American Chemical Suppliers
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Product | Description | |
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GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GW1929 Quick inquiry Where to buy Suppliers range | A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). Synonyms: GW 1929; GW-1929. Grades: >98%. CAS No. 196808-24-9. Molecular formula: C30H29N3O4. Mole weight: 495.57. | |
GW1929 Quick inquiry Where to buy Suppliers range | Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis and apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. GW1929 is an antidiabetic; the glucose-lowering effect in rats is 100-fold more potent than that of troglitazone. Group: Biochemicals. Alternative Names: N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S) - ( (2-Benzoylphenyl) amino-3- [4- [2- (methylpyridin-2-ylamino) ethoxy] phenyl] propionic acid. Grades: Highly Purified. CAS No. 196808-24-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C30H29N3O4. US Biological Life Sciences. | Worldwide |
GW1929 hydrate Quick inquiry Where to buy Suppliers range | >98% (HPLC), solid. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 495.57 (anhydrous basis). Catalog: IAR4241589. Assay: >98% (HPLC). | |
GW 1929 hydrochloride Quick inquiry Where to buy Suppliers range | GW 1929 hydrochloride is a selective and orally bioactive agonist of peroxisome proliferator-activated receptor (PPAR)γ (pEC50 = 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors, respectively). GW 1929 causes a decrease of glucose, fatty acid and triglyceride levels following oral administration in vivo. Synonyms: GW 1929 hydrochloride; GW1929 hydrochloride; GW-1929 hydrochloride; N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride; (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 1217466-21-1. Molecular formula: C30H29N3O4.HCl. Mole weight: 532.03. | |
GW 2580 Quick inquiry Where to buy Suppliers range | GW 2580. Group: Biochemicals. Alternative Names: 5-[[3-Methoxy-4-[ (4-methoxyphenyl) methoxy]phenyl]methyl]-2, 4-pyrimidinediamine. Grades: Highly Purified. CAS No. 870483-87-7. Pack Sizes: 10mg. Molecular Formula: C20H22N4O3, Molecular Weight: 366.41. US Biological Life Sciences. | Worldwide |
GW2580 Quick inquiry Where to buy Suppliers range | GW2580 is an orally bioavailable inhibitor of cFMS kinase. GW2580 was found to completely inhibit human cFMS kinase in vitro at 0.06 microM and was inactive against 26 other kinases. GW2580 at 1 microM completely inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes and completely inhibited bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone. In contrast, GW2580 did not affect the growth of mouse NS0 lymphoblastoid cells, human endothelial cells, human fibroblasts, or five human tumor cell lines. GW2580 also did not affect lipopolysaccharide (LPS)-induced TNF, IL-6, and prostaglandin E2 production in freshly isolated human monocytes and mouse macrophages. After oral administration, GW2580 blocked the ability of exogenous CSF-1 to increase LPS-induced IL-6 production in mice, inhibited the growth of CSF-1-dependent M-NFS-60 tumor cells in the peritoneal cavity, and diminished the accumulation of macrophages in the peritoneal cavity after thioglycolate injection. Unexpectedly, GW2580 inhibited LPS-induced TNF production in mice, in contrast to effects on monocytes and macrophages in vitro. In conclusion, GW2580's selective inhibition of monocyte growth and bone degradation is consistent with cFMS kinase inhibition. The ability of GW2580 to chronically inhibit CSF-1 signaling through cFMS kinase in normal and tumor cells in vivo makes GW2580 a useful tool in assessing the role of cFMS kinase in normal and disease processes. Synonyms: GW 2580; GW-2580; GW2580. Grades: 0.98. CAS No. 870483-87-7. Molecular formula: C20H22N4O3. Mole weight: 366.421. | |
