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| Product | Description | |
|---|---|---|
| EL-HSE High Stability Electrolyte | EL-HSE High Stability Electrolyte. Uses: El-hse high stability electrolyte is a low toxicity liquid electrolyte to achieve ultra-long life in normal operating conditions. this is the "work horse" electrolyte system for long term stability testing. particularly suitable for glass or metal/glass substrate-based dsc systems.outstanding stability has been achieved with el-hse, 25,600 hours of continuous light soaking at 55-60°c and 3,000 hours at 85°c. Group: Organic solar cell (opv) materials. Alternative Names: EL-HSE electrolyte,EL-HSE. Pack Sizes: 10, 50 mL in glass bottle. |  |
| EL-HTE High Temperature Electrolyte | EL-HTE High Temperature Electrolyte. Group: Organic solar cell (opv) materials. | |
| Eliapixant | Eliapixant is a P2X3 receptor antagonist, which is under a clinical trial for refractory chronic cough (RCC) treatment. Synonyms: BAY 1817080. CAS No. 1948229-21-7. Molecular formula: C22H21F3N4O3S. Mole weight: 478.49. |  |
| Eliapixant | Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor , with an IC 50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1817080. CAS No. 1948229-21-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109170. |  |
| Eliglustat | Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC 50 of 24 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Genz 99067. CAS No. 491833-29-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14885. | |
| Eliglustat | Eliglustat is a glucosylceramide synthase inhibitor indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabolizers, intermediate metabolizers , or poor metabolizers in treatment-naive and treatment-experi. Uses: Inhibits glucosylceramide synthase(gcs). Synonyms: Genz-99067; Genz 99067; Genz99067; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide. Grade: ≥98%. CAS No. 491833-29-5. Molecular formula: C23H36N2O4. Mole weight: 404.55. | |
| Eliglustat hemitartrate | Eliglustat hemitartrate is a specific inhibitor of glucosylceramide synthase. It is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1). It was developed by Genzyme Corp and has been listed by the FDA August 2014. Synonyms: Genz-112638; Genz 112638; Genz112638; Eliglustat tartrate; Bis(N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(pyrrolidin-1- ylmethyl)ethyl)octanamide) (2R,3R)-2,3-dihydroxybutanedioate; Octanamide, N-((1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1- pyrrolidinylmethyl)ethyl)-, (2R,3R)-2,3-dihydroxybutanedioate; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide (2R,3R)-2,3-dihydroxybutanedioic acid. Grade: >98%. CAS No. 928659-70-5. Molecular formula: C50H78N4O14. Mole weight: 959.17. | |
| Eliglustat hemitartrate | Eliglustat hemitartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Genz-112638; Eliglustat tartrate. CAS No. 928659-70-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-14885A. | |
| Eliglustat Impurity 5 | Eliglustat Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-((1S,2S)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide. CAS No. 1092472-70-2. Molecular formula: C23H36N2O4. Mole weight: 404.54. Catalog: APB1092472702. |  |
| Eliglustat Impurity 6 | Eliglustat Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-((1S,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide. CAS No. 1092472-66-6. Molecular formula: C23H36N2O4. Mole weight: 404.54. Catalog: APB1092472666. | |
| Elimusertib | Elimusertib (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib has anti-tumor activity [1] [2]. Elimusertib can be used for the research of solid tumors and lymphomas [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1895344. CAS No. 1876467-74-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101566. | |
