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| Product | Description | |
|---|---|---|
| RO-3306, CDK 1 Inhibitor ((5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one) | Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Group: Biochemicals. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. |  Worldwide |
| Ro 363 hydrochloride | Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 250580-70-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123268A. |  |
| Ro 41-0960 comt inhibitor | Heterocyclic Organic Compound. Alternative Names: Lopac-R-108, Ro 41-0960, R108_SIGMA, Lopac0_001044, C13H8FNO5, MLS002153480, OR 1139, MolPort-003-959-437, 2-fluoro-3,4-dihydroxy-5-nitrobenzophenone, CID3495594, OR-1139, Ro41-0960, NCGC00015881-01, NCGC00015881-02, NCGC00015881-04, NCGC00094329-01, NCGC00094329-02, Ro-41-0960, LS-91225, SMR000326831. CAS No. 125628-97-9. Molecular formula: C13H8FNO5. Mole weight: 277.2. Purity: 0.96. IUPACName: (3,4-dihydroxy-5-nitrophenyl)-(2-fluorophenyl)methanone. Canonical SMILES: C1=CC=C (C (=C1)C (=O)C2=CC (=C (C (=C2)O)O)[N+] (=O)[O-])F. Density: 1.536g/cm³. Catalog: ACM125628979. |  |
| Ro 41-1049 hydrochloride | Heterocyclic Organic Compound. Alternative Names: RO 41-1049 HCL MAO-A INHIBITOR;RO 41-1049 HYDROCHLORIDE MAO-A INHIBITOR;Ro 41-1049;N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide;N-(2-Aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide. CAS No. 127500-84-9. Molecular formula: C12H12FN3OS.HCl. Mole weight: 301.77. Appearance: white solid. Catalog: ACM127500849. | |
| Ro 41-1049 hydrochloride | The hydrochloride salt form of Ro 41-1049 which is a MAO-A inhibitor and probably could be used in the study of Parkinson's disease. Uses: The hydrochloride salt form of ro 41-1049 which is a mao-a inhibitor and probably could be used in the study of parkinson's disease. Synonyms: RO-41-1049 hydrochloride; RO 41-1049 hydrochloride; RO-41-1049 HCl; UNII-19Z49HUF4G; N-(2-Aminoethyl)-5-(3-fluorophenyl)-4-thiazolecarboxamide hydrochloride; Ro 41-1049 (hydrochloride); AC1NSKEH; R107_SIGMA. Grades: 98%. CAS No. 127917-66-2. Molecular formula: C12H13ClFN3OS. Mole weight: 301.77. |  |
| Ro 41-?3290 | Ro 41-3290, a desethylated metabolite of Ro 41-3696, has shown to be also a partial agonist at the benzodiazepine receptor. Synonyms: 10-chloro-1-[(3S)-3-hydroxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydrobenzo[a]quinolizin-4-one; Ro 41-3290; Ro-41-3290. CAS No. 143943-72-0. Molecular formula: C24H21ClN2O3. Mole weight: 420.89. | |
| RO4389620 | RO4389620 is a glucokinase activator. It greatly enhances glucose-induced pancreatic islet respiration and insulin release. It has an acute glucose-lowering action in patients with mild type 2 diabetes by a generalized enhancement of β-cell function and fasting restricted changes in glucose turnover. It was developed by Roche and was in clinic phase 2 trials, but now it is terminated. Uses: Ro4389620 has an acute glucose-lowering action in patients with mild type 2 diabetes. Synonyms: RO-4389620; RO 4389620; Piragliatin; (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3-oxocyclopentyl)-N-(pyrazin-2-yl)propanamide. Grades: 98%. CAS No. 625114-41-2. Molecular formula: C19H20ClN3O4S. Mole weight: 421.89. | |
| RO462005 | RO462005 is an endothelin receptor selective agonist. Uses: Endothelin receptor antagonists. Synonyms: RO462005; RO-462005; RO 462005; Ro-46-2005; Ro 46-2005; Ro46-2005. Grades: 98%. CAS No. 150725-87-4. Molecular formula: C23H27N3O6S. Mole weight: 473.54. | |
| RO-46-8443 | RO-46-8443, a benzenesulfonamide derivative, has been found to be a non-peptide endothelin ETB receptor antagonist and could probably be useful in some biological studies of ETB receptors in pathology. Synonyms: RO 46-8443; RO46-8443; RO-46-8443; RO 468443; RO-468443; RO468443; RO 46,8443; RO-46,8443; RO46,8443. 4-tert-butyl-N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl]benzenesulfonamide; AC1NSM3O; SCHEMBL795046; GTPL1011; Ro 46-8443. Grades: 98%. CAS No. 175556-12-4. Molecular formula: C31H35N3O8S. Mole weight: 609.69. | |
