A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: (5S)-(-)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone. Grades: Highly Purified. CAS No. 486-56-6. Pack Sizes: 1g. US Biological Life Sciences.
Melting Point: 214-215°C. Group: Biochemicals. Alternative Names: (S)-(-)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone, Perchlorate. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
Scoulerine
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 ( -site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Scoulerine; Discretamine. CAS No. 6451-73-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1255.
SCR-1481B1
SCR-1481B1, also known as c-Met inhibitor 2, is an effective inhibitor of MET kinase so that probably has anti-tumor activity. It is also found to be an inhibitor of VEGFR. IC50: 1.7 nM for MET kinase. Uses: Scr-1481b1 is an effective inhibitor of met kinase so that probably has anti-tumor activity. Synonyms: SCR-1481B1; SCR-1481B1; SCR-1481B1; c-Met inhibitor 2; c Met inhibitor 2. Grades: 98%. CAS No. 1174161-86-4. Molecular formula: C28H29ClF2N5O10P. Mole weight: 699.98.
Scr7
SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SCR7;5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol;5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone. Product Category: Inhibitors. CAS No. 1533426-72-0. Molecular formula: C18H14N4OS. Mole weight: 0. Product ID: ACM1533426720. Alfa Chemistry ISO 9001:2015 Certified. Categories: SCR-720.
SCR7
SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. Synonyms: SCR7; SCR 7; SCR-7. Grades: >98%. CAS No. 1533426-72-0. Molecular formula: C18H14N4OS. Mole weight: 334.39.
SCR7 pyrazine
SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold, and inhibits nonhomologous end-joining (NHEJ). Synonyms: SCR7 pyrazine; SCR-7 pyrazine; SCR 7 pyrazine; 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 2-mercapto-6,7-diphenylpteridin-4-ol; 6,7-diphenyl-2-sulfanylpteridin-4-ol. Grades: ≥98% by HPLC. CAS No. 14892-97-8. Molecular formula: C18H12N4OS. Mole weight: 332.38.
SCR7 pyrazine also is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. It enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro upt to 19-fold. SCR7 pyrazine is a product of spontaneous cyclization of CRISPR enhancer SCR7 first reported by Srivastava, M., et al.DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.1 It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.1,2,3,4. Group: Biochemicals. Alternative Names: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4 (1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine. Grades: Highly Purified. CAS No. 14892-97-8. Pack Sizes: 10mg. Molecular Formula: C??H??N?OS, Molecular Weight: 332.38. US Biological Life Sciences.
Worldwide
Scrambled 10Panx
Scrambled 10Panx. Group: Biochemicals. Grades: Purified. CAS No. 1315378-72-3. Pack Sizes: 1mg. US Biological Life Sciences.
A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-b/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2ug/ml (6-8uM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Group: Biochemicals. Alternative Names: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide. Grades: Highly Purified. CAS No. 287383-59-9. Pack Sizes: 1mg. US Biological Life Sciences.
Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. Synonyms: GCK 1026; GCK-1026; GCK1026; Scriptaid. Grades: >98%. CAS No. 287383-59-9. Molecular formula: C18H18N2O4. Mole weight: 326.35.
Scriptaid
Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus (EBV)-associated lymphomas treatment. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Scriptide; GCK1026. CAS No. 287383-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15489.
Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGF β/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. Group: Biochemicals. Alternative Names: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide. Grades: Highly Purified. CAS No. 287383-59-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
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SCS
SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 = 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors, respectively). Synonyms: Salicylidene salicylhydrazide; Chel 180. CAS No. 3232-36-8. Molecular formula: C14H12N2O3. Mole weight: 256.26.
SCS
SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABA A receptors with an IC 50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Salicylidene salicylhydrazide. CAS No. 3232-36-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103528.
SCS
SCS. Group: Biochemicals. Grades: Purified. CAS No. 3232-36-8. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Scutebarbatine A
Formula: Group: Biochemicals. Grades: Plant Grade. CAS No. 176520-13-1. Pack Sizes: 10mg, 20mg. US Biological Life Sciences.
