiry Where to buy Suppliers range | PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Group: Biochemicals. Alternative Names: (10R)-9, 10, 11, 12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1, 4]diazepino[5', 6':4, 5]thieno[3, 2-f]quinolin-8-one. Grades: Highly Purified. CAS No. 1276121-88-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-3716556 Quick inquiry Where to buy Suppliers range | PF 3716556 is a potent and selective P-CAB with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease. Synonyms: PF-03716556; PF 03716556; PF03716556; PF-3716556; PF 3716556; PF3716556. Grades: >98%. CAS No. 928774-43-0. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
PF 3758309 dihydrochloride Quick inquiry Where to buy Suppliers range | PF 3758309 dihydrochloride is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 (IC50 = 1.3 nM; Kd = 2.7 nM). PF 3758309 inhibits phosphorylation of a natural PAK4 substrate in cells with an IC50 ~1 nM and inhibits anchorage-independent growth (expected biology for PAK4 inhibition) at 240 pM. Synonyms: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride; PF 3758309 dihydrochloride; PF3758309 dihydrochloride; PF-3758309 dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H30N8OS.2HCl. Mole weight: 563.55. | |
PF-376304 Quick inquiry Where to buy Suppliers range | PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Synonyms: PF 376304; PF376304. Grades: 98%. CAS No. 851757-93-2. Molecular formula: C17H24N8O3. Mole weight: 388.42. | |
PF 3845 Quick inquiry Where to buy Suppliers range | PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-3845 Quick inquiry Where to buy Suppliers range | PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Synonyms: PF3845; PF-3845; PF 3845. Grades: 0.98. CAS No. 1196109-52-0. Molecular formula: C24H23F3N4O2. Mole weight: 456.469. | |
PF-4136309 Quick inquiry Where to buy Suppliers range | PF-4136309 is a potent, selective, and orally bioavailable antagonist of CCR2, a chemokine receptor of the super family of seven-transmembrane G-protein-coupled receptors (GPCRs). Synonyms: (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide; PF4136309; PF 4136309; PF04136309; PF-04136309; INCB8761; INCB 8761; INCB-8761. CAS No. 1341224-83-6. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. | |
PF-4191834 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1029317-21-2. Pack Sizes: 5MG, 25MG. Mole weight: 393.50. Catalog: AP1029317212. Assay: ≥98% (HPLC). | |
PF-4217329 Quick inquiry Where to buy Suppliers range | PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well tolerated in preclinical species. Uses: Pf-04217329 is useful for intraocular pressure of glaucoma. Synonyms: PF-4217329, PF 4217329, PF4217329, PF-04217329, PF04217329, PF 04217329, Taprenepag isopropyl; Propan-2-yl 2- [3- [ [ (4-pyrazol-1-ylphenyl) methyl-pyridin-3-ylsulfonylamino] methyl] phenoxy] acetate; PF4217329; PF-04217329; PF04217329; Isopropyl 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetate. Grades: >98 %. CAS No. 1005549-94-9. Molecular formula: C27H28N4O5S. Mole weight: 520.60. | |
PF 429242 Quick inquiry Where to buy Suppliers range | PF 429242 is a reversible, competitive, cell permeable inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM) without disrupting a panel of serine proteases. Some studies reported that the inhibition of SKI-1/S1P, a master lipo- 387 genic regulator, could impair HCV genome replication, lipid droplet 388 homeostasis and the production of infectious HCV virions. Synonyms: PF-429242; PF 429242; PF429242. Benzamide, 4-[(diethylamino)?methyl]?-N-[2-(2-methoxyphenyl)?ethyl]?-N-(3R)?-3-pyrrolidinyl-; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide. CAS No. 947303-87-9. Molecular formula: C25H35N3O2. Mole weight: 409.56. | |
PF 429242 dihydrochloride Quick inquiry Where to buy Suppliers range | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Synonyms: PF-429242 dihydrochloride; PF429242 dihydrochloride. Grades: ≥97% by HPLC. CAS No. 2248666-66-0. Molecular formula: C25H35N3O2·2HCl. Mole weight: 482.49. | |