GW 274150 Quick inquiry Where to buy Suppliers range | GW 274150 is a potent, long-acting and highly selective inhibitor of iNOS which have a very high degree of selectivity for iNOS versus both eNOS (>100-fold) and nNOS (>80-fold). GW 274150 shows analgesic effects in rat models of inflammatory and neuropath. Synonyms: (2S) -2-amino-4-[2- (1-aminoethylideneamino) ethylsulfanyl]butanoic acidGW-274150; GW 274150; GW274150. CAS No. 210354-22-6. Molecular formula: C8H17N3O2S. Mole weight: 219.30. | |
GW284543 Quick inquiry Where to buy Suppliers range | GW284543 (UNC10225170) is a selective MEK5 inhibitor. It can reduce pERK5 and reduce endogenous MYC protein. Synonyms: CHEMBL531447; BCP31359; MFCD32067894; HY-114189. Grades: 98%. CAS No. 790186-68-4. Molecular formula: C23H20N2O3. Mole weight: 372.4. | |
GW311616 Quick inquiry Where to buy Suppliers range | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
GW311616 hydrochloride Quick inquiry Where to buy Suppliers range | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
GW-3333 Quick inquiry Where to buy Suppliers range | GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases. Synonyms: GW-3333; GW3333; GW 3333; 3-[formyl(hydroxy)amino]-4-methyl-N-[3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide. Grades: >98%. CAS No. 212609-68-2. Molecular formula: C22H36N4O4. Mole weight: 420.55. | |
GW3965 Quick inquiry Where to buy Suppliers range | GW3965 is a potent, selective LXR agonist for hLXRα and hLXR&beta. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay; Potent antagonistic activity against hLXRα and hLXRβ in cell-based assays with EC50 of 190 nM and 30 nM, respectively; In human islets, GW3965 (1 μM) reduces expression of selected pro-inflammatory cytokines including IL-8, monocyte chemotactic protein-1 and tissue factor In Vivo: At a dose of 10 mg/kg upregulates ABCA1 expression 8-fold and raises circulating levels of HDL by 30% with Cmax of 12.7 μg/mL and t1/2 of 2 hours. Uses: A liver x receptor agonist; represses the production of pro-inflammatory cytokines by murine mast cells; in vitro: reduces tissue factor production and inflammatory responses in human islets. Synonyms: GW3965; GW 3965; GW-3965; 2- (3- (3- ( (2-chloro-3- (trifluoromethyl) benzyl) (2, 2-diphenylethyl) amino) propoxy) phenyl) acetic acid hydrochloride. Grades: ≥ 98.0%. CAS No. 405911-09-3. Molecular formula: C33H31ClF3NO3. Mole weight: 582.05. | |
GW3965 Hydrochloride Quick inquiry Where to buy Suppliers range | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Synonyms: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grades: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51. | |
GW 406381 Quick inquiry Where to buy Suppliers range | GW 406381 is a selective cyclooxygenase-2 (COX-2) inhibitor that is effective in the treatment of inflammatory pain, neurodynia, Trauma and others. Uses: The treatment of inflammatory pain. Synonyms: GW-406381; GW 406381; GW406381. 2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine. Grades: 99%. CAS No. 221148-46-5. Molecular formula: C21H19N3O3S. Mole weight: 393.46. | |
GW 4064 Quick inquiry Where to buy Suppliers range | GW 4064. Group: Biochemicals. Alternative Names: 3- [2- [2-Chloro-4- [ [3- (2, 6-dichlorophenyl) -5- (1-methylethyl) -4-isoxazolyl] methoxy] phenyl] ethenyl] -benzoic acid. Grades: Highly Purified. CAS No. 278779-30-9. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C28H22Cl3NO4. US Biological Life Sciences. | Worldwide |
GW4064 Quick inquiry Where to buy Suppliers range | GW4064 is a selective non-steroidal agonist of farnesoid X receptor (FXR) with EC50 value of 15 nM. Synonyms: GW4064; GW-4064; GW 4064. Grades: >98%. CAS No. 278779-30-9. Molecular formula: C28H22Cl3NO4. Mole weight: 542.84. | |
GW438014A Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 469861-49-2. Pack Sizes: 5MG, 25MG. Mole weight: 437.51. Catalog: AP469861492. Assay: ≥98% (HPLC). | |
