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| Product | Description | |
|---|---|---|
| Azathioprine EP Impurity C | Azathioprine EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-chloro-1-methyl-4-nitro-1H-imidazole. Molecular Formula: C4H4ClN3O2. Mole Weight: 161.55. Catalog: APB02967. |  |
| Azathioprine EP Impurity D | Azathioprine EP Impurity D is a metabolite of Azathioprine. Synonyms: 1-Methyl-4-nitro-5-thioimidazole; 1-Methyl-4-nitro-1H-imidazole-5-thiol; 5-Mercapto-1-methyl-4-nitroimidazole. Grades: > 95%. CAS No. 6339-54-4. Molecular formula: C4H5N3O2S. Mole weight: 159.17. |  |
| Azathioprine EP Impurity D | Azathioprine EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6339-54-4. Molecular Formula: C4H5N3O2S. Mole Weight: 159.16. Catalog: APB6339544. | |
| Azathioprine EP Impurity D | Azathioprine EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-methyl-4-nitro-1H-imidazole-5-thiol. Molecular Formula: C4H5N3O2S. Mole Weight: 159.17. Catalog: APB02968. | |
| Azathioprine EP Impurity E | Azathioprine EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 73703-74-9. Molecular Formula: C4H5N3O3. Mole Weight: 143.1. Catalog: APB73703749. | |
| Azathioprine EP Impurity E Sodium Salt | Azathioprine EP Impurity E Sodium Salt is a degradation product of Azathioprine. Synonyms: 5-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt; 1-Methyl-4-nitro-1H-imidazol-5-ol Sodium Salt. Grades: > 95%. CAS No. 35681-68-6. Molecular formula: C4H4N3O3Na. Mole weight: 165.08. | |
| Azathioprine EP Impurity F | Azathioprine EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. CAS No. 68-94-0. Molecular Formula: C5H4N4O. Mole Weight: 136.11. Catalog: APB68940. | |
| Azathioprine EP Impurity F | Azathioprine EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1H-purin-6(7H)-one. Molecular Formula: C5H4N4O. Mole Weight: 136.11. Catalog: APB02965. | |
| Azathioprine EP Impurity G | Azathioprine EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 5581-52-2. Molecular Formula: C9H8N8O2S. Mole Weight: 292.28. Catalog: APB5581522. | |
| Azathioprine EP Impurity G | Azathioprine EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-6,7-dihydro-1H-purin-2-amine. Molecular Formula: C9H10N8O2S. Mole Weight: 294.29. Catalog: APB02964. | |
| Azathioprine Impurity 10 | Azathioprine Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 15965-30-7. Molecular Formula: C3H2Cl2N2. Mole Weight: 136.96. Catalog: APB15965307. | |
| Azathioprine Impurity 15 | Azathioprine Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 304441-05-2. Molecular Formula: C11H9N7O3S. Mole Weight: 319.3. Catalog: APB304441052. | |
| Azathioprine Impurity 16 | Azathioprine Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 152529-79-8. Molecular Formula: C14H14N4O5S. Mole Weight: 350.35. Catalog: APB152529798. | |
| Azathioprine Impurity 17 | Azathioprine Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 5437-25-2. Molecular Formula: C5H4N4S2. Mole Weight: 184.24. Catalog: APB5437252. | |
| Azathioprine Impurity 19 | Azathioprine Impurity 19. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C5H3N5OS. Mole Weight: 181.17. Catalog: APB06508. | |
| Azathioprine Impurity 20 | Azathioprine Impurity 20. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C10H6N8S. Mole Weight: 270.27. Catalog: APB06507. | |
| Azathioprine Impurity 3 | Azathioprine Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 5167-18-0. Molecular Formula: C6H6N4O. Mole Weight: 150.14. Catalog: APB5167180. | |
| Azathioprine Impurity 4 | Azathioprine Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 30467-02-8. Molecular Formula: C6H6N4O. Mole Weight: 150.14. Catalog: APB30467028. | |
| Azathioprine Impurity 5 | Azathioprine Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 253453-91-7. Molecular Formula: C4H5ClN2. Mole Weight: 116.55. Catalog: APB253453917. | |
| Azathioprine Impurity 6 | Azathioprine Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4897-21-6. Molecular Formula: C4H5ClN2. Mole Weight: 116.55. Catalog: APB4897216. | |
| Azathioprine Impurity 7 | Azathioprine Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-7H-purine. Molecular Formula: C9H7N7O2S. Mole Weight: 277.26. Catalog: APB02966. | |
