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| Product | Description | |
|---|---|---|
| Axitinib Impurity 34 | Axitinib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. CAS No. 319463-51-9. Molecular Formula: C22H19ClN4OS. Mole Weight: 422.93. Catalog: APB319463519. |  |
| Axitinib Impurity 4 | Axitinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-N-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfonyl)benzamide. CAS No. 1348536-59-3. Molecular Formula: C22H18N4O3S. Mole Weight: 418.47. Catalog: APB1348536593. | |
| Axitinib Impurity 4 | Cas No. 1443118-73-7. |  |
| Axitinib Impurity 5 | Axitinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-2-(2-(6-((2-(methylcarbamoyl)phenyl)sulfinyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide. Molecular Formula: C22H18N4O3S. Mole Weight: 418.47. Catalog: APB02757. | |
| Axitinib Impurity 6 | Axitinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-2-(2-(6-((2-(methylcarbamoyl)phenyl)sulfonyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide. Molecular Formula: C22H18N4O4S. Mole Weight: 434.47. Catalog: APB02758. | |
| Axitinib Impurity 6 | Axitinib Impurity 6 is an impurity arising from the depths of Axitinib - an oral tyrosine kinase inhibitor profoundly employed in the therapy against advanced renal carcinoma. Synonyms: Axitinib Impurity d. Grades: > 95%. CAS No. 1443118-72-6. Molecular formula: C29H25N5OS. Mole weight: 491.62. | |
| Axitinib Impurity 7 | Axitinib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-2-((1-acetyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide. CAS No. 1639137-80-6. Molecular Formula: C24H20N4O2S. Mole Weight: 428.51. Catalog: APB1639137806. | |
| Axitinib Impurity 8 | Axitinib Impurity 8 is an impurity of axitinib fortifying the therapy against the perilous adversity known as advanced renal carcinoma. Synonyms: 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide; BenzaMide, 2-(1H-indazol-6-ylthio)-N-Methyl-; Axitinib Impurity e. Grades: > 95%. CAS No. 944835-85-2. Molecular formula: C15H13N3OS. Mole weight: 283.35. | |
| Axitinib Impurity 8 | Axitinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-6-nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole. Molecular Formula: C19H18N4O3. Mole Weight: 350.37. Catalog: APB02756. | |
| Axitinib Impurity 9 | Axitinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-methyl-2-((3-(2-(pyridin-2-yl)ethyl)-1H-indazol-6-yl)thio)benzamide. CAS No. 1443118-73-7. Molecular Formula: C22H20N4OS. Mole Weight: 388.49. Catalog: APB1443118737. | |
| Axitinib Intermediate 1 | Axitinib Intermediate 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 70315-70-7. Molecular Formula: C7H4IN3O2. Mole Weight: 289.03. Catalog: APB70315707. | |
| Axitinib Intermediate 3 | Axitinib Intermediate 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 261953-36-0. Molecular Formula: C7H5IN2. Mole Weight: 244.04. Catalog: APB261953360. | |
| Axitinib Intermediate 4 | Axitinib Intermediate 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 886230-76-8. Molecular Formula: C19H20N4O. Mole Weight: 320.4. Catalog: APB886230768. | |
| Axitinib sulfone | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: Sulfonyl axitinib; (E)-N-methyl-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylsulfonyl)benzamide; N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide. Grades: ≥95%. CAS No. 1348536-59-3. Molecular formula: C22H18N4O3S. Mole weight: 418.47. | |
| Axitinib sulfoxide | A major metabolite of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide; Axitinib Impurity A. Grades: > 95%. CAS No. 1347304-18-0. Molecular formula: C22H18N4O2S. Mole weight: 402.48. | |
| Axltide | Axltide is based on mouse insulin receptor substrate 1 (amino acids 979-989). It is also a substrate for the kinases AXL, DDR2, MST1 and JAK2. Synonyms: Axl/Insulin Receptor Substrate Peptide; H-Lys-Lys-Ser-Arg-Gly-Asp-Tyr-Met-Thr-Met-Gln-Ile-Gly-OH; L-lysyl-L-lysyl-L-seryl-L-arginyl-glycyl-L-alpha-aspartyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-glutaminyl-L-isoleucyl-glycine. Grades: ≥98%. CAS No. 143364-95-8. Molecular formula: C63H107N19O20S2. Mole weight: 1514.77. | |
| AY 9944 | Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol ?7-reductase and ?8,7-sterol isomerase. A sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: trans-N1, N4-Bis [ (2-chlorophenyl) methyl ] -1, 4-cyclohexane dimethanamine Hydrochloride; N, N'-Bis (o-chlorobenzyl)-trans-1, 4-cyclohexanebis (methylamine) Dihydrochloride. Grades: Highly Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. | |
| AY-NH2 | AY-NH is a selective proteinase-activated receptor 4 (PAR4) receptor agonist peptide. It stimulates aggregation of rat and human platelets in vitro. It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. It induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips. It also inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. It increases paw thickness in a rat paw edema inflammation model in vivo. Synonyms: PAR-4 Agonist Peptide, amide; L-Alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide; PAR-4-AP; Proteinase-activated Receptor 4 Activating Peptide. Grades: 98%. CAS No. 352017-71-1. Molecular formula: C34H48N8O7. Mole weight: 680.79. | |
