A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Aggrecan, Human, High Control. Group: Molecular Biology. Pack Sizes: 1Vial. US Biological Life Sciences.
Worldwide
Aggrecan, Human, Low Control
Aggrecan, Human, Low Control. Group: Molecular Biology. Pack Sizes: 1Vial. US Biological Life Sciences.
Worldwide
Aggreceride A
It is produced by the strain of Streptomyces sp. OM-3209. Aggreceride had no antibacterial activity. Aggreceride A of 50 ?/ml inhibited thrombin-induced platelet aggregation of 92%. Aggreceride A of 25 ?/ml inhibited thrombin-induced platelet aggregation of 81%. Synonyms: S3L0ID00Y9; 2,3-Dihydroxypropyl 12-methyltetradecanoate; Tetradecanoic acid, 12-methyl-, 2,3-dihydroxypropyl ester; CTK4E0886; DTXSID50172766; (S)-12-Methyltetradecanoic acid (R)-2,3-dihydroxypropyl ester; Tetradecanoic acid,12-methyl-, (2R)-2,3-dihydroxypropyl ester, (12S)-. CAS No. 19207-26-2. Molecular formula: C18H36O4. Mole weight: 316.47.
Aggreceride B
It is produced by the strain of Streptomyces sp. OM-3209. Aggreceride had no antibacterial activity. Synonyms: 2,3-Dihydroxypropyl 14-methylpentadecanoate; Pentadecanoic acid, 14-methyl-, 2,3-dihydroxypropyl ester; Pentadecanoic acid,14-methyl-, 2,3-dihydroxypropyl ester (9CI); SCHEMBL17866968; CTK4A3241; DTXSID20909142. CAS No. 104700-85-8. Molecular formula: C19H38O4. Mole weight: 330.50.
Aggreceride C
It is produced by the strain of Streptomyces sp. OM-3209. Aggreceride had no antibacterial activity. Synonyms: 2,3-Dihydroxypropyl 15-methylhexadecanoate; Hexadecanoic acid, 15-methyl-, 2,3-dihydroxypropyl ester; SCHEMBL17866841; DTXSID80909143; LS-74852. CAS No. 104700-86-9. Molecular formula: C20H40O4. Mole weight: 344.53.
AGI-24512
AGI-24512 is a potent methionine adenosyltransferase 2? (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2201066-53-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-112130.
AGI25696-Analog
AGI25696-Analog is a demethyl analog of AGI-25696, which is a methionine adenosyltransferase 2A (MATA2 ) inhibitor. AGI-25696 is potentially useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many vendors mistakenly listed CAS#2201066-35-3 as its AGI25696. J. Med. Chem. 2021, 64, 8, 4430-4449 published AGI25696 structure (it is CAS#2201065-84-9). Uses: Designed for use in research and industrial production. Additional or Alternative Names: AGI25696-Analog, AGI-25696-demethyl; AGI 25696-demethyl; AGI25696-demethyl. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2201066-35-3. Molecular formula: C27H18N4O. Mole weight: 414.47. Purity: >98%. IUPACName: 2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one. Canonical SMILES: O=C1C(C2=CC=C3N=CC=CC3=C2)=CNC4=C(C5=CC=CC=C5)C(C6=CC=CC=C6)=NN14. Product ID: ACM2201066353. Alfa Chemistry ISO 9001:2015 Certified.
AGI5198
AGI5198. Group: Biochemicals. Alternative Names: N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide. Grades: Highly Purified. CAS No. 1355326-35-0. Pack Sizes: 10mg. Molecular Formula: C27H31FN4O2, Molecular Weight: 462.56. US Biological Life Sciences.
AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity. AGI-5198 shows good potency in the U87 R132H cell based assay and ~90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. AGI-5198 inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0.07 μM and ~0.16 μM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 1355326-35-0. Molecular formula: C27H31FN4O2. Mole weight: 462.56. Purity: >98%. IUPACName: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide. Canonical SMILES: O=C(NC1CCCCC1)C(N(C2=CC=CC(F)=C2)C(CN3C=CN=C3C)=O)C4=CC=CC=C4C. Product ID: ACM1355326350. Alfa Chemistry ISO 9001:2015 Certified.
