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| Product | Description | |
|---|---|---|
| Eprosartan-d3 | Labeled Eprosartan, a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Eprosartan is an antihypertensive. Group: Biochemicals. Alternative Names: (αE)-α-[[2-(Butyl-d3)-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic Acid; (E)-2-(Butyl-d3)-1-(p-carboxybenzyl)-α-2-thenylimidazole-5-acrylic Acid; Navixen-d3; SKB 108566-d3; SKF 108566-d3; Teveten-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Eprosartan ((E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid) | Prototype of the imidazoleacrylic Acid angiotensin II receptor antagonists. Group: Biochemicals. Alternative Names: (E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Eprosartan ethyl methyl diester | Eprosartan ethyl methyl diester. Group: Biochemicals. Alternative Names: (a-E) -a-[[2-Butyl-1-[[4- (methoxycarbonyl) phenyl]methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid ethyl ester; Methyl 4-((5-((E)-2-(ethoxycarbonyl)-3-(thien-2-yl)prop-1-enyl)-2-butyl-1H-imidazol-1-yl)methyl)benzoate. Grades: Highly Purified. CAS No. 133486-13-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C26H30N2O4S. US Biological Life Sciences. | Worldwide |
| Eprosartan Impurity 1 | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: (E)-methyl 4-((2-butyl-5-(3-ethoxy-3-oxo-2-(thiophen-2-ylmethyl)prop-1-en-1-yl)-1H-imidazol-1-yl)methyl)benzoate. Grades: > 95%. Molecular formula: C26H30N2O4S. Mole weight: 466.60. |  |
| Eprosartan Impurity 2 | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: 2-((2-butyl-1-(4-carboxybenzyl)-1H-imidazol-5-yl)methylene)malonic acid. Grades: > 95%. Molecular formula: C19H20N2O6. Mole weight: 372.38. | |
| Eprosartan Impurity 3 | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: (E)-4-((2-butyl-5-(2-carboxyvinyl)-1H-imidazol-1-yl)methyl)benzoic acid. Grades: > 95%. Molecular formula: C18H20N2O4. CH4O3S. Mole weight: 328.37 96.11. | |
| Eprosartan Impurity 4 | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: 4-((2-butyl-5-formyl-1H-imidazol-1-yl)methyl)benzoic acid. Grades: > 95%. CAS No. 152146-59-3. Molecular formula: C16H18N2O3. Mole weight: 286.33. | |
| Eprosartan Impurity 5 | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: (E)-4-((2-butyl-5-(3-carboxy-1,4-di(thiophen-2-yl)but-2-en-2-yl)-1H-imidazol-1-yl)methyl)benzoic acid. Grades: > 95%. Molecular formula: C28H28N2O4S2. Mole weight: 520.69. | |
| eprosartan mesylate | eprosartan mesylate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Eprosartan Methanesulfonate. Product Category: Thiophenes. Appearance: White to Off-White Solid. CAS No. 144143-96-4. Molecular formula: C23H24N2O4S·CH4O3S. Mole weight: 520.62. Purity: 0.99. Product ID: ACM144143964. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Eprosartan mesylate | Eprosartan mesylate. Group: Biochemicals. Grades: Purified. CAS No. 144143-96-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Eprosartan mesylate | Eprosartan mesylate. CAS No: 144143-96-4 |  Sarchem Laboratories New Jersey NJ |
| Eprosartan mesylate | Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC 50 s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF-108566J. CAS No. 144143-96-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15834A. |  |
| Eprosartan Mesylate | Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells. Synonyms: Eprosartan Mesylate; Teveten; Futuran; Navixen; Regulaten; SK and F 108566; SKF-108566. Grades: >98%. CAS No. 144143-96-4. Molecular formula: C23H24N2O4S.CH4O3S. Mole weight: 520.62. | |
| Eprosartan RC A ( (E)-3-(2-Butyl-1H-imidazol-5-yl)-2-(thiophen-2-ylmethyl)acrylic acid(Debenzyl Eprosartan) ) | Eprosartan RC A ( (E)-3-(2-Butyl-1H-imidazol-5-yl)-2-(thiophen-2-ylmethyl)acrylic acid(Debenzyl Eprosartan) ) | Sarchem Laboratories New Jersey NJ |
