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| Product | Description | |
|---|---|---|
| EG00229 trifluoroacetate | EG00229 is a neuropilin 1 (NRP1) receptor antagonist. EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 ?M, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210945-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10799. |  |
| EG 00229 Trifluoroacetate | EG00229 is a small molecule inhibitor of neuropilin-1(Nrp1) with an IC50 of 3μM. EG00229 has been reported to inhibit VEGF-A binding to PAE/NRP1 in the Nrp1and bt-VEGF-A binding to purified Nrp1 b1 domain in a cell-free assay with an IC50 value of 8μM and 3μM, respectively. In addition, EG00229 has also shown the inhibition of VEGF-A binding to VEGFR2, VEGFR1 and Nrp1 in human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner with an IC50 value of 23μM [1]. Besides, EG00229 has been revealed to prevent tuftsin binding to the Nrp1 which is at the cell surface. Moreover, EG00229 has been noted to suppress the anti-inflammatory M2 shift in microglia induced by tuftsin and thus potently prevent tuftsin's action. Synonyms: EG 00229; EG-00229. Grade: >98%. CAS No. 1210945-69-9. Molecular formula: C19H20F3N7O7S3. Mole weight: 611.6. |  |
| EG01377 | EG01377 is a potent, bioavailable and selective neuropilin-1 (NRP1) inhibitor, with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. It has antiangiogenic, antimigratory and antitumor effects. Synonyms: (3-((5-(4-(aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine; N2-({3-[({5-[4-(Aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl}sulfonyl)amino]-2-thienyl}carbonyl)-N5-(diaminomethylene)-L-ornithine. Grade: ≥98%. CAS No. 2227996-00-9. Molecular formula: C26H30N6O6S2. Mole weight: 586.68. | |
| EG01377 dihydrochloride | EG01377 dihydrochloride is a potent, bioavailable and selective neuropilin-1 (NRP1) inhibitor, with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. It has antiangiogenic, antimigratory and antitumor effects. Synonyms: N2-({3-[({5-[4-(Aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl}sulfonyl)amino]-2-thienyl}carbonyl)-N5-(diaminomethylene)-L-ornithine dihydrochloride; L-Ornithine, N2-[[3-[[[5-[4-(aminomethyl)phenyl]-2,3-dihydro-7-benzofuranyl]sulfonyl]amino]-2-thienyl]carbonyl]-N5-(diaminomethylene)-, hydrochloride (1:2). Grade: ≥98%. Molecular formula: C26H32Cl2N6O6S2. Mole weight: 659.60. | |
| EG01377 dihydrochloride | EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 ?M, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2749438-61-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112151A. | |
| EG1 | EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 ( K d =1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 693241-54-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124838. | |
| EG1 | EG1 is a specific inhibitor of specific Paired box 2 (Pax2), which targets the DNA binding domain and inhibits embryonic kidney development. CAS No. 693241-54-2. Molecular formula: C22H18N2O5. Mole weight: 390.39. | |
| Eg5-I | Eg5, also known as KSP and Kif11, is a kinesin-like spindle protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). Synonyms: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol. Grade: ≥98%. CAS No. 1338701-15-7. Molecular formula: C23H25NO2S. Mole weight: 379.5. | |
| Eg5 Inhibitor V, trans-24 | Eg5 Inhibitor V, trans-24 is a potent and specific inhibitor of kinesin Eg5 with an IC50 of 0.65 μM. It can be used in cancer research. Synonyms: 1H-Imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione, 5,6,11,11a-tetrahydro-5-(3-hydroxyphenyl)-2-(phenylmethyl)-, (5R,11aS)-; (5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione; Trans-24. Grade: ≥95%. CAS No. 869304-55-2. Molecular formula: C26H21N3O3. Mole weight: 423.46. | |
| EGA | EGA is an inhibitor of endosomal trafficking. EGA is a small molecule that blocks the entry of anthrax lethal toxin by inhibiting trafficking pathways in acidified endosomes, without affecting endosome pH. It also blocks trafficking of other toxins, except ricin. Synonyms: 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide. Grade: ≥98%. CAS No. 415687-81-9. Molecular formula: C16H16BrN3O. Mole weight: 346.2. | |
| EGA | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| EGA | EGA is an inhibitor that selectively targets the endosomal trafficking pathways. EGA targets the proteins involved in the endosomal trafficking pathways through which multiple toxins and viruses enter cells. EGA exerts its activity by inhibiting the trafficking from early endosomes to late endosomes, blocking the entry of multiple acid-dependent bacterial toxins and viruses into mammalian cells and delaying the lysosomal targeting and degradation of EGFR [1]. X. Uses: Scientific research. Group: Signaling pathways. CAS No. 415687-81-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-125168. | |
