American Chemical Suppliers
A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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Product | Description | |
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PF-04856264 Quick inquiry Where to buy Suppliers range | 1235397-05-3, PF-04856264, 3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide, CHEMBL2324000, 3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide, 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide, SCHEMBL16530690, BDBM50024250, AKOS025148666, CCG-358117, NCGC00485173-01, HY-12811, MS-27840, CS-0012528, F82053, PF-04856264, >=98% (HPLC), F1905-6532. | |
PF-04859989 Quick inquiry Where to buy Suppliers range | PF-04859989 Inhibitor. Uses: Scientific use. Product Category: T28368. CAS No. 177943-33-8. | |
PF-04880594 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1111636-35-1. Pack Sizes: 5MG, 25MG. Mole weight: 394.38. Catalog: AP1111636351. Assay: ≥98% (HPLC). | |
PF-04880594 Quick inquiry Where to buy Suppliers range | PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Synonyms: PF04880594; PF 04880594; 3-((4-(1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propanenitrile. CAS No. 1111636-35-1. Molecular formula: C19H16F2N8. Mole weight: 394.39. | |
PF 04885614 Quick inquiry Where to buy Suppliers range | PF 04885614 is a potent and selective Nav1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), with selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50= 4.2, 7.0, 11, 16 and 27 μM respectively). Synonyms: PF 04885614; PF04885614; PF-04885614; 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine. Grades: ≥98% by HPLC. Molecular formula: C13H14F3N3O. Mole weight: 285.26. | |
PF-04929113 Quick inquiry Where to buy Suppliers range | PF-04929113, also known as SNX-5422, is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate; SNX5422; SNX-5422; SNX 5422; PF4929113; PF-4929113; PF 4929113; PF04929113; PF 04929113; PF-04929113. Grades: >97%. CAS No. 908115-27-5. Molecular formula: C25H30F3N5O4. Mole weight: 521.53. | |
PF-04929113 mesylate Quick inquiry Where to buy Suppliers range | The methlate salt form of PF-04929113 that has potential antineoplastic activity targeting Hsp90. It could probably result in the proteasomal degradation of oncogenic client proteins and the restrain of tumor cell proliferation. Uses: The methlate salt form of pf-04929113 that has potential antineoplastic activity targeting hsp90. Synonyms: PF-04929113 mesylate; PF 04929113 mesylate; PF04929113 mesylate; (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate mesylate; PF-04929113 mesylate; SNX5422; SNX-5422; SNX 5422; PF4929113; PF-4929113; PF 4929113; PF04929113; PF 04929113; PF-04929113. Grades: 98%. CAS No. 1173111-67-5. Molecular formula: C26H34F3N5O7S. Mole weight: 617.64. | |
PF-04937319 Quick inquiry Where to buy Suppliers range | This active molecular is a glucokinase activator originated by Pfizer and EC50 value is 174 nM. PF-04937319 can improve glycemic control in adults with type 2 diabetes when applicated in conjunction with metformin and it can also maintain lower-glucose levels without it resulting in hypoglycemia. However,clinical trials were discontinued for Type 2 diabetes mellitus in 2016. Uses: Type 2 diabetes mellitus. Synonyms: PF-04937319; PF04937319; PF 04937319; PF-4937319; PF 4937319; PF4937319; N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide. Grades: 98%. CAS No. 1245603-92-2. Molecular formula: C22H20N6O4. Mole weight: 432.44. | |
PF-04942487 Quick inquiry Where to buy Suppliers range | PF-4942847 is a novel oral Hsp90 inhibitor, which is a candidate for clinical development in TNBC by collaboratively targeting multiple signaling pathways. In addition, AKT degradation in PBLs may serve as a biomarker in clinical development. Synonyms: PF4942847; PF 4942847; PF-04942847. Grades: >98%. CAS No. 1046859-34-0. Molecular formula: C20H18Cl2F3N7O2. Mole weight: 516.31. | |
PF-04971729 Quick inquiry Where to buy Suppliers range | Cas No. 1210344-57-2. | |
