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| Product | Description | |
|---|---|---|
| AEBSF hydrochloride | AEBSF hydrochloride is an irreversible inhibitor of serine proteases , such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Uses: Scientific research. Group: Signaling pathways. CAS No. 30827-99-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-12821. |  |
| AEBSF hydrochloride (4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride) | 500mg Pack Size. Group: Biochemicals. Formula: C8H10FNO2S ·HCl. CAS No. 30827-99-7. Prepack ID 11939321-500mg. Molecular Weight 239.7. See USA prepack pricing. |  |
| AEC Red Substrate Kit, BioAssay (aminoethyl carbazole), Chromogen Solution (20X) | AEC Red Substrate Kit, BioAssay (aminoethyl carbazole), Chromogen Solution (20X). Group: Molecular Biology. Pack Sizes: 12ml. US Biological Life Sciences. |  Worldwide |
| AEC Red Substrate Kit, BioAssay (aminoethyl carbazole), Hydrogen Peroxide Solution (20X) | AEC Red Substrate Kit, BioAssay (aminoethyl carbazole), Hydrogen Peroxide Solution (20X). Group: Molecular Biology. Pack Sizes: 12ml. US Biological Life Sciences. | Worldwide |
| AEC Red Substrate Kit, BioAssay (aminoethyl carbazole), Substrate Buffer (20X) | AEC Red Substrate Kit, BioAssay (aminoethyl carbazole), Substrate Buffer (20X). Group: Molecular Biology. Pack Sizes: 12ml. US Biological Life Sciences. | Worldwide |
| AEE788 | AEE788 is an inhibitor of the EGFR and ErbB2 with IC 50 values of 2 and 6 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NVP-AEE 788. CAS No. 497839-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10045. | |
| AEE 788 | AEE 788. Group: Biochemicals. Grades: Purified. CAS No. 497839-62-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Synonyms: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: >98%. CAS No. 497839-62-0. Molecular formula: C27H32N6. Mole weight: 440.595. |  |
| AEEA-AEEA | AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid. CAS No. 1143516-05-5. Molecular formula: C12H24N2O7. Mole weight: 308.33. | |
| AEG 3482 | AEG 3482. Group: Biochemicals. Grades: Purified. CAS No. 63735-71-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AEG 3482 | AEG 3482 has been found to be an inhibitor of c-jun N-terminal kinase (JNK) signaling and could probably be useful against some neurological disorders. Synonyms: AEG-3482; AEG 3482; AEG3482; 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide. Grades: ≥99% by HPLC. CAS No. 63735-71-7. Molecular formula: C10H8N4O2S2. Mole weight: 280.33. | |
| AEG 40730 dihydrochloride | AEG 40730 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AEG 40730 dihydrochloride | The dihydrochloride salt form of AEG 40730, which has been found to be an IAP antagonist as well as an apoptosis protein inhibitor and could probably be uesful in cancer research. Synonyms: AEG 40730 dihydrochloride; AEG40730 dihydrochloride; AEG-40730 dihydrochloride; 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1883545-50-3. Molecular formula: C52H68F6N8O8.2HCl. Mole weight: 1120.06. | |
| AEG40826 | AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. Synonyms: HGS-1029; HGS 1029; HGS1029; AEG40826-2HCl; AEG-40826; HGS1029; AEG 40826. Grades: 98%. CAS No. 1107664-44-7. | |
| Aegeline | Aegeline. Group: Biochemicals. Alternative Names: (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide; (E)-(±)-(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide; Egeline; (±)-Aegeline; (±)-Egeline; Aegelin. Grades: Highly Purified. CAS No. 456-12-2. Pack Sizes: 50mg. Molecular Formula: C18H19NO3, Molecular Weight: 297.35. US Biological Life Sciences. | Worldwide |