Worldwide
scutelarin
From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via γ-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. Group: Enzymes. Synonyms: taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase. Enzyme Commission Number: EC 3.4.21.60. CAS No. 93389-45-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4151; scutelarin; EC 3.4.21.60; 93389-45-8; taipan activator; Oxyuranus scutellatus prothrombin-activating proteinase. Cat No: EXWM-4151.
Scutellarein
Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein , its glucuronide conjugated analogue. Group: Biochemicals. Alternative Names: 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,6,7-Tetrahydroxyflavone; 6-Hydroxyapigenin. Grades: Highly Purified. CAS No. 529-53-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Scutellarein
Scutellarein is a natural flavonoid compound with anti-inflammatory effects. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone. CAS No. 529-53-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0752.
Scutellarein
Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz., has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 529-53-3. Molecular formula: C15H10O6. Mole weight: 286.24. Purity: 0.9967. Canonical SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(O)C(O)=C13. Product ID: ACM529533. Alfa Chemistry ISO 9001:2015 Certified.
Scutellarein-d4
Scutellarein-d4. Group: Biochemicals. Alternative Names: 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d4; 4',5,6,7-Tetrahydroxyflavone; 6-Hydroxyapigenin-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C15H5D5O6, Molecular Weight: 291.27. US Biological Life Sciences.
Worldwide
Scutellaria Baicalensis P.E. 80% Baicalin HPLC
Scutellaria Baicalensis P.E. 80% Baicalin HPLC.
CA, FL & NJ
Scutellaria Baicalensis Root Extract
Scutellaria baicalensis root extract is prepared from the herb of a member of the mint family from rich woods and moist soils in eastern North America. Scutellaria baicalensis root extract, also known as skullcap root extract, it was among seven ingredients in a combination oral herbal product known as PC-SPES that was used to treat prostate cancer. Scutellaria baicalensis extract also is used as an herbal remedy for inflammation and traumatic injury. Group: Others. Mole weight: 446.36. Scutellaria Baicalensis Root Extract; Scutellaria Baicalensis Georgi. Cat No: EXTC-030.
Scutellarin
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4',5,6,7-Tetrahydroxyflavone 7-β-D-glucopyranuronoside. Product Category: Inhibitors. Appearance: Yellow powder. CAS No. 27740-01-8. Molecular formula: C21H18O12. Mole weight: 462.36. Purity: 0.98. IUPACName: (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid. Canonical SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O)O)O. Density: 1.810±0.06 g/ml. Product ID: ACM27740018. Alfa Chemistry ISO 9001:2015 Certified.
Scutellarin
Scutellarin. Group: Biochemicals. Grades: Plant Grade. CAS No. 27740-01-8. Pack Sizes: 20mg. Molecular Formula: C21H18O12, Molecular Weight: 462.36. US Biological Life Sciences.
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB , HIV-1(74V) and HIV-1KM018 with EC 50 s of 26 μM, 253 μM and 136 μM, respectively. Uses: Scientific research. Group: Natural products. CAS No. 27740-01-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0751.
S-Cyanoethyl-L-cysteine (2-Amino-3-(2-cyano-ethylsulfanyl)-propionic Acid). Group: Biochemicals. Alternative Names: 2-Amino-3-(2-cyano-ethylsulfanyl)-propionic Acid. Grades: Highly Purified. CAS No. 3958-13-2. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
scyllo-Inosamine
scyllo-Inosamine is an intricately designed synthetic compound widely employed in studying grievous neurodegenerative afflictions such as Alzheimer's and Parkinson's disease. Its exalted status arises from its possession of remarkable neuroprotective attributes and its finesse in modifying enzyme activity. Synonyms: 1-Amino-1-deoxy-scyllo-inositol. CAS No. 16051-25-5. Molecular formula: C6H13NO5. Mole weight: 179.17.
scyllo-inosamine 4-kinase
Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol. Group: Enzymes. Synonyms: scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase. Enzyme Commission Number: EC 2.7.1.65. CAS No. 37278-08-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3096; scyllo-inosamine 4-kinase; EC 2.7.1.65; 37278-08-3; scyllo-inosamine kinase (phosphorylating); scyllo-inosamine kinase; ATP:inosamine phosphotransferase. Cat No: EXWM-3096.
