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| Product | Description | |
|---|---|---|
| ELN484228 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| ELN 484228 | ELN 484228 is an α-Synuclein blocker with activity in cellular models of α-synuclein-mediated dysfunction such as Parkinson's Disease. Study showed that ELN484228 reduced synaptic levels of αSyn in neuronal cultures from both wild type rats and from transgenic mice overexpressing αSyn by not more than two-fold. Synonyms: ELN484228; ELN-484228; ELN 484228. N-(4-Fluorophenyl)benzenesulfonamide. Grade: 99%. CAS No. 312-63-0. Molecular formula: C12H10FNO2S. Mole weight: 251.28. |  |
| ELND006 | ELND006 is one of the newest molecules to be reported on regarding the testing of the β-amyloid hypothesis. ELND006 is a novel oral γ-secretase inhibitor. At the 2010 Alzheimer's Association International Conference on Alzheimer's Disease in which ELND006 was reported to have an in vitro IC50 = 0.34 nM against APP and IC50 = 5.3 nM versus Notch signaling. Synonyms: ELND006; ELND-006; ELND 006. (4R)-4-cyclopropyl-7,8-difluoro-5-[4-(trifluoromethyl)phenyl]sulfonyl-1,4-dihydropyrazolo[4,3-c]quinoline; UNII-7F5QGV49GL; ELND006; ELND-006; 959997-22-9; (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo(4,3-c)quinoline; (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline; 7F5QGV49GL; SCHEMBL486044; GTPL7337; CHEMBL2396778. CAS No. 1333990-84-3. Molecular formula: C20H14F5N3O2S. Mole weight: 455.07. | |
| ELND006 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ELND007 | ELND007 is a γ-secretase inhibitor. Synonyms: ELND007; ELND-007; ELND 007. (R)-4-cyclopropyl-8-fluoro-5-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline; ELND007; ELND-007; ELND 007. CAS No. 1444006-79-4. Molecular formula: C19H14F4N4O2S. Mole weight: 438.08. | |
| Elobixibat | Elobixibat is a potent and selective IBAT inhibitor under development for the treatment of chronic constipation and irritable bowel syndrome with constipation. Uses: Sodium-bile acid cotransporter-inhibitor. Synonyms: AZD-7806; AZD 7806; AZD7806; A 3309; A3309; A-3309; AJG-533; (2R)-N-[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycylglycine. Grade: ≥95%. CAS No. 439087-18-0. Molecular formula: C36H45N3O7S2. Mole weight: 695.89. | |
| Elobixibat | Elobixibat (A 3309; AZD 7806) is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor, with an IC 50 value of 0.53 nM (human IBAT ), 0.13 nM (mouse IBAT), 5.8 nM (canine IBAT). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A 3309; AZD 7806. CAS No. 439087-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15790. |  |
| Elobixibat hydrate | Elobixibat hydrate is a potent ileal bile acid transporter (IBAT) inhibitor, with IC 50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT. Elobixibat hydrate can be used for chronic idiopathic constipation (CIC) research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A 3309 hydrate; AZD 7806 hydrate. CAS No. 1633824-78-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15790A. | |
| Elocalcitol | BXL 628 is a vitamin D3 analogue that competes with vitamin D receptor (VDR) for inhibition of prostate cell growth and RhoA/Rho-kinase signaling, a calcium sensitizing pathway. BXL 628 exhibits anti-proliferative and anti-inflammatory properties in benign prostatic hyperplasia (BPH) treatment. Uses: Potential treatment of benign prostatic hyperplasia (bph). Synonyms: BXL 628; BXL-628; Ro-26-9228; 1alpha-Fluoro-25-hydroxy-16,23E-diene-26,27-bishomo-20-epi-cholecalciferol. Grade: 99%. CAS No. 199798-84-0. Molecular formula: C29H43FO2. Mole weight: 442.65. | |
