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| Product | Description | |
|---|---|---|
| R-(-)-N-Desmethyl mephenytoin | R-(-)-N-Desmethyl mephenytoin. Group: Biochemicals. Alternative Names: R-(-)-Nirvanol, R-(-)-5-ethyl-5-phenylhydantoin. Grades: Highly Purified. CAS No. 65567-32-01. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C11H12N2O2. US Biological Life Sciences. |  Worldwide |
| R-(-)-N-Desmethylmephenytoin (R-(-)-Nirvanol, R-(-)-5-Ethyl-5-phenylhydantoin) | An anticonvulsant, hypnotic. A metabolite of Mephentoin. Group: Biochemicals. Alternative Names: R-(-)-Nirvanol, R-(-)-5-Ethyl-5-phenylhydantoin. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| R(-)-N-Ethylnorapomorphine hydrochloride | R(-)-N-Ethylnorapomorphine hydrochloride is a dopamine D2 receptor agonist. Synonyms: (6aR)-6-ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide. Grades: 99%. CAS No. 123240-93-7. Molecular formula: C18H19NO2.HBr. Mole weight: 362.26. |  |
| Rng 4810 | Heterocyclic Organic Compound. CAS No. 109202-70-2. Purity: 0.96. Catalog: ACM109202702. |  |
| R(-)-Norapomorphine hydrobromide | R(-)-Norapomorphine hydrobromide is a potent dopamine receptor agonist. Synonyms: (R)-5,6,6a,7-Tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide. Grades: 98%. CAS No. 115017-61-3. Molecular formula: C16H15NO2.HBr. Mole weight: 334.21. | |
| R-(-)-Norapomorphine hydrochloride | R-(-)-Norapomorphine hydrochloride. Group: Biochemicals. Alternative Names: (6aR)-5,6,6a,7-Tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride; 6a-b-Noraporphine-10,11-diol hydrochloride; (-)-Norapomorphine hydrochloride. Grades: Highly Purified. CAS No. 420382-69-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C16H16ClNO2. US Biological Life Sciences. | Worldwide |
| RNPA1000 | RNPA1000, an antibiotic , is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC 50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 359600-10-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12824. |  |
| RNPA1000 | RNPA1000 isa RnpA inhibitor as an attractive antimicrobial development candidate. Uses: Rnpa inhibitor. Synonyms: RNPA1000; RNPA-1000; RNPA 1000; 4-[3-[(E)-3-(3-bromoanilino)-2-cyano-3-oxoprop-1-enyl]-2,5-dimethylpyrrol-1-yl]benzoic acid. Grades: ≥98%. CAS No. 359600-10-5. Molecular formula: C23H18BrN3O3. Mole weight: 464.3. | |
| R(-)-N-Propylnorapomorphine hydrobromide | A potent and selective dopamine D2 receptor agonist. Grades: 99%. CAS No. 85199-01-5. Molecular formula: C19H21NO2.HBr. Mole weight: 376.29. | |
| Ro 01-6128 | Ro 01-6128. Group: Biochemicals. Grades: Purified. CAS No. 302841-86-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 01-6128 | Ro 01-6128 is a positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM). Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM. Synonyms: (Diphenylacetyl)-carbamic acid ethy ester; Ro01-6128; Ro-01-6128; Ro 01-6128. Grades: ≥98% by HPLC. CAS No. 302841-86-7. Molecular formula: C17H17NO3. Mole weight: 283.32. | |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D. Group: Inhibitors. Alternative Names: RO0335; RO-0335; RO 0335. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.22. Appearance: Solid powder. Purity: >98%. IUPACName: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide. Canonical SMILES: O=C (NC1=CC=C (S (=O) (N)=O)C=C1Cl)CC2=CC=C (Br)C (OC3=CC (C#N)=CC (Cl)=C3)=C2F. Catalog: ACM867365762. | |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. Synonyms: RO0335; RO 0335; N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoroBenzeneacetamide. Grades: 99%. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.21. | |
| Ro 0437626 | Ro 0437626, a benzimidazole-2-carboxamide derivative, is a selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) with >30-fold selectivity over the P2X 2 , P2X 3 and P2X 2/3 receptors. Synonyms: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide; RO1166446/008; RO116 6446/008; RO116-6446/008; RO116-6446008; RO-0437626; RO 0437626; RO0437626. Grades: ≥98% by HPLC. CAS No. 134362-79-1. Molecular formula: C27H35N5O4S. Mole weight: 525.66. | |
