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| Product | Description | |
|---|---|---|
| ERK1/2 inhibitor 1 | ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2095719-90-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112287. |  |
| ERK1/2 inhibitor 1 | ERK1/2 inhibitor 1 is a potent and orally bioavailable ERK1/2 inhibitor, inhibiting ERK1 up to 60% at 1 nM and inhibiting ERK2 with an IC50 of 3.0 nM. Synonyms: 2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-; (2R)-2-{6-[5-Chloro-2-(tetrahydro-2H-pyran-4-ylamino)-4-pyrimidinyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]propanamide. Grade: ≥95%. CAS No. 2095719-90-5. Molecular formula: C29H32ClN5O4. Mole weight: 550.05. |  |
| ERK1/2 inhibitor 3 | ERK1/2 inhibitor 3, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2021218912A1, compound 1). Synonyms: (S)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. CAS No. 2737294-99-2. Molecular formula: C28H31ClFN5O6S. Mole weight: 620.09. | |
| ERK1/2 inhibitor 4 | ERK1/2 inhibitor 5, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2020238776A1). Synonyms: Thieno[3,2-c]pyridine-5(4H)-acetamide, 2-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]-6,7-dihydro-α-methyl-4-oxo-, (αR)-. CAS No. 2490396-99-9. Molecular formula: C28H31ClFN5O5S. Mole weight: 604.09. | |
| ERK1/2 inhibitor 6 | ERK1/2 inhibitor 6, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2021063335A1, compound 1). Synonyms: (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-4-oxopyrrolo[2,1-f][1,2,4]triazin-3(4H)-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. CAS No. 2634816-13-8. Molecular formula: C27H29ClFN7O5. Mole weight: 586.01. | |
| ERK1, active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| ERK1, active, untagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| ERK2, active, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| ERK2 IN-1 | ERK2 IN-1 is a selective inhibitor of ERK2 with an IC50 of 7 nM. Synonyms: (3S)-N-[3-(4-Fluorophenyl)-1H-indazol-5-yl]-3-(methylsulfanyl)-1-(2-oxo-2-{4-[4-(2-pyrimidinyl)phenyl]-3,6-dihydro-1(2H)-pyridinyl}ethyl)-3-pyrrolidinecarboxamide; 3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(2-pyrimidinyl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-3-(methylthio)-, (3S)-. Grade: ≥95%. CAS No. 1093061-47-2. Molecular formula: C36H34FN7O2S. Mole weight: 647.76. | |
| ERK5, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| ERK5-IN-1 | ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1234479-76-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14403. | |
| ERK5-IN-2 | ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 ?M, 3 ?M for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1888305-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128341. | |
| ERK5-IN-2 | ERK5-IN-2 is a submicromolar selective ERK5 inhibitor with oral activity, which can inhibit tumor xenograft growth and basic fibroblast growth factor (bFGF)-driven Matrigel plug angiogenesis. Synonyms: 4-(2-Bromanyl-6-Fluoranyl-Phenyl)Carbonyl-{N}-Pyridin-3-Yl-1{H}-Pyrrole-2-Carboxamide; SCHEMBL17607180; BCP32587; EX-A4938. Grade: 98%. CAS No. 1888305-96-1. Molecular formula: C17H11BrFN3O2. Mole weight: 388.2. | |
| ERK5-IN-5 | ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC 50 value of 6.23 μg/mL for A549 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2318792-30-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156450. | |
| ERK Activation Inhibitor Peptide I, Cell-Permeable | The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| ERK Activation Inhibitor Peptide II, Cell-Permeable | The ERK Activation Inhibitor Peptide II, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| ERK-IN-2 | ERK-IN-2, an ERK2 inhibitor probe (IC50 = 1.8 nM), may cause off-target toxicity and/or off-target activity at doses >10 μM. Synonyms: 1-[4-(Hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-[(1R)-1-phenylethyl]urea hydrochloride (1:1); Urea, N-[4-(hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-N'-[(1R)-1-phenylethyl]-, hydrochloride (1:1). Grade: ≥95%. Molecular formula: C16H18ClN5O2. Mole weight: 347.80. | |