| Aegeline | Aegeline, is a compound that can be extracted from Aegle marmelos leaves, a tree that grows in India. Research has found the essential oil of the tree to be effective against 21 types of bacteria. Aegeline, has also shown to have anti-obesity effects. Synonyms: (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide; (E)-(±)-(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide. Grades: > 95%. CAS No. 456-12-2. Molecular formula: C18H19NO3. Mole weight: 297.36. | |
| Aegeline | Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 456-12-2. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W042156. | |
| Aegeline-d3 | Aegeline-d3. Group: Biochemicals. Alternative Names: (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide-d3; (E)-(±)-(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide-d3; Egeline-d3; (±)-Aegeline-d3; (±)-Egeline-d3; Aegelin-d3. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C18H16D3NO3, Molecular Weight: 300.37. US Biological Life Sciences. | Worldwide |
| Aegelinol | Aegelinol is a coumarin isolated from Angelica gigas. Synonyms: (±)-Prantschimgin; 3',4'-dihydro-3'-hydroxy-Xanthyletin. Grades: 0.98. CAS No. 5993-18-0. Molecular formula: C14H14O4. Mole weight: 246.3. | |
| a-Ergocryptine | a-Ergocryptine. Group: Biochemicals. Alternative Names: 12'-Hydroxy-2'-(1-methylethyl)-5'-a-(2-methylpropyl)ergotaman-3',6',18-trione. Grades: Highly Purified. CAS No. 511-09-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C32H41N5O5. US Biological Life Sciences. | Worldwide |
| a-Ergocryptinine | a-Ergocryptinine. Group: Biochemicals. Alternative Names: Ergokryptinine; Isoergokryptine; a-Ergocryptinine. Grades: Highly Purified. CAS No. 511-10-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C32H41N5O5. US Biological Life Sciences. | Worldwide |
| Aerobactin | Akrabicin is a siderophore produced by the culture of Aerobacter aerogenes, Escherichia coli and Klebsiella pneumoniae under iron deficiency. Synonyms: Ferric-aerobactin; 3,9,15,21-Tetraazatricosane-8,12,16-tricarboxylic acid, 3,12,21-trihydroxy-2,10,14,22-tetraoxo-, [S-(R*,R*)]-. CAS No. 26198-65-2. Molecular formula: C22H36N4O13. Mole weight: 564.54. | |
| Aerobactin | Aerobactin is a siderophore produced by bacteria. Aerobactin is a highly potent pathogenic factor [1]. Uses: Scientific research. Group: Natural products. CAS No. 26198-65-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-122280. | |
| aerobactin synthase | Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citric acid. This enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate. Group: Enzymes. Synonyms: iucC (gene name). Enzyme Commission Number: EC 6.3.2.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5756; aerobactin synthase; EC 6.3.2.39; iucC (gene name). Cat No: EXWM-5756. |  |
| aerobic carbon monoxide dehydrogenase | This enzyme, found in carboxydotrophic bacteria, catalyses the oxidation of CO to CO2 under aerobic conditions. The enzyme contains a binuclear Mo-Cu cluster in which the copper is ligated to a molybdopterin center via a sulfur bridge. The enzyme also contains two [2Fe-2S] clusters and FAD, and belongs to the xanthine oxidoreductase family. The CO2 that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor. cf. EC 1.2.7.4, anaerobic carbon monoxide dehydrogenase. Group: Enzymes. Synonyms: MoCu-CODH; coxSML (gene names); molybdoenzyme carbon monoxide dehydrogenase. Enzyme Commission Number: EC 1.2.5.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1222; aerobic carbon monoxide dehydrogenase; EC 1.2.5.3; MoCu-CODH; coxSML (gene names); molybdoenzyme carbon monoxide dehydrogenase. Cat No: EXWM-1222. | |