| Elimusertib free base | Elimusertib, also known as BAY-1895344, is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Elimusertib, free base; BAY-1895344; BAY 1895344; BAY1895344. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1876467-74-1. Molecular formula: C20H21N7O. Mole weight: 375.44. Purity: >98%. IUPACName: (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. Canonical SMILES: CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24. Product ID: ACM1876467741. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Elimusertib hydrochloride | Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity[1][2]. Elimusertib hydrochloride can be used for the research of solid tumors and lymphomas[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1895344 hydrochloride. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101566A. | |
| Elinafide | Elinafide, an isoquinoline derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in anticancer studies. Synonyms: Elinafide; UNII-HL580335SI; Elinafide [INN]; 2-[2-[3-[2-(1,3-dioxobenzo[de]isoquinolin-2-yl)ethylamino]propylamino]ethyl]benzo[de]isoquinoline-1,3-dione; LU-79553. Grade: 98%. CAS No. 162706-37-8. Molecular formula: C31H28N4O4. Mole weight: 520.59. | |
| Elinogrel | Elinogrel is a P2Y12 antagonist displaying antiplatelet activity. Synonyms: 5-Chloro-N-[[[4-[6-Fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide. Grade: ≥98% by HPLC. CAS No. 936500-94-6. Molecular formula: C20H15ClFN5O5S2. Mole weight: 523.95. | |
| Elinogrel | Elinogrel. Group: Biochemicals. Grades: Purified. CAS No. 936500-94-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Elinogrel | Elinogrel, also known as PRT 060128, is P2Y12 inhibitor. Similarly to ticagrelor and in contrast to clopidogrel, elinogrel was a reversible inhibitor that acted fast and short (for about 12 hours), and it was not a prodrug but pharmacologically active itself. The substance was used in form of its potassium salt, intravenously for acute treatment and orally for long-term treatment. Development was terminated in 2012. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PRT 060128; PRT-060128; PRT060128; Elinogrel. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 936500-94-6. Molecular formula: C20H15ClFN5O5S2. Mole weight: 523.94. Purity: >98%. IUPACName: 5-chloro-N-((4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)carbamoyl)thiophene-2-sulfonamide. Canonical SMILES: O=C(NC1=CC=C(N2C(NC3=C(C=C(F)C(NC)=C3)C2=O)=O)C=C1)NS(=O)(C4=CC=C(Cl)S4)=O. Product ID: ACM936500946-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Elinogrel | Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y 12 antagonist ( IC 50 =20 nM). It is orally and intravenously available and has potent antiplatelet effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRT060128. CAS No. 936500-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11021. | |
| Elintaal | Elintaal (Acetaldehyde Ethyl Linalyl Acetal). CAS No. 40910-49-4. VIGON Item # 503213. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| Elinzanetant | Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NT-814; BAY3427080. CAS No. 929046-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109171. | |
| Elinzanetant | Elinzanetant is a neurokinin receptors antagonist that may help reduce the frequency and severity of hot flushes during menopause. Elinzanetant reduces Estradiol and Progesterone in Healthy Women. Synonyms: BAY 3427080; BAY-3427080; BAY3427080; NT 814; NT-814; NT814; GSK1144814A; GSK-1144814A; GSK 1144814A. Grade: 98%. CAS No. 929046-33-3. Molecular formula: C33H35F7N4O3. Mole weight: 668.66. | |
| Elipovimab | Elipovimab is a potent broadly neutralizing HIV-1 antibody for the targeted elimination of HIV-infected cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2101210-43-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99937. | |
| Eliprodil | Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: SL-820715. CAS No. 119431-25-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12881. | |