| ERK-IN-3 | ERK-IN-3 is a potent and orally active ERK inhibitor that can be used in cancer research caused by RAS mutations. It inhibits ERK1/2 with low single-digit nM IC50 values. Synonyms: N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide; ASN007 free base; NSC-828319; N-[(1S)-2-Amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(tetrahydro-2H-pyran-4-ylamino)-4-pyrimidinyl]-1H-imidazole-4-carboxamide. Grade: ≥99%. CAS No. 2055597-12-9. Molecular formula: C22H25ClFN7O2. Mole weight: 473.93. | |
| ERK-IN-3 benzenesulfonate | ERK-IN-3 benzenesulfonate is a potent and orally active ERK inhibitor that can be used in cancer research caused by RAS mutations. It inhibits ERK1/2 with low single-digit nM IC50 values. Synonyms: 1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-, compd. with benzenesulfonate (1:1). Grade: ≥98%. CAS No. 2055597-39-0. Molecular formula: C28H31ClFN7O5S. Mole weight: 632.11. | |
| ERK Inhibitor | ERK inhibitor, a reversible thiazolidinedione compound, is a cell-permeable inhibitor that binds ERK2 near its docking domain with a KD of 5 μM and prevents its interaction with protein substrates. Synonyms: Extracellular Regulated Kinase Inhibitor; 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione, monohydrochloride. Grade: ≥95%. CAS No. 1049738-54-6. Molecular formula: C14H16N2O3S·HCl. Mole weight: 328.8. | |
| ERK Inhibitor - CAS 1049738-54-6 | The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| ERK Inhibitor II, FR180204 - CAS 865362-74-9 | ERK Inhibitor II, FR 180204, CAS 865362-74-9, is a cell-permeable, potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC?? = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| ERK Inhibitor III - CAS 331656-92-9 | The ERK Inhibitor III, also referenced under CAS 331656-92-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 | The ERK Inhibitor II, Negative Control, also referenced under CAS 1177970-73-8, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| ERK Inhibitor VIII ((S)-4-(2-(2-Chloro-4-fluorophenylamino)-5-methylpyrimidin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide) | A cell-permeable pyrimidylpyrrole compound that acts as an active site-targeting, highly potent and selective ERK1/2 inhibitor (KI <2nM against Erk2; [ATP] = 65uM), while inhibiting GSK-3, Aurora A, Cdk2 only at much higher concentrations (KI = 395, 540, and 852nM, respectively) and exhibiting much reduced or little potency toward a panel of more than 130 other kinases (KI ≥1.4uM; IC50 ≥1uM). Shown to effectively inhibit human colon carcinoma HT-29 proliferation (IC50 = 48nM) and restore EGFR inhibitor WZ4002 antiproliferation activity in WZR10 cultures (84% and no inhibition, respectively, by 100nM WZ4002 with or without 1uM Erk Inhibitor VIII co-treatment). Orally available in both mice and rats in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 896720-20-0. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?FN?O?. US Biological Life Sciences. |  Worldwide |
| Erlizumab | Erlizumab is a humanized monoclonal antibody that targets CD18. Erlizumab has been investigated as a therapy for hemorrhagic shock. Synonyms: rhuMAb. Grade: 95%. CAS No. 211323-03-4. | |
| Erlose | Erlose is a widely utilized pharmaceutical in the biomedical sector, serving as a prominent role for studying Type 2 diabetes. Its mechanism of action entails augmenting glycemic regulation while concurrently amplifying the responsiveness of cells towards insulin. Synonyms: a-D-Glc-(1→4)-a-D-Glc-(1→2)-b-D-Fru; a-Maltosyl b-fructofuranoside; β-D-Fructofuranosyl O-α-D-glucopyranosyl-(1→4)-α-D-glucopyranoside; Fructomaltose. CAS No. 13101-54-7. Molecular formula: C18H32O16. Mole weight: 504.44. | |