| Eprosartan RC B (3-(Thiophen-2-yl)propanoic acid (Thiophenpropionic acid) | Eprosartan RC B (3-(Thiophen-2-yl)propanoic acid (Thiophenpropionic acid) | Sarchem Laboratories New Jersey NJ |
| Eprosartan RC C (2-[(Thiophene-2-yl)methyl] malonic acid (Bromomethylbenzoic acid)) | Eprosartan RC C (2-[(Thiophene-2-yl)methyl] malonic acid (Bromomethylbenzoic acid)) | Sarchem Laboratories New Jersey NJ |
| Eprosartan RC D (4-Bromomethylbenzoic acid (Bromomethylbenzoic acid)) | Eprosartan RC D (4-Bromomethylbenzoic acid (Bromomethylbenzoic acid)). CAS No: 6232-88-8 | Sarchem Laboratories New Jersey NJ |
| Eprosartan RC F ((Z) -4-({2-Butyl-5-[2-carboxy-3-(thiophen-2-yl) prop-1-enyl]-1H-imidazol-1-yl}methyl)benzoic acid(Z-Eprosartan)) | Eprosartan RC F ((Z) -4-({2-Butyl-5-[2-carboxy-3-(thiophen-2-yl) prop-1-enyl]-1H-imidazol-1-yl}methyl)benzoic acid(Z-Eprosartan)) | Sarchem Laboratories New Jersey NJ |
| Eprosartan related compound A | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: N-Descarboxyphenyl eprospartan; ((E)-3-(2-Butyl-1H-imidazol-5-yl)-2-(thiophen-2-ylmethyl)Acrylic Acid. Grades: > 95%. CAS No. 1169702-90-2. Molecular formula: C15H18N2O2S. Mole weight: 290.39. | |
| Eprosartan Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. |  |
| Eprosartan Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Eprosartan related compound C | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: (2-Thenyl)malonic acid, 2-(2-Thienylmethyl)propanedioic acid, 2-(Thiophen-2-ylmethyl)malonic acid. Grades: > 95%. CAS No. 4475-24-5. Molecular formula: C8H8O4S. Mole weight: 200.21. | |
| Eprosartan Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Eprosartan Related Compound D | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Eprosartan Related Compound E | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Eprosartan related compound F | An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Synonyms: (Z)-Eprosartan; (αZ)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic Acid. Grades: > 95%. CAS No. 148674-39-9. Molecular formula: C23H24N2O4S. Mole weight: 424.52. | |
| Eprotirome | Eprotirome is a synthetic thyroid hormone mimetic as a thyroid hormone receptor beta agonists, lowers total and low-density lipoprotein cholesterol up to 40% without affecting high-density lipoprotein cholesterol levels and without deleterious side effects to the cardiovascular system. Uses: Thyroid hormone receptor beta agonists. Synonyms: KB-2115; KB 2115; KB2115; Eprotirome.3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)phenoxy]phenyl]amino-3-oxo-propanoic acid. Grades: ≥98%. CAS No. 355129-15-6. Molecular formula: C18H17Br2NO5. Mole weight: 487.14. | |
| Eprotirome | Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TR&alpha. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KB2115. CAS No. 355129-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10473. | |
| epsilon-Caprolactone | Liquid;COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. Group: Polymers. CAS No. 502-44-3. Product ID: oxepan-2-one. Molecular formula: 114.14g/mol. Mole weight: C6H10O2;C6H10O2. C1CCC(=O)OCC1. InChI=1S / C6H10O2 / c7-6-4-2-1-3-5-8-6 / h1-5H2. PAPBSGBWRJIAAV-UHFFFAOYSA-N. |  |
| epsilon-Cyclodextrin | epsilon-Cyclodextrin is a modified cyclodextrin widely used in the biomedical industry. It facilitates the delivery of drugs by forming inclusion complexes, enhancing their solubility and stability. With its unique structure, epsilon-Cyclodextrin is applied in the research of various diseases, including cancer, diabetes and Alzheimer's. Synonyms: Cyclomaltodecaose; CD10. CAS No. 156510-98-4. Molecular formula: C60H100O50. Mole weight: 1621.41. | |
| epsilon-Dinitrophenyllysine | Synonyms: Dinitrophenyl-lysine; epsilon-Dinitrophenylated-lysine; DNP-L-Lys; N(6)-(2,4-dinitrophenyl)-L-lysine; epsilon-N-(2,4-Dinitrophenyl)-L-lysine; H-Lys(Dnp)-OH. CAS No. 1094-76-4. Molecular formula: C12H16N4O6. Mole weight: 312.28. | |
