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Acts only on long-chain polyprenyl phosphates and α-dihydropolyprenyl phosphates that are larger than C35. Group: Enzymes. Synonyms: GDP-Man:DolP mannosyltransferase; dolichyl mannosyl phosphate synthase; dolichyl-phospho-mannose synthase; GDP-mannose:dolichyl-phosphate mannosyltransferase; guanosine diphosphomannose-dolichol phosphate mannosyltransferase; dolichol phosphate mannose synthase; dolichyl phosphate mannosyltransferase; dolichyl-phosphate mannose synthase; GDP-mannose-dolichol phosphate mannosyltransferase; GDP-mannose. Enzyme Commission Number: EC 2.4.1.83. CAS No. 62213-44-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2624; dolichyl-phosphate β-D-mannosyltransferase; EC 2.4.1.83; 62213-44-9; GDP-Man:DolP mannosyltransferase; dolichyl mannosyl phosphate synthase; dolichyl-phospho-mannose synthase; GDP-mannose:dolichyl-phosphate mannosyltransferase; guanosine diphosphomannose-dolichol phosphate mannosyltransferase; dolichol phosphate mannose synthase; dolichyl phosphate mannosyltransferase; dolichyl-phosphate mannose synthase; GDP-mannose-dolichol phosphate mannosyltransferase; GDP-mannose-dolichylmonophosphate mannosyltransferase; mannosylphosphodolichol synthase; mannosylphosphoryldolichol synthase. Cat No: EXWM-2624.
dolichyl-phosphate β-glucosyltransferase
Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly. Group: Enzymes. Synonyms: polyprenyl phosphate:UDP-D-glucose glucosyltransferase; UDP-glucose dolichyl-phosphate glucosyltransferase; uridine diphosphoglucose-dolichol glucosyltransferase; UDP-glucose:dolichol phosphate glucosyltransferase; UDP-glucose:dolicholphosphoryl glucosyltransferase; UDP-glucose:dolichyl monophosphate glucosyltransferase; UDP-glucose:dolichyl phosphate glucosyltransferase. Enzyme Commission Number: EC 2.4.1.117. CAS No. 71061-42-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2343; dolichyl-phosphate β-glucosyltransferase; EC 2.4.1.117; 71061-42-2; polyprenyl phosphate:UDP-D-glucose glucosyltransferase; UDP-glucose dolichyl-phosphate glucosyltransferase; uridine diphosphoglucose-dolichol glucosyltransferase; UDP-glucose:dolichol phosphate glucosyltransferase; UDP-glucose:dolicholphosphoryl glucosyltransferase; UDP-glucose:dolichyl monophosphate glucosyltransferase; UDP-glucose:dolichyl phosphate glucosyltransferase. Cat No: EXWM-2343.
dolichyl-phosphate D-xylosyltransferase
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase. Group: Enzymes. Enzyme Commission Number: EC 2.4.2.32. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2660; dolichyl-phosphate D-xylosyltransferase; EC 2.4.2.32. Cat No: EXWM-2660.
dolichylphosphate-glucose phosphodiesterase
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. This enzyme participates in n-glycan biosynthesis. Group: Enzymes. Synonyms: dolichol phosphoglucose phosphodiesterase; Dol-P-Glc phosphodiesterase. Enzyme Commission Number: EC 3.1.4.48. CAS No. 89287-42-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3731; dolichylphosphate-glucose phosphodiesterase; EC 3.1.4.48; 89287-42-3; dolichol phosphoglucose phosphodiesterase; Dol-P-Glc phosphodiesterase. Cat No: EXWM-3731.
dolichylphosphate-mannose phosphodiesterase
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. Group: Enzymes. Synonyms: mannosylphosphodolichol phosphodiesterase. Enzyme Commission Number: EC 3.1.4.49. CAS No. 111839-07-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3732; dolichylphosphate-mannose phosphodiesterase; EC 3.1.4.49; 111839-07-7; mannosylphosphodolichol phosphodiesterase. Cat No: EXWM-3732.