| AY-NH2 | AY-NH2. Group: Biochemicals. Grades: Purified. CAS No. 352017-71-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AZ0108 | AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S) -4- ( (3- (3- (1, 1-difluoroethyl) -6-methyl-5, 6, 7, 8-tetrahydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7-carbonyl) phenyl) difluoromethyl) phthalazin-1 (2H) -one; AZ0108; AZ-0108; AZ 0108. Grades: >98%. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. | |
| AZ 10397767 | AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). It significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grades: ≥98% by HPLC. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88. | |
| AZ 10417808 | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grades: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
| AZ 10606120 dihydrochloride | AZ 10606120 dihydrochloride is the dihydrochloride salt of AZ 10606120, which is a potent and negative allosteric modulator of the human P2X7 receptor. Its KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively. It binds in a positive cooperative manner to sites and acts as a negative allosteric modulator. It is a key modulator of the PI3K/GSK3β/VEGF signaling network. It inhibits tumor growth and shows antiangiogenic effects in mice. Synonyms: AZ10606120; AZ 10606120; AZ-10606120; N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide Dihydrochloride; 2- (1-Adamantyl) -N-[2-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]quinolin-5-yl]acetamide Dihydrochloride. Grades: ≥98% by HPLC. CAS No. 607378-18-7. Molecular formula: C25H36N4O2Cl2. Mole weight: 495.48. | |
| AZ10606120 dihydrochloride | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC 50 of about 10?nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 607378-18-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108669. |  |
| AZ11645373 | AZ11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Uses: Purinergic p2x receptor antagonists. Synonyms: 2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-; 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione; AZ 11645373; AZ-11645373; 3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione. Grades: >98%. CAS No. 227088-94-0. Molecular formula: C24H21N3O5S. Mole weight: 463.51. | |
| AZ 11645373 | AZ 11645373. Group: Biochemicals. Alternative Names: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione. Grades: Highly Purified. CAS No. 227088-94-0. Pack Sizes: 5mg. Molecular Formula: C24H21N3O5S, Molecular Weight: 463.51. US Biological Life Sciences. | Worldwide |
| AZ11665362 | AZ11665362 is a potent CRTH2 antagonist. It blocks the migration of eosinophils and basophils, and the rapid mobilization of eosinophils from bone marrow. It might be useful for the treatment of allergic diseases. Uses: Az11665362 might be useful for the treatment of allergic diseases. Synonyms: AZ-11665362; AZ 11665362; AZ11665362; (2,5-Dimethyl-3-(8-methyl-4-quinolinyl)-1H-indol-1-yl)acetic acid. Grades: 98%. CAS No. 629645-40-5. Molecular formula: C22H20N2O2. Mole weight: 344.41. | |
| AZ 12080282 dihydrochloride | AZ 12080282 dihydrochloride is a potent Hh inhibitor with IC50 value <0.012 μM. It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency. Synonyms: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride. Grades: ≥98%. Molecular formula: C23H20N4O2·2HCl. Mole weight: 457.35. | |
| AZ 12216052 | AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grades: ≥98% by HPLC. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35. | |
| AZ 12216052 | AZ 12216052. Group: Biochemicals. Grades: Purified. CAS No. 1290628-31-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AZ-1355 | AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I 2 /thromboxane A 2 ratio in vitro. Uses: Scientific research. Group: Signaling pathways. CAS No. 75451-07-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101692. | |
| AZ13705339 | AZ13705339 is a potent and selective PAK1 inhibitor (IC50 = 0.33 nM). PAK1 is commonly overexpressed in breast tumors. Synonyms: AZ13705339; AZ 13705339; AZ-13705339; 2-[[N-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile. Grades: 99%. CAS No. 2016806-57-6. Molecular formula: C33H36FN7O3S. Mole weight: 629.75. | |
| AZ191 | AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Synonyms: AZ191; AZ 191; AZ-191. Grades: >98%. CAS No. 1594092-37-1. Molecular formula: C24H27N7O. Mole weight: 429.52. | |
| AZ20 | In vitro, AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Synonyms: AZ20; AZ-20; AZ 20. Grades: >98%. CAS No. 1233339-22-4. Molecular formula: C21H24N4O3S. Mole weight: 412.51. | |