| Erlosiban | Erlosiban, an iminopyrrolidin derivative, has been found to be a nonpeptide oxytocin receptor antagonist that could probably be used in the treatment of female infertility and preterm labour. It is still under Phase II clinical trail in Preterm labour. Synonyms: UOBE-001; OBE001; OBE001; NII-3765U8A1EC; CHEMBL1254025; 3765U8A1EC; Erlosiban; Erlosiban [INN]; [(2S,4Z)-2-(hydroxymethyl)-4-methoxyiminopyrrolidin-1-yl]-[4-(2-methylphenyl)phenyl]methanone. Grade: 98%. CAS No. 1477482-19-1. Molecular formula: C20H22N2O3. Mole weight: 338.41. | |
| Erlotinib | Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib has been indicated for non-small cell lung cancer (NSCLC) and pancreatic cancer therapy. Synonyms: CP358774; CP 358774; CP-358774; NSC 718781; NSC718781; NSC-718781. Grade: >98%. CAS No. 183321-74-6. Molecular formula: C22H23N3O4. Mole weight: 393.44. | |
| Erlotinib | Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC 50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC 50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer [1]. Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-358774; NSC 718781; OSI-774. CAS No. 183321-74-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-50896. | |
| Erlotinib-[13C6] Hydrochloride | Erlotinib-[13C6] Hydrochloride is the labelled salt of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Erlotinib is a medication used to treat non-small cell lung cancer and pancreatic cancer. Synonyms: Erlotinib-13C6 Hydrochloride; N-[3-ethynyl(1,2,3,4,5,6-13C6)phenyl]-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride; Tarceva-13C6. Grade: 95% by HPLC; 98% atom 13C. CAS No. 1210610-07-3. Molecular formula: C16[13C]6H23N3O4.HCl. Mole weight: 435.82. | |
| Erlotinib-3-vinyl Hydrochloride | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6,7-Bis(2-methoxyethoxy)-N-(3-vinylphenyl)quinazolin-4-amine hydrochloride; 4-Quinazolinamine, N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1). Grade: 95%. CAS No. 1624294-38-7. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. | |
| Erlotinib Carboxylic Acid | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Erlotinib Metabolite M6; Erlotinib Acid. Grade: > 95%. Molecular formula: C22H25N3O6. Mole weight: 427.46. | |
| Erlotinib-d6 | Erlotinib-d 6 (CP-358774 D6) is a deuterium labeled Erlotinib (CP-358774). Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR[1]. Erlotinib-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: CP-358774-d6; NSC 718781-d6; OSI-774-d6. CAS No. 1034651-23-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-50896S. | |
| Erlotinib-[d6] | Erlotinib-[d6] is the labelled analogue of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Erlotinib is a medication used to treat non-small cell lung cancer and pancreatic cancer. Synonyms: Erlotinib D6. Grade: 95% by HPLC; 98% atom D. CAS No. 1034651-23-4. Molecular formula: C22H17D6N3O4. Mole weight: 399.48. | |
| Erlotinib-d6 hydrochloride | Erlotinib-d 6 (hydrochloride) a deuterium labeled Erlotinib Hydrochloride. Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM[1]. Erlotinib-d6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride. CAS No. 1189953-78-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12008S. | |
| Erlotinib-[d6] Hydrochloride | Erlotinib-[d6] Hydrochloride is the labelled analogue of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Erlotinib is a medication used to treat non-small cell lung cancer and pancreatic cancer. Synonyms: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride; 6,7-Bis(2-methoxyethoxy-d3)-4-(3-ethynylanilino)quinazoline Hydrochloride; [6,7-Bis(2-methoxyethoxy-d3)quinazolin-4-yl]-(3-ethynylphenyl)amine Hydrochloride; Erlotinib D6 Hydrochloride. Grade: 98% by CP; 98% atom D. CAS No. 1189953-78-3. Molecular formula: C22H18D6ClN3O4. Mole weight: 435.93. | |
| Erlotinib-d6, Hydrochloride Salt (N- (3-Ethynylphenyl) -6, 7-bis (2-tride uteromethoxyethoxy) -4-quinazolinamine, Hydrochloride Salt) | Source: Synthetic. Group: Biochemicals. Alternative Names: N- (3-Ethynylphenyl) -6, 7-bis (2-tride uteromethoxyethoxy) -4-quinazolinamine, Hydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Erlotinib hydrochloride | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C22H24ClN3O4. CAS No. 183319-69-9. Prepack ID 82977875-1g. Molecular Weight 429.9. See USA prepack pricing. |  |