| Epsilon-polylysine | Cas No. 28211-04-3. | |
| Epsom Salt | Epsom Salt (Magnesium Sulfate, Heptahydrate). Products can be packaged according to specific requirements and as per international standards for export shipments. Categories: magnesium sulfate heptahydrate; 10034-99-8; epsom salt. |  Worldwide |
| Ept | Ept. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOLE-3-ONE;5-ETHYL-4-(2-PHENOXYETHYL)-1,2,4-TRIAZOL-3-ONE;5-ETHYL-4-(2-PHENOXYETHYL)-2H-1,2,4-TRIAZOL 3(4H)-ONE;5-ETHYL-4-(2-PHENOXYETHYL)-2H-1,2,4-TRIAZOL-3-ONE;5-Ethyl-4-(2-phenoxyethyl)-2H-1,2,4-triazole-3-(4H)-one;EPT;5-Ethyl-2,4-Dihydro-4-(2-Phenoxyethyl)-3h-1,2,4-Triazol-3-One;5-Ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazole-3-one (EPT). CAS No. 95885-13-5. Molecular formula: C12H15N3O2. Mole weight: 233.27. Purity: 0.96. IUPACName: 3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5-one. Canonical SMILES: CCC1=NNC(=O)N1CCOC2=CC=CC=C2. Density: 1.21g/cm³. Product ID: ACM95885135. Alfa Chemistry ISO 9001:2015 Certified. | |
| Eptapirone | Eptapirone, a triazine derivative, has been found to be a 5-HT1A receptor agonist and was once studied as an antidepressant agent. pKi: 8.33. Synonyms: F11440; F-11440; F 11440; Eptapirone; L0068; L-0068; L 0068; Eptapirone; Eptapirone [INN]; F 11440; 4-methyl-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,4-triazine-3,5-dione. Grades: 98%. CAS No. 179756-85-5. Molecular formula: C16H23N7O2.C4H4O4. Mole weight: 461.47. | |
| Eptaplatin | A coordination compound for treatment of cervix cancer. Group: Biochemicals. Alternative Names: (SP-4-2)-[(4R, 5R)-2-(1-Methylethyl-1, 3-dioxolane4, 5-dimethanamine-kN4, kN5][propanedioato(2-)-kO1, kO3]platinum; Heptaplatin; cis-[ (4R, 5R)-4, 5-bis (aminomethyl)-2-isopropyl-1, 3-dioxolane] (malonate)platinum (II); SKI 2053R. Grades: Highly Purified. CAS No. 146665-77-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Eptaplatin | (Sp-4-2)-[(4R,5R)-2-isopropyl-1,3-dioxolane-4,5-bis(methanamine)-N,N'][propanedioato(2-)-o,o']platinum. Grades: CAS No. 146665-77-2. Product ID: 8-04509. Molecular formula: C11H20N2O6Pt. Mole weight: 471.37. |  |
| Eptifibatide | Eptifibatide. Categories: eptifibatide; 188627-80-7. |  CA, FL & NJ |
| Eptifibatide | Eptifibatide is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor , with anti-platelet activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 188627-80-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0686. | |
| Eptifibatide | Eptifibatide. Group: Biochemicals. Grades: Purified. CAS No. 188627-80-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Eptifibatide | An arginin-glycin-aspartat-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events. Uses: Platelet aggregation inhibitors. Synonyms: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1?6)-disulfide; Eftifibatide; Integrelin; Integrilin; Intrifiban; Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2; deamino-cysteinyl-L-homoarginyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->7)-disulfide. Grades: 98%. CAS No. 188627-80-7. Molecular formula: C35H49N11O9S2. Mole weight: 831.97. | |
| Eptifibatide acetate | Eptifibatide acetate, an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class, is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. It reversibly binds to platelets to reduce the risk of cardiac ischemic events. Synonyms: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1?6)-disulfide, acetate (1:x); deamino-Cys(1)-hArg-Gly-Asp-Trp-Pro-Cys(1)-NH2.xCH3CO2H; deamino-cysteinyl-L-homoarginyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->7)-disulfide acetic acid; Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 acetate. Grades: ≥95%. CAS No. 881997-86-0. Molecular formula: C35H49N11O9S2.xC2H4O2. Mole weight: 831.97 (free base). | |