AGI-5198
AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. Synonyms: AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35. Grade: >98%. CAS No. 1355326-35-0. Molecular formula: C27H31FN4O2. Mole weight: 462.56.
AGI-6780
AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50 of 190±8.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1432660-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15734.
AGI-6780
AGI-6780 is an IDH2 inhibitor that potently and selectively inhibits the tumor-associated mutant IDH2/R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50of 190±8.1 nM. Synonyms: AGI6780; AGI 6780; AGI-6780. CAS No. 1432660-47-3. Molecular formula: C21H18F3N3O3S2. Mole weight: 481.508.
AGI-6780. Group: Biochemicals. Alternative Names: N-Cyclopropyl-4- (thiphen-3-yl) -3- (3- (3- (trifluoromethyl) phenyl) ureido) benzenesulfonamide. Grades: Highly Purified. CAS No. 1432660-47-3. Pack Sizes: 2.5mg. Molecular Formula: C21H18F3N3O3S2, Molecular Weight: 481.51. US Biological Life Sciences.
Worldwide
AGI-B4
AGI-B4 is a substance produced by Aspergillus sp. Y80118 that inhibits the growth of endothelial cells. It inhibits the proliferation of human umbilical vein endothelial cells (HUVECs) induced by vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell growth factor (ECGS) with IC50 of 1.4 μmol/ L, 2.8 μmol/L and 6.2 μmol/L. Synonyms: (7R,8R)-AGI-B4. CAS No. 1313588-44-1. Molecular formula: C16H14O7. Mole weight: 318.28.
Agistatin B ((2R,4S,4aR,5R,6R,8aR)-6-Ethyloctahydro-2H-2,5-epoxy-chromene-4,4a-diol)
Tricyclic analog of agistatin A. Cholesterol biosynthesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 144096-46-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
Agistatin D ((4aS,5R,6R)-6-Ethyl-4a,5-dihydroxy-4a,5,6,7-tetrahydro-4H-chromen-4-one)
Analog of agistatin A. Cholesterol biosynthesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 144096-47-9. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Agistatin E
Agistatin E is a novel pyranacetal isolated from fungus FH-A 6239. It has been used as a cholesterol biosynthesis inhibitor. Mycotoxin. Synonyms: Agistatin E; 144096-48-0; (1S,3S,6R,7R,8R)-6-ethyl-3,8-dihydroxy-2,11-dioxatricyclo[5.3.1.03,8]undecan-9-one; HY-N10232; CS-0109121; J-007915. Grade: ≥98%. CAS No. 144096-48-0. Molecular formula: C11H16O5. Mole weight: 228.24.
Agistatin E ((2S,4aR,5S,8R,8aR)-8-Ethyl-4a,5-dihydroxy-hexahydro-2H-2,5-epoxychromen-4(3H)-one)
Tricyclic analog of agistatin A. Cholesterol biosynthesis inhibitor. Mycotoxin. Group: Biochemicals. Grades: Highly Purified. CAS No. 144096-48-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
Agitoxin 2
Agitoxin 2. Group: Biochemicals. Grades: Purified. CAS No. 168147-41-9. Pack Sizes: 10ug. US Biological Life Sciences.
Worldwide
Agitoxin 2
Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. Synonyms: AGTX2; H-Gly-Val-Pro-Ile-Asn-Val-Ser-Cys(1)-Thr-Gly-Ser-Pro-Gln-Cys(2)-Ile-Lys-Pro-Cys(3)-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys(1)-Met-Asn-Arg-Lys-Cys(2)-His-Cys(3)-Thr-Pro-Lys-OH; glycyl-L-valyl-L-prolyl-L-isoleucyl-L-asparagyl-L-valyl-L-seryl-L-cysteinyl-L-threonyl-glycyl-L-seryl-L-prolyl-L-glutaminyl-L-cysteinyl-L-isoleucyl-L-lysyl-L-prolyl-L-cysteinyl-L-lysyl-L-alpha-aspartyl-L-alanyl-glycyl-L-methionyl-L-arginyl-L-phenylalanyl-glycyl-L-lysyl-L-cysteinyl-L-methionyl-L-asparagyl-L-arginyl-L-lysyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-threonyl-L-prolyl-L-lysine (8->28),(14->33),(18->35)-tris(disulfide). Grade: >98%. CAS No. 168147-41-9. Molecular formula: C169H278N54O48S8. Mole weight: 4090.87.