GW 441756 Quick inquiry Where to buy Suppliers range | GW 441756 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor (IC50 = 2 nM), reducing cell proliferation and potentiates the effects of chemotherapeutic agents. Uses: A specific tropomyosin-related kinase a (trka) inhibitor. Synonyms: GW-441756; GW 441756; GW441756. 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one;(3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one. Grades: ≥98%. CAS No. 504433-23-2. Molecular formula: C17H13N3O. Mole weight: 275.30. | |
Gw4869 Quick inquiry Where to buy Suppliers range | Gw4869. Group: Heterocyclic Organic Compound. CAS No. 6823-69-4. Product ID: ACM6823694. Molecular formula: C30H30N6Cl2O2. Mole weight: 577.50. | |
GW4869 Quick inquiry Where to buy Suppliers range | GW4869 is a cell-permeable, specific and non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). Synonyms: (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride; GW 4869; GW-4869. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.5. | |
GW4869 Quick inquiry Where to buy Suppliers range | GW4869 Inhibitor. Uses: Scientific use. Product Category: T3640. CAS No. 6823-69-4. | |
GW 501516 Quick inquiry Where to buy Suppliers range | An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol. Grades: Highly Purified. CAS No. 317318-70-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??F?NO?S?, Molecular Weight: 453.5. US Biological Life Sciences. | Worldwide |
GW 501516 Methyl Ester Quick inquiry Where to buy Suppliers range | Precursor to GW 501516. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid. Grades: Highly Purified. CAS No. 317318-69-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
GW5074 Quick inquiry Where to buy Suppliers range | GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have therapeutic value against neurodegenerative pathologies in humans. Synonyms: GW5074; GW 5074; GW-5074. CAS No. 220904-83-6. Molecular formula: C15H8Br2INO2. Mole weight: 520.94. | |
GW 542573X Quick inquiry Where to buy Suppliers range | GW 542573X. Group: Biochemicals. Alternative Names: 4- [ [ [ [ (2-Methoxyphenyl) amino] carbonyl] oxy] methyl] -1-piperidinecarboxylic Acid; tert-Butyl 4- [ [ [ [ (2-Methoxyphenyl) amino] carbonyl] oxy] methyl] piperidine-1-carboxylate. Grades: Highly Purified. CAS No. 660846-41-3. Pack Sizes: 25mg. Molecular Formula: C19H28N2O5, Molecular Weight: 364.44. US Biological Life Sciences. | Worldwide |
GW 542573X Quick inquiry Where to buy Suppliers range | GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2) with selectivity for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1). Synonyms: GW542573X; GW 542573X; GW-542573X. 4-[[[[ (2-Methoxyphenyl) amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester; tert-butyl 4-[ (2-methoxyphenyl) carbamoyloxymethyl]piperidine-1-carboxylate. Grades: ≥99% by HPLC. CAS No. 660846-41-3. Molecular formula: C19H28N2O5. Mole weight: 364.44. | |
GW542573X Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 660846-41-3. Pack Sizes: 5MG, 25MG. Mole weight: 364.44. Catalog: AP660846413. Assay: ≥98% (HPLC). | |
GW 583340 dihydrochloride Quick inquiry Where to buy Suppliers range | GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 = 0.01 and 0.014 μM, respectively). GW 583340 selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 = 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). it is used in the treatment of breast cancer. Synonyms: GW 583340 dihydrochloride; GW-583340 dihydrochloride; GW583340 dihydrochloride; N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride. Grades: ≥97% by HPLC. CAS No. 1173023-85-2. Molecular formula: C28H25ClFN5O3S2.2HCl. Mole weight: 671.03. | |
GW583340 dihydrochloride Quick inquiry Where to buy Suppliers range | ≥97% (HPLC), solid. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG, 5MG. Mole weight: 671.03. Catalog: IAR4241584. Assay: ≥97% (HPLC). | |
