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| Product | Description | |
|---|---|---|
| PG-KII | PG-KII is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2; H-Pyr-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2; L-pyroglutamyl-L-prolyl-L-asparagyl-L-prolyl-L-alpha-aspartyl-L-alpha-glutamyl-L-phenylalanyl-L-valyl-glycyl-L-leucyl-L-methioninamide; L-Methioninamide, 5-oxo-L-prolyl-L-prolyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-α-glutamyl-L-phenylalanyl-L-valylglycyl-L-leucyl-; Kassinin-Like Peptide K-II; Recombinant Pseudophryne guentheri Kassinin-like peptide K-II. Grades: ≥95%. CAS No. 127633-77-6. Molecular formula: C55H81N13O17S. Mole weight: 1228.37. |  |
| PG-KIII | PG-KIII is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-His-Pro-Asn-Glu-Phe-Val-Gly-Leu-Met-NH2; Kassinin-Like Peptide K-III; Recombinant Pseudophryne guentheri Kassinin-like peptide K-III. Grades: ≥97%. Molecular formula: C57H83N15O15S. Mole weight: 1250.44. | |
| PG-L | PG-L is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: H-Glu-Gly-Gly-Gly-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; pGlu-Gly-Gly-Gly-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; litorin-like peptide L (PG-L); Recombinant Pseudophryne guentheri Bombesin-like peptide L; L-alpha-glutamyl-glycyl-glycyl-glycyl-L-prolyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide. Grades: ≥97%. Molecular formula: C62H86N18O16S. Mole weight: 1371.52. | |
| PGL-135 hydrochloride monohydrate | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| PGLa | PGLa is an antimicrobial peptide (AMP) composed of 21 amino acids which form an alpha-helical secondary structure. It has a wide variety of antimicrobial activity including activity against fungi, viruses, gram-negative and gram-positive bacteria, and cancer cells. Synonyms: PYLa/PGLa precursor; Gla peptide. Grades: ≥97% by HPLC. CAS No. 102068-15-5. Molecular formula: C88H162N26O22S. Mole weight: 1968.48. | |
| PGLa acetate | PGLa is an antimicrobial peptide (AMP) composed of 21 amino acids which form an alpha-helical secondary structure. It has a wide variety of antimicrobial activity including activity against fungi, viruses, gram-negative and gram-positive bacteria, and cancer cells. Synonyms: PYLa/PGLa precursor acetate; Gla peptide acetate. Molecular formula: C90H166N26O24S. Mole weight: 2028.51. | |
| PGLa-AM1 | PGLa-AM1 is an antimicrobial peptide found in Xenopus amieti (skin secretions of the African volcano frog, Pipidae), and has antibacterial activity. Synonyms: Gly-Met-Ala-Ser-Lys-Ala-Gly-Ser-Val-Leu-Gly-Lys-Val-Ala-Lys-Val-Ala-Leu-Lys-Ala-Ala-Leu-NH2. Grades: ≥95%. Molecular formula: C92H169N27O24S. Mole weight: 2069.59. | |
| PGLa-H | PGLa-H is an antimicrobial peptide found in Xenopus laevis (African clawed frog), and has antibacterial activity. Synonyms: Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu. Grades: ≥97%. CAS No. 1350308-37-0. Molecular formula: C50H95N13O11. Mole weight: 1054.37. | |
| PGLa-St2 | PGLa-St2 is an antimicrobial peptide found in the African clawed frog Silurana tropicalis, and has anti-gram-positive bacteria, gram-negative bacteria, fungal and Mammalian cells activity. Synonyms: Gly-Met-Ala-Thr-Lys-Ala-Gly-Thr-Ala-Phe-Gly-Lys-Ala-Ala-Lys-Ala-Ile-Ile-Gly-Ala-Ala-Leu-NH2. Grades: ≥96%. Molecular formula: C90H156N26O24S. Mole weight: 2018.46. | |
| pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin trifluoroacetate salt | ?96% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| pGlu-Arg-Thr-Lys-Arg-MCA | Synonyms: Pyr-Arg-Thr-Lys-Arg-AMC; L-Argininamide, 5-oxo-L-prolyl-L-arginyl-L-threonyl-L-lysyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; l-pyroglutamyl-l-arginyl-l-threonyl-l-lysyl-l-arginine 4-methylcoumaryl-7-amide. CAS No. 155575-02-3. Molecular formula: C37H57N13O9. Mole weight: 827.93. | |