| AZ20 | AZ20 is a potent and selective inhibitor of ATR with an IC 50 of 5 nM, and has 8-fold selectivity against mTOR (IC 50 =38 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1233339-22-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15557. | |
| AZ-2088 | AZ-2088 is a powerful and discriminating inhibitor exhibiting its prowess by selectively antagonizing the Akt pathway. Synonyms: AZ 2088; AZ2088; Dimethylheptyl(1-hydroxy-p-menth-2-yl)ammonium bromide; N-Heptyl-2-hydroxy-N,N,2-trimethyl-5-(propan-2-yl)cyclohexan-1-aminium bromide. Grades: >98%. CAS No. 20091-61-6. Molecular formula: C19H40BrNO. Mole weight: 378.44. | |
| AZ 23 | AZ 23 is a potent and selective tyrosine kinase (Trk) inhibitor with the potential for therapeutic utility in neuroblastoma and multiple other cancer indications. Uses: Multiple cancer therapy. Synonyms: AZ-23; AZ 23; AZ23; UNII-009OMI967N; 5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine. Grades: 99%. CAS No. 915720-21-7. Molecular formula: C17H19ClFN7O. Mole weight: 391.83. | |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grades: ≥98%. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC 50 s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 ( IC 50 , 6 nM), CSF1R ( IC 50 , 35 nM). Anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942507-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117273. | |
| AZ31 | AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC 50 of <1.2 nM for ATM enzyme, and an IC 50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088113-98-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112198. | |
| AZ31 | AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grades: ≥98%. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grades: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZ32; AZ-32; AZ 32. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.38. Purity: >98%. IUPACName: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Canonical SMILES: O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32. Product ID: ACM2288709964. Alfa Chemistry ISO 9001:2015 Certified. Categories: AZD-2327. |  |
| AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grades: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
| Az-33 | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grades: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
| AZ 3451 | AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling. Synonyms: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide; AZ-3451; AZ3451. Grades: ≥98%. CAS No. 2100284-59-9. Molecular formula: C30H27BrN4O3. Mole weight: 571.46. | |
| AZ505 | AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ505; AZ 505; AZ-505. Grades: >98%. CAS No. 1035227-43-0. Molecular formula: C29H38Cl2N4O4. Mole weight: 577.54. | |
| AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ505 ditrifluoroacetate; AZ 505 ditrifluoroacetate; AZ-505 ditrifluoroacetate. Grades: >98%. CAS No. 1035227-44-1. Molecular formula: C33H40Cl2F6N4O8. Mole weight: 805.59. | |
| AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC 50 of 0.12 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1035227-44-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15226A. | |
| AZ5104 | AZ5104 is a potent EGFR inhibitor and a derivative of AZD 9291. AZ5104 exhibits reduced selectivity against wild-type EGFR but five-fold potentcy compared to AZD 9291. Synonyms: AZ-5104; AZ 5104; N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide. CAS No. 1421373-98-9. Molecular formula: C27H31N7O2. Mole weight: 485.592. | |
| AZ 5704 | AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM in an enzyme inhibition assay. It exhibits 600-fold selectivity for ATM over other kinases. AZ 5704 is also orally bioavailable. Synonyms: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide; AZ-5704; AZ5704. Grades: ≥98%. CAS No. 1941214-06-7. Molecular formula: C23H23FN6O2. Mole weight: 434.47. | |
| AZ6102 | AZ6102 is a moderate oral bioavailable dual inhibitor of TNKS1/2 with excellent selectivity against other PARP family enzymes including PARP-1, PARP-2 and PARP-6. It also inhibits Wnt signaling in DLD-1 cells. IC50: TNKS2= 1 nM; TNKS1= 3 nM; Wnt signaling. Synonyms: 2-[4-[6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-oneAZ6102; AZ-6102; AZ 6102.AZ 6102|rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidi. CAS No. 1645286-75-4. Molecular formula: C25H28N6O. Mole weight: 428.53. | |
| AZ 628 | AZ628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). It displays selectivity for Raf kinases over a panel of 150 other kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Synonyms: AZ628; AZ-628; AZ 628. Grades: >98%. CAS No. 878739-06-1. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ 628 | AZ 628 is a pan-Raf kinase inhibitor with IC 50 s of 105, 34 and 29 nM for B-Raf , B-RafV600E , and c-Raf-1 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 878739-06-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-11004. | |