PF-04991532 Quick inquiry Where to buy Suppliers range | This active molecular is a hepatoselective glucokinase activator that reduces MDG (mean daily glucose), FPG (fasting plasma glucose) and glucose excursion in humans. PF-04991532 may offer glycemic control without inducing hepatic steatosis. PF-04991532 was developed by Pfizer but was discontinued in Phase-II for Type-2 diabetes mellitus in USA in 2012. Uses: Type 2 diabetes mellitus. Synonyms: PF-04991532; PF 04991532; PF04991532; PF-4991532; PF4991532; PF 4991532; UNII-AJ212MS2O2; CHEMBL2165620; AJ212MS2O2; SCHEMBL1711504; BDBM50394681; 6-[[(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)imidazol-1-yl]propanoyl]amino]pyridine-3-carboxylic acid. Grades: 98%. CAS No. 1215197-37-7. Molecular formula: C18H19F3N4O3. Mole weight: 396.37. | |
PF-04995274 Quick inquiry Where to buy Suppliers range | PF-04995274 is a 5-HT4 receptor partial agonist with Ki = 0.15 - 0.46 nM for 5-HT4 isoforms a, b, d and e, developed for the treatment of Alzheimer's disease (AD). Synonyms: (R)-4-((4-(((4-(Tetrahydrofuran-3-yloxy)-1,2-benzisoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol; PF-04995274; PF 04995274; PF04995274; PF-4995274; PF 4995274; PF4995274. CAS No. 1331782-27-4. Molecular formula: C23H32N2O6. Mole weight: 432.52. | |
PF-05020182 Quick inquiry Where to buy Suppliers range | PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener originated by Pfizer. It can inhibit convulsions in the MES assay at doses tested, consistent with in vitro activity measure. PF-05020182 may be applicated for adjunctive treatment of refractory epilepsy. Uses: Refractory epilepsy. Synonyms: PF05020182; PF-05020182; PF 05020182; PF5020182; PF-5020182; PF 5020182. N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl-butanamide. Grades: 98%. CAS No. 1354712-92-7. Molecular formula: C18H30N4O4. Mole weight: 366.46. | |
PF-05082566 Quick inquiry Where to buy Suppliers range | A fully humanized monoclonal antibody (mAb) that stimulates signaling through 4-1BB (CD-137), a protein expressed in many immune cells. Synonyms: Utomilumab; PF-2566; PF-5082566; PF 2566; PF 5082566; PF2566; PF5082566. CAS No. 1417318-27-4. | |
PF-05089771 Quick inquiry Where to buy Suppliers range | PF-05089771, a Nav1.7 channel blocker, has been studied to have potential effect in the treatment of chronic neuropathic pain. It is still under Phase II clinical trial. IC50: 8.6 nM. Uses: Pf-05089771 is a nav1.7 channel blocker that has been studied to have potential effect in the treatment of chronic neuropathic pain. Synonyms: PF 05089771; PF05089771; PF-05089771; 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide; SCHEMBL1095065; CHEMBL2325014; ZYSCOUXLBXGGIM-UHFFFAOYSA-N. Grades: 98%. CAS No. 1235403-62-9. Molecular formula: C18H12Cl2FN5O3S2. Mole weight: 500.35. | |
PF 05089771 tosylate Quick inquiry Where to buy Suppliers range | PF 05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. It exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Synonyms: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate; PF-05089771; PF05089771; PF 05089771 Tosylate. Grades: ≥98% by HPLC. CAS No. 1430806-04-4. Molecular formula: C18H12Cl2FN5O3S2.C7H8O3S. Mole weight: 672.56. | |
PF 05105679 Quick inquiry Where to buy Suppliers range | PF-05105679 is a selective TRPM8 Antagonist with clinical efficacy in cold-related pain. IC50 value is 103 nM. It shows >100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels. In Sep 2011, Pfizer completed a phase I trial for the treatment of neuropathic pain in Healthy volunteers in Belgium. Uses: Neuropathic pain;cold-related pain. Synonyms: PF-05105679; PF 05105679; PF05105679; PF-5105679; PF 5105679; PF5105679. 3-[[[(1R)-1-(4-Fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]-benzoic acid, PF05105679, [(R)-3-[(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)amino]methylbenzoic acid. Grades: 98%. CAS No. 1398583-31-7. Molecular formula: C26H21FN2O3. Mole weight: 428.45. | |
PF-05139962 Quick inquiry Where to buy Suppliers range | PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor. Synonyms: PF 05139962; PF05139962. CAS No. 1393712-18-9. Molecular formula: C21H27N5O4S. Mole weight: 445.54. | |
