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| Product | Description | |
|---|---|---|
| Eflornithine hydrochloride hydrate | Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate. CAS No. 96020-91-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0744B. |  |
| Eflornithine hydrochloride, hydrate | Eflornithine hydrochloride, hydrate is a drug found to be effective in the treatment of facial hirsutism. It is a "suicide inhibitor," irreversibly binding to Ornithine Decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site. It is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis. It displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways. It also demonstrates antiparasitic activity in a model of C. parvum infection. Synonyms: DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; MDL 71782 hydrochloride hydrate; RMI 71782 hydrochloride hydrate; MDL71782 hydrochloride hydrate; RMI71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate; Vaniqa hydrochloride hydrate. Grades: 98%. CAS No. 96020-91-6. Molecular formula: C6H15ClF2N2O3. Mole weight: 236.64. |  |
| Eflornithine Hydrochloride Monoydrate | Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism. Group: Biochemicals. Alternative Names: 2-(Difluoromethyl)-DL-ornithine Hydrochloride Hydrate; 2- (Difluoromethyl) ornithine; DFMO; DL-2- (Difluoromethyl) ornithine; DL-α - (Difluoromethyl) ornithine; Elfornithine; MDL 71782; MDL 71782A; Ornidyl; RFI 71782; RMI 71782; α , δ -Diamino-α - (difluoromethyl) valeric Acid; α-(Difluoromethyl)-DL-ornithine; α - (Difluoromethyl) ornithine. Grades: Highly Purified. CAS No. 96020-91-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C?H??ClF?N?O?, Molecular Weight: 236.64. US Biological Life Sciences. |  Worldwide |
| Efloxate | Efloxate, a flavone derivative, could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator. Uses: Efloxate could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator. Synonyms: RE 1-0185; RE-1-0185; RE1-0185; efloxate; EFLOXATE/EFLOXATEM; Corosamin; Domucor; Eflocor; Oxyflavyl; Recordil; 2-(4-keto-2-phenyl-chromen-7-yl)oxyacetic acid ethyl ester. Grades: 98%. CAS No. 119-41-5. Molecular formula: C19H16O5. Mole weight: 324.33. | |
| Efmarodocokin alfa | Efmarodocokin alfa is a fusion protein of human IL-22 and the IgG4 crystallizable fragment. Efmarodocokin alfa activates IL-22 signaling. Efmarodocokin alfa can be used for the research of severe COVID-19 pneumonia [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2247840-74-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99919. | |
| Efonidipine | Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). Uses: Scientific research. Group: Signaling pathways. Alternative Names: NZ-105; (±)-Efonidipine. CAS No. 111011-63-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12502. | |
| EFONIDIPINE | Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. It could also present as the hydrochloride salt form. Uses: Efonidipine could be effective in the treatment of cardiovascular disease as a blocker of t-type and l-type calcium channels. Synonyms: NZ-105; NZ 105; NZ105; Efonidipine; Efonidipine[INN]; 111011-63-3; C34H38N3O7P; Efonidipine(INN); Landel. Grades: 95%. CAS No. 111011-63-3. Molecular formula: C34H38N3O7P. Mole weight: 631.66. | |
| EFONIDIPINE HCL | The hydrochloride salt form of Efonidipine which could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channels. Uses: The hydrochloride salt form of efonidipine which could be effective in the treatment of cardiovascular disease as a blocker of t-type and l-type calcium channels. Synonyms: EFONIDIPINE HCL;Efonidipine hydrochloride. Grades: 95%. CAS No. 111011-53-1. Molecular formula: C34H38N3O7P.HCl. Mole weight: 668.12. | |
| Efonidipine hydrochloride monoethanolate | Efonidipine hydrochloride monoethanolate. Group: Biochemicals. Grades: Purified. CAS No. 111011-76-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Efonidipine hydrochloride monoethanolate | The hydrochloride monoethanolate salt form of Efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders. Uses: The hydrochloride monoethanolate salt form of efonidipine which has been launched for hypertension and discontinued for cerebrovascular disorders. Synonyms: Efonidipine hydrochloride ethanol; Efonidipine hydrochloride ethanolate; NZ 105 ethanolate; NZ105 ethanolate; NZ-105 ethanolate; EFONIDIPINE HYDROCHLORIDE MONOETHANOLATE; 111011-76-8; Efonidipine.HCl ethanolate. Grades: >98%. CAS No. 111011-76-8. Molecular formula: C36H45ClN3O8P. Mole weight: 631.66. | |
| Efonidipine hydrochloride monoethanolate | Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB). Uses: Scientific research. Group: Signaling pathways. Alternative Names: NZ-105 hydrochloride monoethanolate. CAS No. 111011-76-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12502A. | |
| Efonidipine hydrochloride monoethanolate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Efpeglenatide | Efpeglenatide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA). Efpeglenatide has been developed as an injection for type 2 diabetes mellitus (T2DM). Synonyms: efpeg. CAS No. 1296200-77-5. | |