PF-429242 dihydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 947303-87-9 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 482.49. Catalog: ALP947303879. Assay: ≥98% (HPLC). | |
PF 431396 Quick inquiry Where to buy Suppliers range | PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences. | Worldwide |
PF-431396 Quick inquiry Where to buy Suppliers range | PF-431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Synonyms: PF-431396; PF 431396; PF431396. Grades: >98%. CAS No. 717906-29-1. Molecular formula: C22H21F3N6O3S. Mole weight: 506.5. | |
PF-431396 hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 717906-29-1 (anhydrous). Pack Sizes: 5MG, 25MG. Mole weight: 506.50 (anhydrous basis). Catalog: ALP717906291. Assay: ≥98% (HPLC). | |
PF 4693627 Quick inquiry Where to buy Suppliers range | PF 4693627 is a potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) that has the potential to treat inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). Uses: Potential treatment of inflammation. Synonyms: PF-4693627; PF 4693627; PF4693627. 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide. Grades: 99%. CAS No. 1312815-93-2. Molecular formula: C26H29Cl2N3O3. Mole weight: 502.43. | |
PF-4708671 Quick inquiry Where to buy Suppliers range | PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR. Synonyms: PF-4708671; PF4708671; PF 4708671. Grades: 0.98. CAS No. 1255517-76-0. Molecular formula: C19H21F3N6. Mole weight: 390.40545. | |
PF-4708671 Quick inquiry Where to buy Suppliers range | PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Group: Biochemicals. Alternative Names: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671. Grades: Highly Purified. CAS No. 1255517-76-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF 477736 Quick inquiry Where to buy Suppliers range | Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
PF-477736 Quick inquiry Where to buy Suppliers range | PF-477736 is a proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. Synonyms: PF-477736; PF-477736; PF-477736; PF-00477736; PF00477736; PF 00477736. CAS No. 952021-60-2. Molecular formula: C22H25N7O2. Mole weight: 419.489. | |
PF 4778574 Quick inquiry Where to buy Suppliers range | PF 4778574 is a potent brain penetrant AMPA receptor positive allosteric modulator (PAM) (Ki = 85 nM) that has been shown to enhance cognition in animal models. Synonyms: PF-4778574; PF 4778574; PF4778574. N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide. Grades: ≥98% by HPLC. CAS No. 1219633-99-4. Molecular formula: C19H22N2O3S2. Mole weight: 390.52. | |
PF 4800567 Quick inquiry Where to buy Suppliers range | PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM). Synonyms: PF 4800567; PF4800567; PF-4800567; 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine. Grades: 98%. CAS No. 1188296-52-7. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
PF 4800567 hydrochloride Quick inquiry Where to buy Suppliers range | PF 4800567 is a casein kinase 1e (CK1e) selective inhibitor that is 22 fold selective for the CK1e isoform over CK1d (IC50= 32 and 711 nM for CK1ε and CK1δ respectively). Synonyms: PF 4800567 hydrochloride; PF-4800567 hydrochloride; PF4800567 hydrochloride; 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 1391052-28-0. Molecular formula: C17H18ClN5O2.HCl. Mole weight: 396.27. | |
PF-4800567 Hydrochloride Quick inquiry Where to buy Suppliers range | PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. Group: Biochemicals. Alternative Names: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-4840154 Quick inquiry Where to buy Suppliers range | PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively. Uses: Pf-4840154 has been foundd to be superior than mustard oil as a trpa1 agonists. Synonyms: PF-4840154; PF 4840154; PF4840154. CHEMBL1818218; GTPL-6309; CS-5066; GTPL 6309; CS 5066; GTPL6309; CS5066; SCHEMBL17185544; BDBM50350947. Grades: 98%. CAS No. 1332708-14-1. Molecular formula: C26H38N6O2. Mole weight: 466.62. | |