The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain α-dihydropolyprenyl derivatives, larger than C35. Group: Enzymes. Synonyms: dolichol phosphomannose-protein mannosyltransferase; protein O-D-mannosyltransferase; dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase. Enzyme Commission Number: EC 2.4.1.109. CAS No. 74315-99-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2335; dolichyl-phosphate-mannose-protein mannosyltransferase; EC 2.4.1.109; 74315-99-4; dolichol phosphomannose-protein mannosyltransferase; protein O-D-mannosyltransferase; dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase. Cat No: EXWM-2335.
The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins. It is different from EC 2.4.99.18, dolichyl-diphosphooligosaccharide-protein glycotransferase, which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes. The enzyme participates in the N-glycosylation of proteins in some archaea. It requires Mn2+. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is α,ω-saturated and it may have additional unsaturated positions in the chain. Group: Enzymes. Synonyms: AglB; archaeal oligosaccharyl transferase; dolichyl-monophosphooligosaccharide-protein glycotransferase. Enzyme Commission Number: EC 2.4.99.21. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2706; dolichyl-phosphooligosaccharide-protein glycotransferase; EC 2.4.99.21; AglB; archaeal oligosaccharyl transferase; dolichyl-monophosphooligosaccharide-protein glycotransferase. Cat No: EXWM-2706.
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl β-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3. Group: Enzymes. Synonyms: Man5GlcNAc2-PP-Dol mannosyltr. Enzyme Commission Number: EC 2.4.1.258. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2488; dolichyl-P-Man:Man5GlcNAc2-PP-dolichol α-1,3-mannosyltransferase; EC 2.4.1.258; Man5GlcNAc2-PP-Dol mannosyltransferase; ALG3; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Not56-like protein; Alg3 α-1,3-mannosyl transferase; Dol-P-Man:Man5GlcNAc2-PP-Dol α-1,3-mannosyltransferase; dolichyl β-D-mannosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α-1,3-mannosyltransferase. Cat No: EXWM-2488.
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl β-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different α-1,2-mannose residues - the addition of α-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of α-1,2-mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261). G...Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2489; dolichyl-P-Man:Man6GlcNAc2-PP-dolichol α-1,2-mannosyltransferase; EC 2.4.1.259; ALG9; ALG9 α1,2 mannosyltransferase; dolichylphosphomannose-dependent ALG9 mannosyltransferase; ALG9 mannosyltransferase; Dol-P-Man:Man6GlcNAc2-PP-Dol α-1,2-mannosyltransferase; dolichyl β-D-mannosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?3)-D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α-1,2-mannosyltransferase. Cat No: EXWM-2489.
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl β-D-mannosyl phosphate. Group: Enzymes. Synonyms: ALG12; ALG12 mannosyltransferase; ALG12 α1,6mannosyltransferase. Enzyme Commission Number: EC 2.4.1.260. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2491; dolichyl-P-Man:Man7GlcNAc2-PP-dolichol α-1,6-mannosyltransferase; EC 2.4.1.260; ALG12; ALG12 mannosyltransferase; ALG12 α1,6mannosyltransferase; dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase; dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl α6-mannosyltransferase; EBS4; Dol-P-Man:Man7GlcNAc2-PP-Dol α-1,6-mannosyltransferase; dolichyl β-D-mannosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?3)-D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol α-1,6-mannosyltransferase. Cat No: EXWM-2491.
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl β-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different α-1,2-mannose residues: the addition of α-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of α-1,2-mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261). Gr... term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2492; dolichyl-P-Man:Man8GlcNAc2-PP-dolichol α-1,2-mannosyltransferase; EC 2.4.1.261; ALG9; ALG9 α1,2 mannosyltransferase; dolichylphosphomannose-dependent ALG9 mannosyltransferase; ALG9 mannosyltransferase; Dol-P-Man:Man8GlcNAc2-PP-Dol α-1,2-mannosyltransferase; dolichyl β-D-mannosyl phosphate:D-Man-α-(1?2)-D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?2)-D-Man-α-(1?3)-[D-Man-α-(1?6)]-D-Man-α-(1?6)]-D-Man-β-(1?4)-D-GlcNAc-β-(1?4)-D-GlcNAc-diphosphodolichol 2-α-D-mannosyltransferase. Cat No: EXWM-2492.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase. Group: Enzymes. Enzyme Commission Number: EC 2.4.2.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2661; dolichyl-xylosyl-phosphate-protein xylosyltransferase; EC 2.4.2.33. Cat No: EXWM-2661.