| Eliprodil | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| Eliprodil | Eliprodil. Group: Biochemicals. Grades: Purified. CAS No. 119431-25-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Eliprodil | Eliprodil, a NR2B-NMDA receptor antagonist, was found to have neuroprotective activity in study of ischemia. Uses: Eliprodil is a nr2b-nmda receptor antagonist that was found to have neuroprotective activity in study of ischemia. Synonyms: -(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, SL-82,0715; SL82,0715; SL 82,0715; SL-820715; SL820715; SL 820715; Eliprodil. Grade: 95%. CAS No. 119431-25-3. Molecular formula: C20H23ClFNO. Mole weight: 347.85. | |
| Eliprodil (alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX) | A negative allosteric modulator selective for NR2B containingnMDA receptors (IC50 = 1, >100, and >100uM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for alpha1 receptor (Ki = 0.013uM), one of the two types of unique non-opioid, non-phencyclidine brain alpha receptors. Blocks neuronal voltage-gated Ca2+. Group: Biochemicals. Grades: Highly Purified. CAS No. 119431-25-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Elironrasib | Elironrasib is an orally active and covalent inhibitor of KRASG12C(ON). Elironrasib forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Thus, Elironrasib prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. Elironrasib inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. Elironrasib also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMC-6291. CAS No. 2641998-63-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153346. | |
| elisabethatriene synthase | Requires Mg2+ or less efficiently Mn2+. The enzyme is also able to use farnesyl diphosphate and geranyl diphosphate. Group: Enzymes. Synonyms: elisabethatriene cyclase. Enzyme Commission Number: EC 4.2.3.41. CAS No. 334022-59-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5200; elisabethatriene synthase; EC 4.2.3.41; 334022-59-2; elisabethatriene cyclase. Cat No: EXWM-5200. |  |
| Elisartan | Elisartan, also known as HN-65021, is an orally active non-peptide prodrug of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, 1-((ethoxycarbonyl)oxy)ethyl ester; HN 65021; HN-65021. CAS No. 149968-26-3. Molecular formula: C27H29ClN6O5. Mole weight: 553.01. | |
| Elisidepsin | Elisidepsin is a marine-derived, synthetic cyclic depsipeptide with potential antineoplastic activity. Elisidepsin is a derivative of a natural marine compound that belongs to a family of dehydro aminobutyric acid-containing peptides (kahalalides) isolated from the herbivorous marine mollusk Elysia rufescens. Although the primary mechanism of action has yet to be elucidated, this agent exhibits anti-proliferative activity in a wide variety of cancer cell types, including breast, colon, pancreas, lung, and prostate; it appears to induce oncolytic rather than apoptotic cell death. Synonyms: PM-02734; N-[(4S)-4-methylhexanoyl]-D-valyl-L-threonyl-L-valyl-D-valyl-D-prolyl-L-ornithyl-N-{(3S,6Z,9S,12R,15R,18R,19R)-9-benzyl-15-[(2S)-butan-2-yl]-6-ethylidene-3,12-diisopropyl-19-methyl-2,5,8,11,14,17-hexaoxo-1-oxa-4,7,10,13,16-pentaazacyclononadecan-18-yl}-D-alloisoleucinamide. CAS No. 681272-30-0. Molecular formula: C75H124N14O16. Mole weight: 1477.90. | |
| Elizabethin | It is produced by the strain of Streptomyces elizabethii. It has antifungal activity. CAS No. 78361-81-6. Molecular formula: C35H58O12. Mole weight: 670.83. | |
| ELK1, GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Ellagicacid | Ellagicacid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone. Product Category: Material of cosmetics. Appearance: Yellow-brown fluid fine powder. CAS No. 476-66-4. Molecular formula: C14H6O8. Mole weight: 302.19. Product ID: ACM476664. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ellagic acid. | |