GW-590735 Quick inquiry Where to buy Suppliers range | GW-590735 is a potent and selective agonist of PPAR&alpha. Its EC50 value is 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity than PPARγ and PPAR&delta. It significantly increased HDL cholesterol and decreased LDL and VLDL cholesterol. It also significantly reduced triglycerides. Uses: Gw-590735 significantly increased hdl cholesterol and decreased ldl and vldl cholesterol. it also significantly reduced triglycerides. Synonyms: GW590735; GW-590735; GW 590735. 2-Methyl-2-(4-((4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid; 2-Methyl-2- [4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -1, 3-thiazole-5-carbonyl] amino] methyl] phenoxy] propanoic acid. Grades: 98%. CAS No. 622402-22-6. Molecular formula: C23H21F3N2O4S. Mole weight: 478.49. | |
GW 610 Quick inquiry Where to buy Suppliers range | GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity. Group: Biochemicals. Alternative Names: 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole. Grades: Highly Purified. CAS No. 872726-44-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Gw 627368x Quick inquiry Where to buy Suppliers range | Gw 627368x. Group: Heterocyclic Organic Compound. Alternative Names: GW 627368X;GW 627368;4-(4,9-Diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)benzeneacetamide. CAS No. 439288-66-1. Product ID: ACM439288661. Molecular formula: C30H28N2O6S. Mole weight: 0. | |
GW 627368X Quick inquiry Where to buy Suppliers range | GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively). Uses: A potent and selective competitive antagonist. Synonyms: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide; 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. Grades: ≥96%. CAS No. 439288-66-1. Molecular formula: C30H28N2O6S. Mole weight: 544.62. | |
GW 6471 Quick inquiry Where to buy Suppliers range | GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Group: Biochemicals. Alternative Names: N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propen-1-yl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide; N- [ (2S) -2- [ [ (1Z) -1-Methyl-3-oxo-3- [4- (trifluoromethyl) phenyl] -1-propenyl] amino] -3- [4- [2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy] phenyl] propyl] propanamide. Grades: Highly Purified. CAS No. 880635-03-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GW6471 Quick inquiry Where to buy Suppliers range | GW6471 is a PPARα antagonist (IC50 = 0.24 μM). GW6471 enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. Synonyms: GW-6471; GW 6471; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; N-[ (2S) -2-[[ (1Z) -1-Methyl-3-oxo-3-[4- (trifluoromethyl) phenyl]-1-propen-1-yl]amino]-3-[4-[2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy]phenyl]propyl]propanamide; Propanamide, N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propenyl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-; (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide. Grades: ≥95%. CAS No. 880635-03-0. Molecular formula: C35H36F3N3O4. Mole weight: 619.67. | |
GW-6604 Quick inquiry Where to buy Suppliers range | GW6604 is a potent and selective ALK-5 inhibitor with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. Uses: Alk-5 inhibitor. Synonyms: GW6604; GW-6604; GW 6604. 2-phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine. Grades: ≥98%. CAS No. 452342-37-9. Molecular formula: C19H14N4. Mole weight: 298.34. | |
GW 7647 Quick inquiry Where to buy Suppliers range | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPAR&delta. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPAR&alpha. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[ (Cyclohexylamino) carbonyl] (4-cyclohexylbutyl) amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grades: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
GW 788388 Quick inquiry Where to buy Suppliers range | GW 788388. Group: Biochemicals. Alternative Names: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)benzamide. Grades: Highly Purified. CAS No. 452342-67-5. Pack Sizes: 10mg. Molecular Formula: C25H23N5O2, Molecular Weight: 425.48. US Biological Life Sciences. | Worldwide |