| Pglu-his-gly amide trifluoroacetate salt | Pglu-his-gly amide trifluoroacetate salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PGLU-HIS-GLY AMIDE TRIFLUOROACETATE SALT;PGLU-HIS-GLY AMIDE TRIFLUOROACETATE. Product Category: Heterocyclic Organic Compound. CAS No. 174450-52-3. Molecular formula: C13H18N6O4. Mole weight: 322.32. Product ID: ACM174450523. Alfa Chemistry ISO 9001:2015 Certified. |  |
| pGlu-K(-NBD)-Q-R-L-G-N-Q-W-A-V-G-H-L-M-N | Synonyms: pGlu-K(-NBD)-QRLGNQWAVGHLMN; N6-(7-nitrobenzo[d][1,2,3]oxadiazol-4-yl)-N2-((S)-5-oxopyrrolidine-2-carbonyl)-L-lysyl-L-glutaminyl-L-arginyl-L-leucylglycyl-L-asparaginyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-L-methionyl-L-asparagine; H-Pyr-Lys(NBD)-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-Asn-OH. Grades: ≥95%. Molecular formula: C87H128N30O25S. Mole weight: 2026.23. | |
| pGlu-Leu-Thr-Phe-Thr-Ser-Ser-Trp-Gly-NH2 | pGlu-Leu-Thr-Phe-Thr-Ser-Ser-Trp-Gly-NH2 is a peptide hormone that stimulates the synthesis of 1,2-diacyl-sn-glycerols in the Manduca sexta fat body. Synonyms: AKH (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta); Pyr-Leu-Thr-Phe-Thr-Ser-Ser-Trp-Gly-NH2; Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta); L-pyroglutamyl-L-leucyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-seryl-L-tryptophyl-glycinamide; 5-Oxo-L-prolyl-L-leucyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-seryl-L-tryptophylglycinamide. Grades: ≥95%. CAS No. 99886-31-4. Molecular formula: C47H65N11O14. Mole weight: 1008.08. | |
| pGlu-Phe-Leu p-nitroanilide | protease substrate. Group: Fluorescence/luminescence spectroscopy. | |
| pGlu-Pro-Arg-MNA | pGlu-Pro-Arg-MNA is a peptide compound that has potential biology activity in many areas. Uses: Pglu-pro-arg-mna is a peptide compound that has potential biology activity in many areas. Synonyms: pGlu-PR-MNA; L-Argininamide, 5-oxo-L-prolyl-L-prolyl-N-(2-methoxy-4-nitrophenyl)-. Grades: 98%. CAS No. 130835-45-9. Molecular formula: C23H32N8O7. Mole weight: 532.55. | |
| PGMEA | PGMEA. Group: Solvents. Alternative Names: Propylene glycol monomethyl ether acetate. CAS No. 108-65-6. |  |
| pGp | pGp is a vital protein transporter found in many human tissues. It plays a crucial role in determining drug resistance in various cancers such as breast cancer and leukemia. Understanding the mechanisms of pGp in drug efflux can open up new avenues for drug development and personalized medicine. Synonyms: guanosine 3',5'-diphosphate; guanosine 3',5'-bis(dihydrogen phosphate). Grades: ≥90% by AX-HPLC. Molecular formula: C10H15N5O11P2. Mole weight: 443.20. | |
| PGP-4008 | PGP-4008 is a selective P-glycoprotein (P-gp) inhibitor without modulating multidrug resistance-related protein 1 (MRP1). In combination with doxorubicin, PGP-4008 inhibited tumor growth in a murine syngeneic Pgp-mediated MDR solid tumor model. Synonyms: N-(1-Benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide. Grades: ≥95%. CAS No. 365565-02-2. Molecular formula: C26H23N3O. Mole weight: 393.5. | |
| PGP-4008 | PGP-4008 is a specific P-glycoprotein ( Pgp ) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 365565-02-2. Pack Sizes: 10 mM * 1 mL; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119823. |  |
| pGpA | A STING agonist negative control (pGpA). Synonyms: 3'5'-pGpA sodium salt; 3'3'-cGAMP Control. CAS No. 20137-01-3. Molecular formula: C20H23N10O14P2.3Na. Mole weight: 758.38. | |
| PGPC | PGPC is an oxidized phospholipid formed under conditions of oxidative stress. It is a potent PPARα agonist. Synonyms: 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-glutaryl phosphatidylcholine; 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine; 2-O-glutaroyl-1-O-palmitoyl-sn-glycero-3-phosphocholine; PC(16:0/5:0(COOH)). Grades: ≥98%. CAS No. 89947-79-5. Molecular formula: C29H56NO10P. Mole weight: 609.73. | |