| Ro 48-8071 | Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Synonyms: Ro-48-8071. Grades: >98%. CAS No. 161582-11-2. Molecular formula: C23H27BrFNO2. Mole weight: 448.37. | |
| Ro 48-8071 fumarate | Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC 50 of appr 6.5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 189197-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18630A. | |
| Ro 48-8071 fumarate | Ro 48-8071 fumarate. Group: Biochemicals. Grades: Purified. CAS No. 189197-69-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 48-8071 fumarate | Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Synonyms: Ro 48-8071; Ro48-8071; Ro-48-8071; Ro 488071; Ro488071; Ro-488071. Grades: >98%. CAS No. 189197-69-1. Molecular formula: C27H31BrFNO6. Mole weight: 564.44. | |
| RO4927350 | RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback increase in MEK phosphorylation, which has been observed with other MEK inhibitors. Synonyms: RO 4927350; RO-4927350. CAS No. 876755-27-0. Molecular formula: C27H28N4O6S. Mole weight: 536.60. | |
| RO4929097 | RO4929097 is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively and in Phase 2. Group: Fluorinated apis. CAS No. 847925-91-1. Molecular formula: C22H20F5N3O3. Mole weight: 469.4. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide. Catalog: OFC847925911. | |
| RO4929097 | RO4929097, a small-molecule inhibitor of γ secretase (IC50 = 4 nM, EC50=5 nM), inhibits cellular processing of Aβ40 (EC50 = 14 nM) and Notch (EC50 = 5 nM). It was shown to decrease the levels of Notch transcriptional target HES1 in human primary melanoma cell lines. Uses: Enzyme inhibitors. Synonyms: RO-4929097; 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide. Grades: >98%. CAS No. 847925-91-1. Molecular formula: C22H20F5N3O3. Mole weight: 469.4. | |
| RO4987655 | RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: RO4987655; RO-4987655; RO 4987655; CH4987655; CH-4987655; CH 4987655. CAS No. 874101-00-5. Molecular formula: C20H19F3IN3O5. Mole weight: 565.288. | |
| RO-5028442 | RO-5028442 is a potent and brain-penetrant hV1a antagonist. RO-5028442 is undergoing clinical trials for autistic disorder therapy. Synonyms: RO-5028442; RO 5028442; RO5028442. [6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone. CAS No. 920022-47-5. Molecular formula: C25H28ClN3O2. Mole weight: 437.968. | |
| RO5045337 | RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Synonyms: R7112, RG7112, RG 7112; RG-7112; RO5045337; RO 5045337; RO-5045337. CAS No. 939981-39-2. Molecular formula: C38H48Cl2N4O4S. Mole weight: 727.786. | |
| RO5068760 | RO5068760 is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation. Synonyms: RO5068760; RO 5068760; RO-5068760. CAS No. 947182-25-4. Molecular formula: C28H27FIN3O6. Mole weight: 647.44. | |
| Ro 51 | Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3 (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively), without significant activity on other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Synonyms: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol; Ro51; Ro-51; CHEMBL494161; 1050670-85-3; SCHEMBL4970553. Grades: ≥98% by HPLC. CAS No. 1050670-85-3. Molecular formula: C17H23IN4O4. Mole weight: 474.29. | |
| Ro 51 | Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3. P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Group: Biochemicals. Alternative Names: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2-pyrimidinyl]amino]-1,3-propanediol; RO-51. Grades: Highly Purified. CAS No. 1050670-85-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| RO5126766 | RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis. Synonyms: RO5126766; RO 5126766; RO-5126766; CH5126766; CH-5126766; CH 5126766. Grades: >98%. CAS No. 946128-88-7. Molecular formula: C21H18FN5O5S. Mole weight: 471.463. | |
