A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
| Product | Description | |
|---|---|---|
| PF 5274857 hydrochloride | PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM), with >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. When administered orally, it distributes through plasma to skin and tumor and remains metabolically stable. PF 5274857 also penetrates the blood-brain barrier and inhibits Smo activity in the brain. Synonyms: PF 5274857 hydrochloride; PF5274857 hydrochloride; PF-5274857 hydrochloride; 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 1613439-62-5. Molecular formula: C20H25ClN4O3S.HCl. Mole weight: 473.42. |  |
| PF-5274857 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF-543 | PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(I) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. Uses: Enzyme inhibitors. Synonyms: PF-543; PF543; PF 543. Grades: 0.98. CAS No. 1415562-82-1. Molecular formula: C27H31NO4S. Mole weight: 465.60. | |
| PF-543 | PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II. CAS No. 1415562-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15425. |  |
| PF-543 Citrate | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 Citrate induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II Citrate. CAS No. 1415562-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15425A. | |
| PF-543 Citrate | Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Synonyms: PF543 Citrate; PF 543 Citrate. Grades: >98%. CAS No. 1415562-83-2. Molecular formula: C33H39NO11S. Mole weight: 657.73. | |
| PF-543 hydrochloride | The hydrochloride salt form of PF-543, a novel SphK1 inhibitor that could exhibit activity in induceing necrosis in human colorectal cancer cells in biological studies. IC50: 2 nM; Ki: 3.6 nM. Synonyms: PF-543 hydrochloride; PF 543 hydrochloride; PF543 hydrochloride; (2R) -1-[[4-[[3-Methyl-5-[ (phenylsulfonyl) methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol Hydrochloride. Grades: 98%. CAS No. 1706522-79-3. Molecular formula: C27H31NO4S.HCl. Mole weight: 502.07. | |
| PF-543 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-562271 | Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences. |  Worldwide |
| PF-562271 | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Synonyms: PF-562271; PF 562271; PF562271. Grades: >98%. CAS No. 717907-75-0. Molecular formula: C21H20F3N7O3S. Mole weight: 507.49. | |
| PF-562271 | PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VS-6062. CAS No. 717907-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10459. | |
| PF-562,271 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-562271 besylate | PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Synonyms: PF-562271 besylate; PF 562271 besylate; PF562271 besylate. Grades: >98%. CAS No. 939791-38-5. Molecular formula: C21H20F3N7O3S.C6H6O3S. Mole weight: 665.66. | |
| PF-562271 hydrochloride | PF-562271 is an ATP-competitive, reversible inhibitor of FAK/PYK2. It blocked phosphorylation of FAK in a dose-dependent manner, inhibited migration of tumor cells, cancer-associated fibroblasts, and macrophages, resulting in suppression of tumor growth, invasion, and metastases. Synonyms: PF-562271 HCl; N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide hydrochloride. CAS No. 939791-41-0. Molecular formula: C21H21ClF3N7O3S. Mole weight: 543.95. | |
| PF-573228 | A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-573228 | PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50= 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. PF573228 was recognized to affect cell adhesion and migration in many types of cells. Synonyms: PF-573228; PF 573228; PF573228; PF573,228; PF-573; 228; PF 573; 228. Grades: 0.98. CAS No. 869288-64-2. Molecular formula: C22H20F3N5O3S. Mole weight: 491.489. | |
| PF-573228 | PF-573228 Inhibitor. Uses: Scientific use. Product Category: T2001. CAS No. 869288-64-2. |  |
| PF-573228 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-573228 | PF-573228 is a potent and selective FAK inhibitor with IC 50 of 4 nM for purified recombinant catalytic fragment of FAK. Uses: Scientific research. Group: Signaling pathways. CAS No. 869288-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10461. | |
| PF-622 | PF-622 is an irreversible FAAH inhibitor with selectivity for FAAH relative to other serine hydrolases. Synonyms: N-Phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide. Grades: >98%. CAS No. 898235-65-9. Molecular formula: C21H22N4O. Mole weight: 346.4. | |