| PGPC | PGPC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-Palmitoyl-2-glutaryl phosphatidylcholine; 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-glutaryl phosphatidylcholine; 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine. Product Category: Heterocyclic Organic Compound. CAS No. 89947-79-5. Molecular formula: C29H56NO10P. Mole weight: 609.7. Purity: ≥98%. IUPACName: [(2R)-2-(4-carboxybutanoyloxy)-3-hexadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate. Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCC(=O)O. Product ID: ACM89947795. Alfa Chemistry ISO 9001:2015 Certified. Categories: PGPCoder. | |
| pGpG | pGpG is a STING agonist negative control and c-diGMP metabolite. Synonyms: P; -(5'-Guanosyl)-P; -(5'-guanosyl)-(3'?5')-diphosphate, Sodium salt. Grades: ≥ 95 % by HPLC. CAS No. 33008-99-0. Molecular formula: C20H26N10O15P2(free acid). Mole weight: 708.43 (free acid). | |
| P-gp inhibitor 1 | P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein -mediated multidrug resistance. Uses: Scientific research. Group: Signaling pathways. CAS No. 2050747-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101791. | |
| PGS-IN-1 | PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) (IC50= 0.28 μM) and also an inhibitor of 5-lipoxygenase (IC50= 1.05 μM). Synonyms: (3E)-3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]oxolan-2-one; alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)gamma-butyrolactone; KME 4; KME-4. CAS No. 102271-49-8. Molecular formula: C19H26O3. Mole weight: 302.41. | |
| PG-SPI | PG-SPI is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Phe-Gly-Leu-Met-NH2; Substance P-like peptide 1; Recombinant Pseudophryne guentheri Substance P-like peptide 1; H-Pyr-Pro-Asn-Pro-Asp-Glu-Phe-Phe-Gly-Leu-Met-NH2; L-pyroglutamyl-L-prolyl-L-asparagyl-L-prolyl-L-alpha-aspartyl-L-alpha-glutamyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl-L-methioninamide; (4S)-5-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-4-oxo-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-5-oxopentanoic acid. Grades: ≥96%. Molecular formula: C59H81N13O17S. Mole weight: 1276.43. | |
| PG-SPII | PG-SPII is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-Asn-Pro-Asn-Glu-Phe-Phe-Gly-Leu-Met-NH2; Substance P-Like Peptide II; Recombinant Pseudophryne guentheri Substance P-like peptide II. Grades: ≥96%. Molecular formula: C59H82N14O16S. Mole weight: 1275.45. | |
| PGW-310 | PGW-310 is a blood type O glycosylceramide. Synonyms: α-L-Fucosyl-β-D-lactosyl-β-ceramide; Fucosyl-lactosyl-beta-ceramide; Fuc1-α-2Gal1-β-4Glc-β-Ceramide. Molecular formula: C62H117NO17. Mole weight: 1148.59. | |
| PH-002 | PH-002 is an inhibitor of apolipoprotein E4 (ApoE4) intramolecular domain interaction in neuronal cells. It prevents impairments of mitochondrial motility and neurite outgrowth. Synonyms: Tert-butyl 4- [ [4- [ [2- (3-methyl-4-oxophthalazin-1-yl) acetyl] amino] phenyl] methyl] piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1311174-68-1. Molecular formula: C27H33N5O4. Mole weight: 491.58. | |
| PH-002 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PH-064 | PH-064 is a sodium channel inhibitor. It is extracted from patent FR 2879460 A1. Synonyms: BIM-46187; BIM 46187; BIM46187; PH-064; PH 064; PH064; (2R)-2-amino-3-[[(2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl)-2-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]-3-oxopropyl]disulfanyl]-1-[(8S)-8-(cyclohexylmethyl)-2-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]propan-1-one;Imidazo[1,2-a]pyrazine, 7,7'-[dithiobis[(2R)-2-aMino-1-oxo-3,1-propanediyl]]bis[8-(cyclohexylMethyl)-5,6,7,8-tetrahydro-2-phenyl-, (8S,8'S)- (9CI). Grades: >98 %. CAS No. 892546-37-1. Molecular formula: C44H58N8O2S2. Mole weight: 795.11. | |
