A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Antimigraine. Group: Biochemicals. Alternative Names: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine; FI-6026. Grades: Highly Purified. CAS No. 84625-59-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
DOTATATE
DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-88-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106244.
DOTATATE acetate
DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-89-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106244A.
DOTA-tris(tBu)ester NHS ester
DOTA-tris(tBu)ester NHS ester is a derivative of DOTA for the labeling of peptides and antibodies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 819869-77-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-131326.
DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 137076-54-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W034551.
DOTA-[Tyr3]-Octreotide Acid
DOTA-TATE, DOTATATE or DOTA-octreotate is a substance which, when bound to various radionuclides, has been tested for the treatment and diagnosis of certain types of cancer, mainly neuroendocrine tumours. Synonyms: DOTATATE; DOTA-(Tyr3,Thr8)-Octreotide; DOTA-[Tyr3] Octreotide Acid (Octreotate); 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond). Grades: 98%. CAS No. 177943-89-4. Molecular formula: C65H90N14O19S2. Mole weight: 1435.63.
Dothiepin
Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dosulepin; Dothep. CAS No. 113-53-1. Pack Sizes: 1 mg. Product ID: HY-12394.
Dothiepin
A tricyclic antidepressant. Group: Biochemicals. Alternative Names: 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-. Grades: Highly Purified. CAS No. 113-53-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Dothiepin-d3
Labeled Dothiepin. A tricyclic antidepressant. Group: Biochemicals. Alternative Names: 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N-methyl-N-(methyl-d3)-. Grades: Highly Purified. CAS No. 136765-31-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Dotinurad Impurity 1
Dotinurad Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 3336-41-2. Molecular Formula: C7H4Cl2O3. Mole Weight: 207.01. Catalog: APB3336412.
Dotinurad Impurity 10
Dotinurad Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C15H11Cl2NO4S. Mole Weight: 372.22. Catalog: APB12096.
Dotinurad Impurity 11
Dotinurad Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C21H11Cl4NO6S. Mole Weight: 547.18. Catalog: APB12095.
Dotinurad Impurity 12
Dotinurad Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C21H12Cl3NO5S. Mole Weight: 496.74. Catalog: APB12097.
Dotinurad Impurity 2
Dotinurad Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 37908-97-7. Molecular Formula: C8H6Cl2O3. Mole Weight: 221.03. Catalog: APB37908977.
Dotinurad Impurity 3
Dotinurad Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 29568-76-1. Molecular Formula: C8H5Cl3O2. Mole Weight: 239.48. Catalog: APB29568761.
Dotinurad Impurity 4
Dotinurad Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1285573-42-3. Molecular Formula: C15H11Cl2NO2S. Mole Weight: 340.22. Catalog: APB1285573423.
Dotinurad Impurity 5
Dotinurad Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1285573-47-8. Molecular Formula: C15H11Cl2NO3S. Mole Weight: 356.22. Catalog: APB1285573478.
Dotinurad Impurity 6
Dotinurad Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1285573-44-5. Molecular Formula: C15H11Cl2NO4S. Mole Weight: 372.22. Catalog: APB1285573445.
Dotinurad Impurity 7
Dotinurad Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1285572-55-5. Molecular Formula: C14H9Cl2NO3S. Mole Weight: 342.19. Catalog: APB1285572555.
Dotinurad Impurity 8
Dotinurad Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H11Cl2NO4S. Mole Weight: 360.21. Catalog: APB12094.
Dotinurad Impurity 9
Dotinurad Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C28H18Cl4N2O8S2. Mole Weight: 716.38. Catalog: APB12092.
DOTMA
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DOTMA; 1,2-di-O-octadecenyl-3-trimethylammonium propane. Product Category: Others. Appearance: Solid powder. CAS No. 104872-42-6. Molecular formula: C42H84ClNO2. Mole weight: 670.59. Purity: >98%. IUPACName: N,N,N-trimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride. Canonical SMILES: CCCCCCCC/C=C\CCCCCCCCOCC(OCCCCCCCC/C=C\CCCCCCCC)C[N+](C)(C)C.[Cl-]. Product ID: ACM104872426. Alfa Chemistry ISO 9001:2015 Certified.