| PF-6260933 | PF-6260933 is a potent and selective inhibitor of MAP4K4. Synonyms: 5-(6-Aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine. CAS No. 1811510-56-1. Molecular formula: C16H13ClN4. Mole weight: 296.75. | |
| PF 6274484 | PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively). Synonyms: PF 6274484; PF6274484; PF-6274484; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide. Grades: ≥98% by HPLC. CAS No. 1035638-91-5. Molecular formula: C18H14ClFN4O2. Mole weight: 372.78. | |
| PF-6274484 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-6422899 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 670462 | PF 670462. Group: Biochemicals. Grades: Purified. CAS No. 950912-80-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-670462 | PF-670462 is a potent and selective inhibitor of CK1ε in isolated enzyme preparations. It inhibits PER protein nuclear translocation causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo. It less effectively inhibits a wide variety of related or common kinases. It disrupts circadian rhythms in cells and animals and blocks the locomotor response to amphetamines in mice. It remains unclear whether one of the kinases has a predominant role in regulating the circadian clock. Synonyms: PF-670462; PF 670462; PF670462;PF-670462 HCl; PF-670462 hydrochloride. Grades: >98%. CAS No. 950912-80-8. Molecular formula: C19H22Cl2FN5. Mole weight: 410.32. | |
| PF-670462 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-670462 dihydrochloride | PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase ( CK1ε and CK1δ ) , with IC 50 s of 7.7 nM and 14 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 950912-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15490. | |
| PF-6808472 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-68742 | PF-68742 is a new entry inhibitor of CCR5- and CXCR4- tropical strains of human immunodeficiency virus type 1 (HIV-1), targeting a new site on gp41. Synonyms: PF 68742; PF68742. Grades: ≥98% by HPLC. Molecular formula: C28H33FN4O6S. Mole weight: 572.65. | |
| PF-739 | PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1852452-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117755. | |
| PF74 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 750 | PF 750 is a potent, time-dependent, irreversible FAAH inhibitor (IC50 = 16.2 nM) that exhibits no activity at a range of other serine hydrolases. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. Synonyms: PF-750; PF 750; PF750. N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 959151-50-9. Molecular formula: C22H23N3O. Mole weight: 345.44. | |
| PF 750 | Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system. Group: Biochemicals. Alternative Names: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide; N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide. Grades: Highly Purified. CAS No. 959151-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF8380 | PF8380. Group: Biochemicals. Alternative Names: 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic Acid 3,5-Dichlorobenzyl Ester; 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic Acid (3,5-Dichlorophenyl)methyl Ester. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C22H21Cl2N3O5, Molecular Weight: 478.33. US Biological Life Sciences. | Worldwide |
| PF 8380 | PF 8380. Group: Biochemicals. Grades: Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-8380 | PF-8380 is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 1144035-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344. | |
| PF-8380 | PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester. Grades: ≥95%. CAS No. 1144035-53-9. Molecular formula: C22H21Cl2N3O5. Mole weight: 478.33. | |
| PF-8380 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-8380 hydrochloride | PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344A. | |
| PF 915275 | PF-915275 is a selective and potent and inhibitor of human 11β-hydroxysteroid dehydrogenase type 1(11βHSD1) inhibitor with Ki 2.3 nM. It has good preclinical pharmacokinetic properties. It inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. It maintains potency in our cellular assay against human 11βHSD1 and is selective against human 11βHSD2 in vitro. It displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. It has good in vitro pharmacokinetic properties. It has low clearance and high permeability. It has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. Uses: Pf-915275 inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. it has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. Synonyms: PF-915275; PF 915275; PF915275; N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide;[1,1'-Bip;4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide. Grades: >98 %. CAS No. 857290-04-1. Molecular formula: C18H14N4O2S. Mole weight: 350.39. | |