| RO5166017 | RO5166017 is a highly potent, selective, and orally active agonist for the trace amine-associated receptor 1(TAAR1) with no significant activity at other targets. It is weak and rapidly metabolized (endogenous ligands). It has strong pharmacological activity at other targets. Uses: Ro5166017 has strong pharmacological activity. Synonyms: RO5166017; RO 5166017; RO-5166017; (4S)-4-[(N-ethylanilino)methyl]-4,5-dihydro-1,3-oxazol-2-amine;RO-5166017;(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine. Grades: >98 %. CAS No. 1048346-74-2. Molecular formula: C12H17N3O. Mole weight: 219.29. | |
| Ro5203280 | Ro5203280 is a small-molecular PLK1 inhibitor. Ro5203280 shows a high efficacy for suppressing nasopharyngeal carcinoma growth with low toxicity in mouse studies. It suppresses nasopharyngeal carcinoma growth by inducing G2-M arrest and mitotic arrest and finally induces apoptosis through inhibiting PLK1 phosphorylation. Ro5203280 may be a potential chemotherapeutic agent for nasopharyngeal carcinoma treatment. Synonyms: RO3280; RO-3280; RO 3280; Ro5203280; Ro-5203280; Ro 5203280. Grades: 0.98. CAS No. 1062243-51-9. Molecular formula: C27H35F2N7O3. Mole weight: 543.62. | |
| RO-5203648 | RO-5203648 is a novel selective full agonist of the trace amine-associated receptor 1 (TAAR1). It showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. It increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. It displayed clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties. Uses: Ro-5203648 displayed clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties. Synonyms: RO-5203648; RO 5203648; RO5203648; (4S)-4-(3,4-dichlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine;RO5203648;(S)-4-(3,4-dichlorophenyl)-4,5-dihydrooxazol-2-amine. Grades: >99 %. CAS No. 1043491-54-8. Molecular formula: C9H8Cl2N2O. Mole weight: 231.07. | |
| RO-5256390 | RO-5256390 is a novel selective full agonist of the trace amine-associated receptor 1 (TAAR1). It blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties. It promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models. It may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain. It may be used as treatment of cocaine addiction. Uses: Ro-5256390 has antipsychotic-like properties. it may be used as treatment of cocaine addiction. Synonyms: RO5256390; RO 5256390; RO-5256390; (S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine;(4S)-4-[(2S)-2-phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine. Grades: >98 %. CAS No. 1043495-96-0. Molecular formula: C13H18N2O. Mole weight: 218.30. | |
| RO 5263397 | RO5263397 is a selective trace amine-associated receptor 1(TAAR1) agonist. TAAR1 is a drug discovery target for cocaine addiction. RO5263397 is efficacious in reducing cocaine-mediated behaviors and it can dose-dependently prevent cocaine-induced lowering of ICSS thresholds. Uses: Cocaine addiction. Synonyms: RO 5263397; RO5263397; RO-5263397; (4S)?-4-(3-Fluoro-2-methylphenyl)?-4,?5-dihydro-2-oxazolamine. Grades: 98%. CAS No. 1357266-05-7. Molecular formula: C10H11FN2O. Mole weight: 194.21. | |
| Ro 5-3335 | Ro 5-3335, a benzodiazepine, is a core binding factor (CBF) leukemia inhibitor. It is highly active in vitro (IC50 = 0.1-1.0 microM [corrected]) against HIV-1 viruses of AIDS resistant or non-resistant to zidovudine (AZT). Synonyms: Ro 5-3335; Ro-5-3335; Ro 5 3335; 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-pyrrol-2-yl- (7CI,8CI); NSC 66020; NSC66020; NSC-66020. Grades: ≥98% by HPLC. CAS No. 30195-30-3. Molecular formula: C13H10ClN3O. Mole weight: 259.69. | |
| Ro 5-3335 | Ro 5-3335. Group: Biochemicals. Grades: Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro5-3335 | Ro5-3335 Inhibitor. Uses: Scientific use. Product Category: T4687. CAS No. 30195-30-3. |  |
| RO5454948 | Mirk-IN-1 (Dyrk1B/A-IN-1) is a highly efficient and selective inhibitor of Dyrk1B and Dyrk1A, with IC50 values of 68 and 22nM respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mirk-IN-1; Dyrk1B/A-IN-1. CAS No. 1386979-55-0. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12838. | |