Agitoxin-2 from scorpion venom
recombinant, expressed in E. coli, ?98% (SDS-PAGE), lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
AGK2
AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 ?M. AGK2 inhibits SIRT1 and SIRT3 with IC50s of 30 and 91 ?M, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 304896-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100578.
AGK2
AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Synonyms: AGK-2; AGK 2; 2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide. Grade: >98%. CAS No. 304896-28-4. Molecular formula: C23H13Cl2N3O2. Mole weight: 434.27.
AGK 2. Group: Biochemicals. Grades: Purified. CAS No. 304896-28-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
AGK7
AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. Synonyms: SIRT2 Inhibitor (Inactive Control); 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide. Grade: ≥95%. CAS No. 304896-21-7. Molecular formula: C23H13Cl2N3O2. Mole weight: 434.3.
AGL 2263
AGL 2263 is an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R; IC50 = 0.43 μM). Synonyms: (E)-2-(3,4-dihydroxybenzoyl)-3-(2-oxo-3H-1,3-benzoxazol-5-yl)prop-2-enenitrile. Grade: ≥98%. CAS No. 638213-98-6. Molecular formula: C17H10N2O5. Mole weight: 322.3.
Aglafoline
Aglafoline, isolated from Aglaia elliptifolia Merr, is a selective PAF-induced platelet aggregation inhibitor. And studies have shown that because aglafoline blocked the high-K+-induced contraction of rat thoracic aorta, it may also possess Ca+- channel b. Synonyms: methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate Aglafoline Methyl rocaglate AGLAFOLIN CHEBI:65374 CMLDBU00002646 143901-35-3 methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydr. CAS No. 143901-35-3. Molecular formula: C28H28O8. Mole weight: 492.52.
Aglain C
Aglain C, an organic alkaloid of natural origins, demonstrates anti-tumor activity, thus possessing potential application in diverse cancer treatment modalities. It elicits apoptosis, or cell death, in malignant cells, and exhibits anti-inflammatory properties. To ascertain its therapeutic value comprehensively, additional examination is warranted. Synonyms: N-((S)-1-((2R,3S,4R,5R,10S)-5,10-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-3-phenyl-2,3,4,5-tetrahydro-2,5-methanobenzo[b]oxepine-4-carbonyl)pyrrolidin-2-yl)-2-methylbutanamide. Grade: 96%. CAS No. 177468-85-8. Molecular formula: C36H42N2O8. Mole weight: 630.727.
Aglaxiflorin D
Aglaxiflorin D is an alkaloid compound isolated from the leaves of Aglaia abbriviata. Synonyms: (R)-N-((S)-1-((2R,3S,4R,5R,10S)-5,10-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-3-phenyl-2,3,4,5-tetrahydro-2,5-methanobenzo[b]oxepine-4-carbonyl)pyrrolidin-2-yl)-2-hydroxy-2-methylbutanamide. Grade: 95%. CAS No. 269739-78-8. Molecular formula: C36H42N2O9. Mole weight: 646.727.
Aglepristone
Aglepristone is used as a treatment to induce parturition in ewes and their newborns. A competitive progesterone antagonist for treatment of various progesterone-dependent physiology and pathology conditions, and effective means of terminating pregnancy in most species. Also, it prevents sperm progression toward the oviducts and fertilization in inseminated females. Group: Biochemicals. Grades: Highly Purified. CAS No. 124478-60-0. Pack Sizes: 500mg, 1g. Molecular Formula: C29H37NO2, Molecular Weight: 431.61. US Biological Life Sciences.