PF-4942847 Quick inquiry Where to buy Suppliers range | PF-4942847. Group: Biochemicals. Alternative Names: 2-Amino-4-[4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide; PF04942847. Grades: Highly Purified. CAS No. 1207961-33-8. Pack Sizes: 5mg. Molecular Formula: C22H23ClF3N7O2, Molecular Weight: 509.91. US Biological Life Sciences. | Worldwide |
PF-4981517 Quick inquiry Where to buy Suppliers range | PF-4981517 (CYP3cide) is a potent, efficient, and specific time-dependent inactivator of human CYP3A4. Synonyms: CYP3cide, PF-04981517; PF 4981517; PF4981517. Grades: >98%. CAS No. 1390637-82-7. Molecular formula: C26H32N8. Mole weight: 456.59. | |
PF-4989216 Quick inquiry Where to buy Suppliers range | PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. Although PF-4989216 inhibits the phosphorylation of PI3K downstream molecules in the NSCLCs with PTEN loss (NCI-H1650), PF-4989216 does not sufficiently induce anti-tumor efficacy in NCI-H1650. PF-4989216 is a potential cancer drug candidate for erlotinib resistant non-small-cell lung cancer patients with PIK3CA mutation. Synonyms: PF-4989216; PF 4989216; PF4989216. CAS No. 1276553-09-3. Molecular formula: C18H13FN6OS. Mole weight: 380.401. | |
PF 5006739 Quick inquiry Where to buy Suppliers range | PF 5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) (IC50 values are 3.9 and 17 nM, respectively). It mediates circadian rhythm phase-delaying effects in vivo. Synonyms: PF 5006739; PF5006739; PF-5006739; 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-Pyrimidinamine; 4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine. Grades: ≥98% by HPLC. CAS No. 1293395-67-1. Molecular formula: C22H22FN7O. Mole weight: 419.46. | |
PF 5081090 Quick inquiry Where to buy Suppliers range | PF 5081090, a pyridone methylsulfone hydroxamate, is a potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa). Synonyms: PF 5081090; PF5081090; PF-5081090; (α R)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide; (2R)-4-[4-(2-Fluoro-4-methoxyphenyl)-2-oxo-2H-pyridin-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide. Grades: ≥98% by HPLC. CAS No. 1312473-63-4. Molecular formula: C18H21FN2O6S. Mole weight: 412.43. | |
PF-5081090 Quick inquiry Where to buy Suppliers range | PF-5081090 is a pyridone methylsulfone hydroxamate LpxC inhibitor. PF-5081090 is used as an antibiotic in the treatment of serious gram-negative infections. Group: Biochemicals. Alternative Names: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide. Grades: Highly Purified. CAS No. 1312473-63-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PF 514273 Quick inquiry Where to buy Suppliers range | PF 514273. Group: Biochemicals. Grades: Purified. CAS No. 851728-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PF 514273 Quick inquiry Where to buy Suppliers range | PF 514273 is a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. Synonyms: PF 514273; PF514273; PF-514273; 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one. Grades: ≥98% by HPLC. CAS No. 851728-60-4. Molecular formula: C21H17Cl2F2N3O2. Mole weight: 452.28. | |
PF-514273 Quick inquiry Where to buy Suppliers range | A novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. Group: Biochemicals. Alternative Names: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one. Grades: Highly Purified. CAS No. 851728-60-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-5190457 Quick inquiry Where to buy Suppliers range | PF-5190457 is a selective Growth hormone secretagogue receptor inverse agonist and it can increase insulin secretion in glucose-stimulated human islets. No recent reports of development were reported for phase-I development in Type-2-diabetes-mellitus. Uses: Type 2 diabetes mellitus. Synonyms: PF-5190457; PF 5190457; PF5190457; PF-05190457; PF05190457; PF 05190457; (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one. Grades: 95%. CAS No. 1334782-79-4. Molecular formula: C29H32N6OS. Mole weight: 512.67. | |