Dolomite
Dolomite. Uses: For analytical and research use. Group: Process materials, geological, cement & soils. Catalog: APS001582. Shipping: Room Temperature.
Dolomite(Calcium Magnesium Carbonate) Powder
Dolomite(Calcium Magnesium Carbonate) Powder.
CA, FL & NJ
Dolomitic Limestone
Dolomitic Limestone. Uses: For analytical and research use. Group: Process materials, geological, cement & soils. Catalog: APS001585.
Dolutegravir
Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC 50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC 50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC 50 =3.6-5.8 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S/GSK1349572. CAS No. 1051375-16-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13238.
Dolutegravir
Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Group: Biochemicals. Alternative Names: (4R, 12aS)-N-[(2, 4-Difluorophenyl)methyl]-3, 4, 6, 8, 12, 12a-hexahydro-7-hydroxy-4-methyl-6, 8-dioxo-2H-pyrido[1', 2':4, 5]pyrazino[2, 1-b][1, 3]oxazine-9-carboxamide; GSK 1349572; S/GSK1349572. Grades: Highly Purified. CAS No. 1051375-16-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H19F2N3O5, Molecular Weight: 419.38. US Biological Life Sciences.
Worldwide
Dolutegravir
Dolutegravir is a two-metal-binding HIV-1 integrase inhibitor with IC50 of 2.7 nM, with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. It blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). Synonyms: GSK-1349572; GSK 1349572; GSK1349572; Tivicay. Grade: ≥98%. CAS No. 1051375-16-6. Molecular formula: C20H19F2N3O5. Mole weight: 419.38.
Dolutegravir
Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Alternative Names: GSK1349572. S/GSK1349572. Tivicay. CAS No. 1051375-16-6. Product ID: API1051375166. Molecular formula: C20H19F2N3O5. Mole weight: 419.4. EINECS: 809-888-1. SMILES: CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O. Appearance: White to off-white (Solid). Category: Antivirus APIs.
Dolutegravir-[d3]
Dolutegravir-[d3] is a deuterium labelled form of Dolutegravir. Dolutegravir is an antiretroviral medication used to treat HIV/AIDS. Synonyms: (4R,12aS)-N-((2,4-difluorophenyl-3-d)methyl-d2)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide; Dolutegravir D3; Dolutegravir-d3; GSK 1349572-d3; S/GSK1349572-d3; Soltegravir-d3; Tivicay-d3. Grade: 95% by CP; 98% atom D. CAS No. 2673270-25-0. Molecular formula: C20H18D3F2N3O4. Mole weight: 422.42.
Dolutegravir-d5
Dolutegravir-d5 is used as an internal standard for the quantification of dolutegravir by GC- or LC-MS. Dolutegravir is a potent and orally bioavailable HIV integrase strand transfer inhibitor of HIV integrase. It prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) in peripheral blood mononuclear cells (PBMCs). Synonyms: (4R,12aS)-N-((2,4-difluorophenyl-3,5,6-d3)methyl-d2)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. Grade: ≥99% atom D. Molecular formula: C20H14D5F2N3O5. Mole weight: 424.41.
Dolutegravir Impurity 25
Dolutegravir Impurity 25. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid. CAS No. 1246616-73-8. Molecular formula: C13H14N2O6. Mole weight: 294.09. Catalog: APB1246616738.
Dolutegravir Impurity 7
Dolutegravir Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. CAS No. 1863916-88-4. Molecular formula: C20H20FN3O5. Mole weight: 401.39. Catalog: APB1863916884.
Dolutegravir Impurity 8
Dolutegravir Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,12aS)-N-(2-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. CAS No. 1863916-87-3. Molecular formula: C20H20FN3O5. Mole weight: 401.39. Catalog: APB1863916873.
Dolutegravir Impurity B
An impurity of Dolutegravir. Dolutegravir is an antiretroviral drug belonging to the integrase strand transfer inhibitor (INSTI) class. Synonyms: N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-(3-hydroxy-1-methylpropyl)-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide; Dolutegravir ring open impurity; N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide. Grade: ≥95%. CAS No. 2374716-73-9. Molecular formula: C20H19F2N3O5. Mole weight: 419.38.