| Eptifibatide Acetate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardspharmaceutical toxicology. Alternative Names: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-?-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1?6)-disulfide, acetate (9CI), Eptifibatide acetate,L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-?-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1?6)-disulfide, acetate (1:?). | |
| Eptifibatide monoacetate | Eptifibatide monoacetate, an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class, is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. It reversibly binds to platelets to reduce the risk of cardiac ischemic events. Synonyms: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1?6)-disulfide, acetate (1:1); deamino-Cys(1)-hArg-Gly-Asp-Trp-Pro-Cys(1)-NH2.CH3CO2H; deamino-cysteinyl-L-homoarginyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->7)-disulfide acetic acid; Eptifibatide acetate; Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 acetate. Grades: ≥95%. CAS No. 1248559-53-6. Molecular formula: C35H49N11O9S2.C2H4O2. Mole weight: 892.02. | |
| Eptinezumab | Eptinezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Eptinezumab has been used for the preventive treatment of migraine in adults. Synonyms: Vyepti. CAS No. 1644539-04-7. | |
| Eptinezumab | Eptinezumab is a humanized monoclonal antibody. Eptinezumab binds to calcitonin gene-related peptide (CGRP) and blocks its interaction with the receptor. Eptinezumab is used for the prevention of migraine in adults [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1644539-04-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99017. | |
| eptotermin alfa | eptotermin alfa. Uses: Designed for use in research and industrial production. Additional or Alternative Names: eptotermin alfa. Product Category: Heterocyclic Organic Compound. CAS No. 129805-33-0. Molecular formula: Na+. Purity: 0.96. IUPACName: sodium(1+). Canonical SMILES: [Na+]. Product ID: ACM129805330. Alfa Chemistry ISO 9001:2015 Certified. | |
| e-Pyrrole-lysine 99+% (HPLC) | e-Pyrrole-lysine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| EPZ004777 | EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model. These results provide compelling support for DOT1L inhibition as a basis for targeted therapeutics against MLL. Uses: Reprogramming. Synonyms: EPZ004777; EPZ 004777; EPZ-004777. Grades: 0.98. CAS No. 1338466-77-5. Molecular formula: C28H41N7O4. Mole weight: 539.681. | |
| EPZ004777 hydrochloride | EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells. EPZ004777 selectively inhibits proliferation of MLL-AF10 and CALM-AF10-transformed murine bone marrow cells. DOT1L inhibition by EPZ004777 results in significantly decreased proliferation, decreased expression of MLL-AF6 target genes, and cell cycle arrest of MLL-AF6-transformed cells. Synonyms: EPZ 004777 hydrochloride; EPZ-004777 hydrochloride; EPZ004777 hydrochloride. Grades: >98%. CAS No. 1380316-03-9. Molecular formula: C28H42ClN7O4. Mole weight: 576.13. | |
| EPZ005687 | EPZ005687 is a selective EZH2 enzyme inhibitor with Ki of 24 nM. It is 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. EPZ005687 can block trimethylation of the PRC2 target histone 3 lysine 27 with IC50 value of 80 nM, decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2. No development of preclinical research for the treatment of Cancer, Lymphoma and Solid tumours was reported. Uses: Cancer; lymphoma; solid tumours. Synonyms: EPZ005687; EPZ 005687; EPZ-005687; 1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide; 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide. Grades: 98%. CAS No. 1396772-26-1. Molecular formula: C32H37N5O3. Mole weight: 539.67. | |