| PH11 | PH11, an imidazotriazin derivative, has been found to be a FAK inhibitor that could have probable activity in anticancer studies. Synonyms: PH11; PH-11; PH 11; methyl 2-((4-((3,4,5-trimethoxyphenyl)amino)imidazo[1,2-a][1,3,5]triazin-2-yl)amino)benzoate. Grades: 98%. CAS No. 1627843-95-1. Molecular formula: C22H22N6O5. Mole weight: 450.46. | |
| pH 12.5 Buffer - 500mL | certified reference material. Group: Certified reference materials (crms). | |
| pH <791> PT | Proficiency Testing Material. Group: Atomic absorption spectroscopy (aas). | |
| PH-797804 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PH-797804 | PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase. PH-797804 exhibited exceptionally high specificity against MAP kinases and the related kinases. No cross-reactivity was observed in large panels of kinase screens (selectivity ratio of >500-fold). In cellular assays, PH-797804 demonstrated superior potency and selectivity consistent with the biochemical measurements. PH-797804 has met safety criteria in human phase I studies and is under clinical development for several inflammatory conditions. Understanding the rationale for selectivity at the molecular level helps elucidate the biological function and design of specific p38alpha kinase inhibitors. Synonyms: PH 797804; PH797804; 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide. CAS No. 586379-66-0. Molecular formula: C22H19BrF2N2O3. Mole weight: 477.30. | |
| PH-797804 | PH-797804 is a ATP-competitive, selective p38?/p38? inhibitor (IC50=26 nM and Ki=5.8 nM for p38?; Ki=40 nM for p38?) and does not inhibit JNK2. Uses: Scientific research. Group: Signaling pathways. CAS No. 586379-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10403. | |
| PHA 408 | PHA 408 is a selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50 = 40 nM), which binds IKK-2 tightly with a relatively slow off rate. Synonyms: PHA 408; PHA408; PHA-408; 8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide. Grades: 99%. CAS No. 503555-55-3. Molecular formula: C29H27ClFN7O2. Mole weight: 560.02. | |
| PHA-408 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PHA-543613 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PHA-543613 | PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a K i of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors [1]. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 478149-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105670. | |
| PHA 543613 dihydrochloride | PHA 543613 dihydrochloride is a potent and selective α7 nicotinic acetylcholine receptor (nAChR) agonist with rapid brain penetration and high oral bioavailability. PHA 543613 is potentially used for the treatment of cognitive deficits in schizophrenia. Uses: Potential treatment of cognitive deficits in schizophrenia. Synonyms: PHA 543613 dihydrochloride; PHA543613 dihydrochloride; PHA-543613 dihydrochloride; N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide dihydrochloride. Grades: 99%. CAS No. 478148-58-2. Molecular formula: C15H17N3O2.2HCl. Mole weight: 344.24. | |
| PHA-543613 Dihydrochloride | PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer?s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays. Group: Biochemicals. Alternative Names: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride;PHA 543613E. Grades: Highly Purified. CAS No. 478148-58-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PHA 543613 hydrochloride | PHA 543613 is a potent and selective α7 nAChR agonist. It was shown to reduce Aβ-induced cognitive deficits and increase the α7 protein level and subsequent neuron survival. It has been developed as a potential therapeutic agent for cognitive deficits in schizophrenia. Synonyms: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride; N-(1-azabicyclo[2.2.2]octan-3-yl)furo[2,3-c]pyridine-5-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1586767-92-1. Molecular formula: C15H17N3O2·HCl. Mole weight: 307.78. | |