| Aerocavin | Aerocavin is a macrolide antibiotic produced in Chromobacterium violaceum. Aerocavin has anti-Gram-positive bacteria and weak anti-negative bacteria activity. Synonyms: Oxacyclotetradeca-3,6,9-triene-4-acetic acid, 12-hydroxy-14-(2-hydroxyundecyl)-10-methyl-2-oxo-, (3E,6E,9E,12R*,14S*(R*))-(+)-; 2-[(3E,6Z,9Z,12R,14S)-12-hydroxy-14-[(2R)-2-hydroxyundecyl]-10-methyl-2-oxo-1-oxacyclotetradeca-3,6,9-trien-4-yl]acetic acid. CAS No. 113702-00-4. Molecular formula: C27H44O6. Mole weight: 464.63. | |
| Aerocyanidin | Aerocyanidin is an antibiotic produced in Chromobacterium violaceum. Aerocyanidin has strong anti-Gram-positive quotient activity, weak effect on negative bacteria. Synonyms: 11-(3-isocyano-3-methyloxiran-2-yl)undecaneperoxoic acid; kappa-Hydroxy-3-isocyano-3-methyloxiraneundecanoic acid (2-alpha(R*),3-alpha)-(-)-; Oxiraneundecanoic acid, kappa-hydroxy-3-isocyano-3-methyl-, (2-alpha(R*),3-alpha)-(-)-. Grades: >98%. CAS No. 113701-99-8. Molecular formula: C15H25NO4. Mole weight: 283.36. | |
| Aerosil 200 | Aerosil 200. Group: Biochemicals. Grades: Highly Purified. CAS No. 7631-86-9. Pack Sizes: 5kg, 10kg, 25kg. US Biological Life Sciences. | Worldwide |
| Aerosol 22 | Aerosol 22. Uses: Designed for use in research and industrial production. Appearance: Liquid. CAS No. 38916-42-6. Product ID: ACM38916426. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Aerosol Monitor, Polystyrene 25 mm, mixed cellulose esters, 0.8 μm, white, with pad | Aerosol Monitor, Polystyrene 25 mm, mixed cellulose esters, 0.8 μm, white, with pad. Uses: Product filters out: airborne particles, trace metals, particulate fluorides sample collection and particle analysis. Group: Polystyrene (ps). |  |
| Aerothionin | Aerothionin is a dimeric spiroisoxazoline derived from marine sponges that demonstrates antimycobacterial activity. Synonyms: (+)-aerothionin. Grades: ≥97%. CAS No. 28714-26-3. Molecular formula: C24H26Br4N4O8. Mole weight: 818.1. | |
| AES-350 | AES-350 is an effective and orally active HDAC6 inhibitor with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 shows higher HDAC isoform selectivity, higher MV4-11 cell cytotoxicity, improved treatment window and more effective absorption through cells and lipid membranes. Synonyms: Tert-Butylbenzamido Hydroxylbenzamide. Grades: 98%. CAS No. 847249-57-4. Molecular formula: C18H20N2O3. Mole weight: 312.4. | |
| Aescin | Escin, (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid. tumor cell inhibitor. CAS No. 6805-41-0. Product ID: 8-04423. Molecular formula: C55H86O24. Mole weight: 1131.27. |  |
| Aescin A | Aescin A. Group: Biochemicals. CAS No. 123748-68-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aescin B | Aescin B. Group: Biochemicals. CAS No. 26339-90-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aescin C | Aescin C. Group: Biochemicals. CAS No. 219944-39-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aescine | Aescine. Group: Polysaccharide. Alternative Names: AESCINE, 6805-41-0. CAS No. 6805-41-0. Product ID: 6-[[(4S, 6aR, 6bS, 8aR, 14bR)-9-acetyloxy-8-hydroxy-4, 8a-bis(hydroxymethyl)-4, 6a, 6b, 11, 11, 14b-hexamethyl-10-(2-methylbut-2-enoyloxy)-1, 2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14, 14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3, 5-bis[[3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-. Molecular formula: 1131.26. Mole weight: C55< / sub>H86< / sub>O24< / sub>. CC=C (C)C (=O)OC1C (C2 (C (CC1 (C)C)C3=CCC4C5 (CCC (C (C5CCC4 (C3 (CC2O)C)C) (C)CO)OC6C (C (C (C (O6)C (=O)O)OC7C (C (C (C (O7)CO)O)O)O)O)OC8C (C (C (C (O8)CO)O)O)O)C)CO)OC (=O)C. AXNVHPCVMSNXNP-VJLKZOTMSA-N. Purity >95%. | |
| Aescin IIA | anti-inflammatory. Uses: Anti-inflammatory. Synonyms: escin IIa; AESCIN IIA. Grades: >98%. CAS No. 158732-55-9. Molecular formula: C54H84O23. Mole weight: 1101.25. | |