| Elomotecan | Elomotecan (BN-80927) belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilization, thus indicating catalytic inhibition. Moreover, a Topo I-altered cell line (KBSTP2), resistant to SN38, remains sensitive to BN80927, suggesting that a part of the antiproliferative effects of BN80927 are mediated by a Topo I-independent pathway. This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G(0)-G(1) synchronized). In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC(50) values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate | |
| Elomotecan HCl salt | Elomotecan, also referred to BN 80927 and R 1559, characterized by a stable seven-membered beta-hydroxylactone ring, is a DNA topoisomerase inhibitor. In vivo elomotecan shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Synonyms: 220997-99-9; 220998-10-7 (Elomotecan free base); (5R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methylpiperidin-1-yl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione hydrochloride (1:1). Grade: >98%. CAS No. 220997-99-9. Molecular formula: C29H33Cl2N3O4. Mole weight: 558.5. | |
| elongation factor 2 kinase | Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+. Group: Enzymes. Synonyms: Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Enzyme Commission Number: EC 2.7.11.20. CAS No. 116283-83-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3140; elongation factor 2 kinase; EC 2.7.11.20; 116283-83-1; Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Cat No: EXWM-3140. |  |
| Eloralintide | Eloralintide (LY 3841136) is an AMYR agonist, which is promising for research of type 2 diabetes and obesity[1]. Uses: Scientific research. Group: Peptides. Alternative Names: LY-3841136. CAS No. 2883634-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10798. | |
| Elotuzumab | Elotuzumab is a monoclonal antibody used in the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. It targets the SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7) protein found on the surface of myeloma cells and natural killer cells. Elotuzumab is typically used in combination with other drugs, such as lenalidomide and dexamethasone, to increase its effectiveness. It is administered via intravenous infusion and is used in patients who have received prior therapies for multiple myeloma. Synonyms: Elotuzumab (anti-SLAMF7); Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse HuLuc63 κ-chain, dimer; BMS 901608; Empliciti; HuLuc 63; PDL 063. CAS No. 915296-00-3. | |
| Elotuzumab | Elotuzumab is a monoclonal antibody directed against the SLAMF7 receptor. Elotuzumab has no significant antimyeloma activity when given as a single agent with relapsed or refractory multiple myeloma (RRMM). Elotuzumab results in improved response and outcome when combined with other antimyeloma agents [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HuLuc 63; PDL 063; BMS 901608. CAS No. 915296-00-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9965. | |
| ELOVL1-IN-1 | ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2227482-41-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145122. | |
| ELOVL1-IN-2 | ELOVL1-IN-2 is an inhibitor of ELOVL1 (elongation of very-long-chain-fatty acid 1). CAS No. 2761063-79-8. Molecular formula: C18H15FN2O. Mole weight: 294.3. | |
| ELOVL1-IN-3 | ELOVL1-IN-3 (Compound 22) is a potent and orally active inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. ELOVL1-IN-3 serves as a useful tool for researching adrenoleukodystrophy (ALD)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2761063-99-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145272. | |
| ELOVL6-IN-2 | ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1067647-43-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12146. | |
| ELOVL6-IN-4 | ELOVL6-IN-4 is a potent, selective, and orally active long chain fatty acid elongase 6 (ELOVL6) inhibitor with IC50s of 79 nM and 94 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-4 shows excellent selectivity over the other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1170321-92-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152947. | |