PF 05175157 Quick inquiry Where to buy Suppliers range | PF-05175157 is a selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 and isoform ACC2 dominant. IC50 values are 27 nM and 33 nM, respectively. It was originated by Pfizer. ACC inihibitors can inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids. In Feb 2015, Phase-II for Type-2 diabetes mellitus in USA was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: PF-05175157; PF05175157; 1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one. Grades: 98%. CAS No. 1301214-47-0. Molecular formula: C23H27N5O2. Mole weight: 405.50. | |
PF 05180999 Quick inquiry Where to buy Suppliers range | PF 05180999 is a potent and selective PDE2A inhibitor (IC50 = 1 nM), with 2000-fold selectivity for PDE2A over PDE10A. PF 05180999 was evaluated for schizophrenia and migraine, but no further development has been reported since 2014. Synonyms: 4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine; PF05180999; PF-05180999; PF 5180999; PF5180999; PF-5180999; PF 5180999; PF999; PF-999; PF 999. Grades: ≥98% by HPLC. CAS No. 1394033-54-5. Molecular formula: C19H17F3N8. Mole weight: 414.39. | |
PF 05212384 (PKI-587) (N-[4-[[4-(Dimethylamino)-1-piperidi nyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1, 3,5-triazin-2-yl)phenyl]urea) Quick inquiry Where to buy Suppliers range | Potent and selective dual inhibitor of PI 3-kinase/mTOR (IC50 values are 0.4, 1.6 and 5.4nm for PI 3-Kalpha, mTOR and PI 3-Kgamma respectively). Exhibits selectivity over 234 other protein kinases (IC50 >10um). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC50 < 100nm). Also exhibits antitumor activity in MDA-361, HCT-116, H1975 and U87MG xenograft models. Group: Biochemicals. Grades: Highly Purified. CAS No. 1197160-78-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF-05221304 Quick inquiry Where to buy Suppliers range | PF-05221304 Inhibitor. Uses: Scientific use. Product Category: T9209. CAS No. 1370448-25-1. | |
PF-05231023 Quick inquiry Where to buy Suppliers range | PF-05231023 is a long-acting FGF21 mimic. PF-05231023 can reduce the weight of non-human primates and patients with type 2 diabetes and improve blood lipid status. It is a PEG-based PROTAC linker that can be used to synthesize PROTAC. Synonyms: Mal-Amido-PEG2-C2-Amido-Ph-C2-CO-AZD; 2, 5-Dihydro-2, 5-Dioxo-N- (2- (2- (3-Oxo-3- ( (4- (3-Oxo-3- (2-Oxo-1-Azetidinyl) Propyl) Phenyl) Amino) Propoxy) Ethoxy) Ethyl) -1H-Pyrrole-1-Propanamide; 2, 5-Dihydro-2, 5-Dioxo-N- [2- [2- [3-Oxo-3- [ [4- [3-Oxo-3- (2-Oxo-1-Azetidinyl) Propyl] Phenyl] Amino] Propoxy] Ethoxy] Ethyl] -1H-Pyrrole-1-Propanamide. Grades: ≥98% by HPLC. CAS No. 1037589-69-7. Molecular formula: C26H32N4O8. Mole weight: 528.6. | |
PF-05236216 hydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1383376-93-9 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 358.80. Catalog: ALP1383376939. Assay: ≥98% (HPLC). | |
PF-05241328 Quick inquiry Where to buy Suppliers range | PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50 = 31nM) for the treatment of pain. But PF-05241328 is studied to have poor solubility and likely solubility limited absorption. Synonyms: PF-05241328; PF 05241328; PF05241328; PF-5241328; PF 5241328; PF5241328. 1-(5-Chloro-6-(2-methylpropoxy)-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide; 1H-Indazole-5-carboxamide, 1-(5-chloro-6-(2-methylpropoxy)-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-. CAS No. 1387633-03-5. Molecular formula: C19H21ClN4O4S. Mole weight: 436.9179. | |
PF-05274857 Hydrochloride Quick inquiry Where to buy Suppliers range | PF-05274857 Hydrochloride. Group: Biochemicals. Alternative Names: 1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one Monohydrochloride. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C20H26Cl2N4O3S, Molecular Weight: 473.42. US Biological Life Sciences. | Worldwide |
PF-05297909 Quick inquiry Where to buy Suppliers range | PF-05297909, is a BACE inhibitor developed by Pfizer. Phase 1. Synonyms: PF-05297909; PF-5297909. | |