| AescinIIB | anti-inflammatory. Uses: Anti-inflammatory. Synonyms: AESCIN IIB; ESCIN IIB. Grades: >98%. CAS No. 158800-83-0. Molecular formula: C54H84O23. Mole weight: 1101.25. | |
| Aescin polysulphate sodium salt | Aescin polysulphate sodium salt is a remarkable biomedical compound with anti-inflammatory and antithrombotic prowess acting as an exquisite derivative of Aescin. Molecular formula: C53H82O36S4. Mole weight: 1423.46. | |
| Aesculetin-7-O-D-Glucopyranoside | Cas No. 531-58-8. | |
| Aestivophoenin A | Aestivophoenin is a nerve cell protective substance produced in Streptomyces purpeofuscus. Aestivophoenin A can reduce the toxicity of L-glutamate to Nl8-RE-105 cells, with an ECso of 15.0 nmol/L, and has an antioxidant effect. CAS No. 171864-91-8. Molecular formula: C31H32N2O7. Mole weight: 544.59. | |
| Aestivophoenin B | Aestivophoenin is a nerve cell protective substance produced in Streptomyces purpeofuscus. Aestivophoenin B can reduce the toxicity of L-glutamate to Nl8-RE-105 cells, with an ECso of 6.2 nmol/L, and has an antioxidant effect. CAS No. 171864-92-9. Molecular formula: C36H40N2O7. Mole weight: 612.71. | |
| a-Ethyl-N-formyl-N- methyl pyridinemethaneamine | a-Ethyl-N-formyl-N- methyl pyridinemethaneamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AEW-541 | AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. Synonyms: NVP-AEW541; NVP-AEW 541; NVP-AEW-541; AEW-541; AEW 541; AEW541. Grades: 0.98. CAS No. 475489-16-8. Molecular formula: C27H29N5O. Mole weight: 439.563. | |
| AEZS-108 | AEZS-108, also known as AN-152 or zoptarelin doxorubicin, is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation. Synonyms: AEZS 108; AEZS108; AN 152; AN-152; AN152; Zoptarelin doxorubicin; Zoptrex; Lys(6)-LHRH-doxorubicin. Grades: 98%. CAS No. 139570-93-7. Molecular formula: C91H117N19O26. Mole weight: 1893.01. | |
| AEZS-112 | AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cytotoxic effect was least pronounced in G2 phase of the cell cycle. AEZS 112 showed anti-tumor activity in human ovarian and endometrial cancer cell lines at low micromolar concns., which could not be abrogated by caspase inhibition and is therefore a good candidate for in vivo studies in these tumors. Synonyms: ZEN012; ZEN 012; ZEN-012; AEZS 112; AEZS112. Grades: 98%. CAS No. 1214741-69-1. Molecular formula: C25H23N3O2. Mole weight: 397.47. | |
| AF 12198 | It is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-Leucinamide; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2. Grades: >98%. CAS No. 185413-30-3. Molecular formula: C96H123N19O22. Mole weight: 1895.14. | |
| AF 12198 | AF 12198. Group: Biochemicals. Grades: Purified. CAS No. 185413-30-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AF 12198 acetate | AF 12198 acetate is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2.CH3CO2H; (N-(N-acetyl-L-phenylalanyl-L-alpha-glutamyl-L-tryptophyl-L-threonyl-L-prolyl-glycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl)-(2S)-azetidine-2-carbonyl)-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate. Grades: ≥95%. Molecular formula: C98H127N19O24. Mole weight: 1955.17. | |
| AF3485 | AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 μM, respectively). Synonyms: CAY10686; N-[9-(2-hydroxyethyl)carbazol-3-yl]-2-(trifluoromethyl)benzamide. Grades: ≥95%. CAS No. 1195786-61-8. Molecular formula: C22H17F3N2O2. Mole weight: 398.4. | |
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grades: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21. | |
