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Fmoc-Thr(tBu)-Phe-OH is a protected dipeptide used in peptide synthesis. It includes an Fmoc (Fluorenylmethyloxycarbonyl) group protecting the N-terminus, preventing unwanted reactions during assembly. The Thr (Threonine) residue is protected at its hydroxyl side chain with a tBu (tert-butyl) group, safeguarding it from side reactions. Phe (Phenylalanine) is the second amino acid in the sequence, contributing aromatic properties. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is used to introduce threonine and phenylalanine residues into peptides, with specific protections in place to allow for controlled synthesis. Synonyms: N-(Fluorenylmethoxycarbonyl)-O3-tert-butyl-L-threonyl-L-phenylalanine; (N-Fmoc-O-tert-butyl-L-threoninyl)-L-phenylalanine; N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-threonyl-L-phenylalanine; (2S)-2-[(2S,3R)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-3-phenylpropanoic acid; TF; Fmoc-Thr(OtBu)-Phe-OH. Grade: ≥95%. CAS No. 1962160-86-6. Molecular formula: C32H36N2O6. Mole weight: 544.65.
Fmoc-Thr(tBu)-Phe-Thr(tBu)-OH
Fmoc-Thr(tBu)-Phe-Thr(tBu)-OH is a protected tripeptide used in peptide synthesis. The Fmoc (Fluorenylmethyloxycarbonyl) group protects the N-terminus of the threonine (Thr) residue, preventing it from reacting during synthesis. The hydroxyl groups on the side chains of both threonine residues are protected by tBu (tert-butyl) groups, ensuring these groups remain unreactive until selective deprotection is performed. Phe (Phenylalanine), the central amino acid, adds aromatic and hydrophobic characteristics to the peptide. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is utilized to introduce threonine and phenylalanine into peptides, with specific protections to control the reactivity of the functional groups, ensuring efficient and selective peptide synthesis. Synonyms: TFT; N-N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-threonyl-L-phenylalanyl-O-(tert-butyl)-L-threonine. Grade: ≥95%. Molecular formula: C40H51N3O8. Mole weight: 701.86.
The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for synthesizing phosphothreonine-containing peptides and peptides modified at the threonine side-chain. The use of trityl-protected amino acids resulted in purer products than when standard t-Bu-protected amino acids were utilized. Uses: Fmoc solid-phase peptide synthesis. Additional or Alternative Names: Fmoc-Thr(Trt)-OH, N-α-Fmoc-O-trityl-L-threonine. Product Category: Amino Acids. CAS No. 133180-01-5. Molecular formula: C38H33NO5. Mole weight: 583.7. Product ID: ACM133180015. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Thr-Wang resin
Excellent resin for the synthesis of peptide acids using Fmoc strategy. Cleavage can be effected by 95% TFA.
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Tic-Wang Resin; (S)-N-(9-Fluorenylmethoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid p-methoxybenzyl alcohol resin.
Fmoc-Tic-OH
Standard building block for introduction of Tic amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tic-OH, N-1-Fmoc-L-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid. Product Category: Amino Acids. CAS No. 136030-33-6. Mole weight: 399.44. Product ID: ACM136030336. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-TOAC-OH is a useful tool for the incorporation of the ESR spin-label TOAC into peptide sequences by Fmoc SPPS. Incorporation of this derivative and the following residue is best achieved using HATU activation. TFA/water/TIS should be used for cleavage of TOAC-containing peptides. The use of EDT should be avoided as it can cause permanent reduction of the nitroxide radical. Following cleavage, the TOAC peptide should be treated with aqueous ammonia in air to regenerate the nitroxide from the hydroxylamine that is generated by the TFA treatment. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-TOAC-OH, 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-(9-fluorenylmethyloxycarbonyl-amino)-4-carboxylic acid. Product Category: Amino Acids. CAS No. 93372-25-9. Mole weight: 437.51. Product ID: ACM93372259-1. Alfa Chemistry ISO 9001:2015 Certified.