| Azathioprine Impurity 8 | Azathioprine Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 873-25-6. Molecular Formula: C4H3Cl3N2. Mole Weight: 185.43. Catalog: APB873256. | |
| Azathioprine Impurity 9 | Azathioprine Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 872-49-1. Molecular Formula: C4H5ClN2. Mole Weight: 116.55. Catalog: APB872491. | |
| Azathioprine Impurity C | Azathioprine Impurity C is an impurity of 6-Mercaptopurine, which is an immunosuppressive drug used to treat leukemia. Synonyms: 6-Mercaptopurine Disulfide; 6,6'-Dithiodi-9H-purine; 6,6'-Dithiodi-purine; Bis(6-purinyl) disulfide; 1,2-Di(9H-purin-6-yl)disulfane; NSC 166569; NSC 77640. Grades: > 95%. CAS No. 49808-20-0. Molecular formula: C10H6N8S2. Mole weight: 302.34. | |
| Azatoxin | Heterocyclic Organic Compound. CAS No. 129564-92-7. Catalog: ACM129564927. |  |
| AZD0156 | AZD0156 is a potent, selective and orally active ATM inhibitor with an IC 50 of 0.58 nM. AZD0156 inhibits the ATM -mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821428-35-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100016. |  |
| AZD0156 | AZD0156 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor, used for cancer treatment. AZD0156 prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. Uses: Protein kinase inhibitors. Synonyms: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one; AZD0156; AZD-0156; AZD 0156. CAS No. 1821428-35-6. Molecular formula: C26H31N5O3. Mole weight: 461.56. | |
| AZD-0284 | AZD-0284 is a reverse agonist of the nuclear receptor (RORγ). AZD-0284 has the potential for the treatment of plaque psoriasis vulgaris and respiratory tract disorders. Synonyms: AZD0284; AZD 0284. CAS No. 2101291-07-8. Molecular formula: C21H18F6N2O5S. Mole weight: 524.43. | |
| AZD 0328 | AZD 0328 is a potent α7 NNR/5HT3 receptor agonist. AZD0328 led to a significant increase in cortical dopamine release in awake rodents and improved both conditioned response learning and memory retention in an object recognition task. Synonyms: (3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]; AZD 0328; AZD-0328; AZD0328; UNII-2B218X5QIY; spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine). Grades: >98%. CAS No. 220099-91-2. Molecular formula: C13H16N2O. Mole weight: 216.28. | |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Synonyms: AZD-0364; AZD 0364; tizaterkib. Grades: ≥98%. CAS No. 2097416-76-5. Molecular formula: C24H24F2N8O2. Mole weight: 494.50. | |
| AZD0424 | AZD0424 is an orally bioavailable small molecule tyrosine kinase inhibitor. It targets both Abl and Src kinases with potential antineoplastic activity. It selectively inhibits both Src and Abl kinase activity and may result in the inhibition of tumor growth in susceptible tumor cells. Uses: Azd0424 has the inhibition of tumor growth in tumor cells. Synonyms: AZD 0424; AZD-0424; 1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one; 7-(2-(4-Acetylpiperazin-1-yl)ethoxy)-4-(5-chloro-2,3-methylenedioxypyridin-4-ylamino)-5-isopropoxyquinazoline. Grades: 98%. CAS No. 692054-06-1. Molecular formula: C25H29ClN6O5. Mole weight: 528.99. | |
| AZD0780 | PCSK9-IN-12 is a heteroaryl compound. PCSK9-IN-12 has bind affinity for PCSK9 with a K d value of ?200 nM. PCSK9-IN-12 can be used for the research of cholesterol metabolism [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCSK9-IN-12. CAS No. 2455427-91-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148673. | |
| AZD-0837 | AZD0837 is an oral direct thrombin inhibitor currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. Uses: Potassium channel antagonist. Synonyms: AZD0837; AZD-0837; AZD 0837; Atecegatran metoxil; Atecegatran fexenetil.1-((2R)-(3-chloro-5- (difluoromethoxy) phenyl) hydroxyacetyl) -N- ( (4- (imino (methoxyamino) methyl) phenyl) methyl) -, (2S) -2-Azetidinecarboxamide; (S) -1- ( (R) -2- (3-chloro-5- (difluoromethoxy) phenyl) -2-hydroxyacetyl) -N- (4- (N-methoxycarbamimidoyl) benzyl) azetidine-2-carboxamide. Grades: ≥95%. CAS No. 433937-93-0. Molecular formula: C22H23ClF2N4O5. Mole weight: 496.89. | |