| Ro 0437626 | Ro 0437626. Group: Biochemicals. Grades: Purified. CAS No. 134362-79-1. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| Ro 04-5595 | Ro 04-5595 hydrochloride is a selective NMDA receptor inhibitor (Ki = 31 nM). Synonyms: 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride. Grades: ≥98% by HPLC. CAS No. 64047-73-0. Molecular formula: C19H22ClNO2.HCl. Mole weight: 368.3. | |
| Ro 04-5595 hydrochloride | Ro 04-5595 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 64047-73-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 04-6790 | Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi= 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Some studies indicate that Ro 04-6790 attenuates behavioural effects related to the hypofunction of the NMDA receptor suggesting that this compound might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. Synonyms: Ro 04-6790; Ro04-6790; Ro-04-6790. 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide; Ro 04-6790; Ro04-6790; Ro-04-6790. Grades: ≥98% by HPLC. CAS No. 202466-68-0. Molecular formula: C12H16N6O2S. Mole weight: 308.36. | |
| Ro 04-6790 | Ro 04-6790. Group: Biochemicals. Grades: Purified. CAS No. 202466-68-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RO 04-6790 hydrochloride | RO 04-6790 hydrochloride is a potent and selective serotonin 5-HT6 receptor antagonist. Synonyms: RO 04-6790 hydrochloride; RO-04-6790 hydrochloride; RO046790 hydrochloride; RO 046790 hydrochloride; 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide Dihydrobromide. Grades: 98%. CAS No. 1197333-95-1. Molecular formula: C12H16N6O2S.2HCl. Mole weight: 381.28. | |
| Ro 08-2750 | Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief. Group: Inhibitors. Alternative Names: Ro 08-2750; Ro08-2750; Ro-08-2750; Ro 082750; Ro -082750; Ro082750. CAS No. 37854-59-4. Molecular formula: C13H10N4O3. Mole weight: 270.25. Appearance: Orange to red solid powder. Purity: >95%. IUPACName: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde. Canonical SMILES: O=CC1=C (C)C=C2N=C3C (NC (N=C3N (C)C2=C1)=O)=O. Catalog: ACM37854594. | |
| Ro 08-2750 | Ro 08-2750. Group: Biochemicals. Grades: Purified. CAS No. 37854-59-4. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 08-2750 | Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief. Synonyms: Ro08-2750; Ro-08-2750; Ro 082750; Ro-82750; Ro082750; 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde. Grades: 98%. CAS No. 37854-59-4. Molecular formula: C13H10N4O3. Mole weight: 270.25. | |
| Ro 09-1679 | Ro 09-1679 is a thrombin inhibitor produced by Mortierella alpina NR6773. It inhibits thrombin, Factor Xa, trypsin and papain with IC50 values of 33.6, 3.3, 0.04 and 0.0346 μmol/L. Synonyms: L-Leucinamide, N2-(3-carboxy-1-oxo-2-propenyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, (S-(E))-. CAS No. 141426-89-3. Molecular formula: C22H39N9O6. Mole weight: 525.61. | |
| RO10-5824 | RO10-5824 is a D4-selective partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM), and is approximately 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors. RO10-5824 is a potent candidate for the management of cocaine use disorders. Synonyms: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine; RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824. CAS No. 189744-46-5. Molecular formula: C17H20N4. Mole weight: 280.37. | |
| Ro 10-5824 dihydrochloride | Ro 10-5824 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 189744-94-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 10-5824 dihydrochloride | Ro 10-5824, a D4R partial agonist, might have beneficial effects on attention and impulsivity by modulating baseline gamma activity in the frontal cortex. Synonyms: Ro 10-5824 dihydrochloride; Ro10-5824 dihydrochloride; Ro-10-5824 dihydrochloride; 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;dihydrochloride; Ro 10-5824 (dihydrochloride). CAS No. 189744-94-3. Molecular formula: C17H22Cl2N4. Mole weight: 353.29. | |