Worldwide
a-Glucametacin
a-Glucametacin, the acclaimed anti-inflammatory wonder, showcases its unparalleled efficacy in combating a myriad of inflammatory afflictions, notably arthritis, while effectively tackling postoperative discomfort. By impeding the production of prostaglandins and leukotrienes, this remarkable drug alleviates pain and curtails inflammation. Synonyms: 2-[[[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-a-D-glucopyranose; a-Glucametacine; a-Glucamethacin; α-D-Glucopyranose, 2-[[[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-. CAS No. 871014-84-5. Molecular formula: C25H27ClN2O8. Mole weight: 518.94.
agmatidine
Agmatidine is a compound, finding application in the biomedical realm for studying assorted ailments comprising cancer and inflammation. Its exceptional attributes encompass anti-inflammatory and anti-carcinogenic effects, rendering it a propitious contender for pharmaceutical development. Synonyms: Agmatidine; agm(2)C; N-(4-carbamimidamidobutyl)-4-imino-1-(beta-D-ribofuranosyl)-1,4-dihydropyrimidin-2-amine; 1221169-70-5; RD252EB5W3; CHEBI:64329; DTXSID701029783; Q4692957; N-(4-Carbamimidamidobutyl)-4-imino-1-(beta-D-ribofuranosyl)-1,4-dihydro-2-pyrimidinamine; GUANIDINE, N-(4-((1,4-DIHYDRO-4-IMINO-1-.BETA.-D-RIBOFURANOSYL-2-PYRIMIDINYL)AMINO)BUTYL)-; N-(4-((1,4-DIHYDRO-4-IMINO-1-.BETA.-D-RIBOFURANOSYL-2-PYRIMIDINYL)AMINO)BUTYL)GUANIDINE. Molecular formula: C14H22N7O4. Mole weight: 356.4.
agmatinase
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups. Group: Enzymes. Synonyms: agmatine ureohydrolase; SpeB. Enzyme Commission Number: EC 3.5.3.11. CAS No. 37289-16-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4513; agmatinase; EC 3.5.3.11; 37289-16-0; agmatine ureohydrolase; SpeB. Cat No: EXWM-4513.
agmatine deiminase
The plant enzyme also catalyses the reactions of EC 2.1.3.3 (ornithine carbamoyltransferase), EC 2.1.3.6 (putrescine carbamoyltransferase) and EC 2.7.2.2 (carbamate kinase), thus functioning as a putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively. Group: Enzymes. Synonyms: agmatine amidinohydrolase. Enzyme Commission Number: EC 3.5.3.12. CAS No. 37289-17-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4514; agmatine deiminase; EC 3.5.3.12; 37289-17-1; agmatine amidinohydrolase. Cat No: EXWM-4514.
agmatine kinase
L-Arginine can act as acceptor, but more slowly. Group: Enzymes. Synonyms: phosphagen phosphokinase; ATP:agmatine 4-N-phosphotransferase. Enzyme Commission Number: EC 2.7.3.10. CAS No. 9076-75-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3181; agmatine kinase; EC 2.7.3.10; 9076-75-9; phosphagen phosphokinase; ATP:agmatine 4-N-phosphotransferase. Cat No: EXWM-3181.
agmatine N4-coumaroyltransferase
This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. Group: Enzymes. Synonyms: p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase; agmatine coumaroyltransferase; 4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase. Enzyme Commission Number: EC 2.3.1.64. CAS No. 85030-72-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2244; agmatine N4-coumaroyltransferase; EC 2.3.1.64; 85030-72-4; p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase; agmatine coumaroyltransferase; 4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase. Cat No: EXWM-2244.
Agmatine sulfate
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Uses: Scientific research. Group: Natural products. CAS No. 2482-00-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-101238.
Agmatine Sulfate
Agmatine Sulfate. Group: Biochemicals. Alternative Names: N-(4-aminobutyl)guanidine Sulfate; NIH 11035. Grades: Highly Purified. CAS No. 2482-00-0. Pack Sizes: 1g. Molecular Formula: C5H16N4O4S, Molecular Weight: 228.27. US Biological Life Sciences.
Agmatine sulfate endogenous agonist at. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AGMATINE SULFATE ENDOGENOUS AGONIST AT;1-(4-aminobutyl)guanidine;2-(4-aminobutyl)guanidine;(4-Aminobutyl) guanidine;N1-(4-Aminobutyl)guanidine;2-(4-azanylbutyl)guanidine;4-Guanidino-1-butanamine;N-(4-Aminobutyl)guanidine. Product Category: Heterocyclic Organic Compound. CAS No. 306-60-5. Molecular formula: C5H14N4. Mole weight: 130.19146. Density: 1.2. Product ID: ACM306605. Alfa Chemistry ISO 9001:2015 Certified.
