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FT-9, a cell-permeable NSAID-like compound, is a partially selective gamma-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the gamma-secretase cleavage of beta-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of 260uM, but there is a less potent effect on gamma-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4uM, is significantly lower than that for APLP1 (25.7 +/- 8.9uM) (P = 0.001). For comparison, the concentration of another gamma-Secretase inhibitor compound E needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27nM for APP versus 0.24nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other gamma-substrates. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?O?. US Biological Life Sciences.
gamma-secretase modulator 2, a triazole derivative, a potent and selective γ-secretase modulator so as to selectively attenuate production of Aβ(1-42) and hence has the potential for treatment of Alzheimer's disease. Synonyms: 6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one; gamma-secretase modulator 2; 1093978-89-2; SCHEMBL3040102; DTXSID70732149; C25H22F4N6O2; 3374AH; ABP000472; BCP9000905; CS-0310; HE070827; HE211077; HY-50754; DB-014988; W-5511; 2H-1-BENZAZEPIN-2-ONE,6-FLUORO-1,3,4,5-TETRAHYDRO-3-[4-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)PHENYL]-1H-1,2,3-TRIAZOL-1-YL]-1-(2,2,2-TRIFLUOROETHYL)-; 6-fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-Benzazepin-2-on; 6-Fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-benzazepin-2-one; 6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]-1h-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2h-1-benzazepin-2-one; 6-FLUORO-3-{4-[3-METHOXY-4-(4-METHYLIMIDAZOL-1-YL)PHENYL]-1,2,3-TRIAZOL-1-YL}-1-(2,2,2-TRIFLUOROETHYL)-4,5-DIHYDRO-3H-1-BENZAZEPIN-2-ONE. CAS No. 1093978-89-2. Molecular formula: C25H22F4N6O2. Mole weight: 514.47.
gamma-secretase modulator 3
gamma-secretase modulator 3 is a γ-secretase inhibitor. Synonyms: 4-(4-fluorophenyl)-N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine; gamma-secretase modulator 3; CS-1149; HY-50889; W-6019; CS 1149; HY 50889; W 6019; CS1149; HY50889; W6019; 1431697-84-5. CAS No. 1431697-84-5. Molecular formula: C24H23FN4OS. Mole weight: 434.53.
gamma-Secretase modulators
gamma-Secretase Modulators is a potent modulator of γ-secretase derived from oxadiazine. (IC50: Aβ42 = 11 nM, Aβ total/ Aβ42 = 1170). Synonyms: (4R,7E,9aS)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one; gamma-Secretase Modulators; 937812-80-1; (E)-(4R,9aS)-7-[3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one; QCR-41; SCHEMBL2589995; DTXSID90647302; C26H24F3N3O3; hexahydro-7-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-4-(3,4,5-trifluorophenyl)-(4R,7E,9aS)-Pyrido[2,1-c][1,4]oxazin-6(1H)-one; 3690AH; ZINC95644683. CAS No. 937812-80-1. Molecular formula: C26H24F3N3O3. Mole weight: 483.48.
Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. Uses: Antiviral agents. Synonyms: Cytovene; BW 759; BW759; BW-759; 2'-Nor-2'-deoxyguanosine. Grades: >98%. CAS No. 82410-32-0. Molecular formula: C9H13N5O4. Mole weight: 255.23.
Ganciclovir
Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Group: Biochemicals. Alternative Names: 2-Amino-1, 9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl) ethoxy]methyl]-6H-purin-6-one; 2-NDG; 2-Nor-2-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert. Grades: Highly Purified. CAS No. 82410-32-0. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C?H??N?O?, Molecular Weight: 255.23. US Biological Life Sciences.
Worldwide
Ganciclovir
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H13N5O4. CAS No. 82410-32-0. Prepack ID 49561891-1g. Molecular Weight 255.23. See USA prepack pricing.
Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1). Group: Inhibitors. Alternative Names: GANCICLOVIR-D5;2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]6H-purin-6-one-d5. CAS No. 1189966-73-1. Molecular formula: C9H13N5O4. Mole weight: 260.26. Appearance: White to Off-White Solid. Canonical SMILES: O=C1N=C (NC2=C1N=CN2COC ([2H]) (C ([2H]) (O)[2H])C ([2H]) (O)[2H])N. Catalog: ACM1189966731.
Labelled Ganciclovir, an antiviral. Group: Biochemicals. Alternative Names: 2-Amino-1, 9-[[2-hydroxy-1- (hydroxymethyl) ethoxy]methyl]6H-purin-6-one-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Ganciclovir Diacetyl Impurity
Ganciclovir Diacetyl Impurity is an impurity of Ganciclovir. Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. Synonyms: 2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)propane-1,3-diyl diacetate; 9-(1,3-diacetate-2-propoxymethyl)guanine; Ganciclovir Impurity 10. CAS No. 86357-19-9. Molecular formula: C13H17N5O6. Mole weight: 339.31.
Ganciclovir EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1797982-93-4. Molecular Formula: C9H10ClN5O2. Mole Weight: 255.66. Catalog: APB1797982934.