| AZD1080 | AZD1080 is a brain-permeable GSK3 inhibitor with Ki values of 6.9 nM and 31 nM for GSK3α and GSK3β, respectively. Study showed that AZD1080 inhibited tau phosphorylation in cells. It also suppresses ovarian cancer cell proliferation, invasion, migration, and lamellipodia formation, and induces G1 arrest. Synonyms: AZD-1080; 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile. Grades: >98%. CAS No. 612487-72-6. Molecular formula: C19H18N4O2. Mole weight: 334.37. | |
| AZD1080 | AZD1080 Inhibitor. Uses: Scientific use. Product Category: T1741. CAS No. 612487-72-6. |  |
| AZD1152-HQPA | Barasertib is a potent and highly selective inhibitor of AURKB with IC50 of 0.37 nM, acting via preventing the transfer of the phosphate group from the ATP molecule to AURKB substrates. The present study demonstrated for the first time, that AURKB inhibition interferes with early regeneration of SGs. Barasertib has been demonstrated that it is 3,700-fold greater selectivity than Aurora A. Synonyms: INH 34; AZD1152-HQPA; AZD2811. Grades: ≥98%. CAS No. 722544-51-6. Molecular formula: C26H30FN7O3. Mole weight: 507.56. | |
| AZD1152, TFA Salt | An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 3-[[7-[3-[Ethyl[2- (phosphonooxy) ethyl]amino]propoxy]-4-quinazolinyl]amino]-N- (3-fluorophenyl) -1H-pyrazole-5-acetamide Trifluoroacetic Acid Salt; Barasertib Trifluoroacetic Acid Salt; AZD-1152 Trifluoroacetic Acid Salt. Grades: Highly Purified. CAS No. 957881-03-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??FN?O?P; x(C ?HF?O?), Molecular Weight: 587.54. US Biological Life Sciences. |  Worldwide |
| AZD1208 | AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1204144-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15604. | |
| AZD-1208 | AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition. Synonyms: AZD1208; AZD 1208. Grades: 0.98. CAS No. 1204144-28-4. Molecular formula: C21H21N3O2S. Mole weight: 379.478. | |
| AZD1283 | AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for 3 and 13, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds. On the basis of these data, compound 3 was progressed into human clinical trials as candidate drug AZD1283. Synonyms: AZD 1283; AZD-1283. Grades: 0.98. CAS No. 919351-41-0. Molecular formula: C23H26N4O5S. Mole weight: 470.544. | |
| AZD1305 | AZD1305 is a potassium channel and sodium channel antagonist. It can inhibit rapidly the activating delayed-rectifier potassium current, L-type calcium current, and inward sodium current. Phase II clinical trials for Arrhythmias, Atrial fibrillation, Atrial flutter and Left ventricular dysfunction were discontinued. Uses: Arrhythmias; atrial fibrillation; atrial flutter; left ventricular dysfunction. Synonyms: AZD-1305; AZD 1305; AZD1305; UNII-CZO834LXQM; UNII-CZO834LXQM; (2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester. Grades: 98%. CAS No. 872045-91-5. Molecular formula: C22H31FN4O4. Mole weight: 434.51. | |
| azd1390 | azd1390 Inhibitor. Uses: Scientific use. Product Category: T5175. CAS No. 2089288-03-7. | |
| AZD1390 | AZD1390 is a first-in-class, orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. It can be used to cross the blood-brain barrier suitable for the treatment of intracranial malignancies. Synonyms: AZD-1390; AZD 1390. Grades: ≥98%. CAS No. 2089288-03-7. Molecular formula: C27H32FN5O2. Mole weight: 477.57. | |
| AZD1390 | AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC 50 of 0.78 nM in cell [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089288-03-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109566. | |
| AZD1480 | AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 1.3nM and 0.26nM, respectively. Group: Biochemicals. Alternative Names: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| AZD-1480 | AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. Synonyms: AZD1480; AZD-1480; AZD 1480. Grades: 0.98. CAS No. 935666-88-9. Molecular formula: C14H14ClFN8. Mole weight: 348.77. | |
| AZD1656 | AZD1656 is a potent, selective and orally active glucokinase activator with an EC 50 of 60 nM. AZD1656 has the potential for type 2 diabetes research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 919783-22-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15675. | |