| RO5 Drug-like Natural Product Library | 2743 is a collection of natural products that meet the "Lipinski's Rule of Five" and have high potential for drug discovery. - Most of the NPs have clear biological activities, with various functions including anti-tumor, anti-inflammatory, antioxidant, neuroprotection and more. - Structural diversity, containing flavonoids, saponins, terpenoids, alkaloids and other categories. - Various detection techniques such as NMR, HPLC/LCMS to ensure accurate structure and high purity of the products and reduce false positives. Uses: Scientific use. Product Category: L6160. Categories: RO5 Drug-like Natural Product Libraries. | |
| Ro60-0175 | Ro60-0175 is a potent and selective agonist of 5-HT 2C receptor. Ro60-0175 reduces self-administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169675-08-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123838. | |
| Ro 60-0175 fumarate | Ro 60-0175 fumarate. Group: Biochemicals. Grades: Purified. CAS No. 169675-09-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 60-0175 fumarate | Ro 60-0175 fumarate is a potent and selective SR-2 agonist. It is a potent, selective 5-HT2 receptor agonist, with selectivity for the 5-HT2C subtype (pKi= 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Synonyms: Ro 60-0175 fumarate; Ro-60-0175 fumarate; Ro 60 0175 fumarate; Ro600175 fumarate; (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate. Grades: ≥98% by HPLC. CAS No. 169675-09-6. Molecular formula: C11H12ClFN2.C4H4O4. Mole weight: 342.75. | |
| Ro60-0175 fumarate | Ro60-0175 fumarate is a potent and selective agonist of 5-HT 2C receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169675-09-6. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-103140. | |
| Ro 61-8048 | Ro 61-8048. Group: Biochemicals. Grades: Purified. CAS No. 199666-03-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 61-8048 | Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Blood-brain barrier permeable. Orally active. Synonyms: Ro61-8048; Ro 61-8048; Ro-61-8048; Ro618048; Ro 618048; Ro-618048. Grades: >98%. CAS No. 199666-03-0. Molecular formula: C17H15N3O6S2. Mole weight: 421.45. | |
| Ro 64-5229 | Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. Synonyms: Ro64-5229; Ro64-5229; Ro64-5229; (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole; (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole; (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole (9CI); 1-[(1Z)-2-(Cycloheptyloxy)-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole. Grades: ≥99% by HPLC. CAS No. 246852-46-0. Molecular formula: C17H19Cl2N3O. Mole weight: 352.26. | |
| Ro 64-5229 | Ro 64-5229. Group: Biochemicals. Grades: Purified. CAS No. 246852-46-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 64-6198 | Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetration N/OFQ receptor (NOP) agonist with an EC 50 value of 25.6 nM. Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. Ro 64-6198 can be used for stress and anxiety, addiction, neuropathic pain, cough, and anorexia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 280783-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-12844. | |
| Ro 67-4853 | Ro 67-4853. Group: Biochemicals. Grades: Purified. CAS No. 302841-89-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 67-4853 | Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1) (pEC50 value is 7.16 for the rat mGlu1a receptor). It also enhance glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors. Synonyms: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester; Ro67-4853; Ro 67-4853; Ro-67-4853. Grades: ≥99% by HPLC. CAS No. 302841-89-0. Molecular formula: C19H19NO4. Mole weight: 325.36. | |
| Ro 67-7476 | Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator without activity at human mGlu1 receptors. Synonyms: Ro67-7476; Ro-67-7476; Ro 67-7476. (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine. Grades: ≥99% by HPLC. CAS No. 298690-60-5. Molecular formula: C17H18FNO2S. Mole weight: 319.39. | |
| Ro 67-7476 | Ro 67-7476 is a potent positive allosteric modulator of mGluR 1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC 50 of 60.1 nM [1] [2]. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate ( EC 50 =163.3 nM) [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 298690-60-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100403. | |