PF 06260933 dihydrochloride Quick inquiry Where to buy Suppliers range | PF 06260933 is a highly selective, orally active and small-molecule inhibitor of MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) (IC50 = 140 nM). It also inhibits MINK and TNIK (IC50= 8 and 13 nM, respectively). PF-06260933 dihydrochloride has been shown to improves fasting hyperglycemia in mice. Synonyms: 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride; PF-06260933 dihydrochloride; PF06260933 dihydrochloride; PF 06260933 dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1883548-86-4. Molecular formula: C16H13ClN4.2HCl. Mole weight: 369.68. | |
PF 06273340 Quick inquiry Where to buy Suppliers range | PF 06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively. PF 06273340 is selective for Trk over a panel of ion channels, receptors and other enzymes. It shows efficacy in a rodent model of inflammatory pain. Synonyms: N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide; PF-06273340; PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340. Grades: ≥98% by HPLC. CAS No. 1402438-74-7. Molecular formula: C23H22ClN7O3. Mole weight: 479.93. | |
PF-06282999 Quick inquiry Where to buy Suppliers range | PF-06282999 is a selective myeloperoxidase Inhibitor originate by Pfizer. It showed good oral pharmacokinetics in preclinical species and robust irreversible inhibition of plasma MPO activity. In Mar 2015, Pfizer terminated phase I trial for the treatment of Acute coronary syndromes in Healthy volunteers in USA. Uses: Acute coronary syndromes. Synonyms: PF-06282999; PF06282999; PF06282999. 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide. Grades: 98%. CAS No. 1435467-37-0. Molecular formula: C13H12ClN3O3S. Mole weight: 325.77. | |
PF-06305591 dihydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1449473-97-5 (anhydrous). Pack Sizes: 5MG, 25MG. Mole weight: 310.39. Catalog: ALP1449473975. Assay: ≥98% (HPLC). | |
PF-06372222 Quick inquiry Where to buy Suppliers range | PF-06372222 is a small molecule negative allosteric modulator (NAM) of glucagon receptor (GCGR), which helps treat type 2 diabetes. It is also an antagonist of the glucagon-like peptide-1 receptor GLP-1R, which can inhibit glucagon secretion and glucose-dependent insulin secretion. Synonyms: N-{4-[(R)-(3,3-Dimethylcyclobutyl)({6-[4-(Trifluoromethyl)-1h-Imidazol-1-Yl]Pyridin-3-Yl}Amino)Methyl]Benzene-1-Carbonyl}-Beta-Alanine. Grades: ≥98% by HPLC. CAS No. 1407592-99-7. Molecular formula: C26H28F3N5O3. Mole weight: 515.5. | |
PF 06409577 Quick inquiry Where to buy Suppliers range | PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively) for the potential treatment of diabetic nephropathy. PF-06409577 showed efficacy in a preclinical model of diabetic nephropathy. Synonyms: PF-06409577; PF06409577; PF-6409577; PF6409577; PF 6409577. Grades: ≥98% by HPLC. CAS No. 1467057-23-3. Molecular formula: C19H16ClNO3. Mole weight: 341.79. | |
PF 06424439 Quick inquiry Where to buy Suppliers range | PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Synonyms: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate; PF-06424439; PF06424439; PF 06424439; PF-6424439; PF-6424439; PF 6424439. Grades: ≥98% by HPLC. CAS No. 1469284-79-4. Molecular formula: C22H26ClN7O.CH4O3S. Mole weight: 536.05. | |
PF-06424439 Free base Quick inquiry Where to buy Suppliers range | PF-06424439, a imidazo-pyridin derivative, has been found to be a selective DGAT2 inhibitor that could be probably effective against dyslipidemic rodent in animal models. Synonyms: PF-06424439; PF06424439; PF 06424439; PF-6424439; PF-6424439; PF 6424439; (R)-(1-(2-(1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl)-3H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone. Grades: 98%. CAS No. 1469284-78-3. Molecular formula: C22H26ClN7O. Mole weight: 439.94. | |
PF-06442609 Quick inquiry Where to buy Suppliers range | PF-06442609 is a potent, metabolic stable γ-secretase modulators. It displayed a favorable rodent pharmacokinetic profile, and robust reductions of brain Aβ42 and Aβ40 were observed in a guinea pig time-course experiment. F-06442609 may be used for the treatment of Alzheimer's disease in the future. Uses: Alzheimer's disease. Synonyms: PF-06442609; PF 06442609; PF06442609; PF-6442609; PF 6442609; PF6442609. 2-((S)-1-(4-fluoro-2-((R)-1,1,1-trifluoropropan-2-yl)phenoxy)propan-2-yl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione. Grades: 98%. CAS No. 1402002-76-9. Molecular formula: C24H24F4N4O3. Mole weight: 492.47. | |
