A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
PFPV. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dioctyl-2,7-divinylenefluorenylene)-alt-{2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene}]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 475101-36-1. Molecular formula: (C48H66O2)n. Product ID: ACM475101361-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFP (enzyme).
PFQa-St2
PFQa-St2 is an antimicrobial peptide found in the African clawed frog Silurana tropicalis, and has anti-gram-positive bacteria, gram-negative bacteria and Mammalian cells activity. Synonyms: Phe-Ile-Gly-Ala-Leu-Leu-Arg-Pro-Ala-Leu-Lys-Leu-Leu-Ala-Gly-Lys. Grades: ≥97%. Molecular formula: C81H141N21O17. Mole weight: 1681.15.
Pfu DNA Polymerase
Pfu DNA Polymerase. Pfu dna polymerase is a fast, high fidelity and high processivity hot start dna polymerase. extension rate is about 2-4 kb/min. amplification of genomic dna fragment up to 15 kb. amplification of plasmid dna fragment up to 20 kb. Group: Cloning Enzymes. Purity: 250U; 500U. Storage: Store at -20 ?. Cat No: CE-3015.
PG 01
PG 01. Group: Biochemicals. Grades: Purified. CAS No. 853138-65-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PG 01
PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and ΔF508. Synonyms: PG 01; PG-01; PG01; N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide. Grades: ≥98% by HPLC. CAS No. 853138-65-5. Molecular formula: C28H29N3O2. Mole weight: 439.55.
PG 01037 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 675599-62-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PG 01037 dihydrochloride
PG 01037 dihydrochloride is a dopamine D3 receptor antagonist, which is more selective for D3 receptors than other D3 antagonists that are currently available with a D2/D3 selectivity ratio of 867 and a D4/D3 selectivity ratio of 13,000 (Ki values are 0.70, 93.3 and 375 nM for D3, D2 and D4 receptors respectively). Synonyms: N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)-benzamide dihydrochloride; PG 01037 dihydrochloride; PG 01037 diHCl; PG 01037; PG01037; PG-01037. Grades: ≥98%. CAS No. 675599-62-9. Molecular formula: C26H26Cl2N4O.2HCl. Mole weight: 554.34.
PG 106
PG 106. Group: Biochemicals. Grades: Purified. CAS No. 944111-22-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
PG 106
PG 106 is a selective human melanocortin receptor 3 (hMC3R) antagonist (IC50 = 210 nM), with no activity at hMC4 receptors and hMC5 receptors. PG 106 may be used to differentiate the substructural features responsible for selectivity at the hMC3R, hMC4R, and hMC5R. Synonyms: PG106; PG-106; Ac-DL-Nle-Asp(1)-bAla-D-2Nal-Arg-Trp-Lys(1)-NH2; N-Acetyl-L-norleucyl-L-α-aspartyl-β-alanyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-Lysinamide(2?7)-lactam; Ac-Nle-cyclo(-Asp-β-Ala-D-2-Nal-Arg-Trp-Lys)-NH2. Grades: >98%. CAS No. 944111-22-2. Molecular formula: C51H69N13O9. Mole weight: 1008.19.
pG(2',5')pA
pG(2',5')pA is a potential metabolite of 2'3'-cGAMP, the metazoan cyclic dinucleotide second messenger. Synonyms: 5'- Phosphoguanylyl- (2' -≥ 5')- adenosine, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 55779-55-0. Molecular formula: C20H26N10O14P2. Mole weight: 692.4.
PG 34
PG 34 is a weak O-GlcNAc transferase ( OGT ) inhibitor ( IC 50 =68 μM), and a close structural analog of OSMI-1 (HY-119738) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1681056-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148113.
PG490-88
PG490-88 is a semisynthetic derivative of the novel compound PG490 (triptolide) purified from a Chinese herb. It has been shown to prolong acute allograft survival in multiple experimental organ transplant models. However, the effect of PG490-88 on prevention of acute and chronic renal allograft rejection has not been determined. Kidneys of ACI or F344 rats were transplanted into bilaterally nephrectomized LEW recipients as the acute or chronic allograft rejection models, respectively. Treatment of LEW recipients with PG490-88 significantly prolonged ACI kidney graft survival in a dose-dependent manner when compared with the untreated allograft controls. LEW recipients of F344 kidney grafts who received PG490-88 for 90 days with a brief course of low-dose FK506 showed normal serum creatinine levels and markedly reduced histological changes of chronic rejection at day 90 after transplantation. These results suggest that PG490-88 significantly prolongs kidney allograft survival in an acute rejection model and prevents chronic allograft rejection in rats. Synonyms: Omtriptolide; PG490 88; YM 262; YM-262; YM262; 4-{[(3bS, 4aS, 5aR, 6R, 6aS, 7aS, 7bS, 8aS, 8bS)-6a-Isopropyl-8b-methyl-1-oxo-1, 3, 3b, 4, 4a, 6, 6a, 7a, 7b, 8b, 9, 10-dodecahydrotrisoxireno[6, 7:8a, 9:4b, 5]phenanthro[1, 2-c]furan-6-yl]oxy}-4-oxobutanoic acid. Grades: ≥98%. CAS No. 195883-06-8. Molecular formula: C24H28O9. Mole weight: 460.47.