| Ro 67-7476 | Ro 67-7476. Group: Biochemicals. Grades: Purified. CAS No. 298690-60-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 6842262 | Ro 6842262 is a potent LPA1 antagonist (IC50 = 25 nM) with >1,200-fold selectivity for LPA1 over LPA3. Synonyms: RO-6842262;RO 6842262; RO6842262; 1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1396006-71-5. Molecular formula: C28H26N4O4. Mole weight: 482.53. | |
| RO6889678 | RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. Group: Inhibitors. Alternative Names: RO6889678; RO-6889678; RO 6889678. CAS No. 1578153-27-1. Molecular formula: C21H20ClFN4O5S. Mole weight: 494.92. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid. Canonical SMILES: O=C ([C@H]1N (CC2=C (C (OC)=O)[C@H] (C3=CC=C (F)C=C3Cl)N=C (C4=NC=CS4)N2)CCOC1)O. Catalog: ACM1578153271. | |
| RO8191 | RO8191 is an agonist of interferon α receptor type 2 (IFNAR2) effective against HCV with EC50 value of 200 nM. RO8191 phosphorylates STAT1 and STAT2, which functions as a gateway to the type I IFN signal cascade, and stimulates the phosphorylation of STAT3, 5 and 6. Synonyms: Ro 494-8191; 2-[2,4-bis(trifluoromethyl)imidazo[1,2-a]1,8-naphthyridin-8-yl]-1,3,4-oxadiazole; 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine. Grades: ≥98%. CAS No. 691868-88-9. Molecular formula: C14H5F6N5O. Mole weight: 373.2. | |
| Ro 8-4304 hydrochloride | Ro 8-4304 hydrochloride is a non-competitive NMDA receptor antagonist with > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Synonyms: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride; Ro 8-4304; Ro84304; Ro-8-4304; Ro 8-4304 hydrochloride; Ro 8-4304 HCl. Grades: ≥99% by HPLC. CAS No. 1312991-77-7. Molecular formula: C21H23FN2O3.HCl. Mole weight: 406.88. | |
| Ro 8-4304 hydrochloride | Ro 8-4304 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1312991-77-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RO8994 | RO8994, a spiroindolinone derivative, is an effective MDM2 inhibitor and has been found to have prabable activity against haematological malignancies. IC50: 5 nM and 20 nM in HTRF binding assays and MTT proliferation assays respectively. Uses: Ro8994 is an effective mdm2 inhibitor and has been found to have prabable activity against haematological malignancies. Synonyms: RO8994; RO-8994; RO 8994. Grades: 98%. CAS No. 1309684-94-3. Molecular formula: C31H31Cl2FN4O4. Mole weight: 613.51. | |
| RO9021 | RO9021 is ATP-competative and selective inhibitor of spleen tyrosine kinase (SYK) with IC50 value of 5.6 nM. RO-9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90). This indicates that SYK is the only kinase with 99% competition with RO-9021 (1 uM) in a total of 392 tested kinases. RO9021 also can selectively suppress B-cell receptor signaling. Synonyms: RO-9021; RO 9021; RO9021. 6-[(1R,2S)-2-Amino-cyclohexylamino]-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide. Grades: 98%. CAS No. 1446790-62-0. Molecular formula: C18H25N7O. Mole weight: 355.45. | |
| Ro 90-7501 | Ro 90-7501. Group: Biochemicals. Grades: Purified. CAS No. 293762-45-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 90-7501 | Ro 90-7501, under the IUPCA name 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine, a type of aminoquinolines, is an inhibitor of Aβ42 fibril assembly so that can reduce Aβ42-induced toxicity (EC50 = 2 μM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: RO 90-7501; RO 90 7501; RO 907501; RO907501; RO-90-7501; 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine; Ro 90-7501; 293762-45-5; GNF-Pf-5510; STK367782; CBChromo1_000149; AC1LGN68; Cambridge id 5180073; CBDivE_006377; R0529_SIGMA; CHEMBL578741; SCHEMBL10002475; STOCK2S-20922; CTK8E9490; DTXSID80356431; HMS3262E21; HMS3269A19; Tox21_500670; ZINC18206988; AKOS000635167; AKOS001483260; CCG-221974; LP00670; MCULE-7528949788; NCGC00094031-06; NCGC00261355-01; BAS 03420670; HE063215; HE332505; ST078196; AB00074940-01; AG-690/09405007; BRD-K58299615-001-02-7; 3B1-004024; 2'-(4-aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine; 2'-(4-aminophenyl)-1H,1'H-2,5'-bibenzimidazol-5-amine; 2-[2-(4-aminophenyl)benzimidazol-6-yl]benzimidazole-6-ylamine; 2'-(4-Amino-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-ylamine; 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine; Ro 90-7501|2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine; 2-[2-(4-aminophenyl)-1H-1,3-benzodiazol-6-yl]-1H-1,3-benzodiazol-6-amine; 2-[2-(4-AMINOPHENYL)-3H-1,3-BENZODIAZOL-5-YL]-3H-1,3-BENZODIAZOL-5-AMINE. CAS No. 293762-45-5. Molecular formula: C20H16N6. Mole weight: 340.39. | |