| AF-353 | AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC 50 of 8.0 for both human and rat P2X3, and with a pIC 50 of 7.3 for human P2X2/3 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro-4. CAS No. 865305-30-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14483. | |
| AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353) | A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min). Group: Biochemicals. Grades: Highly Purified. CAS No. 927887-18-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClIN?O?. US Biological Life Sciences. | Worldwide |
| AF38469 | AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor and shows no activity against the NTR1 receptor. Synonyms: AF 38469; AF-384694. CAS No. 1531634-31-7. Molecular formula: C15H11F3N2O3. Mole weight: 324.25. | |
| AF430 NHS ester | AF430 is a dye. The fluorophore is hydrophilic. It is used in flow cytometry and other applications.,The NHS ester functional group allows to conjugate the fluorophore efficiently with primary and secondary amine groups in both aqueous buffers and anhydrous conditions. Grades: NMR 1H, HPLC-MS (95%). CAS No. 467233-94-9. Molecular formula: C32H42N3F3O9S. Mole weight: 701.75. | |
| AF488 azide | AF488 is a fluorescent dye. AF488 is a fluorophore pH-insensitive over a broad pH range (from 4 to 10). It has an absorption maximum at 495 nm and an emission maximum at 519 nm in the green spectrum region. The dye is hydrophilic and can be used to introduce the fluorescent label into various molecules, including proteins and antibodies. Conjugates of molecules with AF488 have high brightness and photostability and are commonly used in flow cytometry and microscopy. This allows the detection of biological objects with high sensitivity at a longer imaging time.,AF488 azide interacts with alkynyl derivatives of biomolecules in Click Chemistry reactions either in the presence of copper (I) catalyst (with terminal alkynes) or without catalyst (with cyclooctynes), leading to the formation of stable adducts. Grades: NMR 1H, HPLC-MS (95%). CAS No. 1679326-36-3 (with azidohexyl group). Molecular formula: C36H56N8O10S2. Mole weight: 825.01. | |
| AF594 activated ester, 5-isomer | AF594 is a bright water-soluble dye that is not sensitive to pH changes within the range from 4 to 10. This red-fluorescent dye is the best alternative to Texas Red, so it is commonly used for flow cytometry and fluorescent microscopy.,AF594 activated ester is used for labeling proteins, peptides, antibodies, and any molecules containing an -NH2 group (such as amino-modified oligonucleotides); it results in the formation of stable amide bonds between the dye and the target molecule. The best result in conjugation reaction achieved at pH from 7 to 9.,AF594 can be used for protein labeling with a high molar dye-to-protein ratio. The resulting conjugates with a high degree of labeling (DOL) do not exhibit significant fluorescence quenching. In contrast, the conjugates have brighter fluorescence, which allows increasing the lowest limit of detection of the labeled product. Grades: NMR 1H, HPLC-MS (95%). CAS No. 1638544-48-5. Molecular formula: C51H67N5O13S2. Mole weight: 1022.23. | |
| Afabicin | Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI , an enzyme critical to fatty acid biosynthesis in staphylococci. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Debio 1450; AFN-1720. CAS No. 1518800-35-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-109000. | |