scyllo-inosamine-4-phosphate amidinotransferase
1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor. Group: Enzymes. Synonyms: L-arginine:inosamine-P-amidinotransferase; inosamine-P amidinotransferase; L-arginine:inosamine phosphate amidinotransferase; inosamine-phosphate amidinotransferase. Enzyme Commission Number: EC 2.1.4.2. CAS No. 52227-63-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2023; scyllo-inosamine-4-phosphate amidinotransferase; EC 2.1.4.2; 52227-63-1; L-arginine:inosamine-P-amidinotransferase; inosamine-P amidinotransferase; L-arginine:inosamine phosphate amidinotransferase; inosamine-phosphate amidinotransferase. Cat No: EXWM-2023.
scyllo-Inosamine hydrochloride
scyllo-Inosamine hydrochloride is a multifaceted biomedical constituent evolved from inositol, having prospects in studying neurodegenerative ailments like Alzheimer's and Parkinson's. Synonyms: 1-Amino-1-deoxy-scyllo-inositol HCl. CAS No. 4933-84-0. Molecular formula: C6H13NO4 HCl. Mole weight: 199.63.
scyllo-Inositol is a renowned chemical compound, serving as a cornerstone in studying an array of neurological ailments, such as the dreaded Alzheimer's disease and the debilitating Parkinson's disease. Acknowledged for its antioxidative properties, this compound assists in studying the build-up of pernicious proteins within the cerebral domain. Synonyms: inositol; myo-inositol; Scyllo-inositol; epi-Inositol; Muco-Inositol; Allo-inositol; i-Inositol;alloinositol; neoinositol; Hexahydroxycyclohexane; scyllo-Cyclohexanehexol; 1D-myo-Inositol; 1L-myo-Inositol; Inositol, cis-; Inositol, epi-; Inositol, neo-; epi-Cyclohexanehexol; (+)-Inositol; 1,2,3,4,5,6-Cyclohexanehexol; (-)-chiro-Inositol; ELND005; Rat antispectacled eye factor; Levoinositol1111. CAS No. 488-59-5. Molecular formula: C6H12O6. Mole weight: 180.16.
Scyllo-Inositol
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model [1]. Uses: Scientific research. Group: Natural products. CAS No. 488-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W010041.
scyllo-Inositol-1-d
scyllo-Inositol-1-d. Group: Biochemicals. Alternative Names: Scyllitol-1-d; Cocositol-1-d; Quercinitol-1-d; 1,3,5/2,4,6-Hexahydroxycyclohexane-1-d; scyllo-Cyclohexanehexol. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
scyllo-inositol 2-dehydrogenase (NAD+)
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA. Group: Enzymes. Synonyms: iolX (gene name). Enzyme Commission Number: EC 1.1.1.370. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0288; scyllo-inositol 2-dehydrogenase (NAD+); EC 1.1.1.370; iolX (gene name). Cat No: EXWM-0288.
scyllo-inositol 2-dehydrogenase (NADP+)
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)]. Group: Enzymes. Synonyms: iolW (gene name). Enzyme Commission Number: EC 1.1.1.371. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0289; scyllo-inositol 2-dehydrogenase (NADP+); EC 1.1.1.371; iolW (gene name). Cat No: EXWM-0289.
The enzyme from the shark Heterodontus portusjacksoni is able to sulfate the C27 bile salts 5β-scymnol (the natural bile salt) and 5α-cyprinol (the carp bile salt). Enzyme activity is activated by Mg2+ but inhibited by the product 5β-scymnol sulfate. Group: Enzymes. Enzyme Commission Number: EC 2.8.2.32. CAS No. 220581-70-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3392; scymnol sulfotransferase; EC 2.8.2.32; 220581-70-4. Cat No: EXWM-3392.
Scyphostatin
It is a mammalian N-SMase inhibitor produced by the strain of Trichopeziza mollissima SANK 13892. It inhibits N-SMase with IC50 of 1.0 μmol/L. Synonyms: (2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl-hexadeca-2,4,6,12-tetraenoic acid [(S)-1-hydroxymethyl-2-((1S,2S,6S)-2-hydroxy-3-oxo-7-oxa-bicyclo[4.1.0]hept-4-en-2-yl)-ethyl]-amide; (2'S, 2''E, 4S, 4''E, 5S, 6S, 6''E, 8''R, 10''S, 12''E, 14''R)-4, 5-epoxy-6-hydroxy-6-[3'-hydroxy-2'-(8'', 10'', 12'', 14''-tetramethylhexadeca-2'', 4'', 6'', 12''-tetraenoylamino)-propyl]-2-cyclohexen-1-one; (+)-scyphostatin. CAS No. 169062-93-5. Molecular formula: C29H43NO5. Mole weight: 485.66.