| AZD1979 | This active molecular is a MCHr1 (melanin concentrating hormone receptor 1) antagonist originated by AstraZeneca. AZD1979 has excellent DMPK properties and gave good effects on weight loss in animal model. In Jul 2014, AstraZeneca terminated a phase I trial in Obesity in healthy volunteers in USA after stopping criteria were reached. Uses: Obesity. Synonyms: AZD1979; AZD-1979; AZD 1979. (3-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone. Grades: 98%. CAS No. 1254035-84-1. Molecular formula: C25H26N4O5. Mole weight: 462.51. | |
| AZD1981 | AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8. Uses: Scientific research. Group: Signaling pathways. CAS No. 802904-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15950. | |
| AZD1981 | AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM. Synonyms: AZD1981; AZD 1981; AZD-1981. Grades: 98%. CAS No. 802904-66-1. Molecular formula: C19H17ClN2O3S. Mole weight: 388.866. | |
| AZD-2014 | AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Synonyms: AZD2014, AZD-2014, AZD 2014, Vistusertib. Grades: 0.98. CAS No. 1009298-59-2. Molecular formula: C25H30N6O3. Mole weight: 462.554. | |
| AZD 2066 | AZD-2066 is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 activates the BDNF/trkB signaling pathway. AZD 2066 can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease [1] [2] [3] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934282-55-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-110255. | |
| AZD 2066 | AZD 2066 is a mGluR5 anatagonist. It displays discriminative effects in rats. It is brain penetrant and orally bioavailable. It is used to prevent and treat pain, psychiatric, neurological and other diseases. Synonyms: AZD 2066; AZD2066; AZD-2066; 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine. Grades: ≥98% by HPLC. CAS No. 934282-55-0. Molecular formula: C19H16ClN5O2. Mole weight: 381.82. | |
| AZD 2098 | AZD 2098 is a potent and selective CCR4 receptor antagonist (pIC50 = 7.8) used for the treatment of allergic rhinitis. CCR4 is a molecule that can drive the immune cells toward the tumor cells. Uses: The treatment of allergic rhinitis and asthma. Synonyms: AZD-2098; AZD 2098; AZD2098; 2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide. Grades: 99%. CAS No. 566203-88-1. Molecular formula: C11H9Cl2N3O3S. Mole weight: 334.18. | |
| AZD-2461 | AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. AZD2641 is currently in Phase I clinical study. The study is being conducted to see how it may work to treat solid tumors. The study will also assess the blood levels and action of AZD2461 in the body over a period of time and will indicate whether the drug has a therapeutic effect on solid tumors. Synonyms: AZD2461; AZD 2461. Grades: 0.98. CAS No. 1174043-16-3. Molecular formula: C22H22FN3O3. Mole weight: 395.434. | |
| AZD2716 | AZD2716 is a potent sPLA2 inhibitor (IC50 = 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively). When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 = 176 nM). Synonyms: AZD2716; AZD-2716; AZD 2716. (2R)-3-[3-(5-benzyl-2-carbamoylphenyl)phenyl]-2-methylpropanoic acid. Grades: 99%. CAS No. 1845753-81-2. Molecular formula: C24H23NO3. Mole weight: 373.44. | |
| AZD2858 | AZD2858 is a potent and selective GSK3β inhibitor with Ki value of 4.9 nM. It was shown to promote osteoblast differentiation in human adipose-derived stem cells (hADSC) in vitro. Synonyms: AZD-2858; 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide. Grades: >98%. CAS No. 486424-20-8. Molecular formula: C21H23N7O3S. Mole weight: 453.52. | |
| AZD 2858 hydrochloride | The hydrochloride salt form of AZD 2858. AZD 2858 is a potent and selective Glycogen Synthase Kinase-3β (GSK-3β; Ki = 4.9 nM) inhibitor used for Alzheimer's disease therapy with good BBB permeability in a bovine endothelial cell assay. AZD 2858 selectively inhibits GSK-3β-mediated tau phosphorylation (IC50 = 76 nM) in vitro. In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass by GSK-3 mediated inhibition of Wnt canonical signaling, making AZD2858 a possible therapeutic candidate for osteoporosis. Uses: The treatment of alzheimer's disease. Synonyms: AZD 2858 hydrochloride; AZD2858 hydrochloride; AZD-2858 hydrochloride; 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide hydrochloride. Grades: 98%. CAS No. 486424-21-9. Molecular formula: C21H23N7O3S.HCl. Mole weight: 489.98. | |