| Elpetrigine | Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders and epilepsy. Synonyms: 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine; GW273293; GW-273293; GW 273293; JZP-4; JZP 4; JZP4; Elpetrigine. Grade: >98%. CAS No. 212778-82-0. Molecular formula: C10H7Cl3N4. Mole weight: 289.54. | |
| Elphodex Acidic Kit | Elphodex Acidic Kit. Group: Polysaccharide. |  |
| Elphodextrin Starter Kit | Elphodextrin Starter Kit. Group: Polysaccharide. | |
| ELQ-300 | ELQ-300 is a potent and orally bioavailable antimalarial agent, and it is a novel inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (complex III in the electron transport chain). Synonyms: ELQ300; ELQ 300; 6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one. Grade: ≥98%. CAS No. 1354745-52-0. Molecular formula: C24H17ClF3NO4. Mole weight: 475.84. | |
| ELQ-422 | ELQ-422 acts as an inhibitor of the cytochrome bc1 complex in the mitochondrial electron transport chain, thereby inhibiting oxidative phosphorylation. Synonyms: Endochin-like quinolone-422; Ethyl (((6-fluoro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)oxy)methyl) carbonate. Molecular formula: C28H23F4NO7. Mole weight: 561.49. | |
| ELR510444 | ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR510444 potently inhibited cell proliferation with an IC(50) value of 30.9 nM in MDA-MB-231 cells, inhibited the rate and extent of purified tubulin assembly, and displaced colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site. ELR510444 is not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines, suggesting that it circumvents both clinically relevant mechanisms of drug resistance to this class of agents. ELR510444 also shows potent antitumor activity in the MDA-MB-231 xenograft model with at least a 2-fold therapeutic window. Synonyms: ELR510444; ELR-510444; ELR 510444. Grade: >98%. CAS No. 1233948-35-0. Molecular formula: C19H16N2O2S2. Mole weight: 368.47. | |
| Elranatamab | Elranatamab (PF-06863135) is an anti- CD3E/TNFRSF17 human IgG2κ monoclonal antibody [1]. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PF-06863135. CAS No. 2408850-14-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99909. | |
| Elranatamab | Elranatamab is a humanized bispecific IgG2 antibody targeting B cell maturation antigen on myeloma cells and CD3 on T cells. Elranatamab activates and directs T cells to induce a selective cytotoxic T cell response against myeloma cells. Synonyms: PF-06863135; PF 06863135; PF06863135. Grade: 95%. CAS No. 2408850-14-4. Molecular formula: C6440H9958N1738O2010S49. Mole weight: 145.5 kDa. | |
| Elsamicin B | Elsamicin B is produced by the strain of Actinomycetes J904-21. It is an antitumor antibiotic in the Chartreusin group. Aminoglycogen-deficient Elsamicin B shows only minimal antitumor activity. Synonyms: 10-[(3-C-Methyl-6-deoxy-β-D-galactopyranosyl)oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione; Benzo(h)(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,12-dione, 10-((6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl-; 6-Hydroxy-1-methyl-5,12-dioxo-5,12-dihydrobenzo[g][2]benzopyrano[5,4,3-cde][2]benzopyran-10-yl 6-deoxy-3-C-methylhexopyranoside. CAS No. 97068-31-0. Molecular formula: C26H22O10. Mole weight: 494.45. | |
| Elsamitrucin | Elsamitrucin is produced by the strain of Actinomycetes J904-21. It has strong anti-tumor activity of mouse tumor cells such as leukemia P388, L1210 and melanoma B16, and its anti-tumor activity is 10-30 times stronger than Chartreusin. Uses: Antibiotics, antineoplastic. Synonyms: Elsamicin A. Grade: >95%. CAS No. 97068-30-9. Molecular formula: C33H35NO13. Mole weight: 653.63. | |