| Egalognastat | Egalognastat is a specific and orally active O-GlcNAcase (OGA) enzyme inhibitor with IC 50 value of 10.2 nM. Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASN90. CAS No. 1884154-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156586. | |
| Eganelisib | Eganelisib (IPI549) is a potent and selective PI3Kγ inhibitor with an IC 50 of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI-549. CAS No. 1693758-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100716. | |
| EGCG-3''-O-Me | EGCG-3''-O-Me. Group: Biochemicals. Grades: Plant Grade. CAS No. 83104-87-4. Pack Sizes: 5mg. Molecular Formula: C23H20O11, Molecular Weight: 472.4. US Biological Life Sciences. |  Worldwide |
| EGCG Octaacetate | EGCG Octaacetate. Group: Biochemicals. Alternative Names: Pro-epigallocatechin gallate; Peracetylated epigallocatechin-3-gallate; Epigallocatechin Gallate Octaacetate; AcEGCG. Grades: Plant Grade. CAS No. 148707-39-5. Pack Sizes: 20mg. Molecular Formula: C38H34O19, Molecular Weight: 794.671. US Biological Life Sciences. | Worldwide |
| Ege I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (HindIII-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme 70% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GGC↑GCC CCG↓CGG. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: Enterobacter gergoviae. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 50% glycerol. Cat No: ET-1103RE. |  |
| EGF816 | EGF816, also called as Nazartinib, a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M resistance mutation while sparing wild-type EGFR. in vivo: demonstrated strong tumor regressions in several EGFR activating and resistant tumor m. Synonyms: EGF816; EGF-816; EGF 816; NVS-816; NVS 816; NVS816; Nazartinib; N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamideEGF816UNII-KE7K32EME8KE7K32EME8EGF-8161508250-71-2GTPL9204SCHEMBL16767232SCHEMBL16767240EGF 816compound 47 [PMID: 27433829]. CAS No. 1508250-71-2. Molecular formula: C26H31ClN6O2. Mole weight: 495.02. | |
| EGF816 mesylate | EGF816 mesylate is the mesylate salt of EGF816 which is a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M. Synonyms: N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide; methanesulfonic acid. CAS No. 1508250-72-3. Molecular formula: C27H35ClN6O5S. Mole weight: 591.12. | |
| EGF-A Peptide | EGF-A Peptide. Synonyms: Gly-Thr-Asn-Glu-Cys-Leu-Asp-Asn-Asn-Gly-Gly-Cys-Ser-His-Val-Cys-Asn-Asp-Leu-Lys-Ile-Gly-Tyr-Glu-Cys-Leu-Cys-Pro-Asp-Gly-Phe-Gln-Leu-Val-Ala-Gln-Arg-Arg-Cys-Glu-Asp-Ile-NH2 (Disulfide bond Cys5/Cys16, Cys12/Cys25, Cys27/Cys39). Molecular formula: C188H292N58O65S6. Mole weight: 4597.00. | |
| EGF from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGF from rat | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGF human | Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| eGFP mRNA(N1-Me-Pseudo UTP) | The eGFP mRNA will express green fluorescent protein, originally isolated from the jellyfish, Aequorea victoria. The eGFP is a commonly used direct detection reporter in mammalian cell culture, yielding bright green fluorescence with an emission peak at 509 nm. Uses: Scientific research. Group: Fluorescent dye. Pack Sizes: 100 ?g (1 mg/mL * 100 ?L in Water); 500 ?g (1 mg/mL * 500 ?L in Water); 1 mg (1 mg/mL * 1 mL in Water). Product ID: HY-153079. | |
| EGF-R (1138-1147) | A peptide fragment of EGF-R. Epidermal growth factor receptor (EGFR) is a prototypic cell-surface receptor belonging to the ErbB/HER onocogene family. Targeting of EGFR with specific blocking antibodies or inhibitors have been developing for treatment for EGFR-associated tumors. Synonyms: Epidermal growth factor receptor (1138-1147). | |
| EGFR (695-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR Active human | recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EGFR active mouse | recombinant, expressed in baculovirus infected Sf9 cells. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR/CSC-IN-1 | EGFR/CSC-IN-1 is a potential dual inhibitor of EGFR and cancer stem cell (CSC) with an IC50 of 10.52 nM for EGFR. It is used to treat triple negative breast cancer. Synonyms: 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl 4-(((5-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)-4-oxobutanoate. Molecular formula: C54H54Cl2FN7O7S2. Mole weight: 1067.08. | |