PG545
PG545 is an angiogenesis and heparanase inhibitor, which inhibited the proliferation, migration, and colony formation of pancreatic cancer cells in vitro at pharmacologically relevant concentrations. PG545 significantly prolonged animal survival in intraperitoneal and genetic models (mPDAC: LSL-Kras(G12D); Cdkn2a(lox/lox); p48(Cre)) of PDAC. PG545 also inhibited primary tumor growth and metastasis in orthotopic and genetic endpoint studies. PG545 significantly decreased cell proliferation, increased apoptosis, reduced microvessel density, disrupted vascular function, and elevated intratumoral hypoxia. Synonyms: PG 545; PG-545. CAS No. 1144492-69-2. Molecular formula: C51H75Na13O60S13. Mole weight: 2363.75.
PG 931. Group: Biochemicals. Grades: Purified. CAS No. 667430-81-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
PG-931
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor ( IC 50 =0.58 nM) agonist and is more selective than for the hMC3R ( IC 50 =55 nM) or the hMC5R ( IC 50 =2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo [2]. Uses: Scientific research. Group: Peptides. CAS No. 667430-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1208.
PG 97-269
PG 97-269, a selective high affinity VPAC1 receptor antagonist, has negligible affinity for PACAP type I receptors, with Kis of 15±5 and 2±1 nM for the rat and human VPAC1 receptors, respectively. It can be used to evaluate the physiological role of VIP in rats and human tissues. Synonyms: Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27); Ac-His-D-Phe-Asp-Ala-Val-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Lys-Arg-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-NH2; L-Leucinamide, N-acetyl-L-histidyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-lysyl-L-arginyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-. Grades: ≥95%. CAS No. 202463-00-1. Molecular formula: C150H246N44O38. Mole weight: 3273.83.
PG-9 maleate
PG-9 maleate. Group: Biochemicals. Grades: Purified. CAS No. 155649-00-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PG-9 maleate
PG-9 maleate, derived from (+)-R-hyoscyamine, is a potent analgesic and nootropic agent, which increases release of acetylcholine. Synonyms: PG-9 maleate; PG 9 maleate; PG9 maleate; Tropanyl 2-(4-bromophenyl)propionate maleate. CAS No. 155649-00-6. Molecular formula: C17H22BrNO2.C4H4O4. Mole weight: 468.34.
PgAFP
PgAFP is an antimicrobial peptide found in Penicillium chrysogenum RP42C (Penicillium notatum), and has antifungal activity. Synonyms: Antifungal protein; afp. Grades: >98%. Molecular formula: C272H431N89O85S6. Mole weight: 6500.32.
Pg-AMP1
Pg-AMP1 is an antimicrobial peptide found in Psidium guajava (Guava, Psidium pyriferum), and has anti-gram-positive bacteria and gram-negative bacteria activity. Synonyms: Glycine-rich antimicrobial peptide Pg-AMP. Grades: >98%. Mole weight: 6029.00.
PGD2-IN-1
PGD2-IN-1 is an antagonist of DP (IC50 = 0.3 nM). Synonyms: MDK66671; MDK-66671 MDK 66671; PGD2-IN-1; PGD2 IN 1; 2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]phenyl]-2-methylpropanoic acid. CAS No. 885066-67-1. Molecular formula: C23H23Cl2N3O3. Mole weight: 460.35.
Pge2,[5,6,8,11,12,14,15-3h]
Pge2,[5,6,8,11,12,14,15-3h]. Uses: Designed for use in research and industrial production. Additional or Alternative Names: [5,6,8,11,12,14,15(N)-3H]-PROSTAGLANDIN E2;PGE2, [5,6,8,11,12,14,15-3H];PROSTAGLANDIN E2, [5,6,8,11,12,14,15-3H];PROSTAGLANDIN E2-[5,6,8,11,12,14,15-3H(N)]. Product Category: Heterocyclic Organic Compound. CAS No. 84807-93-2. Molecular formula: C20H25O5T7. Mole weight: 366.52. Product ID: ACM84807932. Alfa Chemistry ISO 9001:2015 Certified.