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. Synonyms: EPZ011989; EPZ-011989; EPZ 011989. Grades: 98%. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. | |
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. EPZ011989 represents a powerful tool for the expanded exploration of EZH2 activity in biology. Inhibitors of the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2) may have significant therapeutic potential for the treatment of B cell lymphomas and other cancer indications. The ability of the scientific community to explore fully the spectrum of EZH2-associated pathobiology has been hampered by the lack of in vivo-active tool compounds for this enzyme. Uses: Designed for use in research and industrial production. Additional or Alternative Names: EPZ011989; EPZ-011989; EPZ 011989. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. Purity: >98%. IUPACName: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide. Canonical SMILES: O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C#CCN3CCOCC3)=CC(N(CC)[C@H]4CC[C@H](N(CCOC)C)CC4)=C2C. Product ID: ACM1598383404. Alfa Chemistry ISO 9001:2015 Certified. | |
| EPZ011989 trifluoroacetate | EPZ011989 trifluoroacetate is the trifluoroacetate salt form of EPZ011989. EPZ011989 is a potent and orally bioavailable inhibitor that specifically targets the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2), with significant tumor growth in. Synonyms: EPZ011989 TFA salt; EPZ011989 TFA; EPZ 011989 TFA; EPZ-011989 TFA; N-[ (4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl (methyl)amino]cyclohexyl]amino]-2-methyl-5- (3-morpholin-4-ylprop-1-ynyl)benzamide; 2, 2, 2-trifluoroacetic acidEPZ011989 (trifluoroacetate). CAS No. 1598383-41-5. Molecular formula: C37H52F3N5O6. Mole weight: 719.83. | |
| EPZ015666 | EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. Synonyms: EPZ015666; EPZ-015666; EPZ 015666; GSK3235025; GSK-3235025; GSK 3235025. Grades: >98%. CAS No. 1616391-65-1. Molecular formula: C20H25N5O3. Mole weight: 383.44. | |
| EPZ015666 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| EPZ015666 (PRMT5, HRMT1L5, IBP72, JBP1, SKB1, PRMT Protein) | EPZ015666 is a potent, selective, competitive PRMT5 inhibitor (IC50 = 22nM). EPZ015666 exhibits >10,000-fold specificity for PRMT5 vs. other methyltransferases. EPZ015666 blocks the association of PRMT5 with methylosome protein 50 (WDR77), which is necessary to form an active methyltransferase complex. Treatment of MCL cell lines with nM concentrations of EPZ015666 leads to inhibition of SmD3 methylation and cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 1616391-65-1. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| EPZ015866 | EPZ015866,also called as GSK591, is a chemical probe for PRMT5 which has a role in diverse cellular processes including tumorigenesis. It exhibits excellent selectivity against a panel of methyltransferases. Inhibits the PRMT5/MEP50 complex from methylati. Synonyms: GSK591; GSK-591; GSK 591; EPZ015866; EPZ-015866; EPZ 015866; GSK 3203591; GSK-3203591; GSK3203591; 2- (cyclobutyl amino) -N- [ (2S) -3- (3, 4-di hydro-1H-isoquinolin-2-yl ) -2- hydroxypropyl ] pyridine-4-carboxamide EPZ015866GSK591GTPL8954S CHEMBL16220740GSK32035912- (cyclobutyl amino) -N- [ (2S) -2- hydroxy-3- (1, 2, 3, 4-tetra hydroisoquinolin-2-yl ) propyl ] pyridine-4-carbo. CAS No. 1616391-87-7. Molecular formula: C22H28N4O2. Mole weight: 380.48. | |
| EPZ020411 | EPZ020411, with potent anticancer activity, is an orally bioactive, selective inhibitor of PRMT6/8/1 with over 100-fold selective for other histone methyltransferases including four arginine methyltransferases (PRMT3, PRMT4, PRMT5, and PRMT7). Synonyms: N,N'-dimethyl-N'-[[5-[4-[3-[2-(oxan-4-yl)ethoxy]cyclobutyl]oxyphenyl]-1H-pyrazol-4-yl]methyl]ethane-1,2-diamineEPZ020411; EPZ 020411; EPZ-020411CHEMBL3589039GTPL9243SCHEMBL17 62195749LN, N'-Di methyl -N- ( {3- [4- ( {trans-3- [2- (Tetra hydro-2h-Pyran-4-yl ) ethoxy] cyclobutyl } oxy) pheny l. CAS No. 1700663-41-7. Molecular formula: C25H38N4O3. Mole weight: 442.59. | |