| Efrotomycin | It is produced by the strain of Streptomyces lavendulae. The combination of Efrotomycin with the prolonging factor Tu inhibits protein biosynthesis. It has anti-gram-positive bacteria and negative bacteria activity, and it can inhibit coccidiosis in mice and chickens and promote the growth of pigs. Synonyms: Producil; Antibiotic FR 02A; Efrotomicina; Efrotomycine; Mocimycin, 31-O-(6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha-L-mannopyranosyl)-3-O-methyl-beta-D-allopyranosyl)-1-methyl-. CAS No. 56592-32-6. Molecular formula: C59H88N2O20. Mole weight: 1145.33. | |
| Efruxifermin | Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2375240-92-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99930. | |
| eFT-508 | eFT-508 is a selective inhibitor of MNK1/2 (IC50s = 2.4 nM and 1 nM respectively) inhibiting MNK1/2-mediated signaling and the phosphorylation of certain regulatory proteins. It acts against tumor. Synonyms: SCHEMBL17362622; AKOS030627405; ZINC575623807; CS-5841; CS 5841; CS5841; 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione; eFT508. Grades: 99.83 %. CAS No. 1849590-01-7. Molecular formula: C17H20N6O2. Mole weight: 340.38. | |
| Eftilagimod alfa | Eftilagimod alfa (IMP321) is a recombinant LAG-3Ig fusion protein that binds to MHC class II. Eftilagimod alfa mediates antigen-presenting cell (APC) activation followed by CD8 T-cell activation. Eftilagimod alfa can be used for metastatic melanoma and metastatic breast carcinoma research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IMP321; LAG-3Ig. CAS No. 1800476-36-1. Pack Sizes: 1 mg. Product ID: HY-P99933. | |
| Eftozanermin alfa | Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor ( TRAIL-R ) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABBV-621. CAS No. 1820660-69-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99934. | |
| EG00229 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| EG 00229 | EG 00229 is a neuropilin 1 (NRP1) receptor antagonist, inhibiting VEGFA binding to the NRP1 b1 domain. Synonyms: EG00229; EG-00229; EG 00229; N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine. Grades: ≥98% by HPLC. CAS No. 1018927-63-3. Molecular formula: C17H19N7O5S3. Mole weight: 497.57. | |
| EG 00229 | EG 00229. Group: Biochemicals. Grades: Purified. CAS No. 1018927-63-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| EG 00229 Trifluoroacetate | EG00229 is a small molecule inhibitor of neuropilin-1(Nrp1) with an IC50 of 3μM. EG00229 has been reported to inhibit VEGF-A binding to PAE/NRP1 in the Nrp1and bt-VEGF-A binding to purified Nrp1 b1 domain in a cell-free assay with an IC50 value of 8μM and 3μM, respectively. In addition, EG00229 has also shown the inhibition of VEGF-A binding to VEGFR2, VEGFR1 and Nrp1 in human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner with an IC50 value of 23μM [1]. Besides, EG00229 has been revealed to prevent tuftsin binding to the Nrp1 which is at the cell surface. Moreover, EG00229 has been noted to suppress the anti-inflammatory M2 shift in microglia induced by tuftsin and thus potently prevent tuftsin's action. Synonyms: EG 00229; EG-00229. Grades: >98%. CAS No. 1210945-69-9. Molecular formula: C19H20F3N7O7S3. Mole weight: 611.6. | |
| EG1 | EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 ( K d =1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 693241-54-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124838. | |
| Eg5-I | Eg5, also known as KSP and Kif11, is a kinesin-like spindle protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). Synonyms: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol. Grades: ≥98%. CAS No. 1338701-15-7. Molecular formula: C23H25NO2S. Mole weight: 379.5. | |
| EGA | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| EGA | EGA is an inhibitor of endosomal trafficking. EGA is a small molecule that blocks the entry of anthrax lethal toxin by inhibiting trafficking pathways in acidified endosomes, without affecting endosome pH. It also blocks trafficking of other toxins, except ricin. Synonyms: 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide. Grades: ≥98%. CAS No. 415687-81-9. Molecular formula: C16H16BrN3O. Mole weight: 346.2. | |
| EGA | EGA is an inhibitor that selectively targets the endosomal trafficking pathways. EGA targets the proteins involved in the endosomal trafficking pathways through which multiple toxins and viruses enter cells. EGA exerts its activity by inhibiting the trafficking from early endosomes to late endosomes, blocking the entry of multiple acid-dependent bacterial toxins and viruses into mammalian cells and delaying the lysosomal targeting and degradation of EGFR [1]. X. Uses: Scientific research. Group: Signaling pathways. CAS No. 415687-81-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-125168. | |
| Egalognastat | Egalognastat is a specific and orally active O-GlcNAcase (OGA) enzyme inhibitor with IC 50 value of 10.2 nM. Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASN90. CAS No. 1884154-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156586. | |