| Elsibucol | Elsibucol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ELSIBUCOL. Product Category: Heterocyclic Organic Compound. CAS No. 216167-95-2. Molecular formula: C35H54O4S2. Mole weight: 602.94. Product ID: ACM216167952. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Elsibucol | Elsibucol, a metabolically stable derivative of probucol, inhibits atherosclerosis and preserves endothelial healing following arterial injury. In vitro, elsibucol reduces vascular smooth muscle cell proliferation without affecting cell viability. Synonyms: 4-[2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenoxy]butanoic acid; (4,2,6-di-tert-butyl-4-(1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl)-phenoxy-butyric acid); Elsibucol; AGI 1096; AGI1096; AGI-1096; Elsibucol; UNII-O7T92N1Y8T.elsibucol. Grade: >98%. CAS No. 216167-95-2. Molecular formula: C35H54O4S2. Mole weight: 602.94. | |
| Elsilimomab | Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6) , with a K D of 22 pM and an IC 50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA) [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: B-E8; Anti-IL-6 MAB B-E8; Anti-Human IL6 Recombinant Antibody. CAS No. 468715-71-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99287. | |
| Elsinochrome A | It is produced by the strain of Elsinoe annonae, Sphaceloma randii. It's the same as Hypericin, it has photodynamic activity and inhibits protein kinase C activity. Synonyms: (1r,2r)-1,2-diacetyl-4,11-dihydroxy-3,7,8,12-tetramethoxy-1,2-dihydrobenzo[ghi]perylene-5,10-dione; 1alpha,2beta-Diacetyl-1,2-dihydro-5,10-dihydroxy-3,7,8,12-tetramethoxybenzo[ghi]perylene-4,11-dione; Benzo(ghi)perylene-4,11-dione, 1,2-diacetyl-1,2-dihydro-5,10-dihydroxy-3,7,8,12-tetramethoxy-, trans-. Grade: ≥98%. CAS No. 24568-67-0. Molecular formula: C30H24O10. Mole weight: 544.51. | |
| Elsinochrome B | It is produced by the strain of Elsinoe annonae, Sphaceloma randii. It's the same as Hypericin, it has photodynamic activity and inhibits protein kinase C activity. Synonyms: 1-Acetyl-5,10-dihydroxy-2-(1-hydroxyethyl)-3,7,8,12-tetramethoxy-1,2-dihydrobenzo[ghi]perylene-4,11-dione. Grade: ≥98%. CAS No. 24512-58-1. Molecular formula: C30H26O10. Mole weight: 546.52. | |
| Elsinochrome C | It is produced by the strain of Elsinoe annonae, Sphaceloma randii. It's the same as Hypericin, it has photodynamic activity and inhibits protein kinase C activity. Synonyms: 5,10-Dihydroxy-1,2-bis(1-hydroxyethyl)-3,7,8,12-tetramethoxy-1,2-dihydrobenzo[ghi]perylene-4,11-dione; Benzo[ghi]perylene-4,11-dione,1,2-dihydro-5,10-dihydroxy-1,2-bis(1-hydroxyethyl)-3,7,8,12-tetramethoxy-. Grade: ≥98%. CAS No. 24512-87-6. Molecular formula: C30H28O10. Mole weight: 548.54. | |
| Elsinochrome D | It is produced by the strain of Elsinoe annonae, Sphaceloma randii. It's the same as Hypericin, it has photodynamic activity and inhibits protein kinase C activity. Synonyms: 12,13-Dihydro-2-hydroxy-12,13-bis(1-hydroxyethyl)-1,5,6-trimethoxybenzo[1,12]perylo[2,3-d][1,3]dioxole-3,8-dione. Grade: ≥98%. CAS No. 32500-05-3. Molecular formula: C30H26O10. Mole weight: 546.52. | |
| Elsulfavirine | Elsulfavirine is a reverse transcriptase inhibitors for HIV-1 infection and is a new anti-HIV agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-1206. CAS No. 868046-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109056. | |
| Elsulfavirine | Elsulfavirine is a new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) being developed by Viriom for the treatment and prevention of human immunodeficiency virus (HIV) infections. It is the prodrug of the active compound VM-1500A, a small molecule selective NNRTI, which prevents HIV replication. In June 2017, elsulfavirine received its first global approval in Russia for the treatment of HIV-1 infections in combination with other antiretroviral medicines. Other formulations of this drug are also being evaluated in preclinical and phase II studies for the treatment of HIV infections and/or pre-exposure and post-exposure prophylaxis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Elsulfavirine; Elpida. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 868046-19-9. Molecular formula: C24H17BrCl2FN3O5S. Mole weight: 629.28. Purity: >98%. IUPACName: N-(4-{2-[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetamido}-3-chlorobenzenesulfonyl)propanamide. Canonical SMILES: CCC(NS(=O)(C1=CC=C(NC(CC2=CC=C(Br)C(OC3=CC(C#N)=CC(Cl)=C3)=C2F)=O)C(Cl)=C1)=O)=O. Product ID: ACM868046199. Alfa Chemistry ISO 9001:2015 Certified. | |