| AZ683 | AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R ( K i =8 nM; IC 50 =6 nM). AZ683 has good oral bioavailability. [ 11 C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 953798-95-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159108. | |
| AZ7371 | AZ7371 is a novel non-covalent inhibitor of decaprenylphosphoryl-D-ribose oxidase (DprE1) with IC50 of 10 nM. Synonyms: AZ-7371; AZ 7371; TBA-7371; DprE1-IN-1. Grades: 98%. CAS No. 1494675-86-3. Molecular formula: C18H21N5O3. Mole weight: 355.40. | |
| AZ82 | AZ82 is a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 μM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. Synonyms: AZ-82; AZ 82. Grades: ≥98%. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. | |
| AZ876 | AZ876 is a novel high-affinity LXR agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively, it was previously shown to inhibit progression of atherosclerosis in mice without incurring the aforementioned adverse effects. Whether AZ876 exerts additional protection in the heart remains to be explored. LXR activation with AZ876 attenuated this increase, and significantly reduced TAC-induced increases in heart weight, myocardial fibrosis, and cardiac dysfunction without affecting blood pressure. AZ876 was also 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human. Synonyms: AZ 876; AZ-876; AZ12260493; AZ 12260493; AZ-12260493. Grades: ≥98%. CAS No. 898800-26-5. Molecular formula: C24H29N3O3S. Mole weight: 439.57. | |
| AZ-960 | AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM. Synonyms: (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; 3-Pyridinecarbonitrile, 5-fluoro-2-(((1S)-1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)-; 5-Fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]nicotinonitrile. Grades: >98%. CAS No. 905586-69-8. Molecular formula: C18H16F2N6. Mole weight: 354.36. | |
| AZA | ~4-fold increase in efficiency with OSKM and promotes full reprogramming. Uses: Reprogramming. Synonyms: 3'-Azido-2',3'-dideoxyadenosine; 66323-44-2; 3'-Azido-ddA; 3'-AzddAdo; [(2S,3S,5R)-5-(6-aminopurin-9-yl)-3-azidooxolan-2-yl]methanol; 3'-N3-ddA; [(2S,3S,5R)-5-(6-aminopurin-9-yl)-3-azido-tetrahydrofuran-2-yl]methanol; HG1022; 3'-Azido-2'-deoxyadenosine; CHEMBL590121; SCHEMBL18640424; DTXSID10216534; XDRZJDXXQHFAAE-RRKCRQDMSA-N; MFCD01630963; AKOS037644233; ((2S,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-azidotetrahydrofuran-2-yl)methanol; AS-49374; CS-0199753; A835421; 9-(3-Azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)adenine; 9-(3'-Azido-2',3'-dideoxy-.beta.-D-erythro-pentofuranosyl)adenine; 9-(3'-Azido-2',3'-dideoxy-beta-D-erythro-pentofuranosyl)adenine; [(2S,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-azidooxolan-2-yl]methanol; 9H-purin-6-amine, 9-(3-azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)-. Grades: ≥ 97%. CAS No. 66323-44-2. Molecular formula: C10H12N8O2. Mole weight: 276.26. | |
| Azacetidine Monoacetate | Azacetidine Monoacetate is an impurity of 5-Azacytidine, an antiproliferative/cytotoxic agent for leukemia therapy. Synonyms: ((2R,3S,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl acetate; 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one. CAS No. 1174733-90-4. Molecular formula: C10H14N4O6. Mole weight: 286.24. | |
| Azacitidine | 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one sodium 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5-Azacytidine, Ladakamycin. CAS No. 320-67-2. Product ID: 8-04982. Molecular formula: C8H12N4O5. Mole weight: 244.2. Purity: nucleoside metabolic inhibitor therapeutic for acute myeloid leukemia. |  |
| Azacitidine α-Isomer | Azacitidine α-Isomer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-1-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one. CAS No. 157771-77-2. Molecular Formula: C8H12N4O5. Mole Weight: 244.2. Catalog: APB157771772. | |
| Azacitidine Impurity 1 | Azacitidine Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-1-((2R,3R,4R,5R)-3-(((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one. Molecular Formula: C13H20N4O9. Mole Weight: 376.32. Catalog: APB03066. | |
| Azacitidine Impurity 1 | Azacitidine Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 645-92-1. Molecular Formula: C3H5N5O. Mole Weight: 127.11. Catalog: APB645921. | |
| Azacitidine Impurity 10 | Azacitidine Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-((Z)-N'-(((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)carbamoyl)carbamimidoyl)formamide. Molecular Formula: C8H14N4O6. Mole Weight: 262.22. Catalog: APB03061. | |
| Azacitidine Impurity 11 | Azacitidine Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Azacitidine Impurity 11. Molecular Formula: C7H14N4O5. Mole Weight: 234.21. Catalog: APB03063. | |
| Azacitidine Impurity 12 | Azacitidine Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(Aminoiminomethyl)-N'-ß-D-ribofuranosylurea. CAS No. 2508-80-7. Molecular Formula: C7H14N4O5. Mole Weight: 234.21. Catalog: APB2508807. | |
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