| Ellagic acid | Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have prompted research into its potential health benefits. It has been fraudulently marketed as having the ability to prevent and treat a number of human maladies, including cancer, but such claims have not been proven. Ellagic acid can be used in cosmetics material. Uses: Anti-proliferative; anti-oxidant. Synonyms: Elagostasine, Gallogen; Alizarine Yellow; Benzoaric acid; CCRIS 774; CCRIS774; CCRIS-774; HSDB 7574; HSDB7574; HSDB-7574; Lagistase. Grade: >98%. CAS No. 476-66-4. Molecular formula: C14H6O8. Mole weight: 302.19. | |
| Ellagic acid | Ellagic acid - Product ID: NST-10-60. Category: Polyphenols. Alternative Names: Benzoaric acid ; 4,4',5,5',6,6'-Hexahydroxydiphenic acid. Purity: 98%. Test method: HPLC. CAS No. 476-66-4. Pack Sizes: 50g, 100g, 250g, 500g. Appearance: Grey to brown Powder. Molecular formula: C14H6O8. Mole weight: 302.2. Storage: +2 +8 °C. |  |
| Ellagic acid | Natural Compounds; Herbal Medicinal Products Standards; Fluorescence/Luminescence Spectroscopy. Uses: For analytical and research use. Group: Reagents. CAS No. 476-66-4. | |
| Ellagic acid | Ellagic acid. Synonyms: 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Eleagic acid, Gallogen, Lagistase. CAS No. 476-66-4. Product ID: CDC10-0049. Molecular formula: C14H6O8 xH2O. Category: Antioxidant Cosmetic Chemicals. Product Keywords: Cosmetic Ingredients; Antioxidant Cosmetic Chemicals; Ellagic acid; CDC10-0049; 476-66-4; C14H6O8 xH2O; 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Eleagic acid, Gallogen, Lagistase; 207-508-3; MFCD00006914; 476-66-4. Purity: ≥95% (HPLC). Color: Tan to gray. EC Number: 207-508-3. Physical State: Powder. Solubility: 1 M NaOH: 10 mg/mL. Quality Level: 200. Storage: 2-8°C. Boiling Point: 363.24°C (rough estimate). Melting Point: ≥350 °C. Density: 1.667 g/mL. |  |
| Ellagic acid | 25g Pack Size. Group: Aroma Chemicals, Biochemicals, Flavours and Fragrance Materials. Formula: C14H6O8. CAS No. 476-66-4. Prepack ID 23304412-25g. Molecular Weight 302.19. See USA prepack pricing. |  |
| Ellagic acid | Ellagic acid appears as cream-colored needles (from pyridine) or yellow powder. Odorless. (NTP, 1992);Solid. Group: Monomers. Alternative Names: Eleagicacid. CAS No. 476-66-4. Product ID: 6, 7, 13, 14-Tetrahydroxy-2, 9-dioxatetracyclo[6.6.2.04, 16.011, 15]hexadeca-1(15), 4, 6, 8(16), 11, 13-hexaene-3, 10-dione. Molecular formula: 302.19. Mole weight: C14H6O8. C1=C2C3=C (C (=C1O)O)OC (=O)C4=CC (=C (C (=C43)OC2=O)O)O. InChI=1S/C14H6O8/c15-5-1-3-7-8-4 (14 (20)22-11 (7)9 (5)17)2-6 (16)10 (18)12 (8)21-13 (3)19/h1-2, 15-18H. AFSDNFLWKVMVRB-UHFFFAOYSA-N. 98%. | |
| Ellagic acid | Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2 , with an IC 50 of 40 nM and a K i of 20 nM. Uses: Scientific research. Group: Natural products. CAS No. 476-66-4. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0183. | |
| Ellagic Acid | Ellagic Acid is a phenol antioxidant found naturally in various fruits and vegetables. Ellagic Acid was shown to exhibit high levels of antiproliferative and antioxidant properties in studies, which suggests its potential health benefits following ellagic acid consumption. Group: Biochemicals. Alternative Names: Alizarin yellow; Alizarine Yellow; Benzoaric acid; C.I. 55005; C.I. 75270; Elagostasine; Eleagic acid; G 91006; Gallogen; Gallogen (astringent); LDN 0097519; Lagistase. Grades: Highly Purified. CAS No. 476-66-4. Pack Sizes: 25g. Molecular Formula: C??H?O?, Molecular Weight: 302.19. US Biological Life Sciences. | Worldwide |
| Ellagic acid, 96% | Ellagic acid appears as cream-colored needles (from pyridine) or yellow powder. Odorless. (NTP, 1992);Solid. Group: Monomers. CAS No. 476-66-4. Product ID: 6, 7, 13, 14-tetrahydroxy-2, 9-dioxatetracyclo[6.6.2.04, 16.011, 15]hexadeca-1(15), 4, 6, 8(16), 11, 13-hexaene-3, 10-dione. Molecular formula: 302.19g/mol. Mole weight: C14H6O8. C1=C2C3=C (C (=C1O)O)OC (=O)C4=CC (=C (C (=C43)OC2=O)O)O. InChI=1S/C14H6O8/c15-5-1-3-7-8-4 (14 (20)22-11 (7)9 (5)17)2-6 (16)10 (18)12 (8)21-13 (3)19/h1-2, 15-18H. AFSDNFLWKVMVRB-UHFFFAOYSA-N. | |