| PHA-543,613 (N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (alpha7 nAChR) Agonist, PHA-543613) | A potent agonist highly selective for alpha7 nicotinic acetylcholine receptor (alpha7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of alpha7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 478149-53-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PHA 568487 | Selective α7 nAChR agonist. Agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively, IC50 values are > 100 μM for α3 β4 and α1 β1δγ respectively, and % inhibition is < 1 and 5% for α4 β2 and hERG respectively). Orally active and brain penetrant. Group: Biochemicals. Alternative Names: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide Fumarate. Grades: Highly Purified. CAS No. 527680-57-5. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 404.41. US Biological Life Sciences. | Worldwide |
| PHA 568487 | PHA 568487 is an orally active and brain penetrant agonist of the alpha 7 nicotinic acetylcholine receptor (Ki = 44 and 2800 for α7 and 5-HT3 respectively, IC50=> 100 μM for α3β4 and α1β1δγ respectively, and % inhibition is < 1 and 5% for α4β2 and hERG respectively), which was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability. Synonyms: PHA 568487; PHA568487; PHA-568487; N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate. Grades: ≥99% by HPLC. CAS No. 527680-57-5. Molecular formula: C16H20N2O3.C4H4O4. Mole weight: 404.41. | |
| PHA 568487 free base | PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor ( α-7 nAchR ) agonist. PHA 568487 free base reduces neuroinflammation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 527680-56-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129674. | |
| PHA665752 | PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling c-Met is highly expressed in most tumors from patients with advanced-stage, metastatic NBL. Furthermore, using the NBL cell line SH-EP as a model, PHA665752 was shown to inhibit cMet/HGF/SF signaling in vitro, suggesting c-Met inhibitors may have efficacy for blocking local progression and/or metastatic spread of c-Met-positive NBL in vivo. These are novel findings for this disease and suggest that further studies of agents targeting the c-Met/HGF axis in NBL are warranted. Synonyms: PHA-665752; PHA 665752. Grades: >98%. CAS No. 477575-56-7. Molecular formula: C32H34Cl2N4O4S. Mole weight: 641.608. | |
| PHA-665752 | PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase ( K i=4 nM; IC 50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 477575-56-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11107. | |
| PHA-665752-d8 Hydrate | PHA-665752-d8 Hydrate. Group: Biochemicals. Alternative Names: (3Z) -5-[[ (2, 6-dichlorophenyl) methyl]sulfonyl]-3-[[3, 5-dimethyl-4-[[ (2R) -2- (1-pyrrolidinylmethyl) -1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1, 3-dihydro-2H-indol-2-one-d8 Hydrate; PHA 665752-d8 Hydrate. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C32H26D8Cl2N4O4S; xH2O, Molecular Weight: 649.66. US Biological Life Sciences. | Worldwide |
| PHA-665752 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PHA-665752 Hydrate | PHA-665752 ia a c-Met kinase inhibitor. PHA-665752 is ATP-competitive, an active-site inhibitor with greater than 50-fold selectivity for c-Met vs a panel of tyrosine and serine-threonine kinases. Group: Biochemicals. Alternative Names: (3Z) -5-[[ (2, 6-dichlorophenyl) methyl]sulfonyl]-3-[[3, 5-dimethyl-4-[[ (2R) -2- (1-pyrrolidinylmethyl) -1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1, 3-dihydro-2H-indol-2-one Hydrate; PHA 665752 Hydrate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PHA-680626 | PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 μM), Plk2 (IC50 = 0.07 μM) and Plk3 (IC50 = 1.61 μM). Synonyms: PHA 680626; PHA680626; 1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 15; 4-(4-Methyl-piperazin-1-yl)-N-[5-(2-thiophen-2-yl-acetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-benzamide. Grades: 98%. CAS No. 398493-74-8. Molecular formula: C23H26N6O2S. Mole weight: 450.56. | |