Dolutegravir sodium
Dolutegravir sodium salt is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Uses: Hiv integrase inhibitors. Synonyms: DTG; GSK1349572; GSK 1349572; GSK-1349572. Grade: >98%. CAS No. 1051375-19-9. Molecular formula: C20H18F2N3NaO5. Mole weight: 441.36.
Dolutegravir sodium
Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC 50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC 50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC 50 =3.6-5.8 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S/GSK1349572 sodium. CAS No. 1051375-19-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13238A.
Dolutegravir (Sodium Salt)
Dolutegravir (Sodium Salt). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: sodium (4R,12aS)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate. CAS No. 1051375-19-9. Molecular formula: C20H18F2N3O5·Na. Mole weight: 443.38. Catalog: APB1051375199.
Domagrozumab
Domagrozumab is an anti- myostatin humanized monoclonal antibody with a K D value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PF-06252616. CAS No. 1629605-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99857.
Domatinostat
Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC 50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4SC-202 free base. CAS No. 910462-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16012A.
Domatinostat tosylate
Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC 50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4SC-202. CAS No. 1186222-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16012.
Dominulin-A
Dominulin A has antibacterial activity. The source of Dominulin A is the social paper wasp, Polistes dominulus. Grade: >97% by HPLC.
Dominulin-B
Dominulin-B shows antimicrobial activity against the Gram-positive bacteria B.subtilis, and the Gram-negative bacteria E.coli JM109 (MIC=8 μg/ml).
Domiphen bromide
Domiphen bromide is a chemical antiseptic and a quaternary ammonium compound, used as a cationic surfactant. Uses: Scientific research. Group: Signaling pathways. CAS No. 538-71-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B1467.
Domiphen bromide
25g Pack Size. Group: Biochemicals, Building Blocks, Quaternary Ammonium salts. Formula: C22H40BrNO. CAS No. 538-71-6. Prepack ID 79548603-25g. Molecular Weight 414.46. See USA prepack pricing.
Domiphen bromide is a quaternary ammonium antiseptic with actions as a cationic surfactant. Uses: Anti-infective (topical). Synonyms: NSC-39415; NSC 39415; NSC39415. Grade: >98%. CAS No. 538-71-6. Molecular formula: C22H40NO.Br. Mole weight: 414.46.
Domoic Acid
Domoic acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning associated with ingestion of certain cultured blue mussels. Domoic acid is a structural analog of Kainic acid.Potent agonist at receptors for excitatory amino acids glutamate and kainate; has highest affinity for AMPA/kainate receptor of any kainate agonist; causes excessive excitation of neurons leading to depletion of energy stores. Group: Biochemicals. Alternative Names: (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid; (-)-Domoic Acid; L-Domoic Acid; NSC 288031. Grades: Highly Purified. CAS No. 14277-97-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??NO?, Molecular Weight: 311.33. US Biological Life Sciences.
Worldwide
Domoic Acid
?90% (HPLC). Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy; building blocks. CAS No. 14277-97-5. Pack Sizes: 1MG, 5MG. IUPAC Name: (2S,3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid. Molecular formula: C15H21NO6. Mole weight: 311.33. Catalog: APS14277975. Assay: ?90% (HPLC). SMILES: C[C@H](\C=C\C=C(\C)/[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O)C(=O)O. Format: Neat.
Domperidone
Domperidone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2h-benzimidazol-2-one,1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzi;5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidaz;kw-5338;midazol-1-yl)propyl)-4-piperidinyl)-;DOMPERIDONE;4-(5-chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine;ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]-ALPHA-PHENYL-2-PYRIDINE-ACETAMIDE;5-CHLORO-1-[1-[3-(2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-1-YL)PROPYL]-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE. Appearance: solid. CAS No. 57808-66-9. Molecular formula: C22H24ClN5O2. Mole weight: 425.91. Purity: 98+%. IUPACName: Domperidone. Density: 1.341 g/cm³. Product ID: ACM57808669. Alfa Chemistry ISO 9001:2015 Certified.