| Eganelisib | Eganelisib (IPI549) is a potent and selective PI3Kγ inhibitor with an IC 50 of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI-549. CAS No. 1693758-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100716. | |
| EGCG-3''-O-Me | EGCG-3''-O-Me. Group: Biochemicals. Grades: Plant Grade. CAS No. 83104-87-4. Pack Sizes: 5mg. Molecular Formula: C23H20O11, Molecular Weight: 472.4. US Biological Life Sciences. | Worldwide |
| EGCG Octaacetate | EGCG Octaacetate. Group: Biochemicals. Alternative Names: Pro-epigallocatechin gallate; Peracetylated epigallocatechin-3-gallate; Epigallocatechin Gallate Octaacetate; AcEGCG. Grades: Plant Grade. CAS No. 148707-39-5. Pack Sizes: 20mg. Molecular Formula: C38H34O19, Molecular Weight: 794.671. US Biological Life Sciences. | Worldwide |
| Ege I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (HindIII-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme 70% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GGC↑GCC CCG↓CGG. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: Enterobacter gergoviae. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 50% glycerol. Cat No: ET-1103RE. |  |
| EGF816 | EGF816, also called as Nazartinib, a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M resistance mutation while sparing wild-type EGFR. in vivo: demonstrated strong tumor regressions in several EGFR activating and resistant tumor m. Synonyms: EGF816; EGF-816; EGF 816; NVS-816; NVS 816; NVS816; Nazartinib; N- [7-chloro -1- [ (3R) -1- [ (E) -4- (di methyl amino) but-2-enoyl ] azepan-3-yl ] benzimidazol-2-yl ] -2- methyl pyridine-4-carboxamide EGF816UNII-KE7K32EME8KE7K32EME8EGF-8161508250-71-2GTPL9204SCHEMBL16767232SCHEMBL16767 240EGF 816compound 47 [PMID: 27433829]. CAS No. 1508250-71-2. Molecular formula: C26H31ClN6O2. Mole weight: 495.02. | |
| EGF816 mesylate | EGF816 mesylate is the mesylate salt of EGF816 which is a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M. Synonyms: N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide;methanesulfonic acid. CAS No. 1508250-72-3. Molecular formula: C27H35ClN6O5S. Mole weight: 591.12. | |
| EGF from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGF from rat | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGF human | Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR (695-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR Active human | recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EGFR active mouse | recombinant, expressed in baculovirus infected Sf9 cells. Group: Fluorescence/luminescence spectroscopy. | |
| EGF Receptor (985-996) (human) | EGF Receptor (985-996) (human) exists on the cell surface and is activated by the binding of its specific ligands. EGFR belongs to the tyrosine kinase receptor (RTK) ErbB family. Synonyms: L-Glutamine, L-α-aspartyl-L-valyl-L-valyl-L-α-aspartyl-L-alanyl-L-α-aspartyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-; L-Glutamine, N2-[1-[N-[N-[N-[N-[N-[N-[N-[N-(N-L-α-aspartyl-L-valyl)-L-valyl]-L-α-aspartyl]-L-alanyl]-L-α-aspartyl]-L-α-glutamyl]-L-tyrosyl]-L-leucyl]-L-isoleucyl]-L-prolyl]-; L-α-Aspartyl-L-valyl-L-valyl-L-α-aspartyl-L-alanyl-L-α-aspartyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-L-glutamine; H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH; Epidermal Growth Factor Receptor Peptide. Grades: ≥95%. CAS No. 96249-43-3. Molecular formula: C61H93N13O23. Mole weight: 1376.46. | |
| EGF-receptor human | recombinant, expressed in CHO cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 | The EGFR/ErbB-2/ErbB-4 Inhibitor, also referenced under CAS 881001-19-0, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR/ErbB-2/ErbB-4 Inhibitor II - CAS 944341-54-2 | The EGFR/ErbB-2/ErbB-4 Inhibitor II, also referenced under CAS 944341-54-2, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR/ErbB2 Inhibitor | EGFR/ErbB2 inhibitor is a cell-permeable 4-anilino quinazoline compound, which is a potent and reversible inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively). It inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 μM). Synonyms: 4557W; 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline; EGFR/ErbB-2 Inhibitor. Grades: ≥95%. CAS No. 179248-61-4. Molecular formula: C23H21N3O3. Mole weight: 387.4. | |
| EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 | The EGFR/ErbB-2 Inhibitor, also referenced under CAS 179248-61-4, controls the biological activity of EGFR/ErbB-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR-IN-2 | EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. It showed excellent cellular activity against both the single and double mutants of EGFR, demonstrating target engagement in vivo and ADME-PK properties that are suitable for further evaluation. CAS No. 1643497-70-4. Molecular formula: C26H33N9O3S. Mole weight: 551.66. | |
| EGFR-IN-24 | EGFR-IN-24, a potent EGFR inhibitor, shows inhibition against EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S), respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2757548-54-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-142512. | |