| EGF Receptor (985-996) (human) | EGF Receptor (985-996) (human) exists on the cell surface and is activated by the binding of its specific ligands. EGFR belongs to the tyrosine kinase receptor (RTK) ErbB family. Synonyms: L-Glutamine, L-α-aspartyl-L-valyl-L-valyl-L-α-aspartyl-L-alanyl-L-α-aspartyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-; L-Glutamine, N2-[1-[N-[N-[N-[N-[N-[N-[N-[N-(N-L-α-aspartyl-L-valyl)-L-valyl]-L-α-aspartyl]-L-alanyl]-L-α-aspartyl]-L-α-glutamyl]-L-tyrosyl]-L-leucyl]-L-isoleucyl]-L-prolyl]-; L-α-Aspartyl-L-valyl-L-valyl-L-α-aspartyl-L-alanyl-L-α-aspartyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-L-glutamine; H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH; Epidermal Growth Factor Receptor Peptide. Grade: ≥95%. CAS No. 96249-43-3. Molecular formula: C61H93N13O23. Mole weight: 1376.46. | |
| EGF-receptor human | recombinant, expressed in CHO cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| EGF Receptor Substrate 2 Phospho-Tyr5 | EGF Receptor Substrate 2 Phospho-Tyr5 is a bioactive peptide derived from the autophosphorylation site (Tyr992) of the epidermal growth factor receptor (EGFR). Synonyms: H-Asp-Ala-Asp-Glu-pTyr-Leu-Ile-Pro-Gln-Gln-Gly-OH. Grade: ≥95%. Molecular formula: C54H82N13O24. Mole weight: 1328.28. | |
| EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 | The EGFR/ErbB-2/ErbB-4 Inhibitor, also referenced under CAS 881001-19-0, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR/ErbB-2/ErbB-4 Inhibitor II - CAS 944341-54-2 | The EGFR/ErbB-2/ErbB-4 Inhibitor II, also referenced under CAS 944341-54-2, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR/ErbB2 Inhibitor | EGFR/ErbB2 inhibitor is a cell-permeable 4-anilino quinazoline compound, which is a potent and reversible inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively). It inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC50s = 2.3-2.5 μM). Synonyms: 4557W; 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline; EGFR/ErbB-2 Inhibitor. Grade: ≥95%. CAS No. 179248-61-4. Molecular formula: C23H21N3O3. Mole weight: 387.4. | |
| EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 | The EGFR/ErbB-2 Inhibitor, also referenced under CAS 179248-61-4, controls the biological activity of EGFR/ErbB-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR-IN-1 | EGFR-IN-1 is an orally active and irreversible mutant selective EGFR inhibitor of L858R/T790M that effectively inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. It shows strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. It has antitumor activity. Synonyms: N-{3-[2-({4-[2-(Dimethylamino)ethoxy]-2-methoxyphenyl}amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl}acrylamide; 2-Propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-. Grade: ≥95%. CAS No. 1625677-63-5. Molecular formula: C28H30N6O4. Mole weight: 514.58. | |
| EGFR-IN-11 | EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM against the triple mutant EGFRL858R/T790M/C797S. It significantly inhibits EGFR phosphorylation, induces apoptosis and arrests cell cycle at G0/G1. Synonyms: 9H-Purine-2,8-diamine, 9-[(3R)-1-(cyclopropylsulfonyl)-3-pyrrolidinyl]-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-phenyl-; 9-[(3R)-1-(Cyclopropylsulfonyl)-3-pyrrolidinyl]-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-phenyl-9H-purine-2,8-diamine. Grade: ≥95%. CAS No. 2463200-44-2. Molecular formula: C29H35N9O2S. Mole weight: 573.71. | |
| EGFR-IN-11 | EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM for triple mutant EGFRL858R/T790M/C797S. EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2463200-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130616. | |
| EGFR-IN-15 | EGFR-IN-15, an EGFR inhibitor with an IC50 of 4 nM, can be used in the study of oncological disease. Synonyms: 1H,10H-4,8-Metheno-17H-pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-9-one, 14-bromo-18,19,20,21-tetrahydro-1,6,18-trimethyl-, (18R)-. CAS No. 2573869-16-4. Molecular formula: C24H25BrN6O2. Mole weight: 509.40. | |
| EGFR-IN-16 | EGFR-IN-16 is a potent inhibitor of EGFR with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively. Synonyms: Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-β-oxo-, (αE)-; (E)-2-Benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile; (2E)-2-benzoyl-3-(3,4-dihydroxyphenyl)prop-2-enenitrile; (2E)-2-Benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile. Grade: ≥95%. CAS No. 133550-22-8. Molecular formula: C16H11NO3. Mole weight: 265.26. | |