Domperidone
Domperidone is a medication developed by Janssen Pharmaceutica that acts as a peripherally-selective antagonist of the dopamine D2 and D3 receptors. Uses: Antiemetics. Synonyms: KW 5338; KW5338; KW-5338; Domperidone; Motilium; Domperidona. Grade: >98%. CAS No. 57808-66-9. Molecular formula: C22H24ClN5O2. Mole weight: 425.91.
A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Group: Biochemicals. Alternative Names: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: Highly Purified. CAS No. 57808-66-9. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
Domperidone
Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R33812. CAS No. 57808-66-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0411.
Domperidone-d6
Domperidone-d6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1329614-18-7. Molecular formula: C22H18D6ClN5O2. Mole weight: 431.95. Catalog: APB1329614187.
Domperidone-[d6]
Domperidone-[d6] is a labelled Domperidone. Domperidone is an antagonist of peripherally dopamine D2 used for the treatment of nausea and vomiting. Synonyms: Domperidone D6. Grade: 95% by HPLC; 95% atom D. CAS No. 1329614-18-7. Molecular formula: C22H18D6ClN5O2. Mole weight: 431.95.
Domperidone Impurity
1-(3-Chloropropyl)-1,3-dihydrobenzimidazol-2-one is a benzimidazole derivative used in the preparation of neuroleptic and antiallergic agents. Synonyms: 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one. Grade: > 95%. CAS No. 62780-89-6. Molecular formula: C10H11ClN2O. Mole weight: 210.66.
Domperidone impurity 10
Domperidone impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 103784-04-9. Molecular formula: C10H11BrN2O. Mole weight: 255.12. Catalog: APB103784049.
Domperidone impurity 13
Domperidone impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 107618-26-8. Molecular formula: C14H20ClN3O2. Mole weight: 297.78. Catalog: APB107618268.
Domperidone Impurity A
A metabolite of the gastrokinetic and antinauseant drug Domperidone. Synonyms: 5-Chloro-1-(4-piperidinyl)-2-benzimidazolidinone; Des[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl] Domperidone; 4-(6-Chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidine; 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 5-Chloro-1-(p. Grade: > 95%. CAS No. 53786-28-0. Molecular formula: C12H14ClN3O. Mole weight: 251.71.
Domperidone Impurity B
An impurity of the gastrokinetic and antinauseant drug Domperidone. Synonyms: 4-(6-Chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidine-1-carbaldehyde; 5-Chloro-1-(4-formylpiperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 5-Chloro-1-(4-formylpiperidinyl)-1H-benzimidazol-2(3H)-one. Grade: > 95%. CAS No. 1346598-11-5. Molecular formula: C13H14ClN3O2. Mole weight: 279.72.
Domperidone Impurity C
An oxygenated metabolite of the gastrokinetic and antinauseant drug Domperidone. Synonyms: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-1-oxido-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; Domperidine Impurity C; 5-Chloro-1-[1-[3-[(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]]-1,3-dihydro-2H-benzimidazo. Grade: > 95%. CAS No. 118435-03-3. Molecular formula: C22H24ClN5O3. Mole weight: 441.91.
Domperidone Impurity D
An impurity of the gastrokinetic and antinauseant drug Domperidone. Synonyms: 5-Chloro-3-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one. Grade: > 95%. CAS No. 1614255-34-3. Molecular formula: C32H34ClN7O3. Mole weight: 600.11.
Domperidone Impurity E
An impurity of the gastrokinetic and antinauseant drug Domperidone. Synonyms: 3'-[3-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)propyl] Domperidone; 5-Chloro-1-[1-[3-[2,3-dihydro-2-oxo-3-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-1H-benzimidazol-1-yl]propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one. Grade: > 95%. CAS No. 1346602-50-3. Molecular formula: C32H34ClN7O3. Mole weight: 600.13.
Domperidone Impurity F
An impurity of the gastrokinetic and antinauseant drug Domperidone. Synonyms: 3'-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]propyl Domperidine. Grade: > 95%. CAS No. 1391053-55-6. Molecular formula: C37H42Cl2N8O3. Mole weight: 717.69.