Agmatine Sulfate ≥93% (HPLC)
Agmatine Sulfate ≥93% (HPLC). Group: Biochemicals. Alternative Names: N-(4-aminobutyl)guanidine Sulfate; NIH 11035. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
Agmatine sulfate, the sulfate preparation of Agmatine, is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine displaces clonidine at α2-adrenergic and at imidazoline receptors and produces blockade of the NMDA-receptor associated cation channels. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Agmatine sulfate; 1-(4-Aminobutyl)guanidine sulfate; 1-Amino-4-guanidinobutane sulfate salt; Guanidine, (4-aminobutyl)-, sulfate (1:1). Grade: 98%. CAS No. 2482-00-0. Molecular formula: C5H16N4O4S. Mole weight: 228.27.
AGN 192403 hydrochloride
The hydrochloride salt form of AGN 192403, which has been found to show high affinity to imidazoline I1 receptor. Synonyms: AGN-192403 hydrochloride, AGN192403 hydrochloride, AGN 192403 hydrochloride, AGN-192403 HCl; (±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride. Grade: ≥95% by HPLC. CAS No. 1021868-90-5. Molecular formula: C10H19N.HCl. Mole weight: 189.73.
AGN 192403 hydrochloride
AGN 192403 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1021868-90-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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AGN 192836
AGN 192836 is a potent and selective α2 adrenergic agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively. Synonyms: (1H-Imidazol-2-yl)-(5-methyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-amine; 2-[[(5-Methyl-2,3-dihydro-1,4-benzodioxin)-6-yl]amino]-1H-imidazole. CAS No. 171102-29-7. Molecular formula: C12H13N3O2. Mole weight: 231.25.
Agn 193109
Agn 193109. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid; CD 3106. Product Category: Heterocyclic Organic Compound. Appearance: Off-White Solid. CAS No. 171746-21-7. Molecular formula: C28H24O2. Mole weight: 392.49. Purity: 0.96. IUPACName: 4-[2-[5,5-dimethyl-8-(4-methylphenyl)-6H-naphthalen-2-yl]ethynyl]benzoic acid. Density: 1.21 g/cm³. Product ID: ACM171746217. Alfa Chemistry ISO 9001:2015 Certified.
AGN 193109 has been found to be a pan-retinoic acid receptor (RAR) antagonist. Synonyms: AGN 193109; AGN193109; AGN-193109; 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid. Grade: ≥97% by HPLC. CAS No. 171746-21-7. Molecular formula: C28H24O2. Mole weight: 392.49.
AGN 193109
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs) , with K d s of 2 nM, 2 nM, and 3 nM for RARα , RARβ , and RARγ , respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity. Uses: Scientific research. Group: Signaling pathways. CAS No. 171746-21-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00449.
AGN 193109-d7
A labeled retinoic acid receptor (RAR) antagonist used for treating chemotherapy and radiation therapy side effects. Group: Biochemicals. Alternative Names: 4- [2- [5, 6-Dihydro-5, 5-dimethyl-8- (4-methylphenyl-d7) -2-naphthalenyl] ethynyl] benzoic Acid; CD 3106-d7. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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AGN 193109-[d7]
AGN 193109-[d7] is the labelled analogue of AGN 193109, which is a retinoic acid receptor (RAR) antagonist used for treating chemotherapy and radiation therapy side effects. Synonyms: AGN 193109 D7; 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl-d7)-2-naphthalenyl]ethynyl]benzoic Acid; CD 3106-d7; AGN-193109-d7. Grade: 98%; ≥98% atom D. CAS No. 1216429-25-2. Molecular formula: C28H17D7O2. Mole weight: 399.53.
AGN 193109-d7 Ethyl Ester
Precursor to labeled AGN 193109. Group: Biochemicals. Alternative Names: 4- [2- [5, 6-Dihydro-5, 5-dimethyl-8- (4-methylphenyl-d7) -2-naphthalenyl] ethynyl] benzoic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Agn 193109 ethyl ester
Agn 193109 ethyl ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid Ethyl Ester. Product Category: Heterocyclic Organic Compound. Appearance: Pale Yellow Solid. CAS No. 171568-43-7. Molecular formula: C30H28O2. Mole weight: 420.54. Purity: 0.96. IUPACName: ethyl 4-[2-[5,5-dimethyl-8-(4-methylphenyl)-6H-naphthalen-2-yl]ethynyl]benzoate. Product ID: ACM171568437. Alfa Chemistry ISO 9001:2015 Certified.