| EGFR-IN-47 | EGFR-IN-47 is a potent and orally active EGFR L858R/T790M/C797S inhibitor with an IC 50 of 0.01 μM. EGFR-IN-47 induces cell cycle attest and cell apoptosis. EGFR-IN-47 has the potential for the research of NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3034649-73-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143337. | |
| EGFR-IN-5 | EGFR-IN-5 is a EGFR inhibitor with IC 50 s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFR L858R , EGFR L858R/T790M , and EGFR L858R/T790M/C797S , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225887-26-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111415. | |
| EGFR-IN-69 | EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC 50 values of 4.3, 6.6 and 25.6 nM against EGFR L858R/T790M/C797S , EGFR L858R/T790M , and EGFR 19del/T790M/C797S , respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2433837-65-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150610. | |
| EGFR-IN-7 | EGFR-IN-7 Inhibitor. Uses: Scientific use. Product Category: T11161. CAS No. 2267329-76-8. |  |
| EGFR-IN-70 | EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC 50 values of 23.6 and 307.5 nM for EGFR LR/TM/CS and EGFR WT , respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2926716-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150611. | |
| EGFR-IN-78 | EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, is a reversible inhibitor of EGFR C797S -TK, and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity, inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3042104-73-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-149889. | |
| EGFR-IN-8 | EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48. EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407957-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126320. | |
| EGFR-IN-86 | EGFR-IN-86 (compound 4i) is an EGFR inhibitor ( IC 50 : 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3055550-22-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-149530. | |
| EGFR-IN-89 | EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC 50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413029-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-156284. | |
| EGFR-IN-95 | EGFR-IN-95 (compound 5j) is an 2,4-diaminonicotinamide derivative. EGFR-IN-95 has potent inhibitory activity against EGFR del19/T790M/C797S and L858R/T790M/C797S [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3027135-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-163094. | |
| EGFR Inhibitor | A cell-permeable and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nanomolar range. Inhibition of EGFR induces apoptosis of tumor cells by ownregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim. Uses: Antitumor agent. Synonyms: EGFR inhibitor; EGFR-inhibitor; EGFRinhibitor; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; N- (3- ( (6- ( (3- (Trifluoromethyl) phenyl) amino) pyrimidin-4-yl) amino) phenyl) cyclopropanecarboxamide; K00598a. Grades: 99%. CAS No. 879127-07-8. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| EGFR Inhibitor - CAS 879127-07-8 | The EGFR Inhibitor, also referenced under CAS 879127-07-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 | The EGFR Inhibitor II, BIBX1382, also referenced under CAS 196612-93-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR Inhibitor III - CAS 733009-42-2 | The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR kinase inhibitor 3 | EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC 50 s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922402-03-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162299. | |
| EGFR (L858R) Active human | recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EGFR (L861Q), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR mutant-IN-2 | EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFR L858R/T790M/C797S mutant with an IC 50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFR del19/T790M/C797S mutant with an IC 50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2770009-06-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155005. | |
| EGFR (T790M L858R) Active human | recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EGFR T790M/L858R-IN-8 | EGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR , targeting mutant EGFR T790M/L858R with IC 50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 333419-97-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164056. | |
| EGFR-TK-IN-4 | EGFR-TK-IN-4 (compound 10k) is a potent and selective EGFR-TK inhibitor. EGFR-TK-IN-4 can induce apoptosis. EGFR-TK-IN-4 has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3053485-72-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-161927. | |
| Eggmanone | Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM) displaying >40-fold selectivity over PDE3, PDE10, and PDE11. Eggmanone acts via blocking hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Synonyms: 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one. Grades: ≥98% by HPLC. CAS No. 505068-32-6. Molecular formula: C20H20N2O2S3. Mole weight: 416.58. | |
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