Scytalidin
It is a terpenoid antibiotic produced by the strain of Scytalidium sp. FSC-470. It has antifungal effect. The antibacterial activity is strongest when the pH value of liquid determination is 3.5, and the activity decreases when the pH value increases. Synonyms: Scytalidic-acid; NSC-236264; 1H-Cyclonona(1,2-c:5,6-c')difuran-1,3,6,8(4H)-tetrone, 10-butyl-5,9,10,11-tetrahydro-10-hydroxy-4-pentyl-, (4S,10R)-; 1H-Cyclonona[1,2-c:5,6-c']difuran-1,3,6,8(4H)-tetrone, 10-butyl-5,9,10,11-tetrahydro-10-hydroxy-4-pentyl-, [4S-(4R*,10S*)]-. CAS No. 39012-16-3. Molecular formula: C22H28O7. Mole weight: 404.45.
scytalidopepsin A
Isolated from the imperfect fungus Scytalidium lignicolum. Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenyl)propane. A related enzyme from the same organism, proteinase C, is also insensitive to these inhibitors and has Mr = 406,000. Group: Enzymes. Synonyms: Scytalidium aspartic proteinase A; Scytalidium lignicolum aspartic proteinase; Scytalidium lignicolum aspartic proteinase A-2; Scytalidium lignicolum aspartic proteinase A-I; Scytalidium lignicolum aspartic proteinase C; Scytalidium lignicolum carboxyl proteinase; Scytalidium lignicolum acid proteinase. Enzyme Commission Number: EC 3.4.23.31. CAS No. 42613-34-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4269; scytalidopepsin A; EC 3.4.23.31; 42613-34-3; Scytalidium aspartic proteinase A; Scytalidium lignicolum aspartic proteinase; Scytalidium lignicolum aspartic proteinase A-2; Scytalidium lignicolum aspartic proteinase A-I; Scytalidium lignicolum aspartic proteinase C; Scytalidium lignicolum carboxyl proteinase; Scytalidium lignicolum acid proteinase. Cat No: EXWM-4269.
scytalidopepsin B
A second endopeptidase from Scytalidium lignicolum (see scytalidopepsin A) that is insensitive to pepstatin and methyl 2-diazoacetamidohexanoate. 1,2-Epoxy-3-(p-nitrophenoxy)propane reacts with Glu53, which replaces one of the aspartic residues at the active centre. One of the smallest aspartic endopeptidases active as the monomer, with Mr 22,000. Similarly inhibitor-resistant endopeptidases are found in the basidiomycetes Lentinus edodes and Ganoderma lucidum, and in Polyporus tulipiferae, a second endopeptidase distinct from polyporopepsin, but these are of typical aspartic endopeptidase size, Mr about 36,000. Type example of peptidase family G1. Group: Enzymes. Synonyms: Scytalidium aspartic proteinase B; Ganoderma lucidum carboxyl proteinase; Ganoderma lucidum aspartic proteinase; Scytalidium lignicolum aspartic proteinase B; SLB. Enzyme Commission Number: EC 3.4.23.32. CAS No. 104781-89-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4270; scytalidopepsin B; EC 3.4.23.32; 104781-89-7; Scytalidium aspartic proteinase B; Ganoderma lucidum carboxyl proteinase; Ganoderma lucidum aspartic proteinase; Scytalidium lignicolum aspartic proteinase B; SLB. Cat No: EXWM-4270.
Scytalol A
It is produced by the strain of Scytalidium sp. 36-93. It selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain. Synonyms: 10H-Naphtho[2,3-c]pyran-10-one,1,3,4,4a,5,10a-hexahydro-3,5,9-trihydroxy-7-methoxy-3-methyl-, (3R,4aS,5S,10aR)-rel-(+)-. CAS No. 208183-19-1. Molecular formula: C15H18O6. Mole weight: 294.30.