GW788388 Quick inquiry Where to buy Suppliers range | GW788388 is a selective inhibitor of TGF-beta type I receptor (TGF-βR1/ALK5; IC50=18 nM) with a much improved pharmacokinetic profile compared with SB431542. It inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Synonyms: GW-788388; N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide. Grades: >98%. CAS No. 452342-67-5. Molecular formula: C25H23N5O2. Mole weight: 425.492. | |
GW 788388-d5 Quick inquiry Where to buy Suppliers range | GW 788388-d5. Group: Biochemicals. Alternative Names: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)benzamide-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H18D5N5O2, Molecular Weight: 430.51. US Biological Life Sciences. | Worldwide |
GW788388 Hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 425.48 (anhydrous basis). Catalog: IAR4241633. Assay: ≥98% (HPLC). | |
GW791343 Quick inquiry Where to buy Suppliers range | GW791343, as a P2X7 receptor antagonist, was a negative allosteric modulator of the human P2X(7) receptor but at the rat P2X(7) receptor its predominant effect was positive allosteric modulation. Uses: P2x7 receptor antagonist. Synonyms: GW-791343; GW791343. Grades: ≥98%. CAS No. 309712-73-0. Molecular formula: C20H24F2N4O. Mole weight: 374.4. | |
GW 791343 dihydrochloride Quick inquiry Where to buy Suppliers range | The hydrochlorie salt form of GW791343 that is a non-competitive inhibitor of human P2X7 receptors amd it seems to show species-specific activity which is probably negative allosteric modulators of the human P2X7 receptor and the agonist of the same recep. Uses: The hydrochlorie salt form of gw791343 that is a non-competitive inhibitor of human p2x7 receptors. Synonyms: GW791343 (dihydrochloride); 1019779-04-4; 2-((3,4-Difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride; GW 791343; GW-791343; 3075AH. Grades: >99 %. CAS No. 1019779-04-4. Molecular formula: C20H26Cl2F2N4O. Mole weight: 447.3. | |
GW 791343 hydrochloride Quick inquiry Where to buy Suppliers range | GW 791343 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 309712-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
GW 791343 trihydrochloride Quick inquiry Where to buy Suppliers range | GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. Synonyms: GW791343; GW 791343; GW-791343; 1019779-04-4. Grades: >98%. CAS No. 309712-55-8. Molecular formula: C20H24F2N4O.3HCl. Mole weight: 483.81. | |
GW 791343 Trihydrochloride Quick inquiry Where to buy Suppliers range | GW 791343 Trihydrochloride. Group: Biochemicals. Alternative Names: 2-[ (3, 4-Difluorophenyl) amino]-N-[2-methyl-5- (1-piperazinylmethyl) phenyl]acetamide Trihydrochloride. Grades: Highly Purified. CAS No. 1019779-04-4. Pack Sizes: 10mg. Molecular Formula: C20H27Cl3F2N4O, Molecular Weight: 447.35. US Biological Life Sciences. | Worldwide |
GW 803430 Quick inquiry Where to buy Suppliers range | GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. Synonyms: GW-803430; GW 803430; GW803430. 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. Grades: ≥99% by HPLC. CAS No. 515141-51-2. Molecular formula: C25H24ClN3O3S. Mole weight: 481.99. | |
GW806742X Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 579515-63-2. Pack Sizes: 5MG, 25MG. Mole weight: 573.55. Catalog: AP579515632. Assay: ≥98% (HPLC). | |
GW833972A Quick inquiry Where to buy Suppliers range | ≥98% (HPLC), powder. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1092502-33-4. Pack Sizes: 5MG, 25MG. Mole weight: 444.24. Catalog: AP1092502334. Assay: ≥98% (HPLC). | |
GW841819X Quick inquiry Where to buy Suppliers range | GW841819X, a benzodiazepin derivative, has been found to be a BET bromodomains inhibitor that could be probably significant in the study of myeloma and leukemia at some extent. Synonyms: KB-75882; KB 75882; KB75882; benzyl (1-methyl-6-phenyl-4hbenzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate. Grades: 98%. CAS No. 146135-18-4. Molecular formula: C25H21N5O2. Mole weight: 423.48. | |