| EGFR-IN-17 | EGFR-IN-17 is a potent and selective epidermal growth factor receptor inhibitor (IC50 = 0.0002 μM) that overcomes C797S-mediated resistance. Synonyms: (2-((5-chloro-2-((2-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. Molecular formula: C27H31ClN7O3P. Mole weight: 568.01. | |
| EGFR-IN-18 | EGFR-IN-18 effectively inhibits enzymatic activity in L858R/T790M/C797S mutant EGFR, but has a significantly lower activity for wild-type EGFR. Synonyms: N-[3-[5-(2-acetamidopyridin-4-yl)-2-methylsulfanyl-1H-imidazol-4-yl]phenyl]-2-[(3-oxo-1H-isoindol-2-yl)methyl]benzamide; N-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1H-imidazol-4-yl}phenyl)-2-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzamide; TQA. Molecular formula: C33H28N6O3S. Mole weight: 588.68. | |
| EGFR-IN-1 hydrochloride | EGFR-IN-1 hydrochloride is an orally active and irreversible mutant selective EGFR inhibitor of L858R/T790M that effectively inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. It shows strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. It has antitumor activity. Synonyms: N-{3-[2-({4-[2-(Dimethylamino)ethoxy]-2-methoxyphenyl}amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl}acrylamide hydrochloride (1:1); 2-Propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 2227455-78-7. Molecular formula: C28H31ClN6O4. Mole weight: 551.04. | |
| EGFR-IN-1 TFA | EGFR-IN-1 TFA is an orally active and irreversible mutant selective EGFR inhibitor of L858R/T790M that effectively inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. It shows strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. It has antitumor activity. Synonyms: N-{3-[2-({4-[2-(Dimethylamino)ethoxy]-2-methoxyphenyl}amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl}acrylamide trifluoroacetate (1:1); Acetic acid, 2,2,2-trifluoro-, compd. with N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-2-propenamide (1:1). Grade: ≥99%. Molecular formula: C30H31F3N6O6. Mole weight: 628.60. | |
| EGFR-IN-2 | EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. It showed excellent cellular activity against both the single and double mutants of EGFR, demonstrating target engagement in vivo and ADME-PK properties that are suitable for further evaluation. CAS No. 1643497-70-4. Molecular formula: C26H33N9O3S. Mole weight: 551.66. | |
| EGFR-IN-24 | EGFR-IN-24, a potent EGFR inhibitor, shows inhibition against EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S), respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2757548-54-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-142512. | |
| EGFR-IN-47 | EGFR-IN-47 is a potent and orally active EGFR L858R/T790M/C797S inhibitor with an IC 50 of 0.01 μM. EGFR-IN-47 induces cell cycle attest and cell apoptosis. EGFR-IN-47 has the potential for the research of NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3034649-73-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143337. | |
| EGFR-IN-5 | EGFR-IN-5 is a EGFR inhibitor with IC 50 s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFR L858R , EGFR L858R/T790M , and EGFR L858R/T790M/C797S , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225887-26-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111415. | |
| EGFR-IN-5 | EGFR-IN-5 is an inhibitor of EGFR with IC50s of 10.4, 1.1, 34 and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M and EGFRL858R/T790M/C797S, respectively. Synonyms: mutant EGFR inhibitor B30; (1-(6-((5-(4-(Dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol; 4-Piperidinemethanol, 1-[6-[[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]amino]-2-[(4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-4-yl]-. Grade: ≥95%. CAS No. 2225887-26-1. Molecular formula: C31H38FN9O. Mole weight: 571.69. | |
| EGFR-IN-69 | EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC 50 values of 4.3, 6.6 and 25.6 nM against EGFR L858R/T790M/C797S , EGFR L858R/T790M , and EGFR 19del/T790M/C797S , respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2433837-65-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150610. | |
| EGFR-IN-7 | EGFR-IN-7 Inhibitor. Uses: Scientific use. Product Category: T11161. CAS No. 2267329-76-8. |  |
| EGFR-IN-7 | EGFR-IN-7 is a selective and potent EGFR kinase inhibitor. TQB3804 displays potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM, respectively. Synonyms: TQB3804. CAS No. 2267329-76-8. Molecular formula: C32H41BrN9O2P. Mole weight: 694.60. | |