PG-KI
PG-KI is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-His-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2; Kassinin-Like Peptide K-I; Recombinant Pseudophryne guentheri Kassinin-like peptide K-I. Grades: ≥97%. Molecular formula: C57H82N14O16S. Mole weight: 1251.43.
PG-KII
PG-KII is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2; H-Pyr-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2; L-pyroglutamyl-L-prolyl-L-asparagyl-L-prolyl-L-alpha-aspartyl-L-alpha-glutamyl-L-phenylalanyl-L-valyl-glycyl-L-leucyl-L-methioninamide; L-Methioninamide, 5-oxo-L-prolyl-L-prolyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-α-glutamyl-L-phenylalanyl-L-valylglycyl-L-leucyl-; Kassinin-Like Peptide K-II; Recombinant Pseudophryne guentheri Kassinin-like peptide K-II. Grades: ≥95%. CAS No. 127633-77-6. Molecular formula: C55H81N13O17S. Mole weight: 1228.37.
PG-KIII
PG-KIII is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-His-Pro-Asn-Glu-Phe-Val-Gly-Leu-Met-NH2; Kassinin-Like Peptide K-III; Recombinant Pseudophryne guentheri Kassinin-like peptide K-III. Grades: ≥97%. Molecular formula: C57H83N15O15S. Mole weight: 1250.44.
PG-L
PG-L is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: H-Glu-Gly-Gly-Gly-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; pGlu-Gly-Gly-Gly-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2; litorin-like peptide L (PG-L); Recombinant Pseudophryne guentheri Bombesin-like peptide L; L-alpha-glutamyl-glycyl-glycyl-glycyl-L-prolyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide. Grades: ≥97%. Molecular formula: C62H86N18O16S. Mole weight: 1371.52.
PGLa is an antimicrobial peptide (AMP) composed of 21 amino acids which form an alpha-helical secondary structure. It has a wide variety of antimicrobial activity including activity against fungi, viruses, gram-negative and gram-positive bacteria, and cancer cells. Synonyms: PYLa/PGLa precursor; Gla peptide. Grades: ≥97% by HPLC. CAS No. 102068-15-5. Molecular formula: C88H162N26O22S. Mole weight: 1968.48.
PGLa acetate
PGLa is an antimicrobial peptide (AMP) composed of 21 amino acids which form an alpha-helical secondary structure. It has a wide variety of antimicrobial activity including activity against fungi, viruses, gram-negative and gram-positive bacteria, and cancer cells. Synonyms: PYLa/PGLa precursor acetate; Gla peptide acetate. Molecular formula: C90H166N26O24S. Mole weight: 2028.51.
PGLa-AM1
PGLa-AM1 is an antimicrobial peptide found in Xenopus amieti (skin secretions of the African volcano frog, Pipidae), and has antibacterial activity. Synonyms: Gly-Met-Ala-Ser-Lys-Ala-Gly-Ser-Val-Leu-Gly-Lys-Val-Ala-Lys-Val-Ala-Leu-Lys-Ala-Ala-Leu-NH2. Grades: ≥95%. Molecular formula: C92H169N27O24S. Mole weight: 2069.59.
PGLa-H
PGLa-H is an antimicrobial peptide found in Xenopus laevis (African clawed frog), and has antibacterial activity. Synonyms: Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu. Grades: ≥97%. CAS No. 1350308-37-0. Molecular formula: C50H95N13O11. Mole weight: 1054.37.
PGLa-St2
PGLa-St2 is an antimicrobial peptide found in the African clawed frog Silurana tropicalis, and has anti-gram-positive bacteria, gram-negative bacteria, fungal and Mammalian cells activity. Synonyms: Gly-Met-Ala-Thr-Lys-Ala-Gly-Thr-Ala-Phe-Gly-Lys-Ala-Ala-Lys-Ala-Ile-Ile-Gly-Ala-Ala-Leu-NH2. Grades: ≥96%. Molecular formula: C90H156N26O24S. Mole weight: 2018.46.
pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin trifluoroacetate salt
Pglu-his-gly amide trifluoroacetate salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PGLU-HIS-GLY AMIDE TRIFLUOROACETATE SALT;PGLU-HIS-GLY AMIDE TRIFLUOROACETATE. Product Category: Heterocyclic Organic Compound. CAS No. 174450-52-3. Molecular formula: C13H18N6O4. Mole weight: 322.32. Product ID: ACM174450523. Alfa Chemistry ISO 9001:2015 Certified.
pGlu-Pro-Arg-MNA is a peptide compound that has potential biology activity in many areas. Uses: Pglu-pro-arg-mna is a peptide compound that has potential biology activity in many areas. Synonyms: pGlu-PR-MNA; L-Argininamide, 5-oxo-L-prolyl-L-prolyl-N-(2-methoxy-4-nitrophenyl)-. Grades: 98%. CAS No. 130835-45-9. Molecular formula: C23H32N8O7. Mole weight: 532.55.