| Elsulfavirine | Elsulfavirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment and prevention of human immunodeficiency virus (HIV) infection. Uses: Anti-hiv agents. Synonyms: Elpida; Benzeneacetamide, 4-bromo-3-(3-chloro-5-cyanophenoxy)-N-[2-chloro-4-[[(1-oxopropyl)amino]sulfonyl]phenyl]-2-fluoro-; 4-Bromo-3-(3-chloro-5-cyanophenoxy)-N-[2-chloro-4-[[(1-oxopropyl)amino]sulfonyl]phenyl]-2-fluorobenzeneacetamide. Grade: ≥95%. CAS No. 868046-19-9. Molecular formula: C24H17BrCl2FN3O5S. Mole weight: 629.28. | |
| Eltanexor | Eltanexor (KPT-8602) is an investigational second-generation SINE compound. Eltanexor acts as an orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20-211?nM in 10 AML lines after 3 days exposure. Synonyms: KPT-8602; ONO-7706; ATG-016. Grade: ≥98%. CAS No. 1642300-52-4. Molecular formula: C17H10F6N6O. Mole weight: 428.29. | |
| Eltanexor | Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export ( EC 50 =60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KPT-8602. CAS No. 1642300-52-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100423. | |
| ElteN378 | ElteN378 can inhibit FKBP12e. It can be used in the study of Alzheimer disease, Parkinson disease, Amyotrophic Lateral Sclerosis, proliferation disorders and cancer. Synonyms: (S)-1-(2-oxo-2-phenylacetyl)-N-(3-phenylpropyl)piperidine-2-carboxamide. Grade: 98%. CAS No. 1421366-99-5. Molecular formula: C23H26N2O3. Mole weight: 378.472. | |
| Eltenac | A nonsteroidal anti-inflammatory drug. Group: Biochemicals. Alternative Names: 4-[(2,6-Dichlorophenyl)amino]-3-thiopheneacetic Acid; 4-(2,6-Dichloroanilino)-3-thiopheneacetic Acid; Telzenac; [4- (2, 6-Dichlorophenylamino) thiophen-3-yl]acetic Acid. Grades: Highly Purified. CAS No. 72895-88-6. Pack Sizes: 2.5mg. US Biological Life Sciences. |  Worldwide |
| Eltenac-13C,d3 | Labeled Eltenac. A nonsteroidal anti-inflammatory drug. Group: Biochemicals. Alternative Names: 4-[(2,6-Dichlorophenyl)amino]-3-thiopheneacetic Acid-13C,d3; 4-(2,6-Dichloroanilino)-3-thiopheneacetic Acid-13C,d3; Telzenac-13C,d3; [4- (2, 6-Dichlorophenylamino) thiophen-3-yl]acetic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Eltoprazine | Eltoprazine belongs the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It is closely related to fluprazine and batoprazine, which are similarly acting drugs. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It was found to (synergistically) potentiate the antidyskinetic effect of amantadine. It has been shown to reduce 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-; 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine; DU-28853; DU28853. Grade: >98 %. CAS No. 98224-03-4. Molecular formula: C12H16N2O2. Mole weight: 220.27. | |
| Eltoprazine hydrochloride | Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine hydrochloride has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride; 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride; DU-28853 hydrochloride; DU28853 hydrochloride. Grade: >98 %. CAS No. 98206-09-8. Molecular formula: C12H17N2O2Cl. Mole weight: 256.73. | |
| Eltoprazine hydrochloride | Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DU 28853 hydrochloride. CAS No. 98206-09-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16687A. | |