| Ellagic acid dihydrate | Ellagic acid dihydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 133039-73-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H6O8.2H2O, Molecular Weight: 338.223. US Biological Life Sciences. | Worldwide |
| Ellagic Acid, Dihydrate - CAS 476-66-4 | A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Group: Fluorescence/luminescence spectroscopy. | |
| Ellagic Acid (Hydrate) | Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 314041-08-2. Molecular formula: C14H8O9. Mole weight: 320.21. Product ID: ACM314041082-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ellipticine | Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 71795. CAS No. 519-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-15753. | |
| Ellipticine | Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE;5,11-DIMETHYLPYRIDO[4.3:B]CARBAZOLE;5,11-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE;ELLIPTICINE;3-b)carbazole,5,11-dimethyl-6h-pyrido(;icig770;ELLIPTICINE, FOR FLUORESCENCE;ELLIPTICINE(RG). Product Category: Inhibitors. CAS No. 519-23-3. Molecular formula: C17H14N2. Mole weight: 246.31. Density: 1.257±0.06 g/cm³ (20 ºC 760 Torr). Product ID: ACM519233. Alfa Chemistry ISO 9001:2015 Certified. | |
| ELLIPTICINE | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian evergreen tree of the Apocynaceae family. Ellipticine was found to be an extremely promising anticancer drug. The planar polycyclic structure was found to interact with DNA through intercalation, exhibiting a high DNA binding affinity (10(6) M(-1)). The presence of protonatable ring nitrogens distinguished ellipticine from other simple intercalators. Both monocationic and uncharged species were found to be present under physiological conditions. The positive charge stabilized the binding of ellipticine to nucleic acids, while the more lipophilic uncharged compound was shown to readily penetrate membrane barriers. The structural nature of these compounds offers a plausible basis for the implication of multiple modes of action, including DNA binding, interactions with membrane barriers, oxidative bioactivation and modification of enzyme function; most notably that of topoisomerase II and telomerase. (Curr Med Chem Anticancer Agents. 2004 Mar;4(2):149-72). Synonyms: BRN 0221300; CCG-36483; CCRIS 2003; DB-052047; elliptecine; ellipticine; Elliptisine; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809. Grade: 0.98. CAS No. 519-23-3. Molecular formula: C17H14N2. Mole weight: 246.31. | |
| Ellipticine - CAS 519-23-3 | A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Group: Fluorescence/luminescence spectroscopy. | |
| Ellipticine hydrochloride | Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 71795 hydrochloride. CAS No. 5081-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15753A. | |
| Ellipticine hydrochloride | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is a natural product isolated from the Australian evergreen tree of the Apocynaceae family. Synonyms: NSC 71795 hydrochloride; Ellipticine HCl; PZE. CAS No. 5081-48-1. Molecular formula: C17H15ClN2. Mole weight: 282.77. | |
| Ellipticine (NSC 71795) | Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7uM. Group: Biochemicals. Alternative Names: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole, NSC 71795. Grades: Highly Purified. CAS No. 519-23-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H14N2, Molecular Weight: 246.3. US Biological Life Sciences. | Worldwide |
| Elloramycin | It is produced by the strain of Streptomyces olivaceus Tu 2353. It has weak activity against gram-positive bacteria, streptomycete and L-1210 leukemic cells, but has no effect on mouse leukemic P388 cells in vivo, and also has a strong inhibition of Streptomyces (including the production of bacteria themselves) activity. Synonyms: Elloramycin A; methyl (6aR,7S,10aR)-3-[(6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-6a,7,12-trihydroxy-8,10a-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate; (6aR)-3-[(2-O,3-O,4-O-Trimethyl-6-deoxy-α-L-mannopyranosyl)oxy]-6,6a,7,10,10a,11-hexahydro-6aα,7α,12-trihydroxy-8,10aα-dimethoxy-1-methyl-6,10,11-trioxo-2-naphthacenecarboxylic acid methyl ester. CAS No. 97218-42-3. Molecular formula: C32H36O15. Mole weight: 660.62. | |