PF-06447475 Quick inquiry Where to buy Suppliers range | PF06447475 is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the treatment of PD. Synonyms: PF06447475; PF-06447475; PF 06447475; PF6447475; PF-6447475; PF 6447475. Grades: >98%. CAS No. 1527473-33-1. Molecular formula: C17H15N5O. Mole weight: 305.33. | |
PF-06459988 Quick inquiry Where to buy Suppliers range | PF-06459988 is a third-generation, irreversible epidermal growth factor receptor (EGFR) inhibitor. It can bind to and inhibit mutant forms of EGFR, including the secondary acquired resistance mutation T790M.PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance. Preclinical trials in Non-small cell lung cancer in USA is on-going. Uses: Non-small cell lung cancer. Synonyms: PF-06459988; PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988; 1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one. Grades: 98%. CAS No. 1428774-45-1. Molecular formula: C19H22ClN7O3. Mole weight: 431.88. | |
PF 06465469 Quick inquiry Where to buy Suppliers range | PF 06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase) (IC50 = 2 nM). It also shows inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Synonyms: (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide; PF-06465469; PF 06465469; PF06465469; PF-6465469; PF 6465469; PF6465469. Grades: ≥95% by HPLC. CAS No. 1407966-77-1. Molecular formula: C30H33N7O2. Mole weight: 523.63. | |
PF-06471553 Quick inquiry Where to buy Suppliers range | PF-06471553, isoindoline-5-sulfonamide, selectively inhibits MGAT3 with high in vitro potency and cell efficacy which displayed suitable PK properties in mouse and in vivo MGAT3 inhibition in a transgenic mouse model. Synonyms: PF-06471553; PF 06471553; PF06471553; PF-6471553; PF 6471553; PF6471553. N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2-(2-(3-methoxyphenyl)acetyl)isoindoline-5-sulfonamide. Grades: >98%. CAS No. 1808094-07-6. Molecular formula: C23H25N5O4S. Mole weight: 467.54. | |
PF 06551600 malonate Quick inquiry Where to buy Suppliers range | PF 06551600 is a potent and selective JAK3 inhibitor with IC50 value of 33.1 μM, exhibiting >1,000-fold selectivity over JAK1 and JAK2. It inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. It also inhibits Th1 and Th17 T-cell differentiation and function in vitro. Synonyms: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate. Grades: ≥98% by HPLC. CAS No. 2140301-97-7. Molecular formula: C15H19N5O·C3H4O4. Mole weight: 389.41. | |
PF-06650833 Quick inquiry Where to buy Suppliers range | PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), which is an omnipresently expressed serine/threonine kinase involved in the regulation of innate immunity. PF-06650833 is useful for the treatment of autoimmune and inflammatory diseases associated with lnterleukin-1 Receptor Associated Kinase (IRAK) and more particularly modulates the function of IRAK. It is undergoing testing in a Phase II clinical study. Synonyms: zimlovisertib; PF 06650833; PF06650833. CAS No. 1817626-54-2. Molecular formula: C18H20FN3O4. Mole weight: 361.373. | |
PF-06651600 Quick inquiry Where to buy Suppliers range | PF-06651600 is a selective JAK3 inhibitor with IC50 value of 0.346 nM. It was shown to inhibit Th1 and Th17 cell differentiation and function in vitro. Synonyms: Ritlecitinib; PF 06651600; PF06651600; 2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-. Grades: >98%. CAS No. 1792180-81-4. Molecular formula: C15H19N5O. Mole weight: 285.351. | |
PF-06651600 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1792180-81-4 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 389.41. Catalog: ALP1792180814. Assay: ≥98% (HPLC). | |