GW842166X Quick inquiry Where to buy Suppliers range | GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Synonyms: GW-842166X; 842166X; 842166; GW-842166; GW842166X; GW842166; GW 842166X; GW 842166. Grades: >98%. CAS No. 666260-75-9. Molecular formula: C18H17Cl2F3N4O2. Mole weight: 449.25. | |
GW843682X Quick inquiry Where to buy Suppliers range | GW843682X is a cell-permeable thiophene-benzimidazole compound that acts a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM(PLK1) and 9.1 nM(PLK3). Uses: A polo-like kinase-1 (plk1) and polo-like kinase-3 (plk3) inhibitor. Synonyms: GW843682X; GW 843682X; GW-843682X. 5- (5, 6-dimethoxybenzimidazol-1-yl) -3-[[2- (trifluoromethyl) phenyl]methoxy]thiophene-2-carboxamide; Polo-like Kinase Inhibitor III. Grades: ≥98%. CAS No. 660868-91-7. Molecular formula: C22H18F3N3O4S. Mole weight: 477.46. | |
GW 848687X Quick inquiry Where to buy Suppliers range | GW 848687X is a potent and selective antagonist of EP1 receptor (IC50 = 2.5 nM). GW 848687X displays >400-fold selectivity for EP1 relative to the other EP receptor subtypes, the PGD2 receptor, DP1, and the prostacyclin receptor, IP. Synonyms: 6-[2-[5-chloro-2-[(2,4-digluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid. Grades: ≥98%. CAS No. 612831-24-0. Molecular formula: C24H18ClF2NO3. Mole weight: 441.9. | |
GW-870086 Quick inquiry Where to buy Suppliers range | GW-870086 is a glucocorticoid receptor agonist with a pIC50 of 10.1 in A549 cells expressing NF-κB. It can be used as an anti-inflammatory agent. Synonyms: GW-870086; GW-870086X; 870086; GW870086; GW870086X; GW 870086; GW 870086X. CAS No. 827319-43-7. Molecular formula: C31H39F2NO6. Mole weight: 559.651. | |
GW9508 Quick inquiry Where to buy Suppliers range | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, and stimulates insulin secretion in a glucose-sensitive manner. GW9508 is commonly used in the treatment of type 2 diabetes. Synonyms: GW9508; GW-9508; GW 9508; 3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid. Grades: > 98%. CAS No. 885101-89-3. Molecular formula: C22H21NO3. Mole weight: 347.414. | |
GW9508 Quick inquiry Where to buy Suppliers range | GW9508. Group: Biochemicals. Alternative Names: 4- [ [ (3-Phenoxyphenyl) methyl] amino] benzenepropanoic Acid. Grades: Highly Purified. CAS No. 885101-89-3. Pack Sizes: 5mg. Molecular Formula: C22H21NO3, Molecular Weight: 347.41. US Biological Life Sciences. | Worldwide |
GW 9578 Quick inquiry Where to buy Suppliers range | GW 9578 is a potent agonist of PPARα, which is highly selective for PPARα compared to PPARγ and PPAR&delta. Synonyms: 2- [ [4- [2- [ [ [ (2, 4-difluorophenyl) amino] carbonyl] heptylamino] ethyl] phenyl] thio] -2-methyl-propanoic acid. Grades: ≥98%. CAS No. 247923-29-1. Molecular formula: C26H34F2N2O3S. Mole weight: 492.6. | |
GW 9662 Quick inquiry Where to buy Suppliers range | GW 9662. Group: Biochemicals. Grades: Purified. CAS No. 22978-25-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
GW 9662 (2-Chloro-5-nitrobenzanilide) Quick inquiry Where to buy Suppliers range | A potent, selective and irreversible PPARγ antagonist. Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by > 90% at a dose of 0.1uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 22978-25-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
GW-9820 Quick inquiry Where to buy Suppliers range | GW-9820 is a PPAR-gamma agonist with potential antidiabetic effect. Synonyms: 2-[4-[2-[(4-fluorophenyl)carbamoyl-heptylamino]ethyl]phenoxy]-2-methylpropanoic acid; GW-9820; GW 9820; GW9820. Grades: >98%. CAS No. 195131-60-3. Molecular formula: C26H35FN2O4. Mole weight: 458.57. | |
GX15-070, BCl-2 Inhibitor ((Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole Methanesulfonate) Quick inquiry Where to buy Suppliers range | Cell-permeable. A small molecule pan-Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2-, Bcl-xl-, Bcl-w-, and Mcl-1-mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 803712-79-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