DOTMA
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Synonyms: 1,2-Di-O-Octadecenyl-3-Trimethylammonium Propane; Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride; N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium. Grades: >98%. CAS No. 104872-42-6. Molecular formula: C42H84ClNO2. Mole weight: 670.57.
DOTMA
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 104872-42-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-139200.
DOTMA:Chol (50:50) Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTMA:DOPE (50:50) Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
DOTMA Liposomes
Cationic liposomes are used for the delivery of genetic materials such as various types of DNA and RNA. In order to capture more plasmid efficiently, the negative charge of pDNA is neutralized with positive charge of cationic lipids due to electrostatic interaction and deliver them into cells. So they are researched for use as delivery vectors in gene therapy. Uses: Cancer research; target delivery. Group: Cationic liposome. Categories: Niosomes, ethosomes, and transfersomes.
Dotriacolide
It is produced by the strain of Micromonosporaechinospora MG199-fF35. It has inhibitory effects on β-lactamase, DNA enzyme and Topoisomerase I. Synonyms: Oxacyclodotriacont-3-en-2-one,16,18,30-tris(sulfooxy)-32-(8-(sulfooxy)nonyl)-; (Z)-32-oxo-2-(8-(sulfooxy)nonyl)oxacyclodotriacont-30-ene-4,16,18-triyl tris(hydrogen sulfate). CAS No. 80994-06-5. Molecular formula: C40H76O18S4. Mole weight: 973.28.
Dotriacontane
Dotriacontane is a long-chain alkane. Synonyms: n-Dotriacontane. CAS No. 544-85-4. Molecular formula: C32H66. Mole weight: 450.87.
Dotriacontane
5g Pack Size. Group: Building Blocks, Organics. Formula: C32H66. CAS No. 544-85-4. Prepack ID 68080396-5g. Molecular Weight 450.87. See USA prepack pricing.
Dotriacontane
Dotriacontane is an alkane substance that can be absorbed and metabolized by photosynthetic organisms. It can be labeled with 14 C and used for carbon tracing [1]. Uses: Scientific research. Group: Natural products. CAS No. 544-85-4. Pack Sizes: 5 g; 10 g. Product ID: HY-N9600.
Double-pass AAO Template 1.2 cm(D: 100nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-29. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D: 200nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-24. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D: 300nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-21. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D:40-60nm,hole depth: 40-70 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-20. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D: 50nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-53. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(HD:400nm)
Double-pass AAO Template 1.2 cm(HD:400nm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-50. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template 2.5 cm(D: 100nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-61. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 200nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-6. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 300nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-25. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 400nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-9. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 50nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-32. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template(HD:20-40nm D:1.2cm)
Double-pass AAO Template(HD:20-40nm D:1.2cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-47. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template(HD:20-40nm D:2.5cm)
Double-pass AAO Template(HD:20-40nm D:2.5cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-15. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template(HD:60-80nm D:1.2cm)
Double-pass AAO Template(HD:60-80nm D:1.2cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-14. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template(HD:60-80nm D:2.5cm)
Double-pass AAO Template(HD:60-80nm D:2.5cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
double-stranded RNA adenine deaminase
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity. Group: Enzymes. Synonyms: ADAR; double-stranded RNA adenosine deaminase; dsRAD; dsRNA adenosine deaminase; DRADA1; double-stranded RNA-specific adenosine deaminase. Enzyme Commission Number: EC 3.5.4.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4565; double-stranded RNA adenine deaminase; EC 3.5.4.37; ADAR; double-stranded RNA adenosine deaminase; dsRAD; dsRNA adenosine deaminase; DRADA1; double-stranded RNA-specific adenosine deaminase. Cat No: EXWM-4565.
double-stranded uracil-DNA glycosylase
No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue, significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli. Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA. Group: Enzymes. Synonyms: Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous). Enzyme Commission Number: EC 3.2.2.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3982; double-stranded uracil-DNA glycosylase; EC 3.2.2.28; Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous). Cat No: EXWM-3982.
Double-wall carbon nanotubes
Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSol
Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSo
Double-walled Carbon Nanotubes
Double-walled Carbon Nanotubes. Group: Nanotubes other nano materials double wall cnt. CAS No. 308068-56-6. Product ID: Carbon. Molecular formula: 12.01. C. > 98wt%.