| Erlotinib hydrochloride | Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 = 20 nM), DiFi humancolon cancer cells and MDA MB-468 human breast cancer cells. Uses: Antineoplastic agents. Synonyms: OSI-744; OSI744; OSI 744; Tarceva; 4-(m-Ethynylanilino)-6,7-bis(2-methoxyethoxy)quinazoline monohydrochloride; 6,7-bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride. Grade: >98%. CAS No. 183319-69-9. Molecular formula: C22H23N3O4.HCl. Mole weight: 429.90. | |
| Erlotinib Hydrochloride | Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC 50 of 2 nM. Erlotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride. CAS No. 183319-69-9. Pack Sizes: 100 mg; 500 mg. Product ID: HY-12008. | |
| Erlotinib Hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardspharmaceutical toxicology. Alternative Names: [6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride, 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine,N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine, 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride, OSI 774, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Hydrochloride, Erlotinib hydrochloride, Tarceva, CP 358774. | |
| Erlotinib, Hydrochloride, Free Base, EGFR Inhibitor (CP-358774, OSI-774, Ro 50-8231) | A free base form of the EGFR inhibitor Erlotinib Hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 183321-74-6. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
| Erlotinib (Hydrochloride) (Standard) | Erlotinib (Hydrochloride) (Standard) is the analytical standard of Erlotinib (Hydrochloride). This product is intended for research and analytical applications. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC 50 of 2 nM. Erlotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 183319-69-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12008R. | |
| Erlotinib Hydroxy Metabolite | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Hydroxy Erlotinib; N-(3-Ethynyl-4-hydroxy-phenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl] amine hydrochloride. Grade: > 95%. CAS No. 882420-22-6. Molecular formula: C22H23N3O5. Mole weight: 409.45. | |
| Erlotinib impurity 1 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N-(3-(1-chlorovinyl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine. Grade: > 95%. Molecular formula: C22H24ClN3O4. Mole weight: 429.91. | |
| Erlotinib Impurity 11 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N'-[2-Cyano-4,5-bis(2-methoxyethoxy)phenyl]-N,N-dimethylimidoformamide. Grade: > 95%. CAS No. 950596-59-5. Molecular formula: C16H23N3O4. Mole weight: 321.38. | |
| Erlotinib Impurity 12 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: (E)-2-(((dimethylamino)methylene)amino)-4,5-bis(2-methoxyethoxy)benzamide. Grade: > 95%. Molecular formula: C16H25N3O5. Mole weight: 339.39. | |
| Erlotinib Impurity 13 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile. Grade: > 95%. CAS No. 236750-65-5. Molecular formula: C13H16N2O6. Mole weight: 296.28. | |
| Erlotinib Impurity 14 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-Amino-4,5-bis(2-methoxyethoxy)benzamide. Grade: > 95%. CAS No. 236750-62-2. Molecular formula: C13H20N2O5. Mole weight: 284.31. | |
| Erlotinib Impurity 15 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: ethyl 2-amino-3,4-bis(2-methoxyethoxy)benzoate. Grade: > 95%. Molecular formula: C15H23NO6. Mole weight: 313.35. | |
| Erlotinib Impurity 16 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 3-((7,8-bis(2-methoxyethoxy)quinazolin-4-yl)amino)benzonitrile. Grade: > 95%. Molecular formula: C22H23N3O6. Mole weight: 393.45. | |
| Erlotinib impurity 2 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4-Chloro-6-(2-Chloroethoxy)-7-(2-Methoxyethoxy)-Quinazoline. Grade: > 95%. CAS No. 183322-19-2. Molecular formula: C13H14Cl2N2O3. Mole weight: 317.17. | |