| Elmycin B ((1aR, 3S, 5bR, 11S, 11aR, 11bR)-10, 11, 11a-Trihydroxy-3-methyl-3, 4, 5b, 11, 11a, 11b-hexahydrotetrapheno[5, 6-b]oxirene-5, 6(1aH, 2H)-dion) | Antibiotic. Antibacterial. Moderate cytotoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 128233-09-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| ELN318463 | ELN318463, a selective γ-secretase inhibitor of amyloid precursor protein (APP), has differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 and 656 nM for PS1 and PS2, respectively. It is 51-fold more selective for PS1. Synonyms: N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-hexahydro-2-oxo-1H-azepin-3-yl]-Benzenesulfonamide; N-(4-Bromobenzyl)-4-chloro-N-[(3R)-2-oxo-3-azepanyl]benzenesulfonamide; Benzenesulfonamide, N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-hexahydro-2-oxo-1H-azepin-3-yl]-. Grade: ≥98%. CAS No. 851600-86-7. Molecular formula: C19H20BrClN2O3S. Mole weight: 471.80. | |
| ELN318463 racemate | ELN318463 racemate is the racemate of ELN318463, which is a selective γ-secretase inhibitor of amyloid precursor protein (APP). Synonyms: Benzenesulfonamide, N-[(4-bromophenyl)methyl]-4-chloro-N-(hexahydro-2-oxo-1H-azepin-3-yl)-; N-(4-Bromobenzyl)-4-chloro-N-(2-oxo-3-azepanyl)benzenesulfonamide. Grade: ≥90%. CAS No. 851599-82-1. Molecular formula: C19H20BrClN2O3S. Mole weight: 471.80. | |
| ELN 441958 | ELN441958 is a novel, potent and selective bradykinin B1 receptor antagonist with Ki value of 0.26 nM. It competitively inhibited the binding of the agonist [3H]DAKD to the human B1 receptor in IMR-90 lung fibroblast cell membranes. It is highly selective for B1 over B2 receptors and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor. It also inhibited human μ-, δ-, κ- opioid receptors and muscarinic M1 receptor with Ki values of 0.13, 0.69, 1.5 and 0.37 μM, respectively. It exhibited good permeability and metabolic stability in vitro. It exhibited high oral bioavailability and moderate plasma half-lives in rats and rhesus monkeys. It does not inhibit the activation of the human bradykinin B2 receptor at concentrations up to 10 μM. It has a moderate clearance and volume of distribution in both species following i.v. administration, consistent with the high metabolic stability in rat, rhesus, and human microsomes. Uses: Eln441958 exhibited high oral bioavailability and moderate plasma half-lives. Synonyms: ELN441958; ELN 441958; ELN-441958; 7-Chloro-2-[3-[[9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecan-3-yl]carbonyl]phenyl]-2,3-dihydroisoindol-1-one. Grade: >98%. CAS No. 913064-47-8. Molecular formula: C29H29ClN4O2. Mole weight: 501.02. | |
| ELN484228 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ELN 484228 | ELN 484228 is an α-Synuclein blocker with activity in cellular models of α-synuclein-mediated dysfunction such as Parkinson's Disease. Study showed that ELN484228 reduced synaptic levels of αSyn in neuronal cultures from both wild type rats and from transgenic mice overexpressing αSyn by not more than two-fold. Synonyms: ELN484228; ELN-484228; ELN 484228. N-(4-Fluorophenyl)benzenesulfonamide. Grade: 99%. CAS No. 312-63-0. Molecular formula: C12H10FNO2S. Mole weight: 251.28. | |
| ELND006 | ELND006 is one of the newest molecules to be reported on regarding the testing of the β-amyloid hypothesis. ELND006 is a novel oral γ-secretase inhibitor. At the 2010 Alzheimer's Association International Conference on Alzheimer's Disease in which ELND006 was reported to have an in vitro IC50 = 0.34 nM against APP and IC50 = 5.3 nM versus Notch signaling. Synonyms: ELND006; ELND-006; ELND 006. (4R)-4-cyclopropyl-7,8-difluoro-5-[4-(trifluoromethyl)phenyl]sulfonyl-1,4-dihydropyrazolo[4,3-c]quinoline; UNII-7F5QGV49GL; ELND006; ELND-006; 959997-22-9; (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo(4,3-c)quinoline; (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline; 7F5QGV49GL; SCHEMBL486044; GTPL7337; CHEMBL2396778. CAS No. 1333990-84-3. Molecular formula: C20H14F5N3O2S. Mole weight: 455.07. | |