| PF 915275 | PF 915275. Group: Biochemicals. Grades: Purified. CAS No. 857290-04-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF 9184 | This active molecular is selective mPGES-1 (microsomal prostaglandin E synthase-1 inhibitor. mPGES-1 is an enzyme induced during the inflammatory response and it is for developing anti-inflammatory drugs. PF-9184 inhibited recombinant human mPGES-1 with IC50 value of 16.5nM. PF-9184 had no effect against COX-1 and COX-2 with more than 6500-fold selectivity. PF-9184 inhibited PGE(2) synthesis with IC50 value in the range of 0.5-5 mM in serum-free cell and human whole blood cultures. Uses: Anti-inflammatory agent. Synonyms: N-(3',4'-Dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Grades: 98%. CAS No. 1221971-47-6. Molecular formula: C21H14Cl2N2O4S. Mole weight: 461.31. | |
| PF-9363 | PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CTx-648. CAS No. 2569009-58-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132283. | |
| PF-9366 | PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 72882-78-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107778. | |
| PF 945863 | PF 945863, an orally active macrolide antibiotic, is active against multidrug resistant respiratory tract bacterial strains. Synonyms: PF 945863; PF945863; PF-945863; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone. Grades: ≥98% by HPLC. CAS No. 893556-85-9. Molecular formula: C44H65N5O10. Mole weight: 824.01. | |
| PF-956980 | PF-956980, a close analogue of Tofacitinib, is a JAK3-selective inhibitor used as an anti-inflammatory agent. Besides, some studies showed that PF-956980 strikingly reversed the cytoprotective action of IL-4 on CLL cells. Synonyms: PF-956980; PF 956980; PF956980; Methanone, [(3R,?4R)?-4-methyl-3-(methyl-7H-pyrrolo[2,?3-d]?pyrimidin-4-ylamino)?-1-piperidinyl]?-1-pyrrolidinyl-. CAS No. 1262832-74-5. Molecular formula: C18H26N6O. Mole weight: 342.44. | |
| PF-956980 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-956980 Hydrate | PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. PF-956980 is used as immunosuppressive agent. Group: Biochemicals. Alternative Names: [(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinylmethanone Hydrate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF9601N | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 998425 | PF 998425 is a novel, nonsteroidal androgen receptor (AR) antagonist (IC50= 26 nM and 90 nM in AR binding assays and cellular assays respectively) for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. PF 998425 exhibits low affinity for progesterone receptor (IC50 > 10 μM). Uses: Androgen receptor antagonists. Synonyms: 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile; PF0998425; PF 0998425; PF-0998425. Grades: ≥98% by HPLC. CAS No. 1076225-27-8. Molecular formula: C14H14F3NO. Mole weight: 269.26. | |
| PF-998425 | PF-998425 is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. Group: Biochemicals. Alternative Names: rel- (-) -4-[ (1R, 2R) -2-Hydroxycyclohexyl]-2- (trifluoromethyl) benzonitrile. Grades: Highly Purified. CAS No. 1076225-27-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF9 tetrasodium salt | PF9 tetrasodium salt is an activator of GPR17 (EC50 = 36 pM). Synonyms: PF9 tetrasodium salt; PF 9 tetrasodium salt; PF-9 tetrasodium salt; 2-(Phenylethynyl)adenosine-5'-triphosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 851265-78-6. Molecular formula: C18H16N5Na4O13P3. Mole weight: 695.23. | |
| PF9 tetrasodium salt | PF9 tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 851265-78-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PF-AKT400 | PF-AKT400 is an APT competitor inhibitor of AKR kinase. This compound was first described as compound 42 in J. Med. Chem. 2010, 53, 4615-4622 by a group of Pfizer scientists. The paper describes the design and synthesis of novel, ATP-competitive Akt inhibitors from an elaborated 3-aminopyrrolidine scaffold. Key findings include the discovery of an initial lead that was modestly selective and medicinal chemistry optimization of that lead to provide more selective analogues. Analysis of the data suggested that highly lipophilic analogues would likely suffer from poor overall properties. Central to the discussion is the concept of optimization of lipophilic efficiency and the ability to balance overall druglike propeties with the careful control of lipophilicity in the lead series. Discovery of the nonracemic amide series and subsequent modification produced an advanced analogue that performed well in advanced preclinical assays, including xenograft tumor growth inhibition studies, and this analogue was nominated for clinical development. The compound has no official name, has molecule weight 400.43. We temporally call this compound as PF-AKT400. Synonyms: PF-AKT400; PFAKT400; Lig1; Lig-1; Lig 1; PF AKT400; AKT-0286; AKT 0286; AKT0286. CAS No. 1004990-28-6. Molecular formula: C20H22F2N6O. Mole weight: 400.43. | |