| Afabicin | Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Afabicin; Debio 1450; Debio-1450; Debio1450; AFN-1720; AFN 1720; AFN1720. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1518800-35-5. Molecular formula: C23H24N3O7P. Mole weight: 485.43. Purity: >98%. IUPACName: (E)-(6-(3-(methyl((3-methylbenzofuran-2-yl)methyl)amino)-3-oxoprop-1-en-1-yl)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)methyl dihydrogen phosphate. Canonical SMILES: O=P(O)(OCN1C(CCC2=CC(/C=C/C(N(C)CC(O3)=C(C)C4=C3C=CC=C4)=O)=CN=C12)=O)O. Product ID: ACM1518800355. Alfa Chemistry ISO 9001:2015 Certified. | |
| Afacifenacin | Afacifenacin acts as a sodium/calcium exchanger inhibitor used in the prevention of reperfusion injury associated with restoration of coronary blood flow via surgery. Synonyms: (S)-(+)-3-[1-[3-(Trifluoromethoxy)benzyl]piperidin-4-yl]-4-phenyl-3,4-dihydro-1H-quinazolin-2-one. Grades: > 95%. CAS No. 877606-63-8. Molecular formula: C27H26F3N3O2. Mole weight: 481.52. | |
| A-factor | It is produced by the strain of streptomyces griseus. It can not only promote the formation of spores and air hyphae by streptomycin, but also restore the ability of non-production mutants to produce streptomycin, which is the so-called Autoregulator. Synonyms: 2-Isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone; Q27144309; SCHEMBL6026457; DTXSID00965600; 4-(HYDROXYMETHYL)-3-(6-METHYLHEPTANOYL)OXOLAN-2-ONE; 2(3H)-Furanone, dihydro-4-(hydroxymethyl)-3-(6-methyl-1-oxoheptyl)-, (4R)-; (-)-A factor; (R)-4-Hydroxymethyl-3-(6-methyl-heptanoyl)-dihydro-furan-2-one. CAS No. 51311-41-2. Molecular formula: C13H22O4. Mole weight: 242.31. | |
| Afatinib | Afatinib. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. CAS No. 850140-72-6. Molecular Formula: C24H25ClFN5O3. Mole Weight: 485.94. Catalog: APB850140726. |  |
| Afatinib | Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Uses: Antineoplastic agents. Synonyms: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grades: >98%. CAS No. 850140-72-6. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. | |
| Afatinib | Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family ( EGFR and HER2 ), with IC 50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt , EGFR L858R , EGFR L858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIBW 2992. CAS No. 850140-72-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10261. | |
| Afatinib-[d6] | Afatinib-[d6] is the labelled analogue of Afatinib. Afatinib is a medication approved for the treatment of metastatic non-small cell lung cancer (NSCLC) that has certain EGFR mutations. It acts via inhibiting EGFR and HER2. Synonyms: Afatinib-d6; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide-d6; BIBW 2992-d6; Tovok-d6; Tomtovok-d6. Grades: 97%; ≥99% atom D. CAS No. 1313874-96-2. Molecular formula: C24H19D6ClFN5O3. Mole weight: 491.98. | |
| Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol) | Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl is a reactant in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. Group: Biochemicals. Grades: Highly Purified. CAS No. 314771-76-1. Pack Sizes: 100mg, 1g. Molecular Formula: C18H16ClFN4O2. US Biological Life Sciences. | Worldwide |
| Afatinib dimaleate | Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family ( EGFR and HER2 ), with IC 50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt , EGFR L858R , EGFR L858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIBW 2992MA2. CAS No. 850140-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10261A. | |
| Afatinib impurity 10 | Afatinib impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2223677-63-0. Molecular Formula: C24H25Cl2N5O3. Mole Weight: 502.4. Catalog: APB2223677630. | |
| Afatinib impurity 11 | Afatinib impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2223677-62-9. Molecular Formula: C24H25F2N5O3. Mole Weight: 469.49. Catalog: APB2223677629. | |
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