| ELND006 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ELND007 | ELND007 is a γ-secretase inhibitor. Synonyms: ELND007; ELND-007; ELND 007. (R)-4-cyclopropyl-8-fluoro-5-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline; ELND007; ELND-007; ELND 007. CAS No. 1444006-79-4. Molecular formula: C19H14F4N4O2S. Mole weight: 438.08. | |
| Elobixibat | Elobixibat is a potent and selective IBAT inhibitor under development for the treatment of chronic constipation and irritable bowel syndrome with constipation. Uses: Sodium-bile acid cotransporter-inhibitor. Synonyms: AZD-7806; AZD 7806; AZD7806; A 3309; A3309; A-3309; AJG-533; (2R)-N-[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycylglycine. Grade: ≥95%. CAS No. 439087-18-0. Molecular formula: C36H45N3O7S2. Mole weight: 695.89. | |
| Elobixibat | Elobixibat (A 3309; AZD 7806) is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor, with an IC 50 value of 0.53 nM (human IBAT ), 0.13 nM (mouse IBAT), 5.8 nM (canine IBAT). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A 3309; AZD 7806. CAS No. 439087-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15790. | |
| Elobixibat hydrate | Elobixibat hydrate is a potent ileal bile acid transporter (IBAT) inhibitor, with IC 50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT. Elobixibat hydrate can be used for chronic idiopathic constipation (CIC) research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A 3309 hydrate; AZD 7806 hydrate. CAS No. 1633824-78-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15790A. | |
| Elocalcitol | BXL 628 is a vitamin D3 analogue that competes with vitamin D receptor (VDR) for inhibition of prostate cell growth and RhoA/Rho-kinase signaling, a calcium sensitizing pathway. BXL 628 exhibits anti-proliferative and anti-inflammatory properties in benign prostatic hyperplasia (BPH) treatment. Uses: Potential treatment of benign prostatic hyperplasia (bph). Synonyms: BXL 628; BXL-628; Ro-26-9228; 1alpha-Fluoro-25-hydroxy-16,23E-diene-26,27-bishomo-20-epi-cholecalciferol. Grade: 99%. CAS No. 199798-84-0. Molecular formula: C29H43FO2. Mole weight: 442.65. | |
| Elomotecan | Elomotecan (BN-80927) belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilization, thus indicating catalytic inhibition. Moreover, a Topo I-altered cell line (KBSTP2), resistant to SN38, remains sensitive to BN80927, suggesting that a part of the antiproliferative effects of BN80927 are mediated by a Topo I-independent pathway. This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G(0)-G(1) synchronized). In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC(50) values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate | |
| Elomotecan HCl salt | Elomotecan, also referred to BN 80927 and R 1559, characterized by a stable seven-membered beta-hydroxylactone ring, is a DNA topoisomerase inhibitor. In vivo elomotecan shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Synonyms: 220997-99-9; 220998-10-7 (Elomotecan free base); (5R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methylpiperidin-1-yl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione hydrochloride (1:1). Grade: >98%. CAS No. 220997-99-9. Molecular formula: C29H33Cl2N3O4. Mole weight: 558.5. | |
| elongation factor 2 kinase | Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+. Group: Enzymes. Synonyms: Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Enzyme Commission Number: EC 2.7.11.20. CAS No. 116283-83-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3140; elongation factor 2 kinase; EC 2.7.11.20; 116283-83-1; Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Cat No: EXWM-3140. | |
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