Double-Walled Carbon Nanotubes (DWNTs) 2-4nm. Uses: Double-walled carbon nanotubes (cnts) can be used in various fields including additives in polymers, catalysts, electron field emitters for cathode ray lighting elements, flat panel display, gas-discharge tubes in telecom networks, electromagnetic-wave absorption and shielding, energy conversion, lithium-battery anodes, hydrogen storage, nanotube composites (by filling or coating); nanoprobes for stm, afm, and efm tips, nanolithography, nanoelectrodes, drug delivery sensors, reinforcements in composites, supercapacitor. Additional or Alternative Names: Double-Walled Carbon Nanotubes, Double Wall Carbon Nanotube, Carbon Nanotube, DWNT, DWCNT, CNT. Product Category: Carbon Nanotubes. Appearance: Color: Black. CAS No. 1333-86-4. Purity: >60%. Density: True density: ~2.1 g/cm³. Product ID: ACM1333864-32. Alfa Chemistry ISO 9001:2015 Certified.
DOV-216,303 (Free Base) is a potent triple serotonin , norepinephrine , and dopamine reuptake inhibitor, with IC 50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively [1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66504-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18332C.
Dovitinib
Dovitinib (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma. Synonyms: Dovitinib, TKI258; TKI 258;TKI-258; CHIR 265; CHIR265; CHIR-265; RAF-265; RAF 265; RAF265. Grades: > 95%. CAS No. 405169-16-6. Molecular formula: C21H21FN6O. Mole weight: 392.429.
Dovitinib
Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC 50 s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , CSF-1R , FGFR1/FGFR3 , VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ , respectively. Dovitinib has potent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258; TKI258. CAS No. 405169-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50905.
Dovitinib Dilactic Acid
Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Synonyms: Dovitinib Dilactic acid; TKI258 Dilactic acid; CHIR-258; CHIR 258; CHIR258; TKI258; TKI 258; TKI-258. Grades: >98%. CAS No. 852433-84-2. Molecular formula: C27H33FN6O7. Mole weight: 572.59.
Dovitinib lactate
Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, RET, TrKA, and FLT3, and additionally targets FGFR (IC50 = 5 nM). Synonyms: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one;2-hydroxypropanoic acid; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate; Dovitinib(lactate); 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxy; CTK8B6779. CAS No. 692737-80-7. Molecular formula: C24H27FN6O4. Mole weight: 482.51.
Dovitinib lactate
Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC 50 s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , FGFR1/3 , VEGFR1/2/3 and PDGFRα/β , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258 lactate; TKI-258 lactate. CAS No. 692737-80-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10207.
Dovitinib Lactate
Dovitinib is used in treating melanoma. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-Hydroxypropanoic Acid; CHIR 258; TKI 258. Grades: Highly Purified. CAS No. 692737-80-7. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Dovitinib Lactate Hydrate
Dovitinib lactate hydrate is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate; Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone, hydrate (1:1:1). Grades: >98%. CAS No. 915769-50-5. Molecular formula: C24H29FN6O5. Mole weight: 500.52.
Dov-Val-Dil-OH
Dov-Val-Dil-OH is an intermediate of dolastoxin, a cytotoxic liner peptide produced by Dolabbella auriclaria which exhibits potent antitumor activity. Synonyms: (3R,4S,5S)-4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoic acid; (3R,4S,5S)-3-Methoxy-4-[methyl(N,N-dimethyl-L-Val-L-Val-)amino]-5-methylheptanoic acid. CAS No. 133120-89-5. Molecular formula: C22H43N3O5. Mole weight: 429.59.
Dov-Val-Dil-OH TFA
Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Dov-Val-Dil-OH TFA; Dov-Val-Dil-OH; Dov-Val-Dil-OH; dimethylVal-Val-Dil-COOH. Product Category: Others. Appearance: Solid powder. CAS No. 133120-90-8. Molecular formula: C24H44F3N3O7. Mole weight: 543.63. Purity: >98%. IUPACName: (3R,4S,5S)-4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoic acid trifluoroacetic acid. Canonical SMILES: CC[C@H](C)[C@H](N(C)C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)[C@H](OC)CC(O)=O.O=C(O)C(F)(F)F. Product ID: ACM133120908. Alfa Chemistry ISO 9001:2015 Certified.