| EPZ020411 HCl | EPZ020411 hydrochloride is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM, and it displays >10-fold and 20-fold selectivity over PRMT1/8. Synonyms: EPZ-020411 hydrochloride. Grades: ≥97%. CAS No. 2070015-25-5. Molecular formula: C25H39ClN4O3. Mole weight: 479.06. | |
| EPZ-5676 | EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes. This eventually leads to an induction of apoptosis in the leukemic cells bearing the MLL gene translocations. DOT1L, a non-SET domain-containing histone methyltransferase, specifically methylates H3K79 and plays a key role in normal cell differentiation and in the development of leukemia with MLL gene rearrangement on chromosome 11 and promotes the expression of leukemia-causing genes. Synonyms: EPZ-5676; EPZ5676; EPZ 5676. CAS No. 1380288-87-8. Molecular formula: C30H42N8O3. Mole weight: 562.719. | |
| EPZ-6438 | EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. Synonyms: EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat. Grades: 98%. CAS No. 1403254-99-8. Molecular formula: C34H44N4O4. Mole weight: 572.75. | |
| Equilenin | Equilenin is a B-ring unsaturated estrogen and one of the main ingredients in Premarin, a drug commonly used in estrogen replacement therapy. Equilenin can bind to estrogen receptors in the body and exert effects similar to endogenous estrogen. Equilenin can be used in estrogen replacement therapy and breast cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 517-09-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-116865. | |
| Equilenin | Equilenin is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one; (+)-Equilenin; 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one. Grades: > 95%. CAS No. 517-09-9. Molecular formula: C18H18O2. Mole weight: 266.34. | |
| Equilenin | Equilenin. Group: Biochemicals. Alternative Names: 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one; (+)-Equilenin; 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one. Grades: Highly Purified. CAS No. 517-09-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C18H18O2. US Biological Life Sciences. | Worldwide |
| Equilenin solution | Equilenin solution. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Equilenin solution; EQU; Equilenina; d-Equilenin. Appearance: liquid. CAS No. 517-09-9. Molecular formula: C18H18O2. Mole weight: 266.33. Purity: analytical standard. IUPACName: (13S,14S)-3-hydroxy-13-methyl-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthren-17-one. Canonical SMILES: CC12CCC3=C(C1CCC2=O)C=CC4=C3C=CC(=C4)O. Density: 1.242g/cm³. ECNumber: 208-230-5. Product ID: ACM517099. Alfa Chemistry ISO 9001:2015 Certified. | |
| Equilenin solution | 100 ?g/mL in acetonitrile, analytical standard. Group: Pesticides & metabolites standards. | |
| Equilenin Sulfate Sodium | A metabolite of Equilin. Equilenin is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: 3-(Sulfooxy)-estra-1,3,5,7,9-pentaen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one HydrogenSulfate Monosodium Salt. Grades: > 95%. CAS No. 16680-48-1. Molecular formula: C18H17FO5S Na. Mole weight: 345.40 22.99. | |
| Equilin | Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Uses: An estrogen. Synonyms: 3-Hydroxy-13-methyl-9,11,12,14,15,16-hexahydro-6H-cylcopenta(a)phenanthren-17-one. Grades: > 95%. CAS No. 474-86-2. Molecular formula: C18H20O2. Mole weight: 268.36. | |
| Equilin | Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-Dehydroestrone. CAS No. 474-86-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1176. | |
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