| PHA-680632 | PHA-680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM. PHA-680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic. Synonyms: PHA-680632; PHA 680632; PHA680632. CAS No. 398493-79-3. Molecular formula: C28H35N7O2. Mole weight: 501.62. | |
| PHA-767491 | PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Synonyms: PHA-767491; PHA767491; PHA 767491. CAS No. 845714-00-3. Molecular formula: C12H11N3O. Mole weight: 213.24. | |
| PHA-767491 | PHA-767491 is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CAY10572. CAS No. 845714-00-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13461. | |
| PHA 767491 Dihydrochloride Salt | A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2). Group: Biochemicals. Alternative Names: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride;PHA 767491 Dihydrochloride Salt; PF-02334471. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PHA 767491 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PHA 767491 hydrochloride | PHA 767491 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 942425-68-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PHA-767491 hydrochloride | PHA-767491 hydrochloride is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor, which prevents initiation of DNA replication. It inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. It also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2). Synonyms: CAY-10572 hydrochloride; PHA-767491 hydrochloride; CAY 10572 hydrochloride; PHA 767491 hydrochloride; CAY10572 hydrochloride; PHA767491 hydrochloride. Grades: >98%. CAS No. 942425-68-5. Molecular formula: C12H12ClN3O. Mole weight: 249.7. | |
| PHA-767491 hydrochloride | PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CAY-10572 hydrochloride. CAS No. 942425-68-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13461A. | |
| PHA-793887 | PHA-793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. Although toxicity was acceptable at initial dose levels, PHA-793887 was poorly tolerated at doses ≥44 mg/m2. The most frequent events across all dose levels were gastrointestinal or nervous system events. PHA-793887 induces severe, dose-related hepatic toxicity, which was not predicted by pre-clinical models and currently precludes its further clinical development. Synonyms: PHA 793887; PHA793887. Grades: >98%. CAS No. 718630-59-2. Molecular formula: C19H31N5O2. Mole weight: 361.48. | |
| PHA-793887 | PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC50s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3? with an IC50 of 79 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 718630-59-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11001. | |
| Phaclofen | Phaclofen, a phosphonic acid derivative of Baclofen, is a selective GABAB antagonist. Uses: Gaba antagonists. Synonyms: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid. Grades: ≥97% by HPLC. CAS No. 114012-12-3. Molecular formula: C9H13ClNO3P. Mole weight: 249.63. | |
| Phaclofen | Phaclofen is a selective GABA B receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 114012-12-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-100798. | |
| Phaclofen | Phaclofen. Group: Biochemicals. Grades: Purified. CAS No. 114012-12-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Phaclofen | solid. Group: Fluorescence/luminescence spectroscopy. | |
| Phacolysine sodium salt | Phacolysine sodium salt. Group: Biochemicals. Alternative Names: 5,12-Dihydroquinoxalino[2,3-b]phenazine-2,9-disulfonic acid sodium salt; Jing ming; Phacolin. Grades: Highly Purified. CAS No. 3863-80-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C18H10N4Na2O6S2. US Biological Life Sciences. | Worldwide |
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