| Ro 106-9920 | Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. Group: Biochemicals. Alternative Names: 6- (Phenylsulfinyl) tetrazolo[1, 5-b]pyridazine. Grades: Highly Purified. CAS No. 62645-28-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Ro 106-9920 | Ro 106-9920, a cell-permeable tetrazolopyridazine-phenylsulfoxide compound, is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6 (IC50 < 1 μM in human peripheral blood mononuclear cells). Synonyms: Ro 106-9920; Ro106-9920; Ro-106-9920; 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine. Grades: ≥99% by HPLC. CAS No. 62645-28-7. Molecular formula: C10H7N5OS. Mole weight: 245.26. | |
| RO1138452 | RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Synonyms: RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine. CAS No. 221529-58-4. Molecular formula: C19H23N3O. Mole weight: 309.413. | |
| Ro 1138452 hydrochloride | Ro 1138452 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 1138452 hydrochloride | Ro 1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Synonyms: Ro 1138452 hydrochloride; Ro1138452 hydrochloride; Ro-1138452 hydrochloride; 4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-amine hydrochloride; Ro 1138452 Hcl. Grades: ≥98% by HPLC. Molecular formula: C19H23N3O.HCl. Mole weight: 345.87. | |
| Ro 15-4513 | Ro 15-4513. Group: Biochemicals. Grades: Purified. CAS No. 91917-65-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 15-4513 | Ro 15-4513, a high affinity benzodiazepine ligand, acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Uses: Affinity labels. Synonyms: Ro 15-4513; Ro 154513; Ro-15-4513; 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester. Grades: ≥98% by HPLC. CAS No. 91917-65-6. Molecular formula: C15H14N6O3. Mole weight: 326.31. | |
| Ro15-4513 | Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) [1]. Ro15-4513 is a potent ethanol antagonist [2]. Ro15-4513 has anti-anxiety effect [3]. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 91917-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103476. | |
| Ro18-5362 | Ro18-5362 is the less active prodrug of Ro 18-5364 which is an extremely potent and rapid inhibitor of the gastric mucosal (H+ + K+)-ATPase. Synonyms: 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfanyl]-5,5,7,7-tetramethyl-3H-cyclopenta[f]benzimidazol-6-one; Ro-18-5362. CAS No. 101387-97-7. Molecular formula: C22H25N3O2S. Mole weight: 395.52. | |
| Ro 19-4603 | Ro 19-4603. Group: Biochemicals. Grades: Purified. CAS No. 99632-94-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ro 19-4603 | Ro 19-4603 is a novel potent partial inverse agonist of benzodiazepine (BZ) receptors. Ro19-4603 binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Synonyms: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester; Ro19-4603; Ro 19-4603; Ro-19-4603. Grades: ≥99% by HPLC. CAS No. 99632-94-7. Molecular formula: C15H17N3O3S. Mole weight: 319.38. | |
| Ro 20-1724 | Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. Synonyms: Ro20-1724; Ro 20-1724; Ro-20-1724. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone; 4-[(3-Butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone; 4-(3-Butoxy-4-methoxy benzyl)-2-imidazolidinone; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone; DL-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Roche 20-1724. Grades: ≥99% by HPLC. CAS No. 29925-17-5. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| Ro 20-1724 | Ro 20-1724. Group: Biochemicals. Grades: Purified. CAS No. 29925-17-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) | A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50=2uM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 29925-17-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) | Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 29925-17-5. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| Ro 25-6981 | Ro 25-6981, structurally related to ifenprodil and with no affinity for the known binding sites of non-competitive antagonists such as phencyclidine or MK-801, is a selective and activity-dependent blocker of NMDA receptors containing the NR2B subunit. Synonyms: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;(Z)-but-2-enedioic acid Ro 25-6981 (Maleate) Ro 25-6981 maleate 169274-78-6 1312991-76-6 SCHEMBL16669133 C22H29NO2.C4H4O4 4008AH 4-((1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methyl. Grades: >98 %. CAS No. 169274-78-6. Molecular formula: C22H29NO2.C4H4O4. Mole weight: 455.54. | |