| AZD2932 | AZD2932 is a new quinazoline ether inhibitor and is a high affinity inhibitor of VEFGR-2 and PDGFR. It has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFR&beta. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. Synonyms: AZD2932; AZD 2932; AZD-2932. Grades: >98%. CAS No. 883986-34-3. Molecular formula: C24H25N5O4. Mole weight: 447.49. | |
| AZD-3147 | AZD-3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2. It exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. It has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate. Uses: Azd-3147 has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate. Synonyms: AZD3147; AZD-3147; AZD 3147; (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea. Grades: >98%. CAS No. 1101810-02-9. Molecular formula: C24H31N5O4S2. Mole weight: 517.66. | |
| AZD-3161 | AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued. Uses: Neuropathic pain; pain. Synonyms: UNII-403N302X2Y; CHEMBL2069427; 403N302X2Y; 1369501-46-1; AZD-3161; AZD3161; AZD 3161; SCHEMBL873691;N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide. Grades: 98%. CAS No. 1369501-46-1. Molecular formula: C23H21F3N4O4. Mole weight: 474.44. | |
| AZD3229 | AZD3229 is a potent pan- KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC 50 value of 223.3 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2248003-60-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112802. | |
| AZD3229 | AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It selectively inhibits growth of c-Kit mutant with GI50s of 1971 nM and PDGFR mutant with GI50s of 122 nM). AZD3229 demonstrates excellent cross-species pharmacokinetics, shows strong pharmacodynamic inhibition of target, and is active in several in vivo models of GIST. Synonyms: AZD-3229; AZD 3229; N-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide. Grades: ≥98%. CAS No. 2248003-60-1. Molecular formula: C24H26FN7O3. Mole weight: 479.51. | |
| AZD3229 Tosylate | AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. Uses: Scientific research. Group: Signaling pathways. CAS No. 2248003-71-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112802A. | |
| AZD3264 | AZD3264 is a novel IKK2 inhibitor. Synonyms: AZD 3264; AZD-3264; AZD3264. Grades: 98%. CAS No. 1609281-86-8. Molecular formula: C21H23N5O4S. Mole weight: 441.5. | |
| AZD3293 | AZD3293, a spiro compound, has been found to be a β-secretase inhibitor that has good blood-brain barrier penetration and could probably be significant in studies of Alzheimer's disease. It was just planed a Phase III trial in several areas. IC50: 0.2 nM. Synonyms: AZD-3293; AZD 3293; AZD3293; LY3314814; GTPL7789; LY 3314814; GTPL 7789; LY-3314814; GTPL-7789; SCHEMBL9948271; (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine. Grades: 98%. CAS No. 1628076-74-3. Molecular formula: C26H28N4O. Mole weight: 412.53. | |
| AZD-3293 | AZD-3293. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1383982-64-6. Molecular Formula: C26H28N4O. Mole Weight: 412.54. Catalog: APB1383982646. | |
| AZD-3409 | AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. AZD3409 might be active in gefitinib-resistant breast carcinoma. Synonyms: AZD-3409; AZD 3409; AZD3409. Grades: 98%. CAS No. 345915-10-8. Molecular formula: C34H41FN4O4S2. Mole weight: 652.844. | |
| AZD3463 | AZD3463. Group: Biochemicals. Alternative Names: N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C24H25ClN6O, Molecular Weight: 448.95. US Biological Life Sciences. | Worldwide |
| AZD-3463 | AZD-3463 is a potent ALK/IGF1R inhibitor with potential anticancer activity. Synonyms: AZD 3463; AZD3463. Grades: 0.98. CAS No. 1356962-20-3. Molecular formula: C24H25ClN6O. Mole weight: 448.95. | |
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