Scytalol B
It is produced by the strain of Scytalidium sp. 36-93. Synonyms: 10H-Naphtho[2,3-c]pyran-10-one,1,3,4,4a,5,10a-hexahydro-5,9-dihydroxy-3,7-dimethoxy-3-methyl-, (3R,4aS,5S,10aR)-rel-(+)-. CAS No. 208183-20-4. Molecular formula: C16H20O6. Mole weight: 308.33.
Scytalol C
It is produced by the strain of Scytalidium sp. 36-93. Synonyms: Naphtho[1,2-b]furan-5(4H)-one,2,3,3a,9btetrahydro-6-hydroxy-2,8-dimethoxy-4-(methoxymethylene)-2-methyl-, (2R,3aR,4E,9bR)-rel-(-)-. CAS No. 208183-22-6. Molecular formula: C17H20O6. Mole weight: 320.34.
Scytalol D
It is produced by the strain of Scytalidium sp. 36-93. It selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain. Synonyms: 1(2H)-Naphthalenone, 3,4-dihydro-4,8-dihydroxy-6-methoxy-3-(2-oxopropyl)-, (3R,4R)-rel-(+)-. CAS No. 208183-24-8. Molecular formula: C14H16O5. Mole weight: 264.27.
scytalone dehydratase
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi. Group: Enzymes. Synonyms: scytalone 7,8-hydro-lyase. Enzyme Commission Number: EC 4.2.1.94. CAS No. 118901-79-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5078; scytalone dehydratase; EC 4.2.1.94; 118901-79-4; scytalone 7,8-hydro-lyase. Cat No: EXWM-5078.
Scytonemin
Scytonemin is a biological pigment synthesized by many strains of cyanobacteria. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin (at 3 and 4 μM concentration) inhibited multiple myeloma cell growth associated with downregulation of the activity of Plk1 but no effect on the expression of Plk1. Scytonemin, representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity. Taken together, scytonemin is a promising novel agent for the treatment of multiple myeloma. Synonyms: (3E,3'E)-3,3'-bis(4-hydroxybenzylidene)-[1,1'-bi(cyclopenta[b]indole)]-2,2'(3H,3'H)-dione; (1,1'-Bicyclopent(b)indole)-2,2'(3H,3'H)-dione, 3,3'-bis((4hydroxyphenyl)methylene)-3,3'-Bis((4-hydroxyphenyl)methylene)-(1,1'-bicyclopent(b)indole)-2,2'(3H,3'H)-dione. Grades: 98%. CAS No. 152075-98-4. Molecular formula: C36H20N2O4. Mole weight: 544.56.
Scytonemin
Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC 50 =2.0 μM) of polo-like kinase 1 ( PLK1 )-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 152075-98-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112356.
SD-06
SD-06 is an inhibitor of p38α (IC50=170 nM). It is developed for the treatment of arthritis. Synonyms: SD 0006; SD-0006; SD0006; SD-06; SD-06; SD-06. CAS No. 271576-80-8. Molecular formula: C20H20ClN5O2. Mole weight: 397.86.
Sd1
Sd1 is an antibacterial peptide isolated from Saccharum officinarum (Sugarcane). It has activity against fungi. Synonyms: Arg-Tyr-Cys-Leu-Ser-Gln-Ser-His-Arg-Phe-Lys-Gly-Leu-Cys-Met-Ser-Ser-Ser-Asn-Cys-Ala-Asn-Val-Cys-Gln-Thr-Glu-Asn-Phe-Pro-Gly-Gly-Glu-Cys-Lys-Ala-Asp-Gly-Ala-Thr-Arg-Lys-Cys-Phe-Cys-Lys-Lys-Ile-Cys.
SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor that inhibits activation of STAT3, JAK2 and Src. SD 1008 induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. Synonyms: SD 1008; SD1008; SD-1008; (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester. Grades: ≥99% by HPLC. CAS No. 960201-81-4. Molecular formula: C18H19NO5. Mole weight: 329.35.
SD 1008
SD 1008. Group: Biochemicals. Grades: Purified. CAS No. 960201-81-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SD-1008
SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 960201-81-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107595.