Domperidone maleate
Domperidone maleate is the salt of Domperidone, which is a dopamine antagonist medication used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). Uses: Antiemetics. Synonyms: 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (2Z)-2-butenedioate (1:x); 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (Z)-2-butenedioate (1:x); 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one maleate (1:x). Grade: ≥95%. CAS No. 99497-03-7. Molecular formula: C22H24ClN5O2.xC4H4O4. Mole weight: 425.91 (free base).
Domperidone monomaleate
Domperidone monomaleate is the salt of Domperidone, which is a dopamine antagonist medication used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). Synonyms: 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (2Z)-2-butenedioate (1:1); 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (Z)-2-butenedioate (1:1); Domperidone maleate; 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one maleate. Grade: 95%. CAS No. 83898-65-1. Molecular formula: C22H24ClN5O2.C4H4O4. Mole weight: 541.99.
Domperidone monomaleate
Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R33812 monomaleate. CAS No. 83898-65-1. Pack Sizes: 50 mg; 100 mg. Product ID: HY-B0411A.
Domvanalimab
Domvanalimab (AB154) is an anti- TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AB154. CAS No. 2368219-35-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99858.
Donanemab
Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY3002813. CAS No. 1931944-80-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99859.
Donanemab (Mouse IgG2a)
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease. Uses: Scientific research. Group: Inhibitory antibodies. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991045.
Donepezil
Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor. Alternative Names: 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one. Aricept. Donaz. CAS No. 120014-06-4. Product ID: API120014064. Molecular formula: C24H29NO3. Mole weight: 379.49. SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC. Appearance: White to Off-white Solid. Category: APIs for Alzheimer's Disease.
Donepezil
1g Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C24H29NO3. CAS No. 120014-06-4. Prepack ID 77850944-1g. Molecular Weight 379.5. See USA prepack pricing.
Donepezil
Donepezil, also called Aricept, a centrally acting reversible acetyl cholinesterase inhibitor that the FDA has also approved for the treatment of moderate to severe Alzheimer's disease. It readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. Synonyms: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one; (±)-E 2020; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine; Neuripezil; Tonizep; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Aricept; HSDB 7743; HSDB7743; HSDB-7743; 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Eranz; Aricept ODT; donepezilo; donepezilum; CHEMBL502; donepezil hydrochloride; donepezilium oxalate trihydrate; E 2020; E-2020; E2020; 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one; (RS)-2-[(1-BENZYL-PIPERIDIN-4-YL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE. Grade: > 98%. CAS No. 120014-06-4. Molecular formula: C24H29NO3. Mole weight: 379.49.
Donepezil
Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC 50 s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E2020 free base. CAS No. 120014-06-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14566.
A nootropic. An inhibitor of acetylcholinesterase. Group: Biochemicals. Alternative Names: Aricept-13C3, (+/-)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1H-inden-1-one-1,2,3-13C3. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Donepezil Alkene Pyridine N-Oxide
Donepezil Alkene Pyridine N-Oxide is an impurity of Donepezil, a medication for the treatment of Alzheimer's disease. Synonyms: 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-; 2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one; 4-[(5,6-dimethoxy-1-indanon-2-ylidene)methyl]pyridine N-oxide; 4-((5,6-Dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridine 1-oxide. Grade: ≥95%. CAS No. 896134-06-8. Molecular formula: C17H15NO4. Mole weight: 297.31.
Donepezil Benzyl Bromide (Donepezil Impurity)
An impurity of Donepezil. Group: Biochemicals. Alternative Names: 4-[(2,3-Dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)methyl]-1,1-bis(phenylmethyl). Grades: Highly Purified. CAS No. 844694-85-5. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Donepezil-[d4] Hydrochloride
Donepezil-[d4] Hydrochloride is an isotope labelled Donepezil hydrochloride. Donepezil is used in the treatment of Alzheimer's disease. Donepezil acts as a centrally acting reversible acetylcholinesterase inhibitor. Synonyms: Donepezil-d4 Hydrochloride. Grade: 95% by HPLC; 99% atom D. CAS No. 1219798-88-5. Molecular formula: C24H26D4ClNO3. Mole weight: 419.98.
Donepezil-d5
Donepezil-d 5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: E2020-d5 free base. CAS No. 1128086-25-8. Pack Sizes: 1 mg. Product ID: HY-14566S1.