| EGFR-IN-70 | EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC 50 values of 23.6 and 307.5 nM for EGFR LR/TM/CS and EGFR WT , respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2926716-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150611. | |
| EGFR-IN-78 | EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, is a reversible inhibitor of EGFR C797S -TK, and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity, inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3042104-73-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-149889. | |
| EGFR-IN-8 | EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48. EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407957-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126320. | |
| EGFR-IN-8 | EGFR-IN-8, a dual inhibitor of EGFR and c-Met, may be a promising candidate for further development to target EGFR TKI-resistant NSCLC. Synonyms: N-(3-Chloro-4-(5-(3-(3-(4-(cyclopropanecarboxamido)-3-(trifluoromethyl)phenyl)ureido)phenyl)-1,2,4-oxadiazol-3-yl)phenyl)nicotinamide; N-(3-chloro-4-{5-[3-({[4-cyclopropaneamido-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, N-[3-chloro-4-[5-[3-[[[[4-[(cyclopropylcarbonyl)amino]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]-. Grade: ≥98%. CAS No. 2407957-87-1. Molecular formula: C32H23ClF3N7O4. Mole weight: 662.02. | |
| EGFR-IN-86 | EGFR-IN-86 (compound 4i) is an EGFR inhibitor ( IC 50 : 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3055550-22-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-149530. | |
| EGFR-IN-89 | EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC 50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413029-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-156284. | |
| EGFR-IN-9 | EGFR-IN-9 is a potent inhibitor of EGFR kinase with IC50s of 7 and 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). It has antitumor activity. Synonyms: (S)-N-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)acrylamide; 2-Propenamide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]-. Grade: ≥95%. CAS No. 1226549-39-8. Molecular formula: C29H24N4O3. Mole weight: 476.53. | |
| EGFR-IN-95 | EGFR-IN-95 (compound 5j) is an 2,4-diaminonicotinamide derivative. EGFR-IN-95 has potent inhibitory activity against EGFR del19/T790M/C797S and L858R/T790M/C797S [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3027135-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-163094. | |
| EGFR Inhibitor | A cell-permeable and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nanomolar range. Inhibition of EGFR induces apoptosis of tumor cells by ownregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim. Uses: Antitumor agent. Synonyms: EGFR inhibitor; EGFR-inhibitor; EGFRinhibitor; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide; K00598a. Grade: 99%. CAS No. 879127-07-8. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| EGFR Inhibitor - CAS 879127-07-8 | The EGFR Inhibitor, also referenced under CAS 879127-07-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 | The EGFR Inhibitor II, BIBX1382, also referenced under CAS 196612-93-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR Inhibitor III - CAS 733009-42-2 | The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR kinase inhibitor 3 | EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC 50 s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922402-03-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162299. | |
| EGFR (L858R) Active human | recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| EGFR (L861Q), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| EGFR mutant-IN-1 | EGFR mutant-IN-1 is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor (IC50 = 27.5 nM), and a significantly less potent for EGFRWT (IC50 >1.0 μM). Synonyms: 6-(2-Chloro-3-fluorophenyl)-5-methyl-2-{[3-methyl-4-(4-methyl-1-piperazinyl)phenyl]amino}-8-[(3R)-1-propionyl-3-piperidinyl]pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2-chloro-3-fluorophenyl)-5-methyl-2-[[3-methyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-8-[(3R)-1-(1-oxopropyl)-3-piperidinyl]-. Molecular formula: C34H39ClFN7O2. Mole weight: 632.17. | |
| EGFR mutant-IN-2 | EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFR L858R/T790M/C797S mutant with an IC 50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFR del19/T790M/C797S mutant with an IC 50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2770009-06-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155005. | |
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