PF-06700841 tosylate Quick inquiry Where to buy Suppliers range | PF-06700841 is a potent and selective inhibitor of TYK2 and JAK1. It has the potential to treat plaque psoriasis and lupus erythematosus. Synonyms: Brepocitinib tosylate; [(1S)-2,2-difluorocyclopropyl]-[(1R,5S)-3-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone tosylate. Grades: ≥98%. CAS No. 2140301-96-6. Molecular formula: C18H21F2N7O·C7H8O3S. Mole weight: 561.61. | |
PF-06700841 tosylate salt Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1883299-62-4 (free base). Pack Sizes: 5MG. Mole weight: 561.60. Catalog: ALP1883299624. Assay: ≥98% (HPLC). | |
PF-06726304 Quick inquiry Where to buy Suppliers range | PF-06726304 is a potent and selective EZH2 inhibitor. It also inhibits H3K27me3 with IC50 value of 15 nM. Synonyms: 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one. CAS No. 1616287-82-1. Molecular formula: C22H21Cl2N3O3. Mole weight: 446.33. | |
PF 06726304 acetate Quick inquiry Where to buy Suppliers range | ||
PF-06726304 acetate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1616287-82-1 (free base). Pack Sizes: 5MG. Mole weight: 506.38. Catalog: ALP1616287821. Assay: ≥98% (HPLC). | |
PF-06747775 Quick inquiry Where to buy Suppliers range | PF-06747775, a methylpurin derivative, has been found to be an epidermal growth factor receptor antagonist and could probably be effective against cell lung cancer through restrain EGFR-mediated signaling. It is still under Phase-I trial in Non-small cell lung cancer. Synonyms: YXX2180047; Egfr T790M inhibitor PF-06747775; PF-06747775; N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-methylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide. Grades: 98%. CAS No. 1776112-90-3. Molecular formula: C18H22FN9O2. Mole weight: 415.43. | |
PF-06767832 Quick inquiry Where to buy Suppliers range | PF-06767832 is a cell permeable, potent and selective M1 muscarinic acetylcholine receptor Positive Allosteric Modulator (PAM). Synonyms: PF-06767832; PF 06767832; PF06767832; PF-6767832; PF 6767832; PF6767832; N-[(3R,4S)-3-hydroxyoxan-4-yl]-5-methyl-4-[[4-(1,3-thiazol-4-yl)phenyl]methyl]pyridine-2-carboxamide; GTPL9228; SCHEMBL17440029; PF-06767832; N-[(3R,4S)-3-hydroxyoxan-4-yl]-5-methyl-4-[[4-(1,3-thiazol-4-yl)phenyl]methyl]pyridine-2-carboxamide. Grades: >98%. CAS No. 1859081-58-5. Molecular formula: C22H23N3O3S. Mole weight: 409.50. | |
PF-06821497 Quick inquiry Where to buy Suppliers range | PF-06821497. Group: Active Pharmaceutical Ingredients (APIs). Alternative Names: 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one. Grades: 98%. CAS No. 1844849-10-0. Product ID: ACM1844849100. Molecular formula: C22H24Cl2N2O5. Mole weight: 467.34. | |
PF-06840003 Quick inquiry Where to buy Suppliers range | PF-06840003 is a highly selective inhibitor of IDO1 (IC50 = 0.41mcM), an immunosuppressive enzyme induced by multiple cancers. Study in vitro showed that PF-06840003 led to IDO-1-induced T-cell anergy. Study in vivo revealed that it significantly suppressed tumor growth in combination with avelumab in mouse model. Uses: Antitumor drug. Synonyms: EOS200271, EOS-200271; EOS 200271; PF-06840003; PF 06840003; PF06840003. CAS No. 198474-05-4. Molecular formula: C12H9FN2O2. Mole weight: 232.21. | |
PF-06869206 Quick inquiry Where to buy Suppliers range | PF-06869206 is an orally bioavailable inhibitor of sodium-phosphate cotransporter 2a (NaPi2a), a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Synonyms: NaPi2a inhibitor; 3-Chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile. Grades: ≥98%. CAS No. 2227425-05-8. Molecular formula: C15H14ClF3N4O2. Mole weight: 374.75. | |
PF-06873600 Quick inquiry Where to buy Suppliers range | PF-06873600 Inhibitor. Uses: Scientific use. Product Category: T8463. CAS No. 2185857-97-8. | |
PF-07321332 Quick inquiry Where to buy Suppliers range | PF-07321332 is an orally available SARS-CoV 3C-like protease (3CLPRO) inhibitor. 3C-like protease (3CLPRO) is the main protease found in coronaviruses, which cleaves the coronavirus polyprotein at eleven conserved sites. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase I clinical trial in healthy human participants. Synonyms: PF 07321332; PF07321332. Grades: 98%. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.53. | |