Ganciclovir EP Impurity B
Ganciclovir EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 194159-18-7. Molecular Formula: C12H17N5O5. Mole Weight: 311.3. Catalog: APB194159187.
Ganciclovir EP Impurity C
Ganciclovir EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 108436-36-8. Molecular Formula: C9H12ClN5O3. Mole Weight: 273.68. Catalog: APB108436368.
Ganciclovir EP Impurity C
Ganciclovir EP Impurity C is an Impurity of Ganciclovir. It is a sugar modified acyclic analogue of guanosine. It has potential to exhibit virucidal activity. Synonyms: 2'-Monodehydroxy-2'-chloro Ganciclovir; 9-[[2-Chloro-1- (hydroxymethyl) ethoxy]methyl]guanine; 2-Amino-9-[[2-chloro-1-(hydroxymethyl)ethoxy]methyl]-1,9-dihydro-6H-purin-6-one. Grades: > 95%. CAS No. 108436-36-8. Molecular formula: C9H12ClN5O3. Mole weight: 273.68.
Ganciclovir EP Impurity E
Ganciclovir EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 86357-09-7. Molecular Formula: C9H13N5O4. Mole Weight: 255.23. Catalog: APB86357097.
Ganciclovir EP Impurity H
Ganciclovir EP Impurity H is an impurity of Ganciclovir. Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. Synonyms: 2-((2-Amino-6-hydroxy-7H-purin-7-yl)methoxy)-1,3-propanediol; Ganciclovir Impurity 07; 2-amino-7-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1,7-dihydro-6H-purin-6-one. CAS No. 84222-50-4. Molecular formula: C9H13N5O4. Mole weight: 255.23.
Ganciclovir EP Impurity H
Ganciclovir EP Impurity H. Uses: For analytical and research use. Group: Impurity standards. CAS No. 84222-50-4. Molecular Formula: C9H13N5O4. Mole Weight: 255.23. Catalog: APB84222504.
Ganciclovir EP Impurity I
Ganciclovir EP Impurity I. Uses: For analytical and research use. Group: Impurity standards. CAS No. 86357-20-2. Molecular Formula: C15H21N5O6. Mole Weight: 367.36. Catalog: APB86357202.
Ganciclovir EP Impurity J
Ganciclovir EP Impurity J. Uses: For analytical and research use. Group: Impurity standards. CAS No. 177216-32-9. Molecular Formula: C18H25N5O7. Mole Weight: 423.43. Catalog: APB177216329.
Ganciclovir EP Impurity J
Ganciclovir EP Impurity J is an impurity of Ganciclovir. Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. Synonyms: 2-(2-(Propanoylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)propane-1,3-diyl dipropanoate; Ganciclovir Tripropionate; O,O',N-Tripropanal Ganciclovir; Ganciclovir Impurity 09. Grades: 95% by HPLC. CAS No. 177216-32-9. Molecular formula: C18H25N5O7. Mole weight: 423.42.
Ganciclovir Impurity 1
Ganciclovir Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1401562-16-0. Molecular Formula: C15H25ClN6O5. Mole Weight: 404.85. Catalog: APB1401562160.
Ganciclovir Impurity 10
Ganciclovir Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 86357-19-9. Molecular Formula: C13H17N5O6. Mole Weight: 339.31. Catalog: APB86357199.
Ganciclovir Impurity 11
Ganciclovir Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 96429-68-4. Molecular Formula: C15H19N5O7. Mole Weight: 381.34. Catalog: APB96429684.
Ganciclovir Impurity 13
Ganciclovir Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 298197-26-9. Molecular Formula: C13H17N5O6. Mole Weight: 339.31. Catalog: APB298197269.
Ganciclovir Impurity 14
Ganciclovir Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 130914-71-5. Molecular Formula: C19H31N7O6. Mole Weight: 453.49. Catalog: APB130914715.
Ganciclovir Impurity 15
Ganciclovir Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1356353-76-8. Molecular Formula: C15H24N6O6. Mole Weight: 384.39. Catalog: APB1356353768.
Ganciclovir Impurity 16
Ganciclovir Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1219792-42-3. Molecular Formula: C14H22N6O5. Mole Weight: 354.37. Catalog: APB1219792423.
Ganciclovir Impurity 17
Ganciclovir Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 84245-12-5. Molecular Formula: C11H15N5O5. Mole Weight: 297.27. Catalog: APB84245125.
Ganciclovir Impurity 2
Ganciclovir Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 86357-14-4. Molecular Formula: C15H19N5O7. Mole Weight: 381.34. Catalog: APB86357144.
Ganciclovir Impurity 3
Ganciclovir Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 130914-77-1. Molecular Formula: C35H43N7O10. Mole Weight: 721.77. Catalog: APB130914771.
Ganciclovir Impurity A
Ganciclovir Impurity A is an impurity of Ganciclovir. Synonyms: 9-[[2-Chloroprop-2-en-1-yl)oxy]methyl]guanine; 2-amino-9-[[(2-chloroprop-2-en-yl)oxy]methyl]-1,9-dihydro-6H-purin-6-one. Grades: > 95%. CAS No. 1797982-93-4. Molecular formula: C9H10ClN5O2. Mole weight: 255.67.