| PFB-FDGlu | PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 209540-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139452. | |
| PF-CBP1 | PF-CBP1, also known as PF-06670910, is a selective CBP/p300 bromodomain inhibitor (IC50 values are 125 and 363 nM, respectively) with >100-fold selectivity for CBP over BRD4. Also, PF-CBP1 significantly reduces levels of RGS4 mRNA levels in neurons. Synonyms: 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine; PF-CBP1; PF-CBP-1; PF-CBP 1; PF-06670910; PF 06670910; PF06670910.PF-CBP1; PF CBP1; PFCBP1. CAS No. 1962928-21-7. Molecular formula: C29H36N4O3. Mole weight: 488.63. | |
| PF-CBP1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-CBP1 HCl | PF-CBP1, also known as PF-06670910, is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively) with more than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins. Also, PF-CBP1 significantly reduces levels of RGS4 mRNA levels in neurons. Synonyms: 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride; PF-CBP1 HCl; PF-CBP1; hydrochloride; PF-CBP1; PF-CBP-1; PF-CBP 1; PF-06670910; PF 06670910; PF06670910. CAS No. 2070014-93-4. Molecular formula: C29H37ClN4O3. Mole weight: 525.09. | |
| PFD | PFD. Group: Organic light-emitting diode (oled) materials. Alternative Names: Poly(9,9-di-n-dodecylfluorene). CAS No. 248256-53-3. |  |
| PfDHODH-IN-1 | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183945-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135648. | |
| PF-DMB | PF-DMB. Group: Organic light-emitting diode (oled) materials. Alternative Names: PF-DMB; Poly[(9,9-dihexylfluoren-2,7-diyl)-alt-(2,5-dimethyl-1,4-phenylene)]. CAS No. 579505-48-9. 96%. | |
| PFE-360 | PFE-360 Inhibitor. Uses: Scientific use. Product Category: T16512. CAS No. 1527475-61-1. | |
| PffBT4T-2OD | Band gap: 1.65 eV. Uses: Requires hot ink processing (i.e. coating with ink at temperature 100-110 °c to ensure good coatability). Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials synthetic tools and reagents. Alternative Names: PCE-11, Poly[(5, 6-difluoro-2, 1, 3-benzothiadiazol-4, 7-diyl)-alt-(3, 3'''-di(2-octyldodecyl)-2, 2', 5', 2'', 5'', 2'''-quaterthiophen-5, 5'''-diyl)]. CAS No. 1644164-62-4. Pack Sizes: 100 mg in glass bottle. Mole weight: (C62H88F2N2S5)n. | |
| PffBT4T-C9C13 | PffBT4T-C9C13. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. | |
| PFH-A | PFH-A. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dihexylfluorenyl-2,7-diyl)-co-(9,10-anthracene)]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 474975-22-9. Molecular formula: (C39H40)n. Product ID: ACM474975229-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFC Akademik Sofia. |  |
| PFHB | PFHB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dihexylfluorenyl-2,7-diyl)-alt-(N,N'-bis-{p-butylphenyl}-1,4-diaminophenylene)]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 870517-32-1. Molecular formula: (C51H62N2)n. Product ID: ACM870517321. Alfa Chemistry ISO 9001:2015 Certified. Categories: PHBV. | |
| PFI-1 | PFI-1. Group: Biochemicals. Alternative Names: 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide; 2-Methoxy-N- (1, 2, 3, 4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl) benzenesulfonamide. Grades: Highly Purified. CAS No. 1403764-72-6. Pack Sizes: 5mg. Molecular Formula: C16H17N3O4S, Molecular Weight: 347.39. US Biological Life Sciences. | Worldwide |
| PFI-1 | PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated histone tails. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. Intriguingly, cells exposed to PFI-1 showed significant down-regulation of Aurora B kinase, thus attenuating phosphorylation of the Aurora substrate H3S10 providing an alternative strategy for the specific inhibition of this well established oncology target. Synonyms: PFI1; PFI 1; PFI-1. CAS No. 1403764-72-6. Molecular formula: C16H17N3O4S. Mole weight: 347.39. | |
| PFI-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
Our database is helping our users find suppliers everyday.