PF 1018 Quick inquiry Where to buy Suppliers range | PF1018 is an insecticidal agent isolated from the culture broth of Humicola sp. PF1018. Synonyms: Antibiotic PF 1018; PF1018. CAS No. 131256-42-3. Molecular formula: C28H35NO3. Mole weight: 433.6. | |
PF 1022A Quick inquiry Where to buy Suppliers range | PF1022A, an anthelmintic cyclodepsipeptide isolated from cultured mycelia of Mycelia Sterilia, has very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. It has potent repellant activity against Ascaridiagalli in chicken. In vitro, it has activity against Trichinella spiralis and Nippostrongylus brasiliensis. Synonyms: PF1022A; PF-1022A; cyclo[N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe-N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe]; cyclo[N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl-N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl]; Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]. Grades: >98%. CAS No. 133413-70-4. Molecular formula: C52H76N4O12. Mole weight: 949.18. | |
PF-1057A Quick inquiry Where to buy Suppliers range | PF-1057A is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057A; PF1057A. CAS No. 89162-70-9. Molecular formula: C31H56O10S2. Mole weight: 652.9. | |
PF-1057B Quick inquiry Where to buy Suppliers range | PF-1057B is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057B; PF1057B. CAS No. 89020-47-3. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
PF-1057C Quick inquiry Where to buy Suppliers range | PF-1057C is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057C; PF1057C. CAS No. 89020-48-4. Molecular formula: C35H60O12S2. Mole weight: 737. | |
PF-1057D Quick inquiry Where to buy Suppliers range | PF-1057D is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057D; PF1057D. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
PF-1092A Quick inquiry Where to buy Suppliers range | PF-1092A is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 3.0 x 10 nM. Synonyms: PF 1092A; PF1092A. Molecular formula: C17H20O5. Mole weight: 304.34. | |
PF-1092B Quick inquiry Where to buy Suppliers range | PF-1092B is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(2) nM. Synonyms: PF 1092B; PF1092B. Molecular formula: C17H20O5. Mole weight: 304.34. | |
PF-1092C Quick inquiry Where to buy Suppliers range | PF-1092C is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(3) nM. Synonyms: PF 1092C; PF1092C. Molecular formula: C15H18O4. Mole weight: 262.3. | |
PF-1163A Quick inquiry Where to buy Suppliers range | PF-1163A is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: (3S,10R,13S)-3-[[4-(2-Hydroxyethoxy)phenyl]methyl]-13-[(2S)-2-hydroxypentyl]-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione. Grades: ≥95%. CAS No. 258871-59-9. Molecular formula: C27H43NO6. Mole weight: 477.6. | |
PF-1163B Quick inquiry Where to buy Suppliers range | PF-1163B is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: Antibiotic PF-1163B; (-)-PF 1163B; 3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione. Grades: ≥95%. CAS No. 258871-60-2. Molecular formula: C27H43NO5. Mole weight: 461.63. | |
PF-1355 Quick inquiry Where to buy Suppliers range | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Synonyms: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Molecular formula: C14H15N3O4S. Mole weight: 321.35. | |
PF 184 Quick inquiry Where to buy Suppliers range | PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. Group: Biochemicals. Alternative Names: 8- [ [ [5-Chloro-2- [3, 4-dimethyl-3, 4-bis (hydroxymethyl) -1-pyrrolidinyl] -4-pyridinyl] carbonyl] amino] -1- (4-fluorophenyl) -4, 5-dihydro-1H-benz [g] indazole-3-carboxamide. Grades: Highly Purified. CAS No. 1187460-81-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF 184 Quick inquiry Where to buy Suppliers range | PF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM) with selectivity over 85 other kinases, demonstrating target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. Synonyms: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide; PF-184; PF184; PF 184. Grades: ≥98% by HPLC. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: 619.09. |