| Eltoprazine hydrochloride | Eltoprazine hydrochloride. Group: Biochemicals. Alternative Names: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride; DU 28853; DU 28893. Grades: Highly Purified. CAS No. 98206-09-8. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C12H17ClN2O2. US Biological Life Sciences. | Worldwide |
| Eltrombopag | Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-497115. CAS No. 496775-61-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15306. | |
| Eltrombopag | Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). Uses: Nonpeptide thrombopoietin receptor agonist. Synonyms: SB-497115-GR, SB497115. Grade: >98%. CAS No. 496775-61-2. Molecular formula: C25H22N4O4. Mole weight: 442.47. | |
| Eltrombopag | Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Eltrombopag;3-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2-hydroxy-[1,1-biphenyl]-3-carboxylic acid;(1,1-Biphenyl)-3-carboxylic acid, 3-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene)hydrazino)-2-hydroxy-;Eltrombopag [inn];Promacta;Sb497115;Sb-497115;Unii-S56D65xj9g. Product Category: Inhibitors. Appearance: Solid. CAS No. 496775-61-2. Molecular formula: C25H22N4O4. Mole weight: 442.47. Purity: 0.9973. Canonical SMILES: O=C(C1=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O. Density: 1.33. Product ID: ACM496775612. Alfa Chemistry ISO 9001:2015 Certified. | |
| Eltrombopag | An agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia. Group: Biochemicals. Alternative Names: 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid; SB 497115. Grades: Highly Purified. CAS No. 496775-61-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Eltrombopag-13C4 | Eltrombopag- 13 C 4 (SB-497115- 13 C 4 ) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus ( Staphylococcus aureus ) and can induce apoptosis ( apoptosis ) in liver cancer cells [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: SB-497115- 13 C4. CAS No. 1217230-31-3. Pack Sizes: 1 mg. Product ID: HY-15306S. | |
| Eltrombopag-[13C4] | Eltrombopag-[13C4] is used as an internal standard for the quantification of eltrombopag by GC or LC-MS. Eltrombopag-[13C4] is the labelled analogue of Eltrombopag. Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor which is used as treatment for thrombocytopenia. Synonyms: [13C4]-Eltrombopag; Eltrombopag-13C4; CTK8F9430; (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-(methyl-13C)-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene-3,4,5-13C3)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid; SB 497115-13C4. Grade: > 95% by HPLC; > 98% atom 13C. CAS No. 1217230-31-3. Molecular formula: C21[13C]4H22N4O4. Mole weight: 446.44. | |
| Eltrombopag acyl-β-D-glucuronide | Eltrombopag acyl-β-D-glucuronide. Synonyms: 1-[3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy[1,1'-biphenyl]-3-carboxylate] β-D-glucopyranuronic acid. Molecular formula: C31H30N4O10. Mole weight: 618.59. | |
| Eltrombopag Acyl Glucuronide | Eltrombopag Acyl Glucuronide. Synonyms: Eltrombopag metabolite M2. CAS No. 1396009-05-4. Molecular formula: C31H30N4O10. Mole weight: 618.6. | |
| Eltrombopag Amide | Eltrombopag Amide is a metabolite of Eltrombopag. Synonyms: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxamide. Grade: > 95%. CAS No. 1246929-02-1. Molecular formula: C25H23N5O3. Mole weight: 441.48. | |
| Eltrombopag Amide | Eltrombopag Amide. Group: Biochemicals. Alternative Names: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C25H23N5O3, Molecular Weight: 441.48. US Biological Life Sciences. | Worldwide |
| Eltrombopag Ethyl Ester | Eltrombopag Ethyl Ester. Group: Biochemicals. Alternative Names: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C27H26N4O4, Molecular Weight: 470.52. US Biological Life Sciences. | Worldwide |