| RO-9187 | RO-9187 is a potent inhibitor of HCV virus replication in the replicon system. It is excellent substrates for deoxycytidine kinase and were phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. It is a new class of antiviral nucleoside with promising preclinical properties as potential medicines for the treatment of HCV infection. Synonyms: RO-9187; RO 9187; RO9187. Grades: >98%. CAS No. 876708-03-1. Molecular formula: C9H12N6O5. Mole weight: 284.23. | |
| ROAD-1 | Oral Mucosal Alpha-Defensin is an antimicrobial peptide found in Macaca mulatta (Rhesus monkey), and has antibacterial and antifungal activity. Synonyms: Rhesus macaque oral alpha-defensin-1; Oral Mucosal Alpha-Defensin. Grades: >98%. Molecular formula: C145H245N61O44S6. Mole weight: 3739.35. | |
| Robatumumab | Robatumumab is a human monoclonal antibody directed against insulin-like growth factor 1 receptor (IGF-1R). Robatumumab has been used in the research of colorectal cancer. Synonyms: Sch 717454; 19D12; MK-7454. CAS No. 934235-44-6. | |
| Robatumumab | Robatumumab (Sch 717454) is an anti-human IGF-1R ( insulin-like growth factor receptor-1 ) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Sch 717454; 19D12. CAS No. 934235-44-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99218. | |
| Robenacoxib | Robenacoxib. Uses: For analytical and research use. Group: Impurity standards. CAS No. 220991-32-2. Molecular Formula: C16H13F4NO2. Mole Weight: 327.28. Catalog: APB220991322. |  |
| Robenacoxib | Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective COX-2 inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220991-32-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118078. | |
| Robenacoxib. | A novel COX-2 selective inhibitor, as a. Group: Biochemicals. Alternative Names: 5-Ethyl-2-[ (2, 3, 5, 6-tetrafluorophenyl) amino]benzeneacetic Acid. Grades: Highly Purified. CAS No. 220991-32-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Robenacoxib Impurity 1 | Robenacoxib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C16H8D5F4NO2. Mole Weight: 332.31. Catalog: APB12127. | |
| Robenacoxib Impurity 2 | Robenacoxib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C17H15F4NO2. Mole Weight: 341.31. Catalog: APB12128. | |
| Robenacoxib Impurity 3 | Robenacoxib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 220991-61-7. Molecular Formula: C16H11F4NO. Mole Weight: 309.26. Catalog: APB220991617. | |
| Robenidine-d8hcl[bis(phenyl-d4)] | Heterocyclic Organic Compound. Alternative Names: Robenidine-d8 hydrochloride, 1,3-Bis[(4-chlorobenzylidene)amino]guanidine-d8 monohydrochloride, 1173097-77-2. CAS No. 1173097-77-2. Molecular formula: 378.72. Mole weight: 378.71. Purity: 98 atom % D. IUPACName: 1, 2-bis[ (E) - (4-chloro-2, 3, 5, 6-tetradeuteriophenyl) methylideneamino]guanidine; hydrochloride. Canonical SMILES: C1=CC (=CC=C1C=NNC (=NN=CC2=CC=C (C=C2)Cl)N)Cl. Cl. Catalog: ACM1173097772. | |
| Robenidine hydrochloride | Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC 50 s of 8.1 and 4.7 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 25875-50-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B2157. | |
| Robinetin | Robinetin. Group: Biochemicals. Alternative Names: 3,3',4',5',7-Pentahydroxyflavone. Grades: Highly Purified. CAS No. 490-31-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C15H10O7. US Biological Life Sciences. | Worldwide |
| Robinin | Robinin. Group: Biochemicals. CAS No. 301-19-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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