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Trp-Wang-PEG Resin; N-α-(9-Fluorenylmethoxycarbonyl)-L-tryptophan p-methoxybenzyl alcohol polyethyleneglycol resin.
Fmoc-Trp(Boc)-2-Chlorotrityl Resin
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
Fmoc-Trp(Boc)-Alko-PEG Resin
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Trp(Boc)-Wang-PEG Resin; N-α-(9-Fluorenylmethoxycarbonyl)-1-(t-butoxycarbonyl)-L-tryptophan p-methoxybenzyl alcohol polyethyleneglycol resin.
Fmoc-Trp(Boc)-Alko Resin
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Trp(Boc)-Wang Resin; N-α-(9-Fluorenylmethoxycarbonyl)-1-(t-butoxycarbonyl)-L-tryptophan p-methoxybenzyl alcohol resin.
Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH. Group: Biochemicals. Alternative Names: N(in)-Boc-Na-Fmoc-L-tryptophan. Grades: Highly Purified. CAS No. 143824-78-6. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C31H30N2O6. US Biological Life Sciences.
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Trp-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Trp(Boc)-Ser(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 908601-15-0. Mole weight: 653.72. Product ID: ACM908601150. Alfa Chemistry ISO 9001:2015 Certified. Categories: Fmoc-Trp(Boc)-Ser(Psi(Me,Me)pro)-OH.
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Trp-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Trp(Boc)-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 936707-21-0. Mole weight: 667.75. Product ID: ACM936707210. Alfa Chemistry ISO 9001:2015 Certified.
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Trp(Mts)-Wang-PEG Resin; N-α-(9-Fluorenylmethoxycarbonyl)-1-mesitylene-2-sulfonyl-L-tryptophan p-methoxybenzyl alcohol polyethyleneglycol resin.
Building block for introduction of typtophan by Fmoc SPPS. Superceded by Fmoc-Trp(Boc)-OH. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Trp-OH, N-α-Fmoc-L-tryptophan. Product Category: Amino Acids. CAS No. 35737-15-6. Mole weight: 426.46. Product ID: ACM35737156. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Trp-OH-15N2
Fmoc-Trp-OH-15N2. Uses: Peptide synthesis. Additional or Alternative Names: L-Tryptophan-15N2, α-N-Fmoc derivative. Product Category: Amino Acids. CAS No. 1217472-80-4. Mole weight: 428.45. Canonical SMILES: OC(=O)[C@H](Cc1c[15nH]c2ccccc12)[15NH]C(=O)OCC3c4ccccc4-c5ccccc35. Product ID: ACM1217472804. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-trp-opfp
Fmoc-trp-opfp. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FMOC-L-TRYPTOPHAN PENTAFLUOROPHENYL ESTER;FMOC-TRYPTOPHAN-OPFP;FMOC-TRP-OPFP;N-ALPHA-FMOC-L-TRYPTOPHAN PENTAFLUOROPHENYL ESTER;NALPHA-9-Fluorenylmethoxycarbonyl-L-tryptophanpentafluoroph;NALPHA-9-Fluorenylmethoxycarbonyl-L-tryptophan pentafluorophenyl es. Product Category: Heterocyclic Organic Compound. CAS No. 86069-87-6. Molecular formula: C32H21F5N2O4. Mole weight: 592.52. Purity: 0.96. IUPACName: (2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoate. Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)OC6=C(C(=C(C(=C6F)F)F)F)F. Density: 1.452g/cm³. Product ID: ACM86069876. Alfa Chemistry ISO 9001:2015 Certified.
Excellent resin for the synthesis of peptide acids using Fmoc strategy. Cleavage can be effected by 95% TFA. Synonyms: Fmoc-L-Trp-Wang resin; Nα-Fmoc-L-tryptophan 4-alkoxybenzyl alcohol resin.