Ganciclovir Impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-amino-9-((((1,3-dihydroxypropan-2-yl)oxy)methoxy)methyl)-1H-purin-6(9H)-one. CAS No. 1346598-14-8. Molecular Formula: C10H15N5O5. Mole Weight: 285.26. Catalog: APB1346598148.
Ganciclovir derivative. Group: Biochemicals. Alternative Names: 9-[[2- (Acetyloxy) -1- (hydroxymethyl) ethoxy]methyl]-2-amino-1, 9-dihydro- 6H-Purin-6-one. Grades: Highly Purified. CAS No. 88110-89-8. Pack Sizes: 50mg. US Biological Life Sciences.
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Ganciclovir Mono-O-acetate-d5
Labeled Ganciclovir derivative. Group: Biochemicals. Alternative Names: 9-[[2- (Acetyloxy) -1- (hydroxymethyl) ethoxy]methyl]-2-amino-1, 9-dihydro-6H-purin-6-one-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Ganciclovir Mono-O-propionate
Ganciclovir Mono-O-propionate is a potential prodrug of Ganciclovir. Ganciclovir Mono-O-propionate was also found to exhibit anti-viral activity through experimental studies. Group: Biochemicals. Alternative Names: Ganciclovir Impurity B; 2-Amino-1, 9-dihydro-9-[[1- (hydroxymethyl) -2- (1-oxopropoxy) ethoxy]methyl]-6H-purin-6-one. Grades: Highly Purified. CAS No. 194159-18-7. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Ganciclovir Monopropionate
Ganciclovir Monopropionate is a potential prodrug of Ganciclovir. It was also found to exhibit anti-viral activity through experimental studies. Synonyms: Ganciclovir Mono-O-propionate; Ganciclovir Impurity B; 2-Amino-1,9-dihydro-9-[[1-(hydroxymethyl)-2-(1-oxopropoxy)ethoxy]methyl]-6H-purin-6-one. Grades: > 95%. CAS No. 194159-18-7. Molecular formula: C12H17N5O5. Mole weight: 311.30.
Ganciclovir N,O-Diacetate
It is an impurity of Ganciclovir. Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. Synonyms: Ganciclovir Impurity 13; 2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl acetate. CAS No. 298197-26-9. Molecular formula: C13H17N5O6. Mole weight: 339.12.
Ganciclovir sodium
Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. Group: Inhibitors. Alternative Names: GANCICLOVIR SODIUM;2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one sodium salt;9-[[1-(Hydroxymethyl)-2-hydroxyethoxy]methyl]-2-amino-9H-purine-6(1H)-one/sodium,(1:1) salt;Ganciclovir monosodium salt;6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt;6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt;Rs 21592 sodium;Unii-02L083W284. CAS No. 107910-75-8. Molecular formula: C9H12N5NaO4. Mole weight: 277.21. Purity: 0.9985. Catalog: ACM107910758.
Ganciclovir Sodium
Ganciclovir Sodium is a potent inhibitor of the Herpesvirus family including cytomegalovirus. It is an acyclovir analog. It is used to treat complications from AIDS-associated cytomegalovirus infections. It was developed by Roche and has been listed. Uses: Ganciclovir sodium is used to treat complications from aids-associated cytomegalovirus infections. Synonyms: 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one sodium salt;9-[[1-(Hydroxymethyl)-2-hydroxyethoxy]methyl]-2-amino-9H-purine-6(1H)-one/sodium,(1:1) salt;Ganciclovir monosodium salt;6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt;RS-21592 sodium;RS21592 Sodium;Sodium 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate. Grades: 98%. CAS No. 107910-75-8. Molecular formula: C9H12N5NaO4. Mole weight: 277.21.
Ganciclovir Triphosphate
Ganciclovir Triphosphate, a nucleotide analogue possessing antiviral properties, is a prescribed medication for the management of CMV retinitis among individuals with immunodeficiency disease caused by human immunodeficiency virus (HIV). This nucleoside reverse transcriptase inhibitor subdues the activity of viral DNA polymerase and causes interference with viral DNA processing. Ganciclovir Triphosphate, a prodrug dependent on cellular kinases, undergoes conversion into its active metabolite, Ganciclovir Triphosphate. Uses: Antiviral agents. Synonyms: 9-(1,3-Dihydroxy-2-propoxymethyl)guanine-5'-Triphosphate; DHP-GTP; GCV-TP. Grades: ≥95% by AX-HPLC. CAS No. 86761-38-8. Molecular formula: C9H16N5O13P3. Mole weight: 495.20.
Ganciclovir Triphosphate
Ganciclovir Triphosphate. Group: Biochemicals. Alternative Names: P-[2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl] Ester Triphosphoric Acid. Grades: Highly Purified. CAS No. 86761-38-8. Pack Sizes: 1mg. Molecular Formula: C9H16N5O13P3, Molecular Weight: 495.17. US Biological Life Sciences.