| Ro 25-6981 | Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169274-78-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13993. | |
| RO 25-6981 hydrochloride | RO 25-6981 hydrochloride is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit. Synonyms: Ro 256981 HCl; Ro 25 6981 HCl; Ro 25-6981 HCl; 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol hydrochloride. Grades: 99%. CAS No. 919289-58-0. Molecular formula: C22H29NO2.HCl. Mole weight: 375.93. | |
| Ro 25-6981 maleate | Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro. Group: Biochemicals. Alternative Names: (αR, βS)-α-(4-Hydroxyphenyl)- β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate. Grades: Highly Purified. CAS No. 1312991-76-6. Pack Sizes: 1mg, 10mg, 50mg. Molecular Formula: C22H29NO2.C4H4O4, Molecular Weight: 455.55. US Biological Life Sciences. | Worldwide |
| Ro 25-6981 Maleate | Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312991-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13993A. | |
| Ro 25-6981 Maleate | The Maleate salt form of Ro 25-6981 which is a NMDA receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. IC50: 9 nM. Uses: The maleate salt form of ro 25-6981 which is a nmda receptors blocker and has been found to exhibit neuroprotectant activity in vitro and in vivo. Synonyms: Ro 25-6981 Maleate; Ro25-6981 Maleate; Ro-25-6981 Maleate; αR-(4-hydroxyphenyl)-βS-methyl-4-(phenylmethyl)-1-piperidinepropanol, 2Z-butenedioate. Grades: 98%. CAS No. 1312991-76-6. Molecular formula: C26H33NO6. Mole weight: 455.54. | |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate. Group: Biochemicals. Grades: Purified. CAS No. 1217448-66-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate is a competitive inhibitor of IL-2/ IL-2Rα receptor interaction. Synonyms: methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate; 2,2,2-trifluoroacetic acid; Ro26-4550; Ro-26-4550 trifluoroacetate; Ro 26-4550 trifluoroacetate; Ro264550 trifluoroacetate. CAS No. 1217448-66-2. Molecular formula: C26H30N4O3.CF3CO2H. Mole weight: 560.57. | |
| Ro 27-3225 | Ro 27-3225 is a potent and selective melanocortin 4 receptor (MC4R) agonist. CAS No. 274682-89-2. Molecular formula: C39H52N12O6. Mole weight: 784.90. | |
| RO 28-0450 | RO 28-0450 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO-28-1674; RO 28 1674; RO-28 1674; RO281674; 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide. Grades: 98%. CAS No. 300352-96-9. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO 28-1674 | RO 28-1674 is a glucokinase GK agonist. Synonyms: RO 28-1674; RO 28 1674; RO-28-1674; RO-28 1674; RO281674; (S)-3-cyclopentyl-2-(4-(methylsulfonyl)phenyl)-N-(thiazol-2-yl)propanamide. Grades: 99%. CAS No. 599164-57-5. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| Ro 28-1675 | A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3 mM vs 6 mM with or without 3 μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50 mg/kg via p.o.). Does not affect hexokinase I or II activity. Synonyms: RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675. Grades: >98%. CAS No. 300353-13-3. Molecular formula: C18H22N2O3S2. Mole weight: 378.51. | |
| RO-3 | RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively). RO-3 is used in a combination of compounds to develop a substance used for alleviating pain and skin disorders. Synonyms: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine; RO-3; RO 3; RO3. Grades: ≥98% by HPLC. CAS No. 1026582-88-6. Molecular formula: C16H22N4O2. Mole weight: 302.37. | |
| RO-3 | RO-3 is a potent, CNS-penetrant, and orally active P2X 3 and P2X 2/3 antagonist with pIC 50 s of 5.9 and 7.0 for human homomultimeric P2X 3 and heteromultimeric P2X 2/3 receptors, respectively. RO-3 shows selectivity for P2X 3 and P2X 2/3 over all other functional homomultimeric P2X receptors (IC 50 >10 μM at P2X 1,2,4,5,7 ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026582-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19978. | |