AGN 193109 Ethyl Ester
Precursor to AGN 193109. Group: Biochemicals. Alternative Names: 4- [2- [5, 6-Dihydro-5, 5-dimethyl-8- (4-methylphenyl) -2-naphthalenyl] ethynyl] benzoic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 171568-43-7. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
AGN 193109 Ethyl Ester-[d7]
AGN 193109 Ethyl Ester-[d7] is the labelled analogue of AGN 193109 Ethyl Ester, which is a precursor to AGN 193109. Synonyms: AGN 193109-d7 Ethyl Ester; 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl-d7)-2-naphthalenyl]ethynyl]benzoic Acid Ethyl Ester. Grade: 98%. CAS No. 1246815-93-9. Molecular formula: C30H21D7O2. Mole weight: 427.59.
AGN 193109 Sodium Salt
A retinoic acid receptor (RAR) antagonist used for treating chemotherapy and radiation therapy side effects. Group: Biochemicals. Alternative Names: 4- [2- [5, 6-Dihydro-5, 5-dimethyl-8- (4-methylphenyl) -2-naphthalenyl] ethynyl] benzoic Acid Sodium Salt; CD 3106 Sodium Salt. Grades: Highly Purified. CAS No. 171746-21-7(freebase). Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
AGN 193109 Sodium Salt
AGN 193109 is a potent antagonist of retinoic acid receptors (RARs, Kd = 2, 2, and 3 nM for RARα, β, and γ, respectively). Synonyms: 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoic acid monosodium salt; CD 3106 Sodium Salt; Benzoic acid, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-, sodium salt (1:1); sodium 4-((5,5-dimethyl-8-(p-tolyl)-5,6-dihydronaphthalen-2-yl)ethynyl)benzoate. Grade: 95%. Molecular formula: C28H23NaO2. Mole weight: 414.47.
AGN 194078
AGN 194078, is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. Synonyms: AGN-194078. CAS No. 321995-62-4. Molecular formula: C22H23F2NO4. Mole weight: 403.42.
AGN194204
AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXR?, RXR? and RXR?, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IRX4204; NRX194204; VTP 194204. CAS No. 220619-73-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-13717.
AGN 194310
AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with Kd values of 3 nM, 2 nM, 5 nM for RAR?, RAR?, RAR?, respectively[1][2]. AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VTP-194310. CAS No. 229961-45-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16681.
AGN 194310
A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs=2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis. AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells. The administration of all-trans retinoic acid to VAD mice resulted in a transient reduction in NF-kappaB activity and, conversely, a single dose of the RAR-pan-antagonist, AGN 194310, administered to control mice, led to a marked, transient induction of whole-body luminescence. Mice were treated with AGN194310, a synthetic retinoid that antagonises the physiological function of the three RAR isotypes (alpha, beta, gamma) but does not interact with RXRs. Analyses of the granulocytic lineage using Gr-1, c-Kit and CD11b antibodies, demonstrated that granulocyte numbers were strikingly increased across haemopoietic compartments in all AGN194310-treated mice. A significant increase in the frequency of progenitor cells containing granulocytes was observed in the bone marrow of mice following treatment with AGN194310. Synonyms: AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310. Grade: >98%. CAS No. 229961-45-9. Molecular formula: C28H24O2S. Mole weight: 424.55.
AGN 195183
RX-195183 is an RARα agonist (Kd=3 nM) with potential antineoplastic activity, modulating the transcription of genes responsible for cell differentiation and proliferation. Uses: Rarα agonist. Synonyms: IRX5183; IRX-5183; IRX 5183; NRX195183; NRX-195183; NRX 195183; VTP-195183; VTP195183; VTP 195183; AGN-195183; AGN195183; AGN195183.; 4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid. Grade: ≥98%. CAS No. 367273-07-2. Molecular formula: C22H22ClF2NO4. Mole weight: 437.87.