| Eltrombopag Glucuronide | Eltrombopag Glucuronide. Group: Biochemicals. Alternative Names: 1-[3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene-3-14C]hydrazinyl]-2'-hydroxy[1,1'-biphenyl]-3-carboxylate]- β-D-glucopyranuronic Acid. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C31H30N4O10, Molecular Weight: 618.59. US Biological Life Sciences. | Worldwide |
| Eltrombopag Impurity 5 | Eltrombopag Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxamide. CAS No. 1246929-02-1. Molecular formula: C25H23N5O3. Mole weight: 441.48. Catalog: APB1246929021. | |
| Eltrombopag Impurity 58 | Eltrombopag Impurity 58. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-methyl 3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate. CAS No. 1246929-01-0. Molecular formula: C26H24N4O4. Mole weight: 456.49. Catalog: APB1246929010. | |
| Eltrombopag Methyl Ester | Eltrombopag Methyl Ester. Group: Biochemicals. Alternative Names: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 1246929-01-0. Pack Sizes: 5mg. Molecular Formula: C26H24N4O4, Molecular Weight: 456.49. US Biological Life Sciences. | Worldwide |
| Eltrombopag Methyl Ester | Eltrombopag Methyl Ester is a metabolite of Eltrombopag. Synonyms: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic Acid Methyl Ester. Grade: > 95%. CAS No. 1246929-01-0. Molecular formula: C26H24N4O4. Mole weight: 456.49. | |
| Eltrombopag Olamine | Eltrombopag is a is an agonist of the c-mpl (TpoR) receptor used as treatment for thrombocytopenia.It has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts). Uses: C-mpl agonist. Synonyms: SB-497115-GR; 2-mainoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate). Grade: ≥98%. CAS No. 496775-62-3. Molecular formula: C29H36N6O6. Mole weight: 564.64. | |
| Eltrombopag Olamine | Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag Olamine can be used for the research of cardiovascular. Eltrombopag Olamine also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Eltrombopag diethanolamine salt; SB-497115GR. CAS No. 496775-62-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15306A. | |
| Elubrixin | Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist. It is potentially useful for Inflammatory bowel disease therapies. It inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. It may be an effective agent in neutrophil-predominant diseases. It was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated. Uses: Elubrixin is potentially useful for inflammatory bowel disease therapies. it may be an effective agent in neutrophil-predominant diseases. Synonyms: 1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea; SB-656933; SB656933; SB-656933-AAF; SB-656933-AAA; SB656933AAA; SB656933AAF; 1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea. Grade: 98%. CAS No. 688763-64-6. Molecular formula: C17H17Cl2FN4O4S. Mole weight: 463.30. | |
| Elubrixin tosylate | Elubrixin tosylate, a potent, selective, competitive, reversible and orally active antagonist of CXCR2 and IL-8 receptor, inhibits neutrophil CD11b upregulation (IC50 = 260.7 nM) and shape change (IC50 = 310.5 nM). It has potential in the study of inflammatory diseases, such as inflammatory bowel disease and airway inflammation. Synonyms: SB-656933 tosylate; N-[4-Chloro-2-hydroxy-3-[(piperazin-1-yl)sulfonyl]phenyl]-N'-(2-chloro-3-fluorophenyl)urea p-toluenesulfonate; 1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(1-piperazinylsulfonyl)phenyl]urea 4-methylbenzenesulfonate (1:1); Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-(1-piperazinylsulfonyl)phenyl]-, 4-methylbenzenesulfonate (1:1). Grade: ≥95%. CAS No. 960495-43-6. Molecular formula: C24H25Cl2FN4O7S2. Mole weight: 635.51. | |
| Elubrixin tosylate | Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation ( IC 50 of 260.7 nM) and shape change ( IC 50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-656933 tosylate. CAS No. 960495-43-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18263C. | |
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