PF-5274857 Quick inquiry Where to buy Suppliers range | PF-5274857 is a potent and selective Smoothened (Smo) antagonist that inhibits Hedgehog (Hh) signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood-brain barrier. Synonyms: 1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one. Grades: >98%. CAS No. 1373615-35-0. Molecular formula: C20H25ClN4O3S. Mole weight: 436.96. | |
PF 5274857 hydrochloride Quick inquiry Where to buy Suppliers range | PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM), with >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. When administered orally, it distributes through plasma to skin and tumor and remains metabolically stable. PF 5274857 also penetrates the blood-brain barrier and inhibits Smo activity in the brain. Synonyms: PF 5274857 hydrochloride; PF5274857 hydrochloride; PF-5274857 hydrochloride; 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 1613439-62-5. Molecular formula: C20H25ClN4O3S.HCl. Mole weight: 473.42. | |
PF-5274857 hydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1373615-35-0 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 473.42. Catalog: ALP1373615350. Assay: ≥98% (HPLC). | |
PF-543 Quick inquiry Where to buy Suppliers range | PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(I) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. Uses: Enzyme inhibitors. Synonyms: PF-543; PF543; PF 543. Grades: 0.98. CAS No. 1415562-82-1. Molecular formula: C27H31NO4S. Mole weight: 465.60. | |
PF-543 Citrate Quick inquiry Where to buy Suppliers range | Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Synonyms: PF543 Citrate; PF 543 Citrate. Grades: >98%. CAS No. 1415562-83-2. Molecular formula: C33H39NO11S. Mole weight: 657.73. | |
PF-543 hydrochloride Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of PF-543, a novel SphK1 inhibitor that could exhibit activity in induceing necrosis in human colorectal cancer cells in biological studies. IC50: 2 nM; Ki: 3.6 nM. Synonyms: PF-543 hydrochloride; PF 543 hydrochloride; PF543 hydrochloride; (2R) -1-[[4-[[3-Methyl-5-[ (phenylsulfonyl) methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol Hydrochloride. Grades: 98%. CAS No. 1706522-79-3. Molecular formula: C27H31NO4S.HCl. Mole weight: 502.07. | |
PF-543 hydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1415562-82-1 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 502.07. Catalog: ALP1415562821. Assay: ≥98% (HPLC). | |
PF-562271 Quick inquiry Where to buy Suppliers range | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Synonyms: PF-562271; PF 562271; PF562271. Grades: >98%. CAS No. 717907-75-0. Molecular formula: C21H20F3N7O3S. Mole weight: 507.49. | |
PF-562271 Quick inquiry Where to buy Suppliers range | Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences. | Worldwide |
PF-562271 besylate Quick inquiry Where to buy Suppliers range | PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Synonyms: PF-562271 besylate; PF 562271 besylate; PF562271 besylate. Grades: >98%. CAS No. 939791-38-5. Molecular formula: C21H20F3N7O3S.C6H6O3S. Mole weight: 665.66. | |
PF-562271 hydrochloride Quick inquiry Where to buy Suppliers range | PF-562271 is an ATP-competitive, reversible inhibitor of FAK/PYK2. It blocked phosphorylation of FAK in a dose-dependent manner, inhibited migration of tumor cells, cancer-associated fibroblasts, and macrophages, resulting in suppression of tumor growth, invasion, and metastases. Synonyms: PF-562271 HCl; N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide hydrochloride. CAS No. 939791-41-0. Molecular formula: C21H21ClF3N7O3S. Mole weight: 543.95. | |
PF-573228 Quick inquiry Where to buy Suppliers range | PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50= 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. PF573228 was recognized to affect cell adhesion and migration in many types of cells. Synonyms: PF-573228; PF 573228; PF573228; PF573,228; PF-573; 228; PF 573; 228. Grades: 0.98. CAS No. 869288-64-2. Molecular formula: C22H20F3N5O3S. Mole weight: 491.489. | |