| Erlotinib Impurity 2 (4-Chloro-7-(2-Chloroethoxy)-6-(2-Methoxyethoxy)-Quinazoline) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4-chloro-7-(2-chloroethoxy)-6-(2-methoxyethoxy)quinazoline. Grade: > 95%. CAS No. 183322-20-5. Molecular formula: C13H14Cl2N2O3. Mole weight: 317.17. | |
| Erlotinib impurity 3 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2,4-dichloro-6,7-bis(2-methoxyethoxy)quinazoline. Grade: > 95%. Molecular formula: C14H16Cl2N2O4. Mole weight: 347.20. | |
| Erlotinib Impurity 34 | Erlotinib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-vinylaniline. CAS No. 15411-43-5. Molecular formula: C8H9N. Mole weight: 119.16. Catalog: APB15411435. | |
| Erlotinib impurity 4 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)benzoic acid. Grade: > 95%. Molecular formula: C21H23N3O6. Mole weight: 413.43. | |
| Erlotinib Impurity 5 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6,7-bis(2-methoxyethoxy)-N-phenylquinazolin-4-amine. Grade: > 95%. Molecular formula: C20H25N3O4. Mole weight: 369.42. | |
| Erlotinib impurity, 6-(2-chloroethoxy)-7-(2-methoxyethoxy) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)-4-Quinazolinamine. Grade: > 95%. CAS No. 183321-85-9. Molecular formula: C21H20ClN3O3. Mole weight: 397.86. | |
| Erlotinib impurity, 6-(2-methoxyethoxy)-7-(2-chloroethoxy) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6-(2-chloroethoxy)-N-(3-ethynylphenyl)-7-(2-methoxyethoxy)quinazolin-4-amine. Grade: > 95%. CAS No. 183321-83-7. Molecular formula: C21H20ClN3O3. Mole weight: 397.86. | |
| Erlotinib impurity, 6,7-bis(2-chloroethoxy) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine. Grade: > 95%. CAS No. 183321-82-6. Molecular formula: C20H17Cl2N3O2. Mole weight: 402.28. | |
| Erlotinib Impurity 7 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride. Grade: > 95%. CAS No. 183322-17-0. Molecular formula: C15H23NO6 HCl. Mole weight: 349.81. | |
| Erlotinib Impurity 74 | Erlotinib Impurity 74. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4,5-bis(2-methoxyethoxy)-2-nitrobenzoic acid. CAS No. 1001416-73-4. Molecular formula: C13H17NO8. Mole weight: 315.28. Catalog: APB1001416734. | |
| Erlotinib Impurity 76 | Erlotinib Impurity 76. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-2-(((dimethylamino)methylene)amino)-4,5-bis(2-methoxyethoxy)benzamide. CAS No. 1241475-15-9. Molecular formula: C16H25N3O5. Mole weight: 339.39. Catalog: APB1241475159. | |
| Erlotinib Impurity 8 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N-(3-Desethynylphenyl)-N-(3-bromophenyl) Erlotinib; N-(3-bromophenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. Grade: > 95%. CAS No. 328528-74-1. Molecular formula: C20H22BrN3O4. Mole weight: 448.32. | |
| Erlotinib Impurity 9 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N-(3-cyanophenyl)acetamide. Grade: > 95%. Molecular formula: C24H25N3O5. Mole weight: 435.48. | |
| Erlotinib mesylate | Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. Synonyms: Tarceva; CP-358774; CP 358774; CP358774; OSI-774; OSI 774; OSI774; NSC 718781; NSC718781; NSC-718781; R 1415; R1415; R-1415. Grade: >98%. CAS No. 248594-19-6. Molecular formula: C23H27N3O7S. Mole weight: 489.54. | |
| Erlotinib metabolite M11 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl]oxy]acetic Acid. Grade: > 95%. CAS No. 882172-60-3. Molecular formula: C21H19N3O5. Mole weight: 393.40. | |
| Erlotinib metabolite M12 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline; 2-(4-(3-Ethynylanilino)-7-(2-hydroxyethoxy)quinazolin-6-yl)oxyethanol; 2-[4-(3-ethynylanilino)-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol. CAS No. 183321-84-8. Molecular formula: C20H19N3O4. Mole weight: 365.389. | |
| Erlotinib O-Desmethyl Metabolite Isomer | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Erlotinib 7-O-Desmethyl Metabolite; 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl] oxy]ethanol. Grade: > 95%. CAS No. 183320-29-8. Molecular formula: C21H21N3O4. Mole weight: 379.42. | |
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