| RO-3 | RO-3. Group: Biochemicals. Grades: Purified. CAS No. 1026582-88-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| RO314724 | RO314724 is a MMP and HDAC inhibitor. Synonyms: RO 314724; RO-314724; (R)-N-(N-(2-(2-(Hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)-L-leucyl)-L-alanine ethyl ester. CAS No. 112105-54-1. Molecular formula: C19H35N3O6. Mole weight: 401.50. | |
| RO31-8220 | Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate or diacylglycerols by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells. Uses: Enzyme inhibitors. Synonyms: RO31-8220; RO 31-8220; RO-31-8220; RO318220. Grades: 0.98. CAS No. 125314-64-9. Molecular formula: C25H23N5O2S. Mole weight: 457.552. | |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate. Group: Biochemicals. Grades: Purified. CAS No. 138489-18-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro 31-8220 Mesylate | Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-&epsilon. Synonyms: RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate; Bisindolylmaleimide IX; BIM IX.Bisindolylmaleimide IX Mesylate. Grades: >98%. CAS No. 138489-18-6. Molecular formula: C25H23N5O2S.CH4O3S. Mole weight: 553.65. | |
| RO3201195 | RO3201195 is an orally bioavailable and highly selective inhibitor of p38 MAPK which was selected for advancement into Phase I clinical trials. Synonyms: RO-3201195; RO 3201195; (5-Amino-1-(4-fluoro-phenyl)-1H-pyrazol-4-yl)-(3-(2,3-dihydroxy-propoxy)-phenyl)-methanone. CAS No. 249937-52-8. Molecular formula: C19H18FN3O4. Mole weight: 371.36. | |
| RO3201195 | RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC 50 value of 190 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 249937-52-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-118612. | |
| Ro 32-0432 hydrochloride | Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold greater selectivity for PKC-βI over PKC- &epsilon (IC50 = 108 nM). Synonyms: Ro 32-0432; Ro 320432; Ro-32-0432. 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; RO 32-0432 HCL; RO 32-0432 HYDROCHLORIDE; BISINDOLYLMALEIMIDE XI, HCL; BISINDOLYLMALEIMIDE XI HYDROCHLORIDE; BISINDOLYLMALEIMIDE XL, HCL; BISINDOYLMALEIMIDE XI HYDROCHLORIDE. Grades: ≥99% by HPLC. CAS No. 151342-35-7. Molecular formula: C28H28N4O2.HCl. Mole weight: 489.01. | |
| Ro 32-3555 | Ro 32-3555 is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). It inhibits both the cartilage and bone changes in this mouse model of OA, and thus shows great potential as a treatment of OA in humans. Synonyms: Ro-32-3555; Ro 32 3555; Ro323555; (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide; Cipemastat; Ro32-3555; 190648-49-8; GFUITADOEPNRML-SJORKVTESA-N; UNII-02HQ4TYQ60; Trocade. Grades: ≥97% by HPLC. CAS No. 190648-49-8. Molecular formula: C22H36N4O5. Mole weight: 436.55. | |
| RO3244794 | RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pK i of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 361457-01-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164580. | |
| Ro3280 | Ro3280 is a Polo-like kinase 1 (PLK1) inhibitor. Ro3280 shows strong antitumor activity in xenograft mouse models, has good selectivity against other kinases and has excellent in vitro cellular potency. Group: Biochemicals. Alternative Names: 4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide. Grades: Highly Purified. CAS No. 1062243-51-9. Pack Sizes: 5mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 543.61. US Biological Life Sciences. | Worldwide |
| Ro 3306 | Ro 3306. Group: Biochemicals. Grades: Purified. CAS No. 872573-93-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RO-3306 | Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards. Group: Biochemicals. Alternative Names: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?OS?. US Biological Life Sciences. | Worldwide |
| RO-3306 | RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis. Synonyms: RO-3306; RO 3306; RO3306. Grades: 0.98. CAS No. 872573-93-8. Molecular formula: C18H13N3OS2. Mole weight: 351.44. | |
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