PF-573228 Quick inquiry Where to buy Suppliers range | A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-573228 Quick inquiry Where to buy Suppliers range | PF-573228 Inhibitor. Uses: Scientific use. Product Category: T2001. CAS No. 869288-64-2. | |
PF-622 Quick inquiry Where to buy Suppliers range | PF-622 is an irreversible FAAH inhibitor with selectivity for FAAH relative to other serine hydrolases. Synonyms: N-Phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide. Grades: >98%. CAS No. 898235-65-9. Molecular formula: C21H22N4O. Mole weight: 346.4. | |
PF-6260933 Quick inquiry Where to buy Suppliers range | PF-6260933 is a potent and selective inhibitor of MAP4K4. Synonyms: 5-(6-Aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine. CAS No. 1811510-56-1. Molecular formula: C16H13ClN4. Mole weight: 296.75. | |
PF 6274484 Quick inquiry Where to buy Suppliers range | PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively). Synonyms: PF 6274484; PF6274484; PF-6274484; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide. Grades: ≥98% by HPLC. CAS No. 1035638-91-5. Molecular formula: C18H14ClFN4O2. Mole weight: 372.78. | |
PF-6274484 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1035638-91-5. Pack Sizes: 5MG, 25MG. Mole weight: 372.78. Catalog: AP1035638915. Assay: ≥98% (HPLC). | |
PF 670462 Quick inquiry Where to buy Suppliers range | PF 670462. Group: Biochemicals. Grades: Purified. CAS No. 950912-80-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PF-670462 Quick inquiry Where to buy Suppliers range | PF-670462 is a potent and selective inhibitor of CK1ε in isolated enzyme preparations. It inhibits PER protein nuclear translocation causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo. It less effectively inhibits a wide variety of related or common kinases. It disrupts circadian rhythms in cells and animals and blocks the locomotor response to amphetamines in mice. It remains unclear whether one of the kinases has a predominant role in regulating the circadian clock. Synonyms: PF-670462; PF 670462; PF670462;PF-670462 HCl; PF-670462 hydrochloride. Grades: >98%. CAS No. 950912-80-8. Molecular formula: C19H22Cl2FN5. Mole weight: 410.32. | |
PF-68742 Quick inquiry Where to buy Suppliers range | PF-68742 is a new entry inhibitor of CCR5- and CXCR4- tropical strains of human immunodeficiency virus type 1 (HIV-1), targeting a new site on gp41. Synonyms: PF 68742; PF68742. Grades: ≥98% by HPLC. Molecular formula: C28H33FN4O6S. Mole weight: 572.65. | |
PF 750 Quick inquiry Where to buy Suppliers range | PF 750 is a potent, time-dependent, irreversible FAAH inhibitor (IC50 = 16.2 nM) that exhibits no activity at a range of other serine hydrolases. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. Synonyms: PF-750; PF 750; PF750. N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 959151-50-9. Molecular formula: C22H23N3O. Mole weight: 345.44. | |
PF 750 Quick inquiry Where to buy Suppliers range | Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system. Group: Biochemicals. Alternative Names: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide; N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide. Grades: Highly Purified. CAS No. 959151-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF 8380 Quick inquiry Where to buy Suppliers range | PF 8380. Group: Biochemicals. Grades: Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PF-8380 Quick inquiry Where to buy Suppliers range | PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester. Grades: ≥95%. CAS No. 1144035-53-9. Molecular formula: C22H21Cl2N3O5. Mole weight: 478.33. | |
PF8380 Quick inquiry Where to buy Suppliers range | PF8380. Group: Biochemicals. Alternative Names: 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic Acid 3,5-Dichlorobenzyl Ester; 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic Acid (3,5-Dichlorophenyl)methyl Ester. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C22H21Cl2N3O5, Molecular Weight: 478.33. US Biological Life Sciences. | Worldwide |