PGMEA
PGMEA. Group: Solvents. Alternative Names: Propylene glycol monomethyl ether acetate. CAS No. 108-65-6.
pGp
pGp is a vital protein transporter found in many human tissues. It plays a crucial role in determining drug resistance in various cancers such as breast cancer and leukemia. Understanding the mechanisms of pGp in drug efflux can open up new avenues for drug development and personalized medicine. Synonyms: guanosine 3',5'-diphosphate; guanosine 3',5'-bis(dihydrogen phosphate). Grades: ≥90% by AX-HPLC. Molecular formula: C10H15N5O11P2. Mole weight: 443.20.
PGP-4008
PGP-4008 is a selective P-glycoprotein (P-gp) inhibitor without modulating multidrug resistance-related protein 1 (MRP1). In combination with doxorubicin, PGP-4008 inhibited tumor growth in a murine syngeneic Pgp-mediated MDR solid tumor model. Synonyms: N-(1-Benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide. Grades: ≥95%. CAS No. 365565-02-2. Molecular formula: C26H23N3O. Mole weight: 393.5.
PGP-4008
PGP-4008 is a specific P-glycoprotein ( Pgp ) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 365565-02-2. Pack Sizes: 10 mM * 1 mL; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119823.
pGpA
A STING agonist negative control (pGpA). Synonyms: 3'5'-pGpA sodium salt; 3'3'-cGAMP Control. CAS No. 20137-01-3. Molecular formula: C20H23N10O14P2.3Na. Mole weight: 758.38.
PGPC
PGPC is an oxidized phospholipid formed under conditions of oxidative stress. It is a potent PPARα agonist. Synonyms: 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-glutaryl phosphatidylcholine; 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine; 2-O-glutaroyl-1-O-palmitoyl-sn-glycero-3-phosphocholine; PC(16:0/5:0(COOH)). Grades: ≥98%. CAS No. 89947-79-5. Molecular formula: C29H56NO10P. Mole weight: 609.73.
PGPC
PGPC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-Palmitoyl-2-glutaryl phosphatidylcholine; 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-glutaryl phosphatidylcholine; 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine. Product Category: Heterocyclic Organic Compound. CAS No. 89947-79-5. Molecular formula: C29H56NO10P. Mole weight: 609.7. Purity: ≥98%. IUPACName: [(2R)-2-(4-carboxybutanoyloxy)-3-hexadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate. Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCC(=O)O. Product ID: ACM89947795. Alfa Chemistry ISO 9001:2015 Certified. Categories: PGPCoder.
pGpG
pGpG is a STING agonist negative control and c-diGMP metabolite. Synonyms: P; -(5'-Guanosyl)-P; -(5'-guanosyl)-(3'?5')-diphosphate, Sodium salt. Grades: ≥ 95 % by HPLC. CAS No. 33008-99-0. Molecular formula: C20H26N10O15P2(free acid). Mole weight: 708.43 (free acid).
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) (IC50= 0.28 μM) and also an inhibitor of 5-lipoxygenase (IC50= 1.05 μM). Synonyms: (3E)-3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]oxolan-2-one; alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)gamma-butyrolactone; KME 4; KME-4. CAS No. 102271-49-8. Molecular formula: C19H26O3. Mole weight: 302.41.
PG-SPI
PG-SPI is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Phe-Gly-Leu-Met-NH2; Substance P-like peptide 1; Recombinant Pseudophryne guentheri Substance P-like peptide 1; H-Pyr-Pro-Asn-Pro-Asp-Glu-Phe-Phe-Gly-Leu-Met-NH2; L-pyroglutamyl-L-prolyl-L-asparagyl-L-prolyl-L-alpha-aspartyl-L-alpha-glutamyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl-L-methioninamide; (4S)-5-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-4-oxo-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-5-oxopentanoic acid. Grades: ≥96%. Molecular formula: C59H81N13O17S. Mole weight: 1276.43.
PG-SPII
PG-SPII is an antimicrobial peptide found in Pseudophryne guentheri (Australian myobatrachid frog, Guenther's toadlet), and has antimicrobial activity. Synonyms: pGlu-Pro-Asn-Pro-Asn-Glu-Phe-Phe-Gly-Leu-Met-NH2; Substance P-Like Peptide II; Recombinant Pseudophryne guentheri Substance P-like peptide II. Grades: ≥96%. Molecular formula: C59H82N14O16S. Mole weight: 1275.45.