GX-674 Quick inquiry Where to buy Suppliers range | GX-674 is a Nav1.7 antagonist in the aryl sulfonamide class with higher selectivity for Nav1.7 (IC50= 0.1nM) over other Nav subtypes. Nav1.7 is commonly expressed in olfactory epithelium, sympathetic ganglion, and dorsal root ganglion sensory neurons. GX-674 has the potential to alleviate extreme pains. Synonyms: GX-674; GX674;GX 674; 4-(2-(2-Amino-1H-benzo[d]imidazol-5-yl)-4-chlorophenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide. CAS No. 1432913-36-4. Molecular formula: C21H13ClF2N6O3S2. Mole weight: 534.94. | |
GXpep-3 Quick inquiry Where to buy Suppliers range | GXpep-3 is a novel polypeptide inhibitor of phospholipid hydroperoxidase glutathione peroxidase (GPX4). Currently GPX4 is found to be a target which selectively induces iron-dependent cell death (ferroptosis) in cancer cells that express mutant Ras. GXpep-3 is promisingly developed to be a antitumor drug. Uses: Antitumor. Synonyms: GXpep 3; GXpep3. | |
Gyki 13324 Quick inquiry Where to buy Suppliers range | GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. It can produce long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, seems to be a candidate in the clinical management of colorectal tumors. Uses: Colorectal tumor. Synonyms: GYKI-13324; GYKI 13324; GYKI13324. N- (2-Chloroethyl) -N'- (4- ( ( ( (2-chloroethyl) amino) carbonyl) nitrosamino) -2, 3-dihydroxybutyl) -N-nitrosourea. Grades: 98%. CAS No. 76123-41-6. Molecular formula: C10H18Cl2N6O6. Mole weight: 389.19. | |
GYKI-13380 Quick inquiry Where to buy Suppliers range | GYKI-13380is a bio-active compound. But no detailed information has been published ye. Synonyms: GYKI-13380; GYKI 13380; GYKI13380; LS-79445; LS 79445; LS79445. 4-((3-(Cyclopentyloxy)-4-methoxyphenyl)methyl)-2-imidazolidinone. Grades: 98%. CAS No. 75614-09-4. Molecular formula: C16H22N2O3. Mole weight: 290.36. | |
GYKI 14166 Quick inquiry Where to buy Suppliers range | Efegatran is a thrombin inhibitor under the development of Eli Lilly. It can be used for the treatment of thromboembolic disorders. No development reported was reported for the treatment of Thrombosis. Uses: Thrombosis. Synonyms: Efegatran; RGH 2958; LY 294468; GYKI 14166; RGH2958; LY294468; GYKI14166; RGH-2958; LY-294468; GYKI-14166; (S)-1-(D-phenylalanyl)-N-((S)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide sulfate. Grades: 98%. CAS No. 83997-16-4. Molecular formula: C20H30N6O3.H2O4S. Mole weight: 500.57. | |
GYKI14451 Quick inquiry Where to buy Suppliers range | GYKI14451 is a synthetic tripeptide inhibitor of thrombin. It has anti-atherosclerotic activity. Uses: Gyki14451 has anti-atherosclerotic activity. Synonyms: GYKI-14451; GYKI14451; LY-178207; GYKI 14451;LY 178207; LY178207;Boc-D-Phe-Pro-Arg-H;Tert-butyl ((R)-1-((S)-2-(((S)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate. Grades: 98%. CAS No. 69201-89-4. Molecular formula: C25H38N6O5. Mole weight: 502.61. | |
GYKI-14451 sulfate Quick inquiry Where to buy Suppliers range | GYKI-14451 is a synthetic tripeptide inhibitor of thrombin.It has anti-atherosclerotic activity. Uses: Thrombosis. Synonyms: GYKI-14451 sulfate; GYKI 14451 sulfate; GYKI14451 sulfate; tert-butyl ((R)-1-((S)-2-(((S)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate hemisulfate; LY 178207; LY178207; LY-178207; Boc-D-Phe-Pro-Arg-H;69201-89-4 (free base). Grades: 98%. CAS No. 83861-29-4. Molecular formula: C50H76N12O10.H2O4S. Mole weight: 1103.30. | |
GYKI-16084 Quick inquiry Where to buy Suppliers range | GYKI-16084 is a postsynaptic alpha2-blocker with the potential to treat benign prostatic hyperplasia. Synonyms: 2-[3-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methylamino]propyl]pyridazin-3-one; GYKI16084; GYKI 16084; GYKI-16084R-2-(3-N-(2-benzo(1,4)dioxanylmethyl)-amino-1-propyl)-3(2H)-pyridazinone hydrochloride. Grades: >98%. CAS No. 185739-21-3. Molecular formula: C16H19N3O3. Mole weight: 301.346. |