PGW-310
PGW-310 is a blood type O glycosylceramide. Synonyms: α-L-Fucosyl-β-D-lactosyl-β-ceramide; Fucosyl-lactosyl-beta-ceramide; Fuc1-α-2Gal1-β-4Glc-β-Ceramide. Molecular formula: C62H117NO17. Mole weight: 1148.59.
PH-002
PH-002 is an inhibitor of apolipoprotein E4 (ApoE4) intramolecular domain interaction in neuronal cells. It prevents impairments of mitochondrial motility and neurite outgrowth. Synonyms: Tert-butyl 4- [ [4- [ [2- (3-methyl-4-oxophthalazin-1-yl) acetyl] amino] phenyl] methyl] piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1311174-68-1. Molecular formula: C27H33N5O4. Mole weight: 491.58.
PH-064 is a sodium channel inhibitor. It is extracted from patent FR 2879460 A1. Synonyms: BIM-46187; BIM 46187; BIM46187; PH-064; PH 064; PH064; (2R)-2-amino-3-[[(2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl)-2-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]-3-oxopropyl]disulfanyl]-1-[(8S)-8-(cyclohexylmethyl)-2-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]propan-1-one;Imidazo[1,2-a]pyrazine, 7,7'-[dithiobis[(2R)-2-aMino-1-oxo-3,1-propanediyl]]bis[8-(cyclohexylMethyl)-5,6,7,8-tetrahydro-2-phenyl-, (8S,8'S)- (9CI). Grades: >98 %. CAS No. 892546-37-1. Molecular formula: C44H58N8O2S2. Mole weight: 795.11.
PH11
PH11, an imidazotriazin derivative, has been found to be a FAK inhibitor that could have probable activity in anticancer studies. Synonyms: PH11; PH-11; PH 11; methyl 2-((4-((3,4,5-trimethoxyphenyl)amino)imidazo[1,2-a][1,3,5]triazin-2-yl)amino)benzoate. Grades: 98%. CAS No. 1627843-95-1. Molecular formula: C22H22N6O5. Mole weight: 450.46.
PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase. PH-797804 exhibited exceptionally high specificity against MAP kinases and the related kinases. No cross-reactivity was observed in large panels of kinase screens (selectivity ratio of >500-fold). In cellular assays, PH-797804 demonstrated superior potency and selectivity consistent with the biochemical measurements. PH-797804 has met safety criteria in human phase I studies and is under clinical development for several inflammatory conditions. Understanding the rationale for selectivity at the molecular level helps elucidate the biological function and design of specific p38alpha kinase inhibitors. Synonyms: PH 797804; PH797804; 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide. CAS No. 586379-66-0. Molecular formula: C22H19BrF2N2O3. Mole weight: 477.30.
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a K i of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors [1]. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 478149-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105670.
PHA 543613 dihydrochloride is a potent and selective α7 nicotinic acetylcholine receptor (nAChR) agonist with rapid brain penetration and high oral bioavailability. PHA 543613 is potentially used for the treatment of cognitive deficits in schizophrenia. Uses: Potential treatment of cognitive deficits in schizophrenia. Synonyms: PHA 543613 dihydrochloride; PHA543613 dihydrochloride; PHA-543613 dihydrochloride; N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide dihydrochloride. Grades: 99%. CAS No. 478148-58-2. Molecular formula: C15H17N3O2.2HCl. Mole weight: 344.24.
PHA-543613 Dihydrochloride
PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer?s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays. Group: Biochemicals. Alternative Names: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride;PHA 543613E. Grades: Highly Purified. CAS No. 478148-58-2. Pack Sizes: 10mg. US Biological Life Sciences.
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PHA 543613 hydrochloride
PHA 543613 is a potent and selective α7 nAChR agonist. It was shown to reduce Aβ-induced cognitive deficits and increase the α7 protein level and subsequent neuron survival. It has been developed as a potential therapeutic agent for cognitive deficits in schizophrenia. Synonyms: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride; N-(1-azabicyclo[2.2.2]octan-3-yl)furo[2,3-c]pyridine-5-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1586767-92-1. Molecular formula: C15H17N3O2·HCl. Mole weight: 307.78.
A potent agonist highly selective for alpha7 nicotinic acetylcholine receptor (alpha7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of alpha7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 478149-53-0. Pack